XBIvsARKGETF Comparison
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State Street SPDR S&P Biotech ETF (XBI) belongs to the US Health Care segment. ARK Genomic Revolution ETF (ARKG) is part of the BioTech & Genomics segment. Both ETFs have the same top 3 sector exposures: and Health Care. XBI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.75% for ARKG. XBI is up 9.28% year-to-date (YTD) with -$19M in YTD flows. ARKG performs worse with 1.21% YTD performance, and -$39M in YTD flows. Run a side-by-side ETF comparison of XBI and ARKG below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI vs ARKG performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI ARKG | +11.52%+11.02% | +4.22%-9.12% | +9.28%+1.21% | +65.29%+31.48% | +64.93%-2.03% | -3.74%-67.83% |
| Flows | XBI ARKG | +$314M-$2M | -$560M-$134M | -$19M-$39M | +$404M-$94M | -$1.15B-$617M | +$839M-$3.04B |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI ARKG | +30.22%+42.72% | +25.87%+41.46% | +27.40%+42.56% | +32.69%+45.35% |
| Max drawdown | XBI ARKG | -7.98%-23.75% | -9.66%-27.52% | -32.94%-51.98% | -55.10%-80.16% |
| Max drawdown duration | XBI ARKG | 42d88d | 76d92d | 331d1010d | 1822d1760d |
Trading data
XBI | ARKG | |
Last sale 4/27/2026 at 1:30 PM | $133.00 | $29.90 |
| Previous close 04/24/2026 | $133.28 | $29.54 |
| Consolidated volume 04/24/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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ARKG
is actively managed and doesn’t replicate an indexXBI | ARKG | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
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Main metrics
Last update 4/27/2026 at 1:30 PM
Live
Closed
XBI | ARKG | |
|---|---|---|
| Last price | $133.00 | $29.90 |
| 1D performance | -0.21% | +1.22% |
| AuM | $8.52 B | $1.15 B |
| E/R | 0.35% | 0.75% |
Characteristics
XBI | ARKG | |
|---|---|---|
| Management strategy | Passive | Active |
| Provider | State Street Investment Management | Ark Investment |
| Benchmark | S&P Biotechnology Select Industry Index | - |
| N° of holdings | 122 | 27 |
| Asset class | Equities | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | April 2, 2019 |
| ESG | No | No |
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Exposure
Countries
XBI
USA
95.16%
Other
4.84%
ARKG
USA
70.4%
Switzerland
9.23%
Other
20.37%
Sectors
XBI
Health Care
86.79%
Other
13.21%
ARKG
Health Care
78.38%
Other
21.62%
Diversification
XBI
Total weight of top 15 holdings out of 15
19.71%
ARKG
Total weight of top 15 holdings out of 15
62.5%
Top 15 holdings
Data as of March 31, 2026
XBI
APELLIS PHARMACEUTICALS
1.83%
ALKERMES
1.45%
MADRIGAL PHARMACEUTICALS INC
1.38%
TG THERAPEUTICS
1.35%
INSMED
1.34%
SCHOLAR ROCK HOLDING CORP
1.30%
US03770N1019
1.28%
PROTAGONIST THERAPEUTICS INC
1.25%
US86627T1088
1.24%
UTD THERAPEUT
1.24%
US74006W2070
1.24%
ARROWHEAD PHARMACEUTICALS INC
1.23%
COGENT BIOSCIENCES
1.22%
BRIDGEBIO PHARMA
1.19%
PTC THERAPEUTI/D
1.18%
ARKG
CRISPR THERAPEUTICS
9.23%
10X GENOMICS INC
6.30%
BEAM THERAPEUTICS
4.86%
PERSONALIS INC
4.69%
NATERA
4.48%
ILLUMINA
4.45%
GUARDANT HEALTH INC
4.21%
INTELLIA THERAPEUTICS INC
3.58%
CAREDX INC/D
3.56%
RECURSION PHARMACEUTICALS
3.54%
ABSCI
3.27%
VERACYTE INC/D
2.98%
ADAPTIVE BIOTECHNOLOGIES
2.71%
NURIX THERAPEUTICS
2.45%
SEMA4 HOLDINGS CORP
2.19%
Frequently asked questions about XBI and ARKG
How have the XBI and ARKG ETFs performed in 2026?
As of April 24, 2026, XBI is up 9.28% year-to-date (YTD), while ARKG has returned 1.21%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or ARKG?
Year-to-date, the XBI ETF saw -$19M in flows, compared to -$39M for ARKG.
Which ETF is more volatile: XBI or ARKG?
Over the past year, XBI had a volatility of 25.87%, while ARKG experienced 41.46%.
Which ETF is bigger: XBI or ARKG?
As of April 24, 2026, XBI holds $8.52 B in assets under management (AUM), while ARKG manages $1.15 B.
What sectors do the XBI and ARKG ETFs invest in?
XBI leans toward sectors like Health Care. Meanwhile, ARKG focuses on Health Care.
What are the top holdings of the XBI ETF and ARKG ETF?
XBI top holdings include APELLIS PHARMACEUTICALS, ALKERMES and MADRIGAL PHARMACEUTICALS INC. ARKG holds in its top three: CRISPR THERAPEUTICS, 10X GENOMICS INC and BEAM THERAPEUTICS.
Which ETF is more diversified: XBI or ARKG?
XBI holds 151 securities with 19.71% of its assets in the top 15. ARKG has 27 securities and a top 15 weight of 62.5%.
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