XBIvsETF 2ETF Comparison
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Choose a second ETF to run a side-by-side ETF comparison with XBI, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/22/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI ETF 2 | -6.26%– | -0.22%– | +24.49%– | +42.01%– | +133.43%– | +23.02%– |
| Flows | XBI ETF 2 | +$557M– | +$217M– | +$898M– | +$1.18B– | +$321M– | +$1.98B– |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI ETF 2 | +30.19%– | +28.98%– | +28.46%– | +33.05%– |
| Max drawdown | XBI ETF 2 | -14.89%– | -14.89%– | -32.94%– | -53.28%– |
| Max drawdown duration | XBI ETF 2 | 64d– | 64d– | 331d– | 1622d– |
Trading data
XBI | ETF 2 | |
Last sale 10/23/2026 at 5:27 PM | $149.90 | – |
| Previous close 10/22/2026 | $151.64 | – |
| Consolidated volume 10/22/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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XBI | ETF 2 | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
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Main metrics
Last update 10/23/2026 at 5:27 PM
Live
Closed
XBI | ETF 2 | |
|---|---|---|
| Last price | $149.90 | – |
| 1D performance | -1.15% | – |
| AuM | $10.55 B | – |
| E/R | 0.35% | – |
Characteristics
XBI | ETF 2 | |
|---|---|---|
| Management strategy | Passive | – |
| Provider | State Street Investment Management | – |
| Benchmark | S&P Biotechnology Select Industry Index | – |
| N° of holdings | 149 | – |
| Asset class | Equities | – |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | – |
| ESG | No | – |
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Exposure
Countries
XBI
USA
95.53%
Other
4.47%
ETF 2
Sectors
XBI
Healthcare
99.18%
Other
0.82%
ETF 2
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Diversification
XBI
Total weight of top 15 holdings out of 15
21.91%
ETF 2
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Top 15 holdings
Data as of August 31, 2026
XBI
Moderna, Inc.
2.81%
Twist Bioscience Corp.
1.89%
Apogee Therapeutics, Inc.
1.50%
Kymera Therapeutics, Inc.
1.40%
Halozyme Therapeutics, Inc.
1.39%
Natera, Inc.
1.37%
Praxis Precision Medicines, Inc.
1.34%
Oruka Therapeutics, Inc.
1.33%
Revolution Medicines, Inc.
1.31%
Travere Therapeutics, Inc.
1.30%
Protagonist Therapeutics, Inc.
1.28%
Dianthus Therapeutics, Inc.
1.27%
CG Oncology, Inc.
1.26%
Vaxcyte, Inc.
1.23%
Erasca, Inc.
1.23%
ETF 2
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