XBIvsPSCHETF Comparison
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State Street SPDR S&P Biotech ETF (XBI) and Invesco S&P SmallCap Health Care ETF (PSCH) belong to the same industry segment: US Health Care. Both ETFs have the same top 3 sector exposures: and Health Care. XBI is more expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.29% for PSCH. XBI is up 9.28% year-to-date (YTD) with -$19M in YTD flows. PSCH performs worse with 1.03% YTD performance, and -$19M in YTD flows. Run a side-by-side ETF comparison of XBI and PSCH below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI vs PSCH performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI PSCH | +11.52%+11.60% | +4.22%-1.82% | +9.28%+1.03% | +65.29%+9.11% | +64.93%-1.19% | -3.74%-29.66% |
| Flows | XBI PSCH | +$314M-$4M | -$560M-$18M | -$19M-$19M | +$404M-$33M | -$1.15B-$156M | +$839M-$237M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI PSCH | +30.22%+23.52% | +25.87%+20.90% | +27.40%+21.73% | +32.69%+22.88% |
| Max drawdown | XBI PSCH | -7.98%-13.58% | -9.66%-15.36% | -32.94%-22.97% | -55.10%-47.23% |
| Max drawdown duration | XBI PSCH | 42d88d | 76d123d | 331d448d | 1822d1762d |
Trading data
XBI | PSCH | |
Last sale 4/24/2026 at 1:30 PM | $133.28 | $44.54 |
| Previous close 04/24/2026 | $134.49 | $44.07 |
| Consolidated volume 04/24/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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XBI | PSCH | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/24/2026 at 1:30 PM
Live
Closed
XBI | PSCH | |
|---|---|---|
| Last price | $133.28 | $44.54 |
| 1D performance | -0.90% | +1.07% |
| AuM | $8.52 B | $128.72 M |
| E/R | 0.35% | 0.29% |
Characteristics
XBI | PSCH | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | Invesco |
| Benchmark | S&P Biotechnology Select Industry Index | S&P SmallCap 600 Capped Health Care Index |
| N° of holdings | 122 | 71 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | April 7, 2010 |
| ESG | No | No |
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Exposure
Countries
XBI
USA
95.16%
Other
4.84%
PSCH
USA
96.2%
Other
3.8%
Sectors
XBI
Health Care
86.79%
Other
13.21%
PSCH
Health Care
90.59%
Other
9.41%
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Diversification
XBI
Total weight of top 15 holdings out of 15
19.71%
PSCH
Total weight of top 15 holdings out of 15
44.68%
Top 15 holdings
Data as of March 31, 2026
XBI
APELLIS PHARMACEUTICALS
1.83%
ALKERMES
1.45%
MADRIGAL PHARMACEUTICALS INC
1.38%
TG THERAPEUTICS
1.35%
INSMED
1.34%
SCHOLAR ROCK HOLDING CORP
1.30%
US03770N1019
1.28%
PROTAGONIST THERAPEUTICS INC
1.25%
US86627T1088
1.24%
UTD THERAPEUT
1.24%
US74006W2070
1.24%
ARROWHEAD PHARMACEUTICALS INC
1.23%
COGENT BIOSCIENCES
1.22%
BRIDGEBIO PHARMA
1.19%
PTC THERAPEUTI/D
1.18%
PSCH
MOLINA HLTHCRE
4.25%
KRYSTAL BIOTECH INC
3.90%
GLAUKOS
3.65%
PROTAGONIST THERAPEUTICS INC
3.58%
US10950A1060
3.45%
PTC THERAPEUTI/D
3.27%
TELEFLEX
3.16%
ALKERMES
2.99%
TG THERAPEUTICS
2.66%
MERIT MEDICAL SYSTEMS
2.51%
RADNET
2.41%
LIGAND PHARMACEUTICALS
2.37%
US45579U1097
2.23%
CORCEPT THERAPEUTICS
2.17%
TRANSMEDICS GROUP
2.08%
Frequently asked questions about XBI and PSCH
How have the XBI and PSCH ETFs performed in 2026?
As of April 24, 2026, XBI is up 9.28% year-to-date (YTD), while PSCH has returned 1.03%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or PSCH?
Year-to-date, the XBI ETF saw -$19M in flows, compared to -$19M for PSCH.
Which ETF is more volatile: XBI or PSCH?
Over the past year, XBI had a volatility of 25.87%, while PSCH experienced 20.9%.
Which ETF is bigger: XBI or PSCH?
As of April 24, 2026, XBI holds $8.52 B in assets under management (AUM), while PSCH manages $128.72 M.
What sectors do the XBI and PSCH ETFs invest in?
XBI leans toward sectors like Health Care. Meanwhile, PSCH focuses on Health Care.
What are the top holdings of the XBI ETF and PSCH ETF?
XBI top holdings include APELLIS PHARMACEUTICALS, ALKERMES and MADRIGAL PHARMACEUTICALS INC. PSCH holds in its top three: MOLINA HLTHCRE, KRYSTAL BIOTECH INC and GLAUKOS.
Which ETF is more diversified: XBI or PSCH?
XBI holds 151 securities with 19.71% of its assets in the top 15. PSCH has 75 securities and a top 15 weight of 44.68%.
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