XPHvsXBIETF Comparison
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State Street SPDR S&P Pharmaceuticals ETF (XPH) and State Street SPDR S&P Biotech ETF (XBI) belong to the same industry segment: US Health Care. Both ETFs have the same top 3 sector exposures: and Health Care. Both XPH and XBI have the same Total Expense Ratio (TER) of 0.35%. XPH is up 2.38% year-to-date (YTD) with +$116M in YTD flows. XBI performs better with 7.52% YTD performance, and +$23M in YTD flows. Run a side-by-side ETF comparison of XPH and XBI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XPH vs XBI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/28/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XPH XBI | +11.59%+10.37% | +3.53%+4.13% | +2.38%+7.52% | +42.75%+61.71% | +41.57%+64.28% | +22.36%-5.68% |
| Flows | XPH XBI | +$25M+$514M | +$79M-$371M | +$116M+$23M | +$141M+$555M | +$48M-$1.24B | +$71M+$958M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XPH XBI | +24.42%+30.05% | +21.14%+25.87% | +19.47%+27.40% | +20.46%+32.69% |
| Max drawdown | XPH XBI | -11.78%-7.98% | -11.78%-9.66% | -23.45%-32.94% | -31.59%-55.10% |
| Max drawdown duration | XPH XBI | 50d42d | 50d76d | 322d331d | 1566d1826d |
Trading data
XPH | XBI | |
Last sale 4/29/2026 at 1:30 PM | $56.58 | $128.97 |
| Previous close 04/28/2026 | $57.35 | $131.16 |
| Consolidated volume 04/28/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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XPH | XBI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/29/2026 at 1:30 PM
Live
Closed
XPH | XBI | |
|---|---|---|
| Last price | $56.58 | $128.97 |
| 1D performance | -1.34% | -1.67% |
| AuM | $352.77 M | $8.42 B |
| E/R | 0.35% | 0.35% |
Characteristics
XPH | XBI | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | State Street Investment Management |
| Benchmark | S&P Pharmaceuticals Select Industry Index | S&P Biotechnology Select Industry Index |
| N° of holdings | 48 | 122 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 19, 2006 | January 31, 2006 |
| ESG | No | No |
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Exposure
Countries
XPH
USA
87.77%
Other
12.23%
XBI
USA
95.16%
Other
4.84%
Sectors
XPH
Health Care
82.36%
Other
17.64%
XBI
Health Care
86.79%
Other
13.21%
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Diversification
XPH
Total weight of top 15 holdings out of 15
30.65%
XBI
Total weight of top 15 holdings out of 15
19.71%
Top 15 holdings
Data as of March 31, 2026
XPH
US29337E1029
2.45%
CORCEPT THERAPEUTICS
2.29%
TERNS PHARMACEUTICALS
2.16%
PERRIGO CO PLC
2.10%
AXSOME THERA CMN STK
2.03%
INNOVIVA INC
1.99%
MERCK & CO INC
1.98%
PFIZER
1.97%
ROYALTY PHARMA
1.97%
ELANCO ANIMAL HEALTH INC
1.96%
JAZZ PHARMACEUTICALS
1.96%
ESPERION THERAPEUTICS
1.95%
EDGEWISE THERAPEUTICS
1.95%
US55287L1017
1.95%
BRISTOL-MYERS SQUIBB
1.94%
XBI
APELLIS PHARMACEUTICALS
1.83%
ALKERMES
1.45%
MADRIGAL PHARMACEUTICALS INC
1.38%
TG THERAPEUTICS
1.35%
INSMED
1.34%
SCHOLAR ROCK HOLDING CORP
1.30%
US03770N1019
1.28%
PROTAGONIST THERAPEUTICS INC
1.25%
US86627T1088
1.24%
UTD THERAPEUT
1.24%
US74006W2070
1.24%
ARROWHEAD PHARMACEUTICALS INC
1.23%
COGENT BIOSCIENCES
1.22%
BRIDGEBIO PHARMA
1.19%
PTC THERAPEUTI/D
1.18%
Frequently asked questions about XPH and XBI
How have the XPH and XBI ETFs performed in 2026?
As of April 28, 2026, XPH is up 2.38% year-to-date (YTD), while XBI has returned 7.52%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XPH or XBI?
Year-to-date, the XPH ETF saw +$116M in flows, compared to +$23M for XBI.
Which ETF is more volatile: XPH or XBI?
Over the past year, XPH had a volatility of 21.14%, while XBI experienced 25.87%.
Which ETF is bigger: XPH or XBI?
As of April 28, 2026, XPH holds $352.77 M in assets under management (AUM), while XBI manages $8.42 B.
What sectors do the XPH and XBI ETFs invest in?
XPH leans toward sectors like Health Care. Meanwhile, XBI focuses on Health Care.
What are the top holdings of the XPH ETF and XBI ETF?
XPH top holdings include US29337E1029, CORCEPT THERAPEUTICS and TERNS PHARMACEUTICALS. XBI holds in its top three: APELLIS PHARMACEUTICALS, ALKERMES and MADRIGAL PHARMACEUTICALS INC.
Which ETF is more diversified: XPH or XBI?
XPH holds 57 securities with 30.65% of its assets in the top 15. XBI has 151 securities and a top 15 weight of 19.71%.
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