XBIvsIBBETF Comparison
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SPDR S&P Biotech ETF (XBI) and iShares Biotechnology ETF (IBB) belong to the same industry segment: US Health Care. Both ETFs have the same top 3 sector exposures: and Health Care. XBI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.44% for IBB. XBI is up 1.58% year-to-date (YTD) with -$542M in YTD flows. IBB performs worse with -1.76% YTD performance, and -$271M in YTD flows. Run a side-by-side ETF comparison of XBI and IBB below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI vs IBB performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 03/25/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI IBB | -3.38%-5.35% | -0.86%-3.62% | +1.58%-1.76% | +42.85%+24.91% | +66.13%+32.56% | -7.88%+12.87% |
| Flows | XBI IBB | -$475M-$176M | -$940M-$398M | -$542M-$271M | -$421M+$496M | -$2.35B-$1.78B | +$975M-$2.40B |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI IBB | +27.42%+21.50% | +28.34%+23.68% | +27.35%+19.53% | +32.69%+22.00% |
| Max drawdown | XBI IBB | -9.13%-8.90% | -19.81%-15.77% | -32.94%-24.82% | -55.10%-39.75% |
| Max drawdown duration | XBI IBB | 62d62d | 105d106d | 331d377d | 1792d1611d |
Trading data
XBI | IBB | |
Last sale 3/26/2026 at 1:30 PM | $123.90 | $165.26 |
| Previous close 03/25/2026 | $123.92 | $165.75 |
| Consolidated volume 03/25/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of February 27, 2026
1-year trailing difference
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XBI | IBB | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 3/26/2026 at 1:30 PM
Live
Closed
XBI | IBB | |
|---|---|---|
| Last price | $123.90 | $165.26 |
| 1D performance | -0.02% | -0.30% |
| AuM | $7.45 B | $7.92 B |
| E/R | 0.35% | 0.44% |
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Exposure
Countries
XBI
USA
93.09%
Other
6.91%
IBB
USA
96.06%
Other
3.94%
Sectors
XBI
Health Care
87.1%
Other
12.9%
IBB
Health Care
86.04%
Other
13.96%
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Diversification
XBI
Total weight of top 15 holdings out of 15
22.98%
IBB
Total weight of top 15 holdings out of 15
57.44%
Top 15 holdings
Data as of February 28, 2026
XBI
MODERNA INC
2.22%
ROIVANT SCIENCES LTD
1.72%
VAXCYTE
1.71%
ARCELLX
1.64%
REVOLUTION MEDICINES INC
1.58%
US74006W2070
1.55%
AMGEN-T
1.48%
GILEAD SCIENCES
1.48%
AMICUS THERAPEUTICS
1.46%
MIRUM PHARMACEUTICALS INC
1.39%
KRYSTAL BIOTECH INC
1.38%
BIOMARIN PHARMACEUTICAL
1.38%
VERTEX PHARMACEUTICALS
1.34%
HALOZYME THERAPEUTICS
1.33%
CELCUITY INC
1.32%
IBB
GILEAD SCIENCES
9.16%
VERTEX PHARMACEUTICALS
8.88%
AMGEN-T
8.81%
REGENERON PHARMACEUTICALS
6.68%
ALNYLAM PHARMACEUTICALS
3.68%
INSMED
2.70%
US04016X1019
2.68%
NATERA
2.43%
BIOGEN INC
2.36%
US07725L1026
2.00%
UTD THERAPEUT
1.79%
INCYTE
1.67%
ILLUMINA
1.62%
MODERNA INC
1.54%
REVOLUTION MEDICINES INC
1.45%
Frequently asked questions about XBI and IBB
How have the XBI and IBB ETFs performed in 2026?
As of March 25, 2026, XBI is up 1.58% year-to-date (YTD), while IBB has lost -1.76%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or IBB?
Year-to-date, the XBI ETF saw -$542M in flows, compared to -$271M for IBB.
Which ETF is more volatile: XBI or IBB?
Over the past year, XBI had a volatility of 28.34%, while IBB experienced 23.68%.
Which ETF is bigger: XBI or IBB?
As of March 25, 2026, XBI holds $7.45 B in assets under management (AUM), while IBB manages $7.92 B.
What sectors do the XBI and IBB ETFs invest in?
XBI leans toward sectors like Health Care. Meanwhile, IBB focuses on Health Care.
What are the top holdings of the XBI ETF and IBB ETF?
XBI top holdings include MODERNA INC, ROIVANT SCIENCES LTD and VAXCYTE. IBB holds in its top three: GILEAD SCIENCES, VERTEX PHARMACEUTICALS and AMGEN-T.
Which ETF is more diversified: XBI or IBB?
XBI holds 147 securities with 22.98% of its assets in the top 15. IBB has 253 securities and a top 15 weight of 57.44%.
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Latest news about XBI & IBB
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January 24, 2023
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