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XBIvsBBPETF Comparison
SPDR S&P Biotech ETF (XBI) belongs to the US Health Care segment. Virtus LifeSci Biotech Products ETF (BBP) is part of the Tomorrow's Treatments segment. Both ETFs have the same top 3 sector exposures: and Health Care. XBI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.79% for BBP. XBI is up 3.65% year-to-date (YTD) with -$59M in YTD flows. BBP performs better with 6.54% YTD performance, and +$4M in YTD flows. Run a side-by-side ETF comparison of XBI and BBP below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
XBI vs BBP performance and flow charts
Performance
Cumulative Flows
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI BBP | +1.38%+3.49% | +3.11%+9.58% | +3.65%+6.54% | +47.21%+42.80% | +63.16%+83.49% | -13.71%+60.18% |
| Flows | XBI BBP | -$4M+$4M | -$179M+$16M | -$59M+$4M | +$90M+$19M | -$1.64B+$19M | +$1.20B+$9M |
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI BBP | +25.68%+24.65% | +28.04%+25.47% | +27.26%+23.56% | +32.91%+26.14% |
| Max drawdown | XBI BBP | -8.19%-7.42% | -21.44%-17.97% | -32.94%-25.54% | -57.63%-38.24% |
| Max drawdown duration | XBI BBP | 48d32d | 141d106d | 331d292d | 1822d915d |
XBI | BBP | |
Last sale 3/12/2026 at 1:53 PM | $123.71 | $84.32 |
| Previous close 03/11/2026 | $126.38 | $85.25 |
| Consolidated volume 03/11/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
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XBI | BBP | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
XBI | BBP | |
|---|---|---|
| Last price | $123.71 | $84.32 |
| 1D performance | -2.11% | -1.10% |
| AuM | $8.10 B | $50.98 M |
| E/R | 0.35% | 0.79% |
XBI | BBP | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | SPDR | VIRTUS Investment Partners |
| Benchmark | S&P Biotechnology Select Industry Index | LifeSci Biotechnology Products Index |
| N° of holdings | 123 | 58 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | December 16, 2014 |
| ESG | No | No |
Countries
Sectors
Diversification
Total weight of top 15 holdings out of 15
Total weight of top 15 holdings out of 15
Top 15 holdings
How have the XBI and BBP ETFs performed in 2026?
As of March 11, 2026, XBI is up 3.65% year-to-date (YTD), while BBP has returned 6.54%. That puts BBP better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or BBP?
Year-to-date, the XBI ETF saw -$59M in flows, compared to +$4M for BBP.
Which ETF is more volatile: XBI or BBP?
Over the past year, XBI had a volatility of 28.04%, while BBP experienced 25.47%.
Which ETF is bigger: XBI or BBP?
As of March 11, 2026, XBI holds $8.10 B in assets under management (AUM), while BBP manages $50.98 M.
What sectors do the XBI and BBP ETFs invest in?
XBI leans toward sectors like Health Care. Meanwhile, BBP focuses on Health Care.
What are the top holdings of the XBI ETF and BBP ETF?
XBI top holdings include MODERNA INC, MIRUM PHARMACEUTICALS INC and REVOLUTION MEDICINES INC. BBP holds in its top three: DAY ONE BIOPHARMACEUTICALS, DYNAVAX TECHNOLOGIES and AMICUS THERAPEUTICS.
Which ETF is more diversified: XBI or BBP?
XBI holds 149 securities with 21.6% of its assets in the top 15. BBP has 63 securities and a top 15 weight of 30.11%.
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