XBIvsPTHETF Comparison
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State Street SPDR S&P Biotech ETF (XBI) and Invesco DWA Healthcare Momentum ETF (PTH) belong to the same industry segment: US Health Care. XBI's top 2 sector exposures are Healthcare and Finance. In contrast, PTH's top sector exposures are Healthcare and Consumer Non-Cyclicals. XBI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.72% for PTH. XBI is up 24.49% year-to-date (YTD) with +$898M in YTD flows. PTH performs worse with 18.38% YTD performance, and +$145M in YTD flows. Run a side-by-side ETF comparison of XBI and PTH below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI vs PTH performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/22/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI PTH | -6.26%-5.71% | -0.22%-0.92% | +24.49%+18.38% | +42.01%+30.85% | +133.43%+106.09% | +23.02%+13.73% |
| Flows | XBI PTH | +$557M+$12M | +$217M+$67M | +$898M+$145M | +$1.18B+$155M | +$321M+$98M | +$1.98B-$114M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI PTH | +30.19%+28.90% | +28.98%+26.81% | +28.46%+26.13% | +33.05%+25.90% |
| Max drawdown | XBI PTH | -14.89%-12.72% | -14.89%-12.72% | -32.94%-27.71% | -53.28%-47.24% |
| Max drawdown duration | XBI PTH | 64d64d | 64d64d | 331d353d | 1622d1688d |
Trading data
XBI | PTH | |
Last sale 10/23/2026 at 7:52 PM | $149.73 | $58.61 |
| Previous close 10/22/2026 | $151.64 | $58.91 |
| Consolidated volume 10/22/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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XBI | PTH | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/23/2026 at 7:52 PM
Live
Closed
XBI | PTH | |
|---|---|---|
| Last price | $149.73 | $58.61 |
| 1D performance | -1.26% | -0.51% |
| AuM | $10.55 B | $287.19 M |
| E/R | 0.35% | 0.72% |
Characteristics
XBI | PTH | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | Invesco |
| Benchmark | S&P Biotechnology Select Industry Index | Dorsey Wright Healthcare Technical Leaders Index |
| N° of holdings | 149 | 54 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | October 12, 2006 |
| ESG | No | No |
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Exposure
Countries
XBI
USA
95.53%
Other
4.47%
PTH
USA
90%
Other
10%
Sectors
XBI
Healthcare
99.18%
Other
0.82%
PTH
Healthcare
99.31%
Other
0.69%
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Diversification
XBI
Total weight of top 15 holdings out of 15
21.91%
PTH
Total weight of top 15 holdings out of 15
49.11%
Top 15 holdings
Data as of August 31, 2026
XBI
Moderna, Inc.
2.81%
Twist Bioscience Corp.
1.89%
Apogee Therapeutics, Inc.
1.50%
Kymera Therapeutics, Inc.
1.40%
Halozyme Therapeutics, Inc.
1.39%
Natera, Inc.
1.37%
Praxis Precision Medicines, Inc.
1.34%
Oruka Therapeutics, Inc.
1.33%
Revolution Medicines, Inc.
1.31%
Travere Therapeutics, Inc.
1.30%
Protagonist Therapeutics, Inc.
1.28%
Dianthus Therapeutics, Inc.
1.27%
CG Oncology, Inc.
1.26%
Vaxcyte, Inc.
1.23%
Erasca, Inc.
1.23%
PTH
Revolution Medicines, Inc.
5.32%
Roivant Sciences Ltd.
5.01%
Guardant Health, Inc.
4.73%
Moderna, Inc.
4.51%
BrightSpring Health Services, Inc.
3.76%
Axsome Therapeutics, Inc.
3.57%
Erasca, Inc.
2.89%
10X Genomics, Inc.
2.85%
Oruka Therapeutics, Inc.
2.50%
Replimune Group, Inc.
2.46%
Twist Bioscience Corp.
2.43%
Travere Therapeutics, Inc.
2.38%
Axogen, Inc.
2.31%
Liquidia Corp.
2.29%
Relay Therapeutics, Inc.
2.12%
Frequently asked questions about XBI and PTH
How have the XBI and PTH ETFs performed in 2026?
As of October 22, 2026, XBI is up 24.49% year-to-date (YTD), while PTH has returned 18.38%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or PTH?
Year-to-date, the XBI ETF saw +$898M in flows, compared to +$145M for PTH.
Which ETF is more volatile: XBI or PTH?
Over the past year, XBI had a volatility of 28.98%, while PTH experienced 26.81%.
Which ETF is bigger: XBI or PTH?
As of October 22, 2026, XBI holds $10.55 B in assets under management (AUM), while PTH manages $287.19 M.
What sectors do the XBI and PTH ETFs invest in?
XBI leans toward sectors like Healthcare. Meanwhile, PTH focuses on Healthcare.
What are the top holdings of the XBI ETF and PTH ETF?
XBI top holdings include Moderna, Inc., Twist Bioscience Corp. and Apogee Therapeutics, Inc.. PTH holds in its top three: Revolution Medicines, Inc., Roivant Sciences Ltd. and Guardant Health, Inc..
Which ETF is more diversified: XBI or PTH?
XBI holds 152 securities with 21.91% of its assets in the top 15. PTH has 54 securities and a top 15 weight of 49.11%.
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