XBIvsARKGETF Comparison
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State Street SPDR S&P Biotech ETF (XBI) belongs to the US Health Care segment. ARK Genomic Revolution ETF (ARKG) is part of the BioTech & Genomics segment. XBI's top 2 sector exposures are Healthcare and Finance. In contrast, ARKG's top sector exposures are Healthcare. XBI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.75% for ARKG. XBI is up 25.7% year-to-date (YTD) with +$665M in YTD flows. ARKG performs better with 66.63% YTD performance, and +$215M in YTD flows. Run a side-by-side ETF comparison of XBI and ARKG below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI vs ARKG performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/20/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI ARKG | -3.19%-6.21% | +1.51%+27.18% | +25.70%+66.63% | +39.59%+45.06% | +130.60%+104.79% | +25.18%-35.22% |
| Flows | XBI ARKG | +$328M+$45M | +$34M+$170M | +$665M+$215M | +$914M+$180M | -$16M-$283M | +$1.79B-$1.84B |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI ARKG | +30.69%+48.89% | +29.05%+44.66% | +28.51%+44.72% | +33.05%+46.78% |
| Max drawdown | XBI ARKG | -14.89%-17.81% | -14.89%-27.52% | -32.94%-46.41% | -53.28%-76.56% |
| Max drawdown duration | XBI ARKG | 62d15d | 62d126d | 331d882d | 1622d1811d |
Trading data
XBI | ARKG | |
Last sale 10/21/2026 at 1:30 PM | $152.78 | $49.85 |
| Previous close 10/20/2026 | $153.24 | $48.65 |
| Consolidated volume 10/20/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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ARKG
is actively managed and doesn’t replicate an indexXBI | ARKG | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/21/2026 at 1:30 PM
Live
Closed
XBI | ARKG | |
|---|---|---|
| Last price | $152.78 | $49.85 |
| 1D performance | -0.30% | +2.47% |
| AuM | $10.42 B | $2.16 B |
| E/R | 0.35% | 0.75% |
Characteristics
XBI | ARKG | |
|---|---|---|
| Management strategy | Passive | Active |
| Provider | State Street Investment Management | Ark Investment |
| Benchmark | S&P Biotechnology Select Industry Index | - |
| N° of holdings | 149 | 31 |
| Asset class | Equities | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | April 2, 2019 |
| ESG | No | No |
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Exposure
Countries
XBI
USA
95.53%
Other
4.47%
ARKG
USA
88.62%
Other
11.38%
Sectors
XBI
Healthcare
99.18%
Other
0.82%
ARKG
Healthcare
97.89%
Other
2.11%
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Diversification
XBI
Total weight of top 15 holdings out of 15
21.91%
ARKG
Total weight of top 15 holdings out of 15
74.64%
Top 15 holdings
Data as of August 31, 2026
XBI
Moderna, Inc.
2.81%
Twist Bioscience Corp.
1.89%
Apogee Therapeutics, Inc.
1.50%
Kymera Therapeutics, Inc.
1.40%
Halozyme Therapeutics, Inc.
1.39%
Natera, Inc.
1.37%
Praxis Precision Medicines, Inc.
1.34%
Oruka Therapeutics, Inc.
1.33%
Revolution Medicines, Inc.
1.31%
Travere Therapeutics, Inc.
1.30%
Protagonist Therapeutics, Inc.
1.28%
Dianthus Therapeutics, Inc.
1.27%
CG Oncology, Inc.
1.26%
Vaxcyte, Inc.
1.23%
Erasca, Inc.
1.23%
ARKG
10X Genomics, Inc.
9.58%
Twist Bioscience Corp.
9.13%
Tempus AI, Inc.
7.91%
CRISPR Therapeutics AG
6.10%
Personalis, Inc.
5.93%
Absci Corp.
4.88%
Natera, Inc.
4.06%
Illumina, Inc.
4.04%
Eli Lilly & Co.
3.86%
CareDx, Inc.
3.85%
Guardant Health, Inc.
3.81%
Beam Therapeutics, Inc.
3.56%
Compass Pathways Plc
3.17%
Recursion Pharmaceuticals, Inc.
2.44%
Adaptive Biotechnologies Corp.
2.32%
Frequently asked questions about XBI and ARKG
How have the XBI and ARKG ETFs performed in 2026?
As of October 20, 2026, XBI is up 25.7% year-to-date (YTD), while ARKG has returned 66.63%. That puts ARKG better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or ARKG?
Year-to-date, the XBI ETF saw +$665M in flows, compared to +$215M for ARKG.
Which ETF is more volatile: XBI or ARKG?
Over the past year, XBI had a volatility of 29.05%, while ARKG experienced 44.66%.
Which ETF is bigger: XBI or ARKG?
As of October 20, 2026, XBI holds $10.42 B in assets under management (AUM), while ARKG manages $2.16 B.
What sectors do the XBI and ARKG ETFs invest in?
XBI leans toward sectors like Healthcare. Meanwhile, ARKG focuses on Healthcare.
What are the top holdings of the XBI ETF and ARKG ETF?
XBI top holdings include Moderna, Inc., Twist Bioscience Corp. and Apogee Therapeutics, Inc.. ARKG holds in its top three: 10X Genomics, Inc., Twist Bioscience Corp. and Tempus AI, Inc..
Which ETF is more diversified: XBI or ARKG?
XBI holds 152 securities with 21.91% of its assets in the top 15. ARKG has 31 securities and a top 15 weight of 74.64%.
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ARKG
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