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XBIvsXHEETF Comparison
SPDR S&P Biotech ETF (XBI) and SPDR S&P Health Care Equipment ETF (XHE) belong to the same industry segment: US Health Care. Both ETFs have the same top 3 sector exposures: and Health Care. Both XBI and XHE have the same Total Expense Ratio (TER) of 0.35%. XBI is up 3.65% year-to-date (YTD) with -$59M in YTD flows. XHE performs worse with -6.79% YTD performance, and -$4M in YTD flows. Run a side-by-side ETF comparison of XBI and XHE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
XBI vs XHE performance and flow charts
Performance
Cumulative Flows
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI XHE | +1.38%-4.63% | +3.11%-8.38% | +3.65%-6.79% | +47.21%-1.88% | +63.16%-7.27% | -13.71%-31.62% |
| Flows | XBI XHE | -$4M- | -$179M-$7M | -$59M-$4M | +$90M-$44M | -$1.64B-$295M | +$1.20B-$430M |
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI XHE | +25.68%+18.94% | +28.04%+23.53% | +27.26%+21.07% | +32.91%+24.17% |
| Max drawdown | XBI XHE | -8.19%-12.38% | -21.44%-14.34% | -32.94%-32.63% | -57.63%-49.90% |
| Max drawdown duration | XBI XHE | 48d62d | 141d241d | 331d1053d | 1822d1651d |
XBI | XHE | |
Last sale 3/12/2026 at 1:52 PM | $123.90 | $82.04 |
| Previous close 03/11/2026 | $126.38 | $81.73 |
| Consolidated volume 03/11/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
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XBI | XHE | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
XBI | XHE | |
|---|---|---|
| Last price | $123.90 | $82.04 |
| 1D performance | -1.96% | +0.38% |
| AuM | $8.10 B | $139.64 M |
| E/R | 0.35% | 0.35% |
XBI | XHE | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | SPDR | SPDR |
| Benchmark | S&P Biotechnology Select Industry Index | S&P Health Care Equipment Select Industry Index |
| N° of holdings | 123 | 61 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | January 26, 2011 |
| ESG | No | No |
Countries
Sectors
Diversification
Total weight of top 15 holdings out of 15
Total weight of top 15 holdings out of 15
Top 15 holdings
How have the XBI and XHE ETFs performed in 2026?
As of March 11, 2026, XBI is up 3.65% year-to-date (YTD), while XHE has lost -6.79%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or XHE?
Year-to-date, the XBI ETF saw -$59M in flows, compared to -$4M for XHE.
Which ETF is more volatile: XBI or XHE?
Over the past year, XBI had a volatility of 28.04%, while XHE experienced 23.53%.
Which ETF is bigger: XBI or XHE?
As of March 11, 2026, XBI holds $8.10 B in assets under management (AUM), while XHE manages $139.64 M.
What sectors do the XBI and XHE ETFs invest in?
XBI leans toward sectors like Health Care. Meanwhile, XHE focuses on Health Care.
What are the top holdings of the XBI ETF and XHE ETF?
XBI top holdings include MODERNA INC, MIRUM PHARMACEUTICALS INC and REVOLUTION MEDICINES INC. XHE holds in its top three: NEOGEN, INTEGER HOLDINGS and PENUMBRA.
Which ETF is more diversified: XBI or XHE?
XBI holds 149 securities with 21.6% of its assets in the top 15. XHE has 64 securities and a top 15 weight of 30.47%.
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