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XBIvsPTHETF Comparison

ETF 1
XBI

SPDR S&P Biotech ETF

This fund is part of
US Health Care
-0.31%
Full XBI fund page
VS
ETF 2
PTH

Invesco DWA Healthcare Momentum ETF

This fund is part of
US Health Care
-0.31%
Full PTH fund page

SPDR S&P Biotech ETF (XBI) and Invesco DWA Healthcare Momentum ETF (PTH) belong to the same industry segment: US Health Care. Both ETFs have the same top 3 sector exposures: and Health Care. XBI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.72% for PTH. XBI is up 3.65% year-to-date (YTD) with -$59M in YTD flows. PTH performs worse with -1.66% YTD performance, and -$2M in YTD flows. Run a side-by-side ETF comparison of XBI and PTH below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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XBI vs PTH performance and flow charts

Performance

-2.0-1.00.01.02.03.04.0%Feb 11Feb 19Feb 26Mar 5

Cumulative Flows

-400,000,000-200,000,0000200,000,000400,000,000600,000,000800,000,000Feb 11Feb 19Feb 26Mar 5

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Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Historic performance and flows
Data as of 03/11/2026
1M3MYTD1Y3Y5Y
Perf.
XBI
PTH
+1.38%-0.00%
+3.11%-3.57%
+3.65%-1.66%
+47.21%+29.38%
+63.16%+33.57%
-13.71%-9.43%
Flows
XBI
PTH
-$4M-
-$179M-$2M
-$59M-$2M
+$90M-$12M
-$1.64B-$92M
+$1.20B-$490M
Volatility and drawdown
3M1Y3Y5Y
Volatility
XBI
PTH
+25.68%+21.18%
+28.04%+24.52%
+27.26%+24.28%
+32.91%+25.52%
Max drawdown
XBI
PTH
-8.19%-7.58%
-21.44%-16.12%
-32.94%-29.24%
-57.63%-50.10%
Max drawdown duration
XBI
PTH
48d87d
141d183d
331d271d
1822d1651d
Trading data

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XBI
PTH
Last sale
3/12/2026 at 2:09 PM
$124.15
$48.80
Previous close
03/11/2026
$126.38
$49.20
Consolidated volume
03/11/2026
Average volume
30 days
Average discount or premium
30 days
Average Bid/Ask spread
30 days
Replication quality
Data as of February 27, 2026
1-year trailing difference

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XBI
PTH
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst
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Main metrics
Last update 3/12/2026 at 2:09 PM
Live
Closed
XBI
PTH
Last price
$124.15
$48.80
1D performance
-1.76%
-0.81%
AuM$8.10 B$121.25 M
E/R0.35%0.72%
Characteristics
XBI
PTH
Management strategyPassivePassive
ProviderSPDRInvesco
BenchmarkS&P Biotechnology Select Industry IndexDorsey Wright Healthcare Technical Leaders Index
N° of holdings12346
Asset classEquitiesEquities
Trailing 12m distribution yield
Join
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Inception dateJanuary 31, 2006October 12, 2006
ESGNoNo
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Exposure

Countries

XBI
USA
94.51%
Other
5.49%
PTH
USA
95.61%
Other
4.39%

Sectors

XBI
Health Care
88.03%
Other
11.97%
PTH
Health Care
83.75%
Other
16.25%

Diversification

XBI

Total weight of top 15 holdings out of 15

21.6%
PTH

Total weight of top 15 holdings out of 15

50.37%

Top 15 holdings

Data as of January 31, 2026
XBI
MODERNA INC
1.85%
MIRUM PHARMACEUTICALS INC
1.58%
REVOLUTION MEDICINES INC
1.52%
VAXCYTE
1.50%
AMICUS THERAPEUTICS
1.48%
US74006W2070
1.46%
ALKERMES
1.44%
GILEAD SCIENCES
1.43%
KRYSTAL BIOTECH INC
1.42%
HALOZYME THERAPEUTICS
1.40%
AMGEN-T
1.32%
CELCUITY INC
1.31%
ROIVANT SCIENCES LTD
1.30%
BRIDGEBIO PHARMA
1.30%
VERTEX PHARMACEUTICALS
1.29%
PTH
US74006W2070
4.89%
GUARDANT HEALTH INC
4.41%
ROIVANT SCIENCES LTD
4.39%
TERNS PHARMACEUTICALS
4.11%
ARROWHEAD PHARMACEUTICALS INC
3.97%
NATERA
3.65%
REVOLUTION MEDICINES INC
3.29%
TENET HEALTHCARE
2.93%
CELCUITY INC
2.90%
MEDPACE HOLDINGS INC
2.86%
AXSOME THERA CMN STK
2.86%
HCA HEALTHCARE
2.71%
UTD THERAPEUT
2.54%
BRIDGEBIO PHARMA
2.49%
COGENT BIOSCIENCES
2.36%
Frequently asked questions about XBI and PTH

How have the XBI and PTH ETFs performed in 2026?

As of March 11, 2026, XBI is up 3.65% year-to-date (YTD), while PTH has lost -1.66%. That puts XBI better performer ahead so far this year.

Which ETF is attracting more investor money: XBI or PTH?

Year-to-date, the XBI ETF saw -$59M in flows, compared to -$2M for PTH.

Which ETF is more volatile: XBI or PTH?

Over the past year, XBI had a volatility of 28.04%, while PTH experienced 24.52%.

Which ETF is bigger: XBI or PTH?

As of March 11, 2026, XBI holds $8.10 B in assets under management (AUM), while PTH manages $121.25 M.

What sectors do the XBI and PTH ETFs invest in?

XBI leans toward sectors like Health Care. Meanwhile, PTH focuses on Health Care.

What are the top holdings of the XBI ETF and PTH ETF?

XBI top holdings include MODERNA INC, MIRUM PHARMACEUTICALS INC and REVOLUTION MEDICINES INC. PTH holds in its top three: US74006W2070, GUARDANT HEALTH INC and ROIVANT SCIENCES LTD.

Which ETF is more diversified: XBI or PTH?

XBI holds 149 securities with 21.6% of its assets in the top 15. PTH has 58 securities and a top 15 weight of 50.37%.

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