XBIvsXHEETF Comparison
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State Street SPDR S&P Biotech ETF (XBI) and State Street SPDR S&P Health Care Equipment ETF (XHE) belong to the same industry segment: US Health Care. Both ETFs have the same top 3 sector exposures: and Health Care. Both XBI and XHE have the same Total Expense Ratio (TER) of 0.35%. XBI is up 7.52% year-to-date (YTD) with +$23M in YTD flows. XHE performs worse with -7.98% YTD performance, and -$12M in YTD flows. Run a side-by-side ETF comparison of XBI and XHE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI vs XHE performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/28/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI XHE | +10.37%+6.20% | +4.13%-6.51% | +7.52%-7.98% | +61.71%+2.12% | +64.28%-16.88% | -5.68%-36.24% |
| Flows | XBI XHE | +$514M-$12M | -$371M-$8M | +$23M-$12M | +$555M-$41M | -$1.24B-$308M | +$958M-$410M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI XHE | +30.05%+23.19% | +25.87%+21.35% | +27.40%+21.34% | +32.69%+24.32% |
| Max drawdown | XBI XHE | -7.98%-14.31% | -9.66%-18.20% | -32.94%-32.46% | -55.10%-49.90% |
| Max drawdown duration | XBI XHE | 42d61d | 76d110d | 331d1016d | 1826d1699d |
Trading data
XBI | XHE | |
Last sale 4/29/2026 at 3:14 PM | $129.30 | $79.21 |
| Previous close 04/28/2026 | $131.16 | $81.23 |
| Consolidated volume 04/28/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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XBI | XHE | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/29/2026 at 3:14 PM
Live
Closed
XBI | XHE | |
|---|---|---|
| Last price | $129.30 | $79.21 |
| 1D performance | -1.42% | -2.49% |
| AuM | $8.42 B | $129.75 M |
| E/R | 0.35% | 0.35% |
Characteristics
XBI | XHE | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | State Street Investment Management |
| Benchmark | S&P Biotechnology Select Industry Index | S&P Health Care Equipment Select Industry Index |
| N° of holdings | 122 | 61 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | January 26, 2011 |
| ESG | No | No |
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Exposure
Countries
XBI
USA
95.16%
Other
4.84%
XHE
USA
92.19%
Other
7.81%
Sectors
XBI
Health Care
86.79%
Other
13.21%
XHE
Health Care
89.87%
Other
10.13%
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Diversification
XBI
Total weight of top 15 holdings out of 15
19.71%
XHE
Total weight of top 15 holdings out of 15
26.74%
Top 15 holdings
Data as of March 31, 2026
XBI
APELLIS PHARMACEUTICALS
1.83%
ALKERMES
1.45%
MADRIGAL PHARMACEUTICALS INC
1.38%
TG THERAPEUTICS
1.35%
INSMED
1.34%
SCHOLAR ROCK HOLDING CORP
1.30%
US03770N1019
1.28%
PROTAGONIST THERAPEUTICS INC
1.25%
US86627T1088
1.24%
UTD THERAPEUT
1.24%
US74006W2070
1.24%
ARROWHEAD PHARMACEUTICALS INC
1.23%
COGENT BIOSCIENCES
1.22%
BRIDGEBIO PHARMA
1.19%
PTC THERAPEUTI/D
1.18%
XHE
TELEFLEX
1.86%
STAAR SURGICAL
1.84%
BUTTERFLY NETWORK INC
1.84%
US58507V1070
1.83%
GLAUKOS
1.82%
INTEGER HOLDINGS
1.79%
AXOGEN
1.79%
LIVANOVA
1.78%
MASIMO
1.76%
LEMAITRE VASCULAR
1.75%
ARTIVION INC
1.75%
HOLOGIC
1.74%
STERIS
1.74%
GLOBUS MEDICAL
1.72%
IRHYTHM TECHNOLOGIES
1.72%
Frequently asked questions about XBI and XHE
How have the XBI and XHE ETFs performed in 2026?
As of April 28, 2026, XBI is up 7.52% year-to-date (YTD), while XHE has lost -7.98%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or XHE?
Year-to-date, the XBI ETF saw +$23M in flows, compared to -$12M for XHE.
Which ETF is more volatile: XBI or XHE?
Over the past year, XBI had a volatility of 25.87%, while XHE experienced 21.35%.
Which ETF is bigger: XBI or XHE?
As of April 28, 2026, XBI holds $8.42 B in assets under management (AUM), while XHE manages $129.75 M.
What sectors do the XBI and XHE ETFs invest in?
XBI leans toward sectors like Health Care. Meanwhile, XHE focuses on Health Care.
What are the top holdings of the XBI ETF and XHE ETF?
XBI top holdings include APELLIS PHARMACEUTICALS, ALKERMES and MADRIGAL PHARMACEUTICALS INC. XHE holds in its top three: TELEFLEX, STAAR SURGICAL and BUTTERFLY NETWORK INC.
Which ETF is more diversified: XBI or XHE?
XBI holds 151 securities with 19.71% of its assets in the top 15. XHE has 67 securities and a top 15 weight of 26.74%.
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