XBIvsPTHETF Comparison
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State Street SPDR S&P Biotech ETF (XBI) and Invesco DWA Healthcare Momentum ETF (PTH) belong to the same industry segment: US Health Care. Both ETFs have the same top 3 sector exposures: and Health Care. XBI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.72% for PTH. XBI is up 7.52% year-to-date (YTD) with +$23M in YTD flows. PTH performs worse with 1.75% YTD performance, and -$6M in YTD flows. Run a side-by-side ETF comparison of XBI and PTH below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI vs PTH performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/28/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI PTH | +10.37%+8.86% | +4.13%+4.25% | +7.52%+1.75% | +61.71%+32.72% | +64.28%+30.38% | -5.68%-2.01% |
| Flows | XBI PTH | +$514M-$498K | -$371M-$5M | +$23M-$6M | +$555M-$10M | -$1.24B-$80M | +$958M-$357M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI PTH | +30.05%+27.25% | +25.87%+23.02% | +27.40%+24.62% | +32.69%+25.29% |
| Max drawdown | XBI PTH | -7.98%-7.51% | -9.66%-11.91% | -32.94%-29.24% | -55.10%-50.10% |
| Max drawdown duration | XBI PTH | 42d40d | 76d140d | 331d271d | 1826d1699d |
Trading data
XBI | PTH | |
Last sale 4/29/2026 at 2:49 PM | $129.00 | $50.71 |
| Previous close 04/28/2026 | $131.16 | $52.10 |
| Consolidated volume 04/28/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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XBI | PTH | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/29/2026 at 2:49 PM
Live
Closed
XBI | PTH | |
|---|---|---|
| Last price | $129.00 | $50.71 |
| 1D performance | -1.65% | -2.68% |
| AuM | $8.42 B | $121.40 M |
| E/R | 0.35% | 0.72% |
Characteristics
XBI | PTH | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | Invesco |
| Benchmark | S&P Biotechnology Select Industry Index | Dorsey Wright Healthcare Technical Leaders Index |
| N° of holdings | 122 | 46 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | October 12, 2006 |
| ESG | No | No |
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Exposure
Countries
XBI
USA
95.16%
Other
4.84%
PTH
USA
94.53%
Other
5.47%
Sectors
XBI
Health Care
86.79%
Other
13.21%
PTH
Health Care
85.2%
Other
14.8%
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Diversification
XBI
Total weight of top 15 holdings out of 15
19.71%
PTH
Total weight of top 15 holdings out of 15
52.67%
Top 15 holdings
Data as of March 31, 2026
XBI
APELLIS PHARMACEUTICALS
1.83%
ALKERMES
1.45%
MADRIGAL PHARMACEUTICALS INC
1.38%
TG THERAPEUTICS
1.35%
INSMED
1.34%
SCHOLAR ROCK HOLDING CORP
1.30%
US03770N1019
1.28%
PROTAGONIST THERAPEUTICS INC
1.25%
US86627T1088
1.24%
UTD THERAPEUT
1.24%
US74006W2070
1.24%
ARROWHEAD PHARMACEUTICALS INC
1.23%
COGENT BIOSCIENCES
1.22%
BRIDGEBIO PHARMA
1.19%
PTC THERAPEUTI/D
1.18%
PTH
TERNS PHARMACEUTICALS
6.73%
ROIVANT SCIENCES LTD
5.47%
US74006W2070
5.15%
ARROWHEAD PHARMACEUTICALS INC
3.66%
GUARDANT HEALTH INC
3.47%
REVOLUTION MEDICINES INC
3.32%
TENET HEALTHCARE
3.16%
UTD THERAPEUT
2.99%
NATERA
2.95%
HCA HEALTHCARE
2.89%
CELCUITY INC
2.88%
AXSOME THERA CMN STK
2.58%
MADRIGAL PHARMACEUTICALS INC
2.58%
PROTAGONIST THERAPEUTICS INC
2.43%
COGENT BIOSCIENCES
2.40%
Frequently asked questions about XBI and PTH
How have the XBI and PTH ETFs performed in 2026?
As of April 28, 2026, XBI is up 7.52% year-to-date (YTD), while PTH has returned 1.75%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or PTH?
Year-to-date, the XBI ETF saw +$23M in flows, compared to -$6M for PTH.
Which ETF is more volatile: XBI or PTH?
Over the past year, XBI had a volatility of 25.87%, while PTH experienced 23.02%.
Which ETF is bigger: XBI or PTH?
As of April 28, 2026, XBI holds $8.42 B in assets under management (AUM), while PTH manages $121.40 M.
What sectors do the XBI and PTH ETFs invest in?
XBI leans toward sectors like Health Care. Meanwhile, PTH focuses on Health Care.
What are the top holdings of the XBI ETF and PTH ETF?
XBI top holdings include APELLIS PHARMACEUTICALS, ALKERMES and MADRIGAL PHARMACEUTICALS INC. PTH holds in its top three: TERNS PHARMACEUTICALS, ROIVANT SCIENCES LTD and US74006W2070.
Which ETF is more diversified: XBI or PTH?
XBI holds 151 securities with 19.71% of its assets in the top 15. PTH has 57 securities and a top 15 weight of 52.67%.
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