Keep tabs on your favorite ETFs with a personalized weekly tracker. Create a Watchlist now →
XPHvsXBIETF Comparison
SPDR S&P Pharmaceuticals ETF (XPH) and SPDR S&P Biotech ETF (XBI) belong to the same industry segment: US Health Care. Both ETFs have the same top 3 sector exposures: and Health Care. Both XPH and XBI have the same Total Expense Ratio (TER) of 0.35%. XPH is down -1.12% year-to-date (YTD) with +$88M in YTD flows. XBI performs better with 3.65% YTD performance, and -$59M in YTD flows. Run a side-by-side ETF comparison of XPH and XBI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
XPH vs XBI performance and flow charts
Performance
Cumulative Flows
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XPH XBI | -3.45%+1.38% | -1.36%+3.11% | -1.12%+3.65% | +29.22%+47.21% | +42.98%+63.16% | +9.16%-13.71% |
| Flows | XPH XBI | +$12M-$4M | +$95M-$179M | +$88M-$59M | +$111M+$90M | +$48M-$1.64B | +$36M+$1.20B |
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XPH XBI | +20.33%+25.68% | +23.08%+28.04% | +19.01%+27.26% | +20.26%+32.91% |
| Max drawdown | XPH XBI | -5.97%-8.19% | -17.10%-21.44% | -23.45%-32.94% | -33.10%-57.63% |
| Max drawdown duration | XPH XBI | 14d48d | 140d141d | 322d331d | 1706d1822d |
XPH | XBI | |
Last sale 3/12/2026 at 1:30 PM | $53.64 | $122.64 |
| Previous close 03/11/2026 | $55.49 | $126.38 |
| Consolidated volume 03/11/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Create an account to view replication metrics
XPH | XBI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
XPH | XBI | |
|---|---|---|
| Last price | $53.64 | $122.64 |
| 1D performance | -3.33% | -2.96% |
| AuM | $313.37 M | $8.10 B |
| E/R | 0.35% | 0.35% |
Countries
Sectors
Diversification
Total weight of top 15 holdings out of 15
Total weight of top 15 holdings out of 15
Top 15 holdings
How have the XPH and XBI ETFs performed in 2026?
As of March 11, 2026, XPH is down -1.12% year-to-date (YTD), while XBI has returned 3.65%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XPH or XBI?
Year-to-date, the XPH ETF saw +$88M in flows, compared to -$59M for XBI.
Which ETF is more volatile: XPH or XBI?
Over the past year, XPH had a volatility of 23.08%, while XBI experienced 28.04%.
Which ETF is bigger: XPH or XBI?
As of March 11, 2026, XPH holds $313.37 M in assets under management (AUM), while XBI manages $8.10 B.
What sectors do the XPH and XBI ETFs invest in?
XPH leans toward sectors like Health Care. Meanwhile, XBI focuses on Health Care.
What are the top holdings of the XPH ETF and XBI ETF?
XPH top holdings include LIQUIDIA CORPORATION, US55287L1017 and AXSOME THERA CMN STK. XBI holds in its top three: MODERNA INC, MIRUM PHARMACEUTICALS INC and REVOLUTION MEDICINES INC.
Which ETF is more diversified: XPH or XBI?
XPH holds 57 securities with 32.4% of its assets in the top 15. XBI has 149 securities and a top 15 weight of 21.6%.
Small-Cap Biotech ETFs: High-Risk, High-Reward Opportunities
Are Biotechnology ETFs In the Midst of a Comeback?
Donald Trump’s Executive Orders: ETF Bulls and Bears
Analyzing the Potential ETF Winners & Losers from The Weight-Loss Drug Craze
Two biotech ETFs to watch for the rest of 2022 and beyond
Two biotech ETFs to watch for the rest of 2022 and beyond
Biotech ETFs – Investing in Health Innovation
Active Trader Report: Use of Leveraged & Inverse ETFs Way Up
Direxion partnered with Compound Insights and Vanda to explore what’s driving the evolution of active trading — and how active traders are using leveraged and inverse funds across equities, single stocks, commodities, and volatility.
