XBIvsSBIOETF Comparison
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State Street SPDR S&P Biotech ETF (XBI) belongs to the US Health Care segment. ALPS Medical Breakthroughs ETF (SBIO) is part of the Tomorrow's Treatments segment. XBI's top 3 sector exposures are Healthcare and Finance. In contrast, SBIO's top sector exposures are Healthcare and Non-Corporate. XBI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.5% for SBIO. XBI is up 23.56% year-to-date (YTD) with +$394M in YTD flows. SBIO performs better with 24.58% YTD performance, and +$41M in YTD flows. Run a side-by-side ETF comparison of XBI and SBIO below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI vs SBIO performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI SBIO | +0.59%+4.86% | +13.07%+17.16% | +23.56%+24.58% | +72.81%+91.81% | +81.55%+109.04% | +21.91%+48.00% |
| Flows | XBI SBIO | -$259M+$18M | +$434M+$24M | +$394M+$41M | +$1.35B+$51M | -$541M+$20M | +$1.29B-$24M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI SBIO | +30.66%+35.36% | +26.75%+30.55% | +27.88%+30.92% | +32.89%+33.95% |
| Max drawdown | XBI SBIO | -8.33%-10.73% | -9.66%-12.63% | -32.94%-42.12% | -54.07%-52.50% |
| Max drawdown duration | XBI SBIO | 15d43d | 76d60d | 331d331d | 1685d1479d |
Trading data
XBI | SBIO | |
Last sale 7/24/2026 at 1:30 PM | $150.48 | $63.77 |
| Previous close 07/24/2026 | $152.23 | $64.33 |
| Consolidated volume 07/24/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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XBI | SBIO | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 7/24/2026 at 1:30 PM
Live
Closed
XBI | SBIO | |
|---|---|---|
| Last price | $150.48 | $63.77 |
| 1D performance | -1.15% | -0.88% |
| AuM | $10.02 B | $202.25 M |
| E/R | 0.35% | 0.5% |
Characteristics
XBI | SBIO | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | ALPS |
| Benchmark | S&P Biotechnology Select Industry Index | S-Network Medical Breakthroughs Index |
| N° of holdings | 150 | 103 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | December 30, 2014 |
| ESG | No | No |
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Exposure
Countries
XBI
USA
95.06%
Other
4.94%
SBIO
USA
88.02%
Other
11.98%
Sectors
XBI
Healthcare
99.03%
Other
0.97%
SBIO
Healthcare
99.06%
Other
0.94%
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Diversification
XBI
Total weight of top 15 holdings out of 15
19.19%
SBIO
Total weight of top 15 holdings out of 15
40.08%
Top 15 holdings
Data as of June 30, 2026
XBI
Apogee Therapeutics, Inc.
1.48%
Moderna, Inc.
1.41%
Twist Bioscience Corp.
1.40%
Oruka Therapeutics, Inc.
1.37%
Kymera Therapeutics, Inc.
1.35%
Viking Therapeutics, Inc.
1.30%
Praxis Precision Medicines, Inc.
1.29%
Erasca, Inc.
1.27%
Revolution Medicines, Inc.
1.20%
Rhythm Pharmaceuticals, Inc.
1.20%
CG Oncology, Inc.
1.20%
SELLAS Life Sciences Group, Inc.
1.19%
Vaxcyte, Inc.
1.18%
Dianthus Therapeutics, Inc.
1.18%
Cytokinetics, Inc.
1.17%
SBIO
Apogee Therapeutics, Inc.
4.36%
CG Oncology, Inc.
3.33%
Xenon Pharmaceuticals, Inc.
3.09%
Oruka Therapeutics, Inc.
3.05%
Dianthus Therapeutics, Inc.
2.83%
Travere Therapeutics, Inc.
2.80%
Definium Therapeutics, Inc.
2.73%
Veradermics, Inc.
2.72%
Edgewise Therapeutics, Inc.
2.32%
ACADIA Pharmaceuticals, Inc.
2.30%
Denali Therapeutics, Inc.
2.17%
Relay Therapeutics, Inc.
2.17%
NewAmsterdam Pharma Co. NV
2.10%
Crinetics Pharmaceuticals, Inc.
2.09%
Structure Therapeutics, Inc.
2.02%
Frequently asked questions about XBI and SBIO
How have the XBI and SBIO ETFs performed in 2026?
As of July 24, 2026, XBI is up 23.56% year-to-date (YTD), while SBIO has returned 24.58%. That puts SBIO better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or SBIO?
Year-to-date, the XBI ETF saw +$394M in flows, compared to +$41M for SBIO.
Which ETF is more volatile: XBI or SBIO?
Over the past year, XBI had a volatility of 26.75%, while SBIO experienced 30.55%.
Which ETF is bigger: XBI or SBIO?
As of July 24, 2026, XBI holds $10.02 B in assets under management (AUM), while SBIO manages $202.25 M.
What sectors do the XBI and SBIO ETFs invest in?
XBI leans toward sectors like Healthcare. Meanwhile, SBIO focuses on Healthcare.
What are the top holdings of the XBI ETF and SBIO ETF?
XBI top holdings include Apogee Therapeutics, Inc., Moderna, Inc. and Twist Bioscience Corp.. SBIO holds in its top three: Apogee Therapeutics, Inc., CG Oncology, Inc. and Xenon Pharmaceuticals, Inc..
Which ETF is more diversified: XBI or SBIO?
XBI holds 153 securities with 19.19% of its assets in the top 15. SBIO has 104 securities and a top 15 weight of 40.08%.
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