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XBIvsARKGETF Comparison

ETF 1
XBI

SPDR S&P Biotech ETF

This fund is part of
US Health Care
-0.31%
Full XBI fund page
VS
ETF 2
ARKG

ARK Genomic Revolution ETF

This fund is part of
BioTech & Genomics
-0.12%
Full ARKG fund page

SPDR S&P Biotech ETF (XBI) belongs to the US Health Care segment. ARK Genomic Revolution ETF (ARKG) is part of the BioTech & Genomics segment. Both ETFs have the same top 3 sector exposures: and Health Care. XBI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.75% for ARKG. XBI is up 3.65% year-to-date (YTD) with -$59M in YTD flows. ARKG performs worse with -4.22% YTD performance, and -$14M in YTD flows. Run a side-by-side ETF comparison of XBI and ARKG below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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XBI vs ARKG performance and flow charts

Performance

-4.0-2.00.02.04.06.0%Feb 10Feb 18Feb 25Mar 4Mar 11

Cumulative Flows

-400 M-200 M0 M200 M400 M600 M800 MFeb 10Feb 18Feb 25Mar 4Mar 11

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Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Historic performance and flows
Data as of 03/11/2026
1M3MYTD1Y3Y5Y
Perf.
XBI
ARKG
+1.38%-3.97%
+3.11%-10.24%
+3.65%-4.22%
+47.21%+27.40%
+63.16%+1.75%
-13.71%-68.08%
Flows
XBI
ARKG
-$4M-$69M
-$179M-$81M
-$59M-$14M
+$90M-$206M
-$1.64B-$635M
+$1.20B-$2.75B
Volatility and drawdown
3M1Y3Y5Y
Volatility
XBI
ARKG
+25.68%+39.15%
+28.04%+44.66%
+27.26%+42.31%
+32.91%+45.26%
Max drawdown
XBI
ARKG
-8.19%-19.50%
-21.44%-23.94%
-32.94%-51.98%
-57.63%-80.33%
Max drawdown duration
XBI
ARKG
48d47d
141d77d
331d965d
1822d1821d
Trading data

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XBI
ARKG
Last sale
3/12/2026 at 1:30 PM
$122.64
$26.17
Previous close
03/11/2026
$126.38
$27.67
Consolidated volume
03/11/2026
Average volume
30 days
Average discount or premium
30 days
Average Bid/Ask spread
30 days
Replication quality
Data as of February 27, 2026
1-year trailing difference

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ARKG
is actively managed and doesn’t replicate an index

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XBI
ARKG
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst
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Main metrics
Last update 3/12/2026 at 1:30 PM
Live
Closed
XBI
ARKG
Last price
$122.64
$26.17
1D performance
-2.96%
-5.42%
AuM$8.10 B$1.11 B
E/R0.35%0.75%
Characteristics
XBI
ARKG
Management strategyPassiveActive
ProviderSPDRArk Investment
BenchmarkS&P Biotechnology Select Industry Index-
N° of holdings12330
Asset classEquities-
Trailing 12m distribution yield
Join
Join
Inception dateJanuary 31, 2006April 2, 2019
ESGNoNo
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Exposure

Countries

XBI
USA
94.51%
Other
5.49%
ARKG
USA
73.95%
Switzerland
8.01%
Other
18.04%

Sectors

XBI
Health Care
88.03%
Other
11.97%
ARKG
Health Care
80.46%
Other
19.54%
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Diversification

XBI

Total weight of top 15 holdings out of 15

21.6%
ARKG

Total weight of top 15 holdings out of 15

63.79%

Top 15 holdings

Data as of January 31, 2026
XBI
MODERNA INC
1.85%
MIRUM PHARMACEUTICALS INC
1.58%
REVOLUTION MEDICINES INC
1.52%
VAXCYTE
1.50%
AMICUS THERAPEUTICS
1.48%
US74006W2070
1.46%
ALKERMES
1.44%
GILEAD SCIENCES
1.43%
KRYSTAL BIOTECH INC
1.42%
HALOZYME THERAPEUTICS
1.40%
AMGEN-T
1.32%
CELCUITY INC
1.31%
ROIVANT SCIENCES LTD
1.30%
BRIDGEBIO PHARMA
1.30%
VERTEX PHARMACEUTICALS
1.29%
ARKG
CRISPR THERAPEUTICS
8.01%
PERSONALIS INC
6.15%
GUARDANT HEALTH INC
6.00%
10X GENOMICS INC
5.23%
BEAM THERAPEUTICS
4.81%
ILLUMINA
4.53%
NATERA
4.31%
RECURSION PHARMACEUTICALS
4.01%
CAREDX INC/D
3.44%
VERACYTE INC/D
3.29%
ADAPTIVE BIOTECHNOLOGIES
3.13%
INTELLIA THERAPEUTICS INC
3.10%
ABSCI
2.83%
IONIS PHARMACEUTICALS INC
2.62%
SCHRODINGER
2.33%
Frequently asked questions about XBI and ARKG

How have the XBI and ARKG ETFs performed in 2026?

As of March 11, 2026, XBI is up 3.65% year-to-date (YTD), while ARKG has lost -4.22%. That puts XBI better performer ahead so far this year.

Which ETF is attracting more investor money: XBI or ARKG?

Year-to-date, the XBI ETF saw -$59M in flows, compared to -$14M for ARKG.

Which ETF is more volatile: XBI or ARKG?

Over the past year, XBI had a volatility of 28.04%, while ARKG experienced 44.66%.

Which ETF is bigger: XBI or ARKG?

As of March 11, 2026, XBI holds $8.10 B in assets under management (AUM), while ARKG manages $1.11 B.

What sectors do the XBI and ARKG ETFs invest in?

XBI leans toward sectors like Health Care. Meanwhile, ARKG focuses on Health Care.

What are the top holdings of the XBI ETF and ARKG ETF?

XBI top holdings include MODERNA INC, MIRUM PHARMACEUTICALS INC and REVOLUTION MEDICINES INC. ARKG holds in its top three: CRISPR THERAPEUTICS, PERSONALIS INC and GUARDANT HEALTH INC.

Which ETF is more diversified: XBI or ARKG?

XBI holds 149 securities with 21.6% of its assets in the top 15. ARKG has 30 securities and a top 15 weight of 63.79%.

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