XBIvsPSCHETF Comparison
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State Street SPDR S&P Biotech ETF (XBI) and Invesco S&P SmallCap Health Care ETF (PSCH) belong to the same industry segment: US Health Care. XBI's top 3 sector exposures are Healthcare and Finance. In contrast, PSCH's top sector exposures are Healthcare XBI is more expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.29% for PSCH. XBI is up 24.76% year-to-date (YTD) with +$510M in YTD flows. PSCH performs worse with 20.24% YTD performance, and -$10M in YTD flows. Run a side-by-side ETF comparison of XBI and PSCH below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI vs PSCH performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/22/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI PSCH | +4.20%+5.27% | +10.82%+19.02% | +24.76%+20.24% | +76.10%+36.79% | +83.33%+19.78% | +19.73%-15.14% |
| Flows | XBI PSCH | +$459M+$6M | +$279M+$9M | +$510M-$10M | +$1.45B-$13M | -$425M-$133M | +$1.59B-$230M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI PSCH | +30.98%+17.29% | +26.78%+20.07% | +27.91%+21.86% | +32.90%+22.90% |
| Max drawdown | XBI PSCH | -8.13%-2.96% | -9.66%-15.36% | -32.94%-22.80% | -54.07%-46.32% |
| Max drawdown duration | XBI PSCH | 13d17d | 76d168d | 331d488d | 1685d1786d |
Trading data
XBI | PSCH | |
Last sale 7/24/2026 at 1:30 PM | $150.48 | $52.95 |
| Previous close 07/23/2026 | $152.23 | $52.96 |
| Consolidated volume 07/23/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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XBI | PSCH | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 7/24/2026 at 1:30 PM
Live
Closed
XBI | PSCH | |
|---|---|---|
| Last price | $150.48 | $52.95 |
| 1D performance | -1.15% | -0.02% |
| AuM | $10.24 B | $162.74 M |
| E/R | 0.35% | 0.29% |
Characteristics
XBI | PSCH | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | Invesco |
| Benchmark | S&P Biotechnology Select Industry Index | S&P SmallCap 600 Capped Health Care Index |
| N° of holdings | 150 | 75 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | April 7, 2010 |
| ESG | No | No |
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Exposure
Countries
XBI
USA
95.06%
Other
4.94%
PSCH
USA
95.33%
Other
4.67%
Sectors
XBI
Healthcare
99.03%
Other
0.97%
PSCH
Healthcare
100%
Other
0%
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Diversification
XBI
Total weight of top 15 holdings out of 15
19.19%
PSCH
Total weight of top 15 holdings out of 15
49.48%
Top 15 holdings
Data as of June 30, 2026
XBI
Apogee Therapeutics, Inc.
1.48%
Moderna, Inc.
1.41%
Twist Bioscience Corp.
1.40%
Oruka Therapeutics, Inc.
1.37%
Kymera Therapeutics, Inc.
1.35%
Viking Therapeutics, Inc.
1.30%
Praxis Precision Medicines, Inc.
1.29%
Erasca, Inc.
1.27%
Revolution Medicines, Inc.
1.20%
Rhythm Pharmaceuticals, Inc.
1.20%
CG Oncology, Inc.
1.20%
SELLAS Life Sciences Group, Inc.
1.19%
Vaxcyte, Inc.
1.18%
Dianthus Therapeutics, Inc.
1.18%
Cytokinetics, Inc.
1.17%
PSCH
Molina Healthcare, Inc.
5.29%
BrightSpring Health Services, Inc.
4.82%
Krystal Biotech, Inc.
4.32%
Alkermes Plc
4.06%
Glaukos Corp.
3.75%
Corcept Therapeutics, Inc.
3.69%
Protagonist Therapeutics, Inc.
3.26%
TG Therapeutics, Inc.
3.25%
PTC Therapeutics, Inc.
3.10%
Ligand Pharmaceuticals, Inc.
2.69%
Teleflex, Inc.
2.54%
Liquidia Corp.
2.43%
Indivior Pharmaceuticals, Inc.
2.25%
Veracyte, Inc.
2.13%
RadNet, Inc.
1.90%
Frequently asked questions about XBI and PSCH
How have the XBI and PSCH ETFs performed in 2026?
As of July 22, 2026, XBI is up 24.76% year-to-date (YTD), while PSCH has returned 20.24%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or PSCH?
Year-to-date, the XBI ETF saw +$510M in flows, compared to -$10M for PSCH.
Which ETF is more volatile: XBI or PSCH?
Over the past year, XBI had a volatility of 26.78%, while PSCH experienced 20.07%.
Which ETF is bigger: XBI or PSCH?
As of July 22, 2026, XBI holds $10.24 B in assets under management (AUM), while PSCH manages $162.74 M.
What sectors do the XBI and PSCH ETFs invest in?
XBI leans toward sectors like Healthcare. Meanwhile, PSCH focuses on Healthcare.
What are the top holdings of the XBI ETF and PSCH ETF?
XBI top holdings include Apogee Therapeutics, Inc., Moderna, Inc. and Twist Bioscience Corp.. PSCH holds in its top three: Molina Healthcare, Inc., BrightSpring Health Services, Inc. and Krystal Biotech, Inc..
Which ETF is more diversified: XBI or PSCH?
XBI holds 153 securities with 19.19% of its assets in the top 15. PSCH has 75 securities and a top 15 weight of 49.48%.
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