XBIvsIBBETF Comparison
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State Street SPDR S&P Biotech ETF (XBI) and iShares Biotechnology ETF (IBB) belong to the same industry segment: US Health Care. Both ETFs have the same top 3 sector exposures: and Health Care. XBI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.44% for IBB. XBI is up 15.39% year-to-date (YTD) with +$51M in YTD flows. IBB performs worse with 3.01% YTD performance, and -$464M in YTD flows. Run a side-by-side ETF comparison of XBI and IBB below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI vs IBB performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 06/18/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI IBB | +10.23%+5.96% | +16.21%+6.06% | +15.39%+3.01% | +70.84%+38.48% | +61.35%+34.36% | +5.92%+10.94% |
| Flows | XBI IBB | +$294M+$43M | +$415M-$208M | +$51M-$464M | +$897M+$698M | -$996M-$1.43B | +$1.45B-$2.18B |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI IBB | +32.61%+23.79% | +26.25%+20.26% | +27.64%+20.19% | +32.79%+22.20% |
| Max drawdown | XBI IBB | -8.56%-7.21% | -9.66%-9.61% | -32.94%-24.82% | -54.69%-39.75% |
| Max drawdown duration | XBI IBB | 58d60d | 76d147d | 331d377d | 1754d1611d |
Trading data
XBI | IBB | |
Last sale 6/18/2026 at 1:30 PM | $140.72 | $173.64 |
| Previous close 06/18/2026 | $139.39 | $173.44 |
| Consolidated volume 06/18/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of May 29, 2026
1-year trailing difference
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XBI | IBB | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 6/18/2026 at 1:30 PM
Live
Closed
XBI | IBB | |
|---|---|---|
| Last price | $140.72 | $173.64 |
| 1D performance | +0.95% | +0.12% |
| AuM | $9.05 B | $8.11 B |
| E/R | 0.35% | 0.44% |
Characteristics
XBI | IBB | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | iShares |
| Benchmark | S&P Biotechnology Select Industry Index | ICE Biotechnology Index |
| N° of holdings | 119 | 176 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | February 5, 2001 |
| ESG | No | No |
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Exposure
Countries
XBI
USA
94.81%
Other
5.19%
IBB
USA
94.92%
Other
5.08%
Sectors
XBI
Health Care
85.15%
Other
14.85%
IBB
Health Care
84.68%
Other
15.32%
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Diversification
XBI
Total weight of top 15 holdings out of 15
20.97%
IBB
Total weight of top 15 holdings out of 15
55.04%
Top 15 holdings
Data as of April 30, 2026
XBI
APELLIS PHARMACEUTICALS
1.87%
REVOLUTION MEDICINES INC
1.65%
TRAVERE THERAPEUTICS INC
1.62%
ARROWHEAD PHARMACEUTICALS INC
1.44%
TWIST BIOSCIENCE CORP
1.42%
US86627T1088
1.40%
ALKERMES
1.38%
TG THERAPEUTICS
1.37%
MADRIGAL PHARMACEUTICALS INC
1.36%
BEAM THERAPEUTICS
1.32%
US03770N1019
1.26%
SCHOLAR ROCK HOLDING CORP
1.23%
US74006W2070
1.22%
EXELIXIS
1.21%
MIRUM PHARMACEUTICALS INC
1.21%
IBB
AMGEN-T
7.46%
GILEAD SCIENCES
7.35%
VERTEX PHARMACEUTICALS
7.20%
REGENERON PHARMACEUTICALS
6.67%
ALNYLAM PHARMACEUTICALS
3.77%
US04016X1019
3.32%
INSMED
2.69%
BIOGEN INC
2.57%
NATERA
2.51%
REVOLUTION MEDICINES INC
2.30%
UTD THERAPEUT
2.24%
US07725L1026
1.94%
ILLUMINA
1.74%
INCYTE
1.74%
MODERNA INC
1.54%
Frequently asked questions about XBI and IBB
How have the XBI and IBB ETFs performed in 2026?
As of June 18, 2026, XBI is up 15.39% year-to-date (YTD), while IBB has returned 3.01%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or IBB?
Year-to-date, the XBI ETF saw +$51M in flows, compared to -$464M for IBB.
Which ETF is more volatile: XBI or IBB?
Over the past year, XBI had a volatility of 26.25%, while IBB experienced 20.26%.
Which ETF is bigger: XBI or IBB?
As of June 18, 2026, XBI holds $9.05 B in assets under management (AUM), while IBB manages $8.11 B.
What sectors do the XBI and IBB ETFs invest in?
XBI leans toward sectors like Health Care. Meanwhile, IBB focuses on Health Care.
What are the top holdings of the XBI ETF and IBB ETF?
XBI top holdings include APELLIS PHARMACEUTICALS, REVOLUTION MEDICINES INC and TRAVERE THERAPEUTICS INC. IBB holds in its top three: AMGEN-T, GILEAD SCIENCES and VERTEX PHARMACEUTICALS.
Which ETF is more diversified: XBI or IBB?
XBI holds 148 securities with 20.97% of its assets in the top 15. IBB has 246 securities and a top 15 weight of 55.04%.
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