XBIvsARKGETF Comparison
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State Street SPDR S&P Biotech ETF (XBI) belongs to the US Health Care segment. ARK Genomic Revolution ETF (ARKG) is part of the BioTech & Genomics segment. XBI's top 3 sector exposures are Healthcare and Finance. In contrast, ARKG's top sector exposures are Healthcare XBI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.75% for ARKG. XBI is up 24.76% year-to-date (YTD) with +$510M in YTD flows. ARKG performs better with 33.13% YTD performance, and +$47M in YTD flows. Run a side-by-side ETF comparison of XBI and ARKG below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI vs ARKG performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/22/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI ARKG | +4.20%+6.70% | +10.82%+25.67% | +24.76%+33.13% | +76.10%+49.93% | +83.33%+7.11% | +19.73%-54.57% |
| Flows | XBI ARKG | +$459M+$94M | +$279M+$126M | +$510M+$47M | +$1.45B+$65M | -$425M-$542M | +$1.59B-$2.57B |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI ARKG | +30.98%+45.28% | +26.78%+42.67% | +27.91%+43.44% | +32.90%+45.98% |
| Max drawdown | XBI ARKG | -8.13%-12.10% | -9.66%-27.52% | -32.94%-51.67% | -54.07%-79.29% |
| Max drawdown duration | XBI ARKG | 13d16d | 76d126d | 331d1058d | 1685d1812d |
Trading data
XBI | ARKG | |
Last sale 7/23/2026 at 1:30 PM | $152.23 | $38.81 |
| Previous close 07/22/2026 | $152.11 | $38.85 |
| Consolidated volume 07/22/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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ARKG
is actively managed and doesn’t replicate an indexXBI | ARKG | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 7/23/2026 at 1:30 PM
Live
Closed
XBI | ARKG | |
|---|---|---|
| Last price | $152.23 | $38.81 |
| 1D performance | +0.08% | -0.10% |
| AuM | $10.24 B | $1.58 B |
| E/R | 0.35% | 0.75% |
Characteristics
XBI | ARKG | |
|---|---|---|
| Management strategy | Passive | Active |
| Provider | State Street Investment Management | Ark Investment |
| Benchmark | S&P Biotechnology Select Industry Index | - |
| N° of holdings | 150 | 31 |
| Asset class | Equities | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | April 2, 2019 |
| ESG | No | No |
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Exposure
Countries
XBI
USA
95.06%
Other
4.94%
ARKG
USA
86.99%
Other
13.01%
Sectors
XBI
Healthcare
99.03%
Other
0.97%
ARKG
Healthcare
96.93%
Other
3.07%
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Diversification
XBI
Total weight of top 15 holdings out of 15
19.19%
ARKG
Total weight of top 15 holdings out of 15
74.95%
Top 15 holdings
Data as of June 30, 2026
XBI
Apogee Therapeutics, Inc.
1.48%
Moderna, Inc.
1.41%
Twist Bioscience Corp.
1.40%
Oruka Therapeutics, Inc.
1.37%
Kymera Therapeutics, Inc.
1.35%
Viking Therapeutics, Inc.
1.30%
Praxis Precision Medicines, Inc.
1.29%
Erasca, Inc.
1.27%
Revolution Medicines, Inc.
1.20%
Rhythm Pharmaceuticals, Inc.
1.20%
CG Oncology, Inc.
1.20%
SELLAS Life Sciences Group, Inc.
1.19%
Vaxcyte, Inc.
1.18%
Dianthus Therapeutics, Inc.
1.18%
Cytokinetics, Inc.
1.17%
ARKG
Twist Bioscience Corp.
9.15%
Tempus AI, Inc.
7.64%
Absci Corp.
7.01%
10X Genomics, Inc.
7.00%
CRISPR Therapeutics AG
6.56%
Personalis, Inc.
6.19%
Beam Therapeutics, Inc.
4.34%
Guardant Health, Inc.
4.28%
Natera, Inc.
4.11%
Illumina, Inc.
3.98%
Veracyte, Inc.
3.24%
CareDx, Inc.
3.08%
Recursion Pharmaceuticals, Inc.
2.85%
Eli Lilly & Co.
2.81%
Compass Pathways Plc
2.70%
Frequently asked questions about XBI and ARKG
How have the XBI and ARKG ETFs performed in 2026?
As of July 22, 2026, XBI is up 24.76% year-to-date (YTD), while ARKG has returned 33.13%. That puts ARKG better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or ARKG?
Year-to-date, the XBI ETF saw +$510M in flows, compared to +$47M for ARKG.
Which ETF is more volatile: XBI or ARKG?
Over the past year, XBI had a volatility of 26.78%, while ARKG experienced 42.67%.
Which ETF is bigger: XBI or ARKG?
As of July 22, 2026, XBI holds $10.24 B in assets under management (AUM), while ARKG manages $1.58 B.
What sectors do the XBI and ARKG ETFs invest in?
XBI leans toward sectors like Healthcare. Meanwhile, ARKG focuses on Healthcare.
What are the top holdings of the XBI ETF and ARKG ETF?
XBI top holdings include Apogee Therapeutics, Inc., Moderna, Inc. and Twist Bioscience Corp.. ARKG holds in its top three: Twist Bioscience Corp., Tempus AI, Inc. and Absci Corp..
Which ETF is more diversified: XBI or ARKG?
XBI holds 153 securities with 19.19% of its assets in the top 15. ARKG has 31 securities and a top 15 weight of 74.95%.
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ARKG
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