XBIvsXLVETF Comparison
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State Street SPDR S&P Biotech ETF (XBI) and State Street Health Care Select Sector SPDR ETF (XLV) belong to the same industry segment: US Health Care. Both ETFs have the same top 3 sector exposures: and Health Care. XBI is more expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.08% for XLV. XBI is up 9.28% year-to-date (YTD) with -$19M in YTD flows. XLV performs worse with -6.44% YTD performance, and +$1.23B in YTD flows. Run a side-by-side ETF comparison of XBI and XLV below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI vs XLV performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI XLV | +11.52%-0.41% | +4.22%-8.42% | +9.28%-6.44% | +65.29%+6.83% | +64.93%+12.26% | -3.74%+26.85% |
| Flows | XBI XLV | +$314M-$74M | -$560M-$228M | -$19M+$1.23B | +$404M+$1.16B | -$1.15B-$4.33B | +$839M+$7.32B |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI XLV | +30.22%+15.20% | +25.87%+15.80% | +27.40%+13.72% | +32.69%+14.58% |
| Max drawdown | XBI XLV | -7.98%-10.19% | -9.66%-10.19% | -32.94%-17.05% | -55.10%-17.05% |
| Max drawdown duration | XBI XLV | 42d54d | 76d54d | 331d444d | 1822d444d |
Trading data
XBI | XLV | |
Last sale 4/24/2026 at 1:30 PM | $133.28 | $144.18 |
| Previous close 04/24/2026 | $134.49 | $146.24 |
| Consolidated volume 04/24/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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XBI | XLV | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/24/2026 at 1:30 PM
Live
Closed
XBI | XLV | |
|---|---|---|
| Last price | $133.28 | $144.18 |
| 1D performance | -0.90% | -1.41% |
| AuM | $8.52 B | $38.13 B |
| E/R | 0.35% | 0.08% |
Characteristics
XBI | XLV | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | State Street Investment Management |
| Benchmark | S&P Biotechnology Select Industry Index | S&P Health Care Select Sector Index |
| N° of holdings | 122 | 56 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | December 16, 1998 |
| ESG | No | No |
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Exposure
Countries
XBI
USA
95.16%
Other
4.84%
XLV
USA
97.26%
Other
2.74%
Sectors
XBI
Health Care
86.79%
Other
13.21%
XLV
Health Care
98.29%
Other
1.71%
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Diversification
XBI
Total weight of top 15 holdings out of 15
19.71%
XLV
Total weight of top 15 holdings out of 15
70.96%
Top 15 holdings
Data as of March 31, 2026
XBI
APELLIS PHARMACEUTICALS
1.83%
ALKERMES
1.45%
MADRIGAL PHARMACEUTICALS INC
1.38%
TG THERAPEUTICS
1.35%
INSMED
1.34%
SCHOLAR ROCK HOLDING CORP
1.30%
US03770N1019
1.28%
PROTAGONIST THERAPEUTICS INC
1.25%
US86627T1088
1.24%
UTD THERAPEUT
1.24%
US74006W2070
1.24%
ARROWHEAD PHARMACEUTICALS INC
1.23%
COGENT BIOSCIENCES
1.22%
BRIDGEBIO PHARMA
1.19%
PTC THERAPEUTI/D
1.18%
XLV
LILLY
13.74%
JOHNSON&JOHNSON
11.10%
ABBVIE
7.25%
MERCK & CO INC
5.63%
UNITEDHEALTH GRP
4.62%
AMGEN-T
3.57%
THERMO FISHER SCIENTIFIC
3.48%
ABBOTT LABS
3.37%
GILEAD SCIENCES
3.26%
INTUITIVE SURGICAL
3.09%
PFIZER
3.01%
BRISTOL-MYERS SQUIBB
2.33%
DANAHER
2.25%
VERTEX PHARMACEUTICALS
2.14%
STRYKER
2.13%
Frequently asked questions about XBI and XLV
How have the XBI and XLV ETFs performed in 2026?
As of April 24, 2026, XBI is up 9.28% year-to-date (YTD), while XLV has lost -6.44%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or XLV?
Year-to-date, the XBI ETF saw -$19M in flows, compared to +$1.23B for XLV.
Which ETF is more volatile: XBI or XLV?
Over the past year, XBI had a volatility of 25.87%, while XLV experienced 15.8%.
Which ETF is bigger: XBI or XLV?
As of April 24, 2026, XBI holds $8.52 B in assets under management (AUM), while XLV manages $38.13 B.
What sectors do the XBI and XLV ETFs invest in?
XBI leans toward sectors like Health Care. Meanwhile, XLV focuses on Health Care.
What are the top holdings of the XBI ETF and XLV ETF?
XBI top holdings include APELLIS PHARMACEUTICALS, ALKERMES and MADRIGAL PHARMACEUTICALS INC. XLV holds in its top three: LILLY, JOHNSON&JOHNSON and ABBVIE.
Which ETF is more diversified: XBI or XLV?
XBI holds 151 securities with 19.71% of its assets in the top 15. XLV has 59 securities and a top 15 weight of 70.96%.
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