IBBvsXBIETF Comparison
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iShares Biotechnology ETF (IBB) and SPDR S&P Biotech ETF (XBI) belong to the same industry segment: US Health Care. Both ETFs have the same top 3 sector exposures: and Health Care. IBB is more expensive with a Total Expense Ratio (TER) of 0.44%, versus 0.35% for XBI. IBB is down -0.08% year-to-date (YTD) with -$230M in YTD flows. XBI performs better with 5.67% YTD performance, and +$52M in YTD flows. Run a side-by-side ETF comparison of IBB and XBI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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IBB vs XBI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/07/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | IBB XBI | -1.53%+1.42% | -4.55%+1.95% | -0.08%+5.67% | +45.50%+77.13% | +30.37%+70.14% | +14.84%-1.64% |
| Flows | IBB XBI | -$167M+$60M | -$238M-$566M | -$230M+$52M | +$647M+$345M | -$1.64B-$1.27B | -$1.94B+$1.37B |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | IBB XBI | +22.39%+30.72% | +23.13%+27.87% | +19.73%+27.64% | +22.07%+32.76% |
| Max drawdown | IBB XBI | -9.61%-9.66% | -9.61%-9.66% | -24.82%-32.94% | -39.75%-55.10% |
| Max drawdown duration | IBB XBI | 75d75d | 75d75d | 377d331d | 1611d1805d |
Trading data
IBB | XBI | |
Last sale 4/7/2026 at 1:30 PM | $168.50 | $128.85 |
| Previous close 04/07/2026 | $168.83 | $128.80 |
| Consolidated volume 04/07/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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IBB | XBI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/7/2026 at 1:30 PM
Live
Closed
IBB | XBI | |
|---|---|---|
| Last price | $168.50 | $128.85 |
| 1D performance | -0.20% | +0.04% |
| AuM | $8.10 B | $8.31 B |
| E/R | 0.44% | 0.35% |
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Exposure
Countries
IBB
USA
96.06%
Other
3.94%
XBI
USA
93.09%
Other
6.91%
Sectors
IBB
Health Care
86.04%
Other
13.96%
XBI
Health Care
87.1%
Other
12.9%
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Diversification
IBB
Total weight of top 15 holdings out of 15
57.44%
XBI
Total weight of top 15 holdings out of 15
22.98%
Top 15 holdings
Data as of February 28, 2026
IBB
GILEAD SCIENCES
9.16%
VERTEX PHARMACEUTICALS
8.88%
AMGEN-T
8.81%
REGENERON PHARMACEUTICALS
6.68%
ALNYLAM PHARMACEUTICALS
3.68%
INSMED
2.70%
US04016X1019
2.68%
NATERA
2.43%
BIOGEN INC
2.36%
US07725L1026
2.00%
UTD THERAPEUT
1.79%
INCYTE
1.67%
ILLUMINA
1.62%
MODERNA INC
1.54%
REVOLUTION MEDICINES INC
1.45%
XBI
MODERNA INC
2.22%
ROIVANT SCIENCES LTD
1.72%
VAXCYTE
1.71%
ARCELLX
1.64%
REVOLUTION MEDICINES INC
1.58%
US74006W2070
1.55%
AMGEN-T
1.48%
GILEAD SCIENCES
1.48%
AMICUS THERAPEUTICS
1.46%
MIRUM PHARMACEUTICALS INC
1.39%
KRYSTAL BIOTECH INC
1.38%
BIOMARIN PHARMACEUTICAL
1.38%
VERTEX PHARMACEUTICALS
1.34%
HALOZYME THERAPEUTICS
1.33%
CELCUITY INC
1.32%
Frequently asked questions about IBB and XBI
How have the IBB and XBI ETFs performed in 2026?
As of April 7, 2026, IBB is down -0.08% year-to-date (YTD), while XBI has returned 5.67%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: IBB or XBI?
Year-to-date, the IBB ETF saw -$230M in flows, compared to +$52M for XBI.
Which ETF is more volatile: IBB or XBI?
Over the past year, IBB had a volatility of 23.13%, while XBI experienced 27.87%.
Which ETF is bigger: IBB or XBI?
As of April 7, 2026, IBB holds $8.10 B in assets under management (AUM), while XBI manages $8.31 B.
What sectors do the IBB and XBI ETFs invest in?
IBB leans toward sectors like Health Care. Meanwhile, XBI focuses on Health Care.
What are the top holdings of the IBB ETF and XBI ETF?
IBB top holdings include GILEAD SCIENCES, VERTEX PHARMACEUTICALS and AMGEN-T. XBI holds in its top three: MODERNA INC, ROIVANT SCIENCES LTD and VAXCYTE.
Which ETF is more diversified: IBB or XBI?
IBB holds 253 securities with 57.44% of its assets in the top 15. XBI has 147 securities and a top 15 weight of 22.98%.
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