XLVvsXBIETF Comparison
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State Street Health Care Select Sector SPDR ETF (XLV) and State Street SPDR S&P Biotech ETF (XBI) belong to the same industry segment: US Health Care. Both ETFs have the same top 3 sector exposures: and Health Care. XLV is less expensive with a Total Expense Ratio (TER) of 0.08%, versus 0.35% for XBI. XLV is down -2.77% year-to-date (YTD) with +$113M in YTD flows. XBI performs better with 7.98% YTD performance, and -$50M in YTD flows. Run a side-by-side ETF comparison of XLV and XBI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XLV vs XBI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 05/22/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XLV XBI | +2.41%-4.09% | -5.09%+3.75% | -2.77%+7.98% | +16.83%+66.77% | +19.86%+51.20% | +30.49%+5.29% |
| Flows | XLV XBI | -$1.30B-$281M | -$1.24B+$131M | +$113M-$50M | -$223M+$247M | -$6.53B-$838M | +$4.80B+$1.21B |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XLV XBI | +15.33%+30.60% | +14.49%+25.17% | +13.81%+27.32% | +14.64%+32.66% |
| Max drawdown | XLV XBI | -10.51%-8.56% | -10.51%-9.66% | -17.05%-32.94% | -17.05%-54.69% |
| Max drawdown duration | XLV XBI | 82d33d | 82d76d | 444d331d | 444d1754d |
Trading data
XLV | XBI | |
Last sale 5/22/2026 at 1:30 PM | $149.89 | $131.66 |
| Previous close 05/21/2026 | $148.15 | $132.78 |
| Consolidated volume 05/21/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of April 30, 2026
1-year trailing difference
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XLV | XBI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 5/22/2026 at 1:30 PM
Live
Closed
XLV | XBI | |
|---|---|---|
| Last price | $149.89 | $131.66 |
| 1D performance | +1.17% | -0.84% |
| AuM | $38.47 B | $8.38 B |
| E/R | 0.08% | 0.35% |
Characteristics
XLV | XBI | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | State Street Investment Management |
| Benchmark | S&P Health Care Select Sector Index | S&P Biotechnology Select Industry Index |
| N° of holdings | 56 | 122 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | December 16, 1998 | January 31, 2006 |
| ESG | No | No |
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Exposure
Countries
XLV
USA
97.26%
Other
2.74%
XBI
USA
95.16%
Other
4.84%
Sectors
XLV
Health Care
98.29%
Other
1.71%
XBI
Health Care
86.79%
Other
13.21%
Diversification
XLV
Total weight of top 15 holdings out of 15
70.96%
XBI
Total weight of top 15 holdings out of 15
19.71%
Top 15 holdings
Data as of March 31, 2026
XLV
LILLY
13.74%
JOHNSON&JOHNSON
11.10%
ABBVIE
7.25%
MERCK & CO INC
5.63%
UNITEDHEALTH GRP
4.62%
AMGEN-T
3.57%
THERMO FISHER SCIENTIFIC
3.48%
ABBOTT LABS
3.37%
GILEAD SCIENCES
3.26%
INTUITIVE SURGICAL
3.09%
PFIZER
3.01%
BRISTOL-MYERS SQUIBB
2.33%
DANAHER
2.25%
VERTEX PHARMACEUTICALS
2.14%
STRYKER
2.13%
XBI
APELLIS PHARMACEUTICALS
1.83%
ALKERMES
1.45%
MADRIGAL PHARMACEUTICALS INC
1.38%
TG THERAPEUTICS
1.35%
INSMED
1.34%
SCHOLAR ROCK HOLDING CORP
1.30%
US03770N1019
1.28%
PROTAGONIST THERAPEUTICS INC
1.25%
US86627T1088
1.24%
UTD THERAPEUT
1.24%
US74006W2070
1.24%
ARROWHEAD PHARMACEUTICALS INC
1.23%
COGENT BIOSCIENCES
1.22%
BRIDGEBIO PHARMA
1.19%
PTC THERAPEUTI/D
1.18%
Frequently asked questions about XLV and XBI
How have the XLV and XBI ETFs performed in 2026?
As of May 22, 2026, XLV is down -2.77% year-to-date (YTD), while XBI has returned 7.98%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XLV or XBI?
Year-to-date, the XLV ETF saw +$113M in flows, compared to -$50M for XBI.
Which ETF is more volatile: XLV or XBI?
Over the past year, XLV had a volatility of 14.49%, while XBI experienced 25.17%.
Which ETF is bigger: XLV or XBI?
As of May 22, 2026, XLV holds $38.47 B in assets under management (AUM), while XBI manages $8.38 B.
What sectors do the XLV and XBI ETFs invest in?
XLV leans toward sectors like Health Care. Meanwhile, XBI focuses on Health Care.
What are the top holdings of the XLV ETF and XBI ETF?
XLV top holdings include LILLY, JOHNSON&JOHNSON and ABBVIE. XBI holds in its top three: APELLIS PHARMACEUTICALS, ALKERMES and MADRIGAL PHARMACEUTICALS INC.
Which ETF is more diversified: XLV or XBI?
XLV holds 59 securities with 70.96% of its assets in the top 15. XBI has 151 securities and a top 15 weight of 19.71%.
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