XBIvsXHEETF Comparison
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State Street SPDR S&P Biotech ETF (XBI) and State Street SPDR S&P Health Care Equipment ETF (XHE) belong to the same industry segment: US Health Care. Both ETFs have the same top 2 sector exposures: Healthcare and Finance. Both XBI and XHE have the same Total Expense Ratio (TER) of 0.35%. XBI is up 22.77% year-to-date (YTD) with +$853M in YTD flows. XHE performs worse with 5.54% YTD performance, and -$11M in YTD flows. Run a side-by-side ETF comparison of XBI and XHE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI vs XHE performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/23/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI XHE | -3.93%+1.87% | -1.72%+9.46% | +22.77%+5.54% | +39.61%+14.34% | +130.21%+33.01% | +20.98%-25.86% |
| Flows | XBI XHE | +$229M-$45M | +$343M-$15M | +$853M-$11M | +$1.24B-$21M | +$276M-$225M | +$1.96B-$401M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI XHE | +30.32%+20.85% | +29.02%+22.71% | +28.46%+21.97% | +33.06%+24.86% |
| Max drawdown | XBI XHE | -14.89%-9.09% | -14.89%-18.20% | -32.94%-24.35% | -53.28%-49.37% |
| Max drawdown duration | XBI XHE | 65d65d | 65d207d | 331d565d | 1622d1815d |
Trading data
XBI | XHE | |
Last sale 10/23/2026 at 1:30 PM | $149.54 | $93.08 |
| Previous close 10/22/2026 | $151.64 | $93.34 |
| Consolidated volume 10/22/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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XBI | XHE | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/23/2026 at 1:30 PM
Live
Closed
XBI | XHE | |
|---|---|---|
| Last price | $149.54 | $93.08 |
| 1D performance | -1.38% | -0.28% |
| AuM | $10.36 B | $151.14 M |
| E/R | 0.35% | 0.35% |
Characteristics
XBI | XHE | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | State Street Investment Management |
| Benchmark | S&P Biotechnology Select Industry Index | S&P Health Care Equipment Select Industry Index |
| N° of holdings | 149 | 67 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | January 26, 2011 |
| ESG | No | No |
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Exposure
Countries
XBI
USA
95.53%
Other
4.47%
XHE
USA
93.57%
Other
6.43%
Sectors
XBI
Healthcare
99.18%
Other
0.82%
XHE
Healthcare
97.47%
Other
2.53%
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Diversification
XBI
Total weight of top 15 holdings out of 15
21.91%
XHE
Total weight of top 15 holdings out of 15
30.96%
Top 15 holdings
Data as of August 31, 2026
XBI
Moderna, Inc.
2.81%
Twist Bioscience Corp.
1.89%
Apogee Therapeutics, Inc.
1.50%
Kymera Therapeutics, Inc.
1.40%
Halozyme Therapeutics, Inc.
1.39%
Natera, Inc.
1.37%
Praxis Precision Medicines, Inc.
1.34%
Oruka Therapeutics, Inc.
1.33%
Revolution Medicines, Inc.
1.31%
Travere Therapeutics, Inc.
1.30%
Protagonist Therapeutics, Inc.
1.28%
Dianthus Therapeutics, Inc.
1.27%
CG Oncology, Inc.
1.26%
Vaxcyte, Inc.
1.23%
Erasca, Inc.
1.23%
XHE
AtriCure, Inc.
2.59%
Strive, Inc. (United States)
2.47%
Inspire Medical Systems, Inc.
2.19%
Glaukos Corp.
2.16%
Butterfly Network, Inc.
2.15%
CONMED Corp.
2.02%
Integer Holdings Corp.
2.02%
Tandem Diabetes Care, Inc.
2.00%
Merit Medical Systems, Inc.
1.99%
Artivion, Inc.
1.94%
Haemonetics Corp.
1.93%
UFP Technologies, Inc.
1.89%
Baxter International, Inc.
1.88%
Becton, Dickinson & Co.
1.87%
Neogen Corp.
1.86%
Frequently asked questions about XBI and XHE
How have the XBI and XHE ETFs performed in 2026?
As of October 23, 2026, XBI is up 22.77% year-to-date (YTD), while XHE has returned 5.54%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or XHE?
Year-to-date, the XBI ETF saw +$853M in flows, compared to -$11M for XHE.
Which ETF is more volatile: XBI or XHE?
Over the past year, XBI had a volatility of 29.02%, while XHE experienced 22.71%.
Which ETF is bigger: XBI or XHE?
As of October 23, 2026, XBI holds $10.36 B in assets under management (AUM), while XHE manages $151.14 M.
What sectors do the XBI and XHE ETFs invest in?
XBI leans toward sectors like Healthcare. Meanwhile, XHE focuses on Healthcare.
What are the top holdings of the XBI ETF and XHE ETF?
XBI top holdings include Moderna, Inc., Twist Bioscience Corp. and Apogee Therapeutics, Inc.. XHE holds in its top three: AtriCure, Inc., Strive, Inc. (United States) and Inspire Medical Systems, Inc..
Which ETF is more diversified: XBI or XHE?
XBI holds 152 securities with 21.91% of its assets in the top 15. XHE has 67 securities and a top 15 weight of 30.96%.
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