Open Now: The Global ETF Survey Take the Survey →

Advertisement
Advertisement
Smart Investing

Two biotech ETFs to watch for the rest of 2022 and beyond

Investors with a high tolerance for risk may seek to gain exposure to the growth potential of the biotech industry. We take a look at two ETFs that have rallied over the last month.

Alan Joseph
By Alan Joseph · September 13, 2022
Share
Two biotech ETFs to watch for the rest of 2022 and beyond

Keep up with what matters in ETFs

Get timely ETF insights, market trends, and top ideas straight to your inbox.

Your newsletter subscriptions with us are subject to ETF Central's Privacy Policy and Terms and Conditions.

Biotechnology companies have made several breakthroughs that have contributed to the advancement of medical science. What began decades ago as a daring exploration to better understand genetic engineering has blossomed into a trillion-dollar industry. Some of the biggest breakthroughs the biotech field has accomplished include stem cell research, human genome sequencing, 3D printed organs and more. 

Global ETF Survey 2026

The ETF Industry Is Evolving Fast

From AI infrastructure to active strategies, the ETF landscape is shifting. Share your perspective in the 7th Annual Global ETF Survey and get exclusive early access to the final report.

Take the survey

The uniqueness of the biotech industry

The biotech industry is an anomaly compared to its peers. Unlike other sectors, it is highly regulated as companies have to go through stringent measures before they can have their products and services commercialized. The process of successfully bringing an invention to market through clinical trials can take many years and is often expensive given the high associated costs. Additionally, the success rate of clinical trials is often low given the complexities of molecular biology that scientists face. However, for risk-tolerant investors who can afford to ride out the volatility of the biotech industry, there can be opportunities to make solid returns.  Let’s take a closer look at two ETFs that offer exposure to this growing theme.  

SBIO - (ALPS Medical Breakthroughs ETF)

First on the list is SBIO. This ETF seeks to provide exposure to small-and-mid cap biotech companies, with the stipulation that they have one or more drugs in phase 2 or phase 3 in clinical trials. This is an added bonus for investors as it may significantly shorten the duration of time needed for inventions to reach commercialization. The holdings of this fund have been in the spotlight in recent days as Amgen, one of the largest biopharmaceutical companies in the world, acquired Chemocentryx in a $4 billion dollar deal. Other firms in APLS have had their own success with respect to stronger than expected earnings, and positive news related to progress for pipelines treating eye diseases, depression, and sickle cell disease. With more than $123 million in assets under management, a modest 0.5% in MER fees, and a proven track record of selecting promising companies, this ETF could prove an interesting proposition for investors seeking to gain biotech exposure. 

XBI - (SPDR S&P Biotech ETF)

SPDR has enjoyed a nice rally as of late, with shareholders sure to be pleased with the recent 16.35% spike over the last month. This can largely be attributed to Pfizer’s $5.4 billion dollar acquisition of Global Blood Therapeutics, which makes up 2.45% of XBI as its top holding by weight. The fund also holds Chemocentrix which has given it an additional boost too. As one of the largest biotech ETFs in the world with more than $8.6 billion in assets under management and a small MER fee of 0.35%, this is another interesting option for investors seeking exposure to a diverse set of biotech firms targeting medical breakthroughs.

Please note this article is for information purposes only and does not constitute investment advice.

Advertisement
Advertisement
Advertisement
ETF U
Become a better investor with NYSE: The Home of ETFs
Visit the ETF U homepage
ETF Guides
Advertisement

Recent educational content

The ETF Show - New Autism-Impact ETF Launched

Asset TV

The ETF Show - New Autism-Impact ETF Launched

Defiance ETFs has launched the first ETF, $ASD, focused on the autism ecosystem, investing in companies that provide services, products, and research related to autism and neurodivergence.

Asset TV
By Asset TV · June 4, 2026
Tidal ETF Industry KPIs

ETF Trends

ETF Industry KPIs June 1, 2026

The ETF Industry saw 22 New Launches, 1 Ticker Change and 1 closure last week.

Tidal
By Tidal · June 1, 2026
Tidal ETF Industry KPIs

ETF Trends

ETF Industry KPIs May 20, 2026

The ETF Industry saw 44 New Launches, 3 Mutual Fund Conversions and 9 closures last week.

Tidal
By Tidal · May 19, 2026
The ETF Show - Politics Becomes Investable Trade through ETFs

Asset TV

The ETF Show - Politics Becomes Investable Trade through ETFs

Dan Weiskopf, Senior Portfolio Manager at Tidal Financial Group spoke with the ETF Show about Subversive ETFs that help investors trade like politicians.

Asset TV
By Asset TV · May 18, 2026

Browse all educational columns

Advertisement
ETF INVESTOR RESOURCES

Expert-Built ETF Portfolios, All in One Place

Don’t start from scratch. Discover ready-made ETF portfolios built by professionals to match different goals, timelines, and market views. Use them as inspiration or as a starting point for your own allocation.

Portfolio Builder