XLVvsXBIETF Comparison
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State Street Health Care Select Sector SPDR ETF (XLV) and State Street SPDR S&P Biotech ETF (XBI) belong to the same industry segment: US Health Care. XLV's top 2 sector exposures are Healthcare and Consumer Non-Cyclicals. In contrast, XBI's top sector exposures are Healthcare and Finance. XLV is less expensive with a Total Expense Ratio (TER) of 0.08%, versus 0.35% for XBI. XLV is up 8.63% year-to-date (YTD) with +$288M in YTD flows. XBI performs better with 26.71% YTD performance, and +$254M in YTD flows. Run a side-by-side ETF comparison of XLV and XBI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XLV vs XBI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/02/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XLV XBI | -3.61%-6.61% | +1.72%-3.81% | +8.63%+26.71% | +17.96%+51.13% | +35.76%+119.93% | +43.57%+26.23% |
| Flows | XLV XBI | -$259M-$742M | +$182M-$283M | +$288M+$254M | +$1.69B+$859M | -$4.69B-$600M | +$2.98B+$977M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XLV XBI | +17.19%+28.53% | +15.77%+28.15% | +14.77%+28.31% | +15.15%+32.88% |
| Max drawdown | XLV XBI | -5.81%-10.46% | -10.51%-10.46% | -17.05%-32.94% | -17.05%-53.28% |
| Max drawdown duration | XLV XBI | 44d40d | 116d40d | 444d331d | 444d1622d |
Trading data
XLV | XBI | |
Last sale 10/5/2026 at 1:30 PM | $167.42 | $156.20 |
| Previous close 10/02/2026 | $166.18 | $154.43 |
| Consolidated volume 10/02/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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XLV | XBI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/5/2026 at 1:30 PM
Live
Closed
XLV | XBI | |
|---|---|---|
| Last price | $167.42 | $156.20 |
| 1D performance | +0.75% | +1.15% |
| AuM | $42.81 B | $10.09 B |
| E/R | 0.08% | 0.35% |
Characteristics
XLV | XBI | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | State Street Investment Management |
| Benchmark | S&P Health Care Select Sector Index | S&P Biotechnology Select Industry Index |
| N° of holdings | 59 | 149 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | December 16, 1998 | January 31, 2006 |
| ESG | No | No |
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Exposure
Countries
XLV
USA
97.52%
Other
2.48%
XBI
USA
95.53%
Other
4.47%
Sectors
XLV
Healthcare
97.84%
Other
2.16%
XBI
Healthcare
99.18%
Other
0.82%
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Diversification
XLV
Total weight of top 15 holdings out of 15
71.32%
XBI
Total weight of top 15 holdings out of 15
21.91%
Top 15 holdings
Data as of August 31, 2026
XLV
Eli Lilly & Co.
14.88%
Johnson & Johnson
10.41%
AbbVie, Inc.
7.37%
Merck & Co., Inc.
5.93%
UnitedHealth Group, Inc.
5.75%
Amgen, Inc.
3.77%
Thermo Fisher Scientific, Inc.
3.73%
Abbott Laboratories
3.13%
Gilead Sciences, Inc.
2.95%
Pfizer Inc.
2.64%
Vertex Pharmaceuticals, Inc.
2.25%
Bristol Myers Squibb Co.
2.22%
Danaher Corp.
2.19%
Intuitive Surgical, Inc.
2.17%
CVS Health Corp.
1.95%
XBI
Moderna, Inc.
2.81%
Twist Bioscience Corp.
1.89%
Apogee Therapeutics, Inc.
1.50%
Kymera Therapeutics, Inc.
1.40%
Halozyme Therapeutics, Inc.
1.39%
Natera, Inc.
1.37%
Praxis Precision Medicines, Inc.
1.34%
Oruka Therapeutics, Inc.
1.33%
Revolution Medicines, Inc.
1.31%
Travere Therapeutics, Inc.
1.30%
Protagonist Therapeutics, Inc.
1.28%
Dianthus Therapeutics, Inc.
1.27%
CG Oncology, Inc.
1.26%
Vaxcyte, Inc.
1.23%
Erasca, Inc.
1.23%
Frequently asked questions about XLV and XBI
How have the XLV and XBI ETFs performed in 2026?
As of October 2, 2026, XLV is up 8.63% year-to-date (YTD), while XBI has returned 26.71%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XLV or XBI?
Year-to-date, the XLV ETF saw +$288M in flows, compared to +$254M for XBI.
Which ETF is more volatile: XLV or XBI?
Over the past year, XLV had a volatility of 15.77%, while XBI experienced 28.15%.
Which ETF is bigger: XLV or XBI?
As of October 2, 2026, XLV holds $42.81 B in assets under management (AUM), while XBI manages $10.09 B.
What sectors do the XLV and XBI ETFs invest in?
XLV leans toward sectors like Healthcare. Meanwhile, XBI focuses on Healthcare.
What are the top holdings of the XLV ETF and XBI ETF?
XLV top holdings include Eli Lilly & Co., Johnson & Johnson and AbbVie, Inc.. XBI holds in its top three: Moderna, Inc., Twist Bioscience Corp. and Apogee Therapeutics, Inc..
Which ETF is more diversified: XLV or XBI?
XLV holds 59 securities with 71.32% of its assets in the top 15. XBI has 152 securities and a top 15 weight of 21.91%.
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