XBIvsBBPETF Comparison
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State Street SPDR S&P Biotech ETF (XBI) belongs to the US Health Care segment. Virtus LifeSci Biotech Products ETF (BBP) is part of the Tomorrow's Treatments segment. Both ETFs have the same top 3 sector exposures: and Health Care. XBI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.79% for BBP. XBI is up 9.28% year-to-date (YTD) with -$19M in YTD flows. BBP performs worse with 8.48% YTD performance, and +$12M in YTD flows. Run a side-by-side ETF comparison of XBI and BBP below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI vs BBP performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI BBP | +11.52%+6.93% | +4.22%+1.36% | +9.28%+8.48% | +65.29%+56.78% | +64.93%+68.08% | -3.74%+61.52% |
| Flows | XBI BBP | +$314M+$8M | -$560M+$12M | -$19M+$12M | +$404M+$27M | -$1.15B+$27M | +$839M+$17M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI BBP | +30.22%+28.63% | +25.87%+24.01% | +27.40%+23.75% | +32.69%+26.18% |
| Max drawdown | XBI BBP | -7.98%-9.59% | -9.66%-9.81% | -32.94%-25.54% | -55.10%-38.24% |
| Max drawdown duration | XBI BBP | 42d48d | 76d36d | 331d292d | 1822d915d |
Trading data
XBI | BBP | |
Last sale 4/24/2026 at 1:30 PM | $133.28 | $84.11 |
| Previous close 04/23/2026 | $134.49 | $86.08 |
| Consolidated volume 04/23/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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XBI | BBP | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/24/2026 at 1:30 PM
Live
Closed
XBI | BBP | |
|---|---|---|
| Last price | $133.28 | $84.11 |
| 1D performance | -0.90% | -2.30% |
| AuM | $8.52 B | $60.57 M |
| E/R | 0.35% | 0.79% |
Characteristics
XBI | BBP | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | VIRTUS Investment Partners |
| Benchmark | S&P Biotechnology Select Industry Index | LifeSci Biotechnology Products Index |
| N° of holdings | 122 | 56 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | December 16, 2014 |
| ESG | No | No |
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Exposure
Countries
XBI
USA
95.16%
Other
4.84%
BBP
USA
89.45%
Other
10.55%
Sectors
XBI
Health Care
86.79%
Other
13.21%
BBP
Health Care
88.78%
Other
11.22%
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Diversification
XBI
Total weight of top 15 holdings out of 15
19.71%
BBP
Total weight of top 15 holdings out of 15
33.42%
Top 15 holdings
Data as of March 31, 2026
XBI
APELLIS PHARMACEUTICALS
1.83%
ALKERMES
1.45%
MADRIGAL PHARMACEUTICALS INC
1.38%
TG THERAPEUTICS
1.35%
INSMED
1.34%
SCHOLAR ROCK HOLDING CORP
1.30%
US03770N1019
1.28%
PROTAGONIST THERAPEUTICS INC
1.25%
US86627T1088
1.24%
UTD THERAPEUT
1.24%
US74006W2070
1.24%
ARROWHEAD PHARMACEUTICALS INC
1.23%
COGENT BIOSCIENCES
1.22%
BRIDGEBIO PHARMA
1.19%
PTC THERAPEUTI/D
1.18%
BBP
BIOCRYST PHARMACEUTICALS
2.50%
ROIVANT SCIENCES LTD
2.45%
SYNDAX PHARMACEUTICALS INC
2.40%
GILEAD SCIENCES
2.25%
GERON
2.24%
GB00BRXB0C07
2.23%
KALVISTA PHARMACEUTICALS INC
2.22%
AMGEN-T
2.20%
AXSOME THERA CMN STK
2.20%
AGIOS PHARMA/D
2.18%
BIOGEN INC
2.17%
UTD THERAPEUT
2.13%
LIGAND PHARMACEUTICALS
2.13%
BIOMARIN PHARMACEUTICAL
2.06%
EXELIXIS
2.05%
Frequently asked questions about XBI and BBP
How have the XBI and BBP ETFs performed in 2026?
As of April 24, 2026, XBI is up 9.28% year-to-date (YTD), while BBP has returned 8.48%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or BBP?
Year-to-date, the XBI ETF saw -$19M in flows, compared to +$12M for BBP.
Which ETF is more volatile: XBI or BBP?
Over the past year, XBI had a volatility of 25.87%, while BBP experienced 24.01%.
Which ETF is bigger: XBI or BBP?
As of April 24, 2026, XBI holds $8.52 B in assets under management (AUM), while BBP manages $60.57 M.
What sectors do the XBI and BBP ETFs invest in?
XBI leans toward sectors like Health Care. Meanwhile, BBP focuses on Health Care.
What are the top holdings of the XBI ETF and BBP ETF?
XBI top holdings include APELLIS PHARMACEUTICALS, ALKERMES and MADRIGAL PHARMACEUTICALS INC. BBP holds in its top three: BIOCRYST PHARMACEUTICALS, ROIVANT SCIENCES LTD and SYNDAX PHARMACEUTICALS INC.
Which ETF is more diversified: XBI or BBP?
XBI holds 151 securities with 19.71% of its assets in the top 15. BBP has 61 securities and a top 15 weight of 33.42%.
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