XBIvsXHSETF Comparison
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State Street SPDR S&P Biotech ETF (XBI) and State Street SPDR S&P Health Care Services ETF (XHS) belong to the same industry segment: US Health Care. XBI's top 2 sector exposures are Healthcare and Finance. In contrast, XHS's top sector exposures are Healthcare, Consumer Non-Cyclicals and Business Services. Both XBI and XHS have the same Total Expense Ratio (TER) of 0.35%. XBI is up 22.77% year-to-date (YTD) with +$853M in YTD flows. XHS performs better with 32.24% YTD performance, and +$103M in YTD flows. Run a side-by-side ETF comparison of XBI and XHS below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI vs XHS performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/23/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI XHS | -3.93%+5.46% | -1.72%+7.08% | +22.77%+32.24% | +39.61%+35.98% | +130.21%+78.28% | +20.98%+36.44% |
| Flows | XBI XHS | +$229M-$13M | +$343M+$3M | +$853M+$103M | +$1.24B+$107M | +$276M+$74M | +$1.96B+$37M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI XHS | +30.32%+17.05% | +29.02%+17.59% | +28.46%+18.30% | +33.06%+21.37% |
| Max drawdown | XBI XHS | -14.89%-5.21% | -14.89%-11.97% | -32.94%-14.46% | -53.28%-29.93% |
| Max drawdown duration | XBI XHS | 65d30d | 65d121d | 331d250d | 1622d1477d |
Trading data
XBI | XHS | |
Last sale 10/23/2026 at 1:30 PM | $149.54 | $141.40 |
| Previous close 10/22/2026 | $151.64 | $142.69 |
| Consolidated volume 10/22/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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XBI | XHS | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/23/2026 at 1:30 PM
Live
Closed
XBI | XHS | |
|---|---|---|
| Last price | $149.54 | $141.40 |
| 1D performance | -1.38% | -0.90% |
| AuM | $10.36 B | $221.73 M |
| E/R | 0.35% | 0.35% |
Characteristics
XBI | XHS | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | State Street Investment Management |
| Benchmark | S&P Biotechnology Select Industry Index | S&P Health Care Services Select Industry Index |
| N° of holdings | 149 | 59 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | September 28, 2011 |
| ESG | No | No |
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Exposure
Countries
XBI
USA
95.53%
Other
4.47%
XHS
USA
99.94%
Other
0.06%
Sectors
XBI
Healthcare
99.18%
Other
0.82%
XHS
Healthcare
95.16%
Other
4.84%
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Diversification
XBI
Total weight of top 15 holdings out of 15
21.91%
XHS
Total weight of top 15 holdings out of 15
33.1%
Top 15 holdings
Data as of August 31, 2026
XBI
Moderna, Inc.
2.81%
Twist Bioscience Corp.
1.89%
Apogee Therapeutics, Inc.
1.50%
Kymera Therapeutics, Inc.
1.40%
Halozyme Therapeutics, Inc.
1.39%
Natera, Inc.
1.37%
Praxis Precision Medicines, Inc.
1.34%
Oruka Therapeutics, Inc.
1.33%
Revolution Medicines, Inc.
1.31%
Travere Therapeutics, Inc.
1.30%
Protagonist Therapeutics, Inc.
1.28%
Dianthus Therapeutics, Inc.
1.27%
CG Oncology, Inc.
1.26%
Vaxcyte, Inc.
1.23%
Erasca, Inc.
1.23%
XHS
Tenet Healthcare Corp.
2.65%
NeoGenomics, Inc.
2.60%
Lifestance Health Group, Inc.
2.58%
GeneDx Holdings Corp.
2.56%
Hinge Health, Inc.
2.45%
RadNet, Inc.
2.14%
Concentra Group Holdings Parent, Inc.
2.08%
Aveanna Healthcare Holdings, Inc.
2.07%
Labcorp Holdings, Inc.
2.03%
U.S. Physical Therapy, Inc.
2.03%
PACS Group, Inc.
2.02%
Addus HomeCare Corp.
2.02%
Guardant Health, Inc.
1.99%
Chemed Corp.
1.96%
Quest Diagnostics, Inc.
1.93%
Frequently asked questions about XBI and XHS
How have the XBI and XHS ETFs performed in 2026?
As of October 23, 2026, XBI is up 22.77% year-to-date (YTD), while XHS has returned 32.24%. That puts XHS better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or XHS?
Year-to-date, the XBI ETF saw +$853M in flows, compared to +$103M for XHS.
Which ETF is more volatile: XBI or XHS?
Over the past year, XBI had a volatility of 29.02%, while XHS experienced 17.59%.
Which ETF is bigger: XBI or XHS?
As of October 23, 2026, XBI holds $10.36 B in assets under management (AUM), while XHS manages $221.73 M.
What sectors do the XBI and XHS ETFs invest in?
XBI leans toward sectors like Healthcare. Meanwhile, XHS focuses on Healthcare.
What are the top holdings of the XBI ETF and XHS ETF?
XBI top holdings include Moderna, Inc., Twist Bioscience Corp. and Apogee Therapeutics, Inc.. XHS holds in its top three: Tenet Healthcare Corp., NeoGenomics, Inc. and Lifestance Health Group, Inc..
Which ETF is more diversified: XBI or XHS?
XBI holds 152 securities with 21.91% of its assets in the top 15. XHS has 59 securities and a top 15 weight of 33.1%.
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