XBIvsBBCETF Comparison
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State Street SPDR S&P Biotech ETF (XBI) belongs to the US Health Care segment. Virtus LifeSci Biotech Clinical Trials ETF (BBC) is part of the Tomorrow's Treatments segment. XBI's top 3 sector exposures are Healthcare and Finance. In contrast, BBC's top sector exposures are Healthcare XBI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.65% for BBC. XBI is up 24.76% year-to-date (YTD) with +$510M in YTD flows. BBC performs better with 28.33% YTD performance, and +$5M in YTD flows. Run a side-by-side ETF comparison of XBI and BBC below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI vs BBC performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/22/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI BBC | +4.20%+1.30% | +10.82%+7.83% | +24.76%+28.33% | +76.10%+127.45% | +83.33%+114.85% | +19.73%+13.01% |
| Flows | XBI BBC | +$459M+$83K | +$279M+$7M | +$510M+$5M | +$1.45B+$11M | -$425M+$15M | +$1.59B+$6M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI BBC | +30.98%+38.55% | +26.78%+35.78% | +27.91%+37.03% | +32.90%+39.66% |
| Max drawdown | XBI BBC | -8.13%-11.64% | -9.66%-14.64% | -32.94%-54.25% | -54.07%-70.93% |
| Max drawdown duration | XBI BBC | 13d54d | 76d60d | 331d340d | 1685d1754d |
Trading data
XBI | BBC | |
Last sale 7/24/2026 at 1:30 PM | $150.48 | $49.67 |
| Previous close 07/23/2026 | $152.23 | $50.31 |
| Consolidated volume 07/23/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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XBI | BBC | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 7/24/2026 at 1:30 PM
Live
Closed
XBI | BBC | |
|---|---|---|
| Last price | $150.48 | $49.67 |
| 1D performance | -1.15% | -1.27% |
| AuM | $10.24 B | $47.16 M |
| E/R | 0.35% | 0.65% |
Characteristics
XBI | BBC | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | VIRTUS Investment Partners |
| Benchmark | S&P Biotechnology Select Industry Index | LifeSci Biotechnology Clinical Trials Index |
| N° of holdings | 150 | 125 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | December 16, 2014 |
| ESG | No | No |
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Exposure
Countries
XBI
USA
95.06%
Other
4.94%
BBC
USA
85.4%
Other
14.6%
Sectors
XBI
Healthcare
99.03%
Other
0.97%
BBC
Healthcare
95.19%
Other
4.81%
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Diversification
XBI
Total weight of top 15 holdings out of 15
19.19%
BBC
Total weight of top 15 holdings out of 15
14.01%
Top 15 holdings
Data as of June 30, 2026
XBI
Apogee Therapeutics, Inc.
1.48%
Moderna, Inc.
1.41%
Twist Bioscience Corp.
1.40%
Oruka Therapeutics, Inc.
1.37%
Kymera Therapeutics, Inc.
1.35%
Viking Therapeutics, Inc.
1.30%
Praxis Precision Medicines, Inc.
1.29%
Erasca, Inc.
1.27%
Revolution Medicines, Inc.
1.20%
Rhythm Pharmaceuticals, Inc.
1.20%
CG Oncology, Inc.
1.20%
SELLAS Life Sciences Group, Inc.
1.19%
Vaxcyte, Inc.
1.18%
Dianthus Therapeutics, Inc.
1.18%
Cytokinetics, Inc.
1.17%
BBC
uniQure NV
1.18%
REGENXBIO, Inc.
1.01%
Apogee Therapeutics, Inc.
0.99%
Monopar Therapeutics, Inc.
0.97%
Jade Biosciences, Inc.
0.94%
Aktis Oncology, Inc.
0.94%
MBX Biosciences, Inc.
0.94%
Biohaven Ltd.
0.90%
Kymera Therapeutics, Inc.
0.89%
Cullinan Therapeutics, Inc.
0.89%
SELLAS Life Sciences Group, Inc.
0.89%
Generate Biomedicines, Inc.
0.88%
Nurix Therapeutics, Inc.
0.87%
Intellia Therapeutics, Inc.
0.87%
4D Molecular Therapeutics, Inc.
0.86%
Frequently asked questions about XBI and BBC
How have the XBI and BBC ETFs performed in 2026?
As of July 22, 2026, XBI is up 24.76% year-to-date (YTD), while BBC has returned 28.33%. That puts BBC better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or BBC?
Year-to-date, the XBI ETF saw +$510M in flows, compared to +$5M for BBC.
Which ETF is more volatile: XBI or BBC?
Over the past year, XBI had a volatility of 26.78%, while BBC experienced 35.78%.
Which ETF is bigger: XBI or BBC?
As of July 22, 2026, XBI holds $10.24 B in assets under management (AUM), while BBC manages $47.16 M.
What sectors do the XBI and BBC ETFs invest in?
XBI leans toward sectors like Healthcare. Meanwhile, BBC focuses on Healthcare.
What are the top holdings of the XBI ETF and BBC ETF?
XBI top holdings include Apogee Therapeutics, Inc., Moderna, Inc. and Twist Bioscience Corp.. BBC holds in its top three: uniQure NV, REGENXBIO, Inc. and Apogee Therapeutics, Inc..
Which ETF is more diversified: XBI or BBC?
XBI holds 153 securities with 19.19% of its assets in the top 15. BBC has 125 securities and a top 15 weight of 14.01%.
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