XPHvsXBIETF Comparison
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State Street SPDR S&P Pharmaceuticals ETF (XPH) and State Street SPDR S&P Biotech ETF (XBI) belong to the same industry segment: US Health Care. Both ETFs have the same top 3 sector exposures: and Healthcare. Both XPH and XBI have the same Total Expense Ratio (TER) of 0.35%. XPH is up 22.92% year-to-date (YTD) with +$186M in YTD flows. XBI performs worse with 21.45% YTD performance, and +$299M in YTD flows. Run a side-by-side ETF comparison of XPH and XBI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XPH vs XBI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/29/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XPH XBI | +3.73%-6.52% | +21.66%+14.94% | +22.92%+21.45% | +63.43%+73.15% | +62.99%+76.68% | +41.32%+19.07% |
| Flows | XPH XBI | +$71M-$244M | +$70M+$276M | +$186M+$299M | +$210M+$1.32B | +$139M-$661M | +$151M+$1.34B |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XPH XBI | +24.17%+30.39% | +22.16%+26.74% | +20.24%+27.87% | +20.83%+32.84% |
| Max drawdown | XPH XBI | -8.13%-9.89% | -11.78%-9.89% | -23.45%-32.94% | -30.87%-54.07% |
| Max drawdown duration | XPH XBI | 41d20d | 50d20d | 322d331d | 1452d1685d |
Trading data
XPH | XBI | |
Last sale 7/29/2026 at 1:30 PM | $68.70 | $147.91 |
| Previous close 07/29/2026 | $69.00 | $149.78 |
| Consolidated volume 07/29/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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XPH | XBI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 7/29/2026 at 1:30 PM
Live
Closed
XPH | XBI | |
|---|---|---|
| Last price | $68.70 | $147.91 |
| 1D performance | -0.43% | -1.25% |
| AuM | $491.93 M | $9.76 B |
| E/R | 0.35% | 0.35% |
Characteristics
XPH | XBI | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | State Street Investment Management |
| Benchmark | S&P Pharmaceuticals Select Industry Index | S&P Biotechnology Select Industry Index |
| N° of holdings | 63 | 150 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 19, 2006 | January 31, 2006 |
| ESG | No | No |
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Exposure
Countries
XPH
USA
90.15%
Other
9.85%
XBI
USA
95.06%
Other
4.94%
Sectors
XPH
Healthcare
94.73%
Other
5.27%
XBI
Healthcare
99.03%
Other
0.97%
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Diversification
XPH
Total weight of top 15 holdings out of 15
29.74%
XBI
Total weight of top 15 holdings out of 15
19.19%
Top 15 holdings
Data as of June 30, 2026
XPH
MBX Biosciences, Inc.
2.72%
Alumis, Inc.
2.14%
Trevi Therapeutics, Inc.
2.12%
Enliven Therapeutics, Inc.
2.09%
Amylyx Pharmaceuticals, Inc.
2.04%
Veradermics, Inc.
2.02%
Ligand Pharmaceuticals, Inc.
1.94%
Nuvation Bio, Inc.
1.89%
Edgewise Therapeutics, Inc.
1.88%
Nektar Therapeutics
1.88%
Liquidia Corp.
1.86%
Maze Therapeutics, Inc.
1.85%
Harrow, Inc.
1.81%
EyePoint, Inc.
1.77%
Amneal Pharmaceuticals, Inc.
1.72%
XBI
Apogee Therapeutics, Inc.
1.48%
Moderna, Inc.
1.41%
Twist Bioscience Corp.
1.40%
Oruka Therapeutics, Inc.
1.37%
Kymera Therapeutics, Inc.
1.35%
Viking Therapeutics, Inc.
1.30%
Praxis Precision Medicines, Inc.
1.29%
Erasca, Inc.
1.27%
Revolution Medicines, Inc.
1.20%
Rhythm Pharmaceuticals, Inc.
1.20%
CG Oncology, Inc.
1.20%
SELLAS Life Sciences Group, Inc.
1.19%
Vaxcyte, Inc.
1.18%
Dianthus Therapeutics, Inc.
1.18%
Cytokinetics, Inc.
1.17%
Frequently asked questions about XPH and XBI
How have the XPH and XBI ETFs performed in 2026?
As of July 29, 2026, XPH is up 22.92% year-to-date (YTD), while XBI has returned 21.45%. That puts XPH better performer ahead so far this year.
Which ETF is attracting more investor money: XPH or XBI?
Year-to-date, the XPH ETF saw +$186M in flows, compared to +$299M for XBI.
Which ETF is more volatile: XPH or XBI?
Over the past year, XPH had a volatility of 22.16%, while XBI experienced 26.74%.
Which ETF is bigger: XPH or XBI?
As of July 29, 2026, XPH holds $491.93 M in assets under management (AUM), while XBI manages $9.76 B.
What sectors do the XPH and XBI ETFs invest in?
XPH leans toward sectors like Healthcare. Meanwhile, XBI focuses on Healthcare.
What are the top holdings of the XPH ETF and XBI ETF?
XPH top holdings include MBX Biosciences, Inc., Alumis, Inc. and Trevi Therapeutics, Inc.. XBI holds in its top three: Apogee Therapeutics, Inc., Moderna, Inc. and Twist Bioscience Corp..
Which ETF is more diversified: XPH or XBI?
XPH holds 63 securities with 29.74% of its assets in the top 15. XBI has 153 securities and a top 15 weight of 19.19%.
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