XBIvsPTHETF Comparison
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State Street SPDR S&P Biotech ETF (XBI) and Invesco DWA Healthcare Momentum ETF (PTH) belong to the same industry segment: US Health Care. XBI's top 3 sector exposures are Healthcare and Finance. In contrast, PTH's top sector exposures are Healthcare XBI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.72% for PTH. XBI is up 24.76% year-to-date (YTD) with +$510M in YTD flows. PTH performs worse with 17.82% YTD performance, and +$88M in YTD flows. Run a side-by-side ETF comparison of XBI and PTH below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI vs PTH performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/22/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI PTH | +4.20%+5.19% | +10.82%+12.36% | +24.76%+17.82% | +76.10%+58.30% | +83.33%+56.89% | +19.73%+7.61% |
| Flows | XBI PTH | +$459M+$102M | +$279M+$94M | +$510M+$88M | +$1.45B+$92M | -$425M+$25M | +$1.59B-$192M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI PTH | +30.98%+29.53% | +26.78%+24.63% | +27.91%+25.60% | +32.90%+25.58% |
| Max drawdown | XBI PTH | -8.13%-8.31% | -9.66%-11.91% | -32.94%-27.71% | -54.07%-50.10% |
| Max drawdown duration | XBI PTH | 13d41d | 76d140d | 331d353d | 1685d1756d |
Trading data
XBI | PTH | |
Last sale 7/24/2026 at 1:30 PM | $150.48 | $58.57 |
| Previous close 07/23/2026 | $152.23 | $59.39 |
| Consolidated volume 07/23/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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XBI | PTH | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 7/24/2026 at 1:30 PM
Live
Closed
XBI | PTH | |
|---|---|---|
| Last price | $150.48 | $58.57 |
| 1D performance | -1.15% | -1.38% |
| AuM | $10.24 B | $231.95 M |
| E/R | 0.35% | 0.72% |
Characteristics
XBI | PTH | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | Invesco |
| Benchmark | S&P Biotechnology Select Industry Index | Dorsey Wright Healthcare Technical Leaders Index |
| N° of holdings | 150 | 57 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | October 12, 2006 |
| ESG | No | No |
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Exposure
Countries
XBI
USA
95.06%
Other
4.94%
PTH
USA
92.25%
Other
7.75%
Sectors
XBI
Healthcare
99.03%
Other
0.97%
PTH
Healthcare
100%
Other
0%
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Diversification
XBI
Total weight of top 15 holdings out of 15
19.19%
PTH
Total weight of top 15 holdings out of 15
43.88%
Top 15 holdings
Data as of June 30, 2026
XBI
Apogee Therapeutics, Inc.
1.48%
Moderna, Inc.
1.41%
Twist Bioscience Corp.
1.40%
Oruka Therapeutics, Inc.
1.37%
Kymera Therapeutics, Inc.
1.35%
Viking Therapeutics, Inc.
1.30%
Praxis Precision Medicines, Inc.
1.29%
Erasca, Inc.
1.27%
Revolution Medicines, Inc.
1.20%
Rhythm Pharmaceuticals, Inc.
1.20%
CG Oncology, Inc.
1.20%
SELLAS Life Sciences Group, Inc.
1.19%
Vaxcyte, Inc.
1.18%
Dianthus Therapeutics, Inc.
1.18%
Cytokinetics, Inc.
1.17%
PTH
Roivant Sciences Ltd.
4.95%
Praxis Precision Medicines, Inc.
4.66%
Tango Therapeutics, Inc.
3.70%
SELLAS Life Sciences Group, Inc.
3.36%
United Therapeutics Corp.
2.91%
Tenet Healthcare Corp.
2.89%
Axsome Therapeutics, Inc.
2.74%
BrightSpring Health Services, Inc.
2.54%
Liquidia Corp.
2.52%
Moderna, Inc.
2.49%
Ionis Pharmaceuticals, Inc.
2.30%
Erasca, Inc.
2.29%
HCA Healthcare, Inc.
2.23%
Twist Bioscience Corp.
2.21%
Protagonist Therapeutics, Inc.
2.08%
Frequently asked questions about XBI and PTH
How have the XBI and PTH ETFs performed in 2026?
As of July 22, 2026, XBI is up 24.76% year-to-date (YTD), while PTH has returned 17.82%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or PTH?
Year-to-date, the XBI ETF saw +$510M in flows, compared to +$88M for PTH.
Which ETF is more volatile: XBI or PTH?
Over the past year, XBI had a volatility of 26.78%, while PTH experienced 24.63%.
Which ETF is bigger: XBI or PTH?
As of July 22, 2026, XBI holds $10.24 B in assets under management (AUM), while PTH manages $231.95 M.
What sectors do the XBI and PTH ETFs invest in?
XBI leans toward sectors like Healthcare. Meanwhile, PTH focuses on Healthcare.
What are the top holdings of the XBI ETF and PTH ETF?
XBI top holdings include Apogee Therapeutics, Inc., Moderna, Inc. and Twist Bioscience Corp.. PTH holds in its top three: Roivant Sciences Ltd., Praxis Precision Medicines, Inc. and Tango Therapeutics, Inc..
Which ETF is more diversified: XBI or PTH?
XBI holds 153 securities with 19.19% of its assets in the top 15. PTH has 57 securities and a top 15 weight of 43.88%.
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