XBIvsXPHETF Comparison
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State Street SPDR S&P Biotech ETF (XBI) and State Street SPDR S&P Pharmaceuticals ETF (XPH) belong to the same industry segment: US Health Care. Both ETFs have the same top 3 sector exposures: and Health Care. Both XBI and XPH have the same Total Expense Ratio (TER) of 0.35%. XBI is up 9.28% year-to-date (YTD) with -$19M in YTD flows. XPH performs worse with 2.61% YTD performance, and +$116M in YTD flows. Run a side-by-side ETF comparison of XBI and XPH below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI vs XPH performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI XPH | +11.52%+9.68% | +4.22%+2.44% | +9.28%+2.61% | +65.29%+44.99% | +64.93%+40.83% | -3.74%+22.16% |
| Flows | XBI XPH | +$314M+$25M | -$560M+$82M | -$19M+$116M | +$404M+$141M | -$1.15B+$48M | +$839M+$64M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI XPH | +30.22%+24.78% | +25.87%+21.12% | +27.40%+19.49% | +32.69%+20.45% |
| Max drawdown | XBI XPH | -7.98%-11.78% | -9.66%-11.78% | -32.94%-23.45% | -55.10%-31.59% |
| Max drawdown duration | XBI XPH | 42d50d | 76d50d | 331d322d | 1822d1566d |
Trading data
XBI | XPH | |
Last sale 4/27/2026 at 1:30 PM | $133.04 | $57.90 |
| Previous close 04/24/2026 | $133.28 | $57.40 |
| Consolidated volume 04/24/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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XBI | XPH | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/27/2026 at 1:30 PM
Live
Closed
XBI | XPH | |
|---|---|---|
| Last price | $133.04 | $57.90 |
| 1D performance | -0.18% | +0.87% |
| AuM | $8.52 B | $353.54 M |
| E/R | 0.35% | 0.35% |
Characteristics
XBI | XPH | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | State Street Investment Management |
| Benchmark | S&P Biotechnology Select Industry Index | S&P Pharmaceuticals Select Industry Index |
| N° of holdings | 122 | 48 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | June 19, 2006 |
| ESG | No | No |
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Exposure
Countries
XBI
USA
95.16%
Other
4.84%
XPH
USA
87.77%
Other
12.23%
Sectors
XBI
Health Care
86.79%
Other
13.21%
XPH
Health Care
82.36%
Other
17.64%
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Diversification
XBI
Total weight of top 15 holdings out of 15
19.71%
XPH
Total weight of top 15 holdings out of 15
30.65%
Top 15 holdings
Data as of March 31, 2026
XBI
APELLIS PHARMACEUTICALS
1.83%
ALKERMES
1.45%
MADRIGAL PHARMACEUTICALS INC
1.38%
TG THERAPEUTICS
1.35%
INSMED
1.34%
SCHOLAR ROCK HOLDING CORP
1.30%
US03770N1019
1.28%
PROTAGONIST THERAPEUTICS INC
1.25%
US86627T1088
1.24%
UTD THERAPEUT
1.24%
US74006W2070
1.24%
ARROWHEAD PHARMACEUTICALS INC
1.23%
COGENT BIOSCIENCES
1.22%
BRIDGEBIO PHARMA
1.19%
PTC THERAPEUTI/D
1.18%
XPH
US29337E1029
2.45%
CORCEPT THERAPEUTICS
2.29%
TERNS PHARMACEUTICALS
2.16%
PERRIGO CO PLC
2.10%
AXSOME THERA CMN STK
2.03%
INNOVIVA INC
1.99%
MERCK & CO INC
1.98%
PFIZER
1.97%
ROYALTY PHARMA
1.97%
ELANCO ANIMAL HEALTH INC
1.96%
JAZZ PHARMACEUTICALS
1.96%
ESPERION THERAPEUTICS
1.95%
EDGEWISE THERAPEUTICS
1.95%
US55287L1017
1.95%
BRISTOL-MYERS SQUIBB
1.94%
Frequently asked questions about XBI and XPH
How have the XBI and XPH ETFs performed in 2026?
As of April 24, 2026, XBI is up 9.28% year-to-date (YTD), while XPH has returned 2.61%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or XPH?
Year-to-date, the XBI ETF saw -$19M in flows, compared to +$116M for XPH.
Which ETF is more volatile: XBI or XPH?
Over the past year, XBI had a volatility of 25.87%, while XPH experienced 21.12%.
Which ETF is bigger: XBI or XPH?
As of April 24, 2026, XBI holds $8.52 B in assets under management (AUM), while XPH manages $353.54 M.
What sectors do the XBI and XPH ETFs invest in?
XBI leans toward sectors like Health Care. Meanwhile, XPH focuses on Health Care.
What are the top holdings of the XBI ETF and XPH ETF?
XBI top holdings include APELLIS PHARMACEUTICALS, ALKERMES and MADRIGAL PHARMACEUTICALS INC. XPH holds in its top three: US29337E1029, CORCEPT THERAPEUTICS and TERNS PHARMACEUTICALS.
Which ETF is more diversified: XBI or XPH?
XBI holds 151 securities with 19.71% of its assets in the top 15. XPH has 57 securities and a top 15 weight of 30.65%.
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