XBIvsIBBETF Comparison
VS
State Street SPDR S&P Biotech ETF (XBI) and iShares Biotechnology ETF (IBB) belong to the same industry segment: US Health Care. Both ETFs have the same top 3 sector exposures: and Health Care. XBI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.44% for IBB. XBI is up 9.61% year-to-date (YTD) with -$172M in YTD flows. IBB performs worse with 0.85% YTD performance, and -$404M in YTD flows. Run a side-by-side ETF comparison of XBI and IBB below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
Find out how industry players manage ETF portfolios. Discover our library of Model portfolios
XBI vs IBB performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 05/07/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI IBB | +3.73%+0.93% | +6.05%-2.39% | +9.61%+0.85% | +73.24%+42.72% | +58.23%+31.11% | +5.11%+15.21% |
| Flows | XBI IBB | -$127M-$199M | +$119M-$293M | -$172M-$404M | +$374M+$686M | -$1.36B-$1.53B | +$916M-$2.28B |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI IBB | +29.54%+22.63% | +25.42%+20.58% | +27.31%+19.87% | +32.70%+22.11% |
| Max drawdown | XBI IBB | -7.98%-8.43% | -9.66%-9.61% | -32.94%-24.82% | -54.69%-39.75% |
| Max drawdown duration | XBI IBB | 42d43d | 76d105d | 331d377d | 1754d1611d |
Trading data
XBI | IBB | |
Last sale 5/7/2026 at 1:30 PM | $133.66 | $170.10 |
| Previous close 05/07/2026 | $137.68 | $173.87 |
| Consolidated volume 05/07/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of April 30, 2026
1-year trailing difference
Create an account to view replication metrics
Join for free
XBI | IBB | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
Advertisement
Main metrics
Last update 5/7/2026 at 1:30 PM
Live
Closed
XBI | IBB | |
|---|---|---|
| Last price | $133.66 | $170.10 |
| 1D performance | -2.92% | -2.17% |
| AuM | $8.39 B | $8.00 B |
| E/R | 0.35% | 0.44% |
Characteristics
XBI | IBB | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | iShares |
| Benchmark | S&P Biotechnology Select Industry Index | ICE Biotechnology Index |
| N° of holdings | 122 | 179 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | February 5, 2001 |
| ESG | No | No |
Advertisement
Exposure
Countries
XBI
USA
95.16%
Other
4.84%
IBB
USA
95.97%
Other
4.03%
Sectors
XBI
Health Care
86.79%
Other
13.21%
IBB
Health Care
85.68%
Other
14.32%
Advertisement
Diversification
XBI
Total weight of top 15 holdings out of 15
19.71%
IBB
Total weight of top 15 holdings out of 15
55.88%
Top 15 holdings
Data as of March 31, 2026
XBI
APELLIS PHARMACEUTICALS
1.83%
ALKERMES
1.45%
MADRIGAL PHARMACEUTICALS INC
1.38%
TG THERAPEUTICS
1.35%
INSMED
1.34%
SCHOLAR ROCK HOLDING CORP
1.30%
US03770N1019
1.28%
PROTAGONIST THERAPEUTICS INC
1.25%
US86627T1088
1.24%
UTD THERAPEUT
1.24%
US74006W2070
1.24%
ARROWHEAD PHARMACEUTICALS INC
1.23%
COGENT BIOSCIENCES
1.22%
BRIDGEBIO PHARMA
1.19%
PTC THERAPEUTI/D
1.18%
IBB
GILEAD SCIENCES
7.75%
AMGEN-T
7.51%
VERTEX PHARMACEUTICALS
7.44%
REGENERON PHARMACEUTICALS
7.21%
ALNYLAM PHARMACEUTICALS
3.99%
INSMED
3.20%
US04016X1019
3.07%
BIOGEN INC
2.46%
NATERA
2.41%
UTD THERAPEUT
2.30%
US07725L1026
1.93%
INCYTE
1.70%
MODERNA INC
1.68%
ILLUMINA
1.68%
REVOLUTION MEDICINES INC
1.54%
Frequently asked questions about XBI and IBB
How have the XBI and IBB ETFs performed in 2026?
As of May 7, 2026, XBI is up 9.61% year-to-date (YTD), while IBB has returned 0.85%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or IBB?
Year-to-date, the XBI ETF saw -$172M in flows, compared to -$404M for IBB.
Which ETF is more volatile: XBI or IBB?
Over the past year, XBI had a volatility of 25.42%, while IBB experienced 20.58%.
Which ETF is bigger: XBI or IBB?
As of May 7, 2026, XBI holds $8.39 B in assets under management (AUM), while IBB manages $8.00 B.
What sectors do the XBI and IBB ETFs invest in?
XBI leans toward sectors like Health Care. Meanwhile, IBB focuses on Health Care.
What are the top holdings of the XBI ETF and IBB ETF?
XBI top holdings include APELLIS PHARMACEUTICALS, ALKERMES and MADRIGAL PHARMACEUTICALS INC. IBB holds in its top three: GILEAD SCIENCES, AMGEN-T and VERTEX PHARMACEUTICALS.
Which ETF is more diversified: XBI or IBB?
XBI holds 151 securities with 19.71% of its assets in the top 15. IBB has 249 securities and a top 15 weight of 55.88%.
Advertisement
Latest news about XBI & IBB
Small-Cap Biotech ETFs: High-Risk, High-Reward Opportunities
September 18, 2025
XBI
IBB
Are Biotechnology ETFs In the Midst of a Comeback?
August 20, 2025
XBI
IBB
Investing in the Aging Population: A Look at Bonds and Pharma ETFs
March 27, 2023
IBB
Health is Wealth: A look at the Healthcare Sector
January 24, 2023
IBB
Advertisement
Two biotech ETFs to watch for the rest of 2022 and beyond
September 13, 2022
XBI
Two biotech ETFs to watch for the rest of 2022 and beyond
September 13, 2022
XBI
Biotech ETFs – Investing in Health Innovation
July 21, 2022
XBI
Advertisement
