IBBvsXBIETF Comparison
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iShares Biotechnology ETF (IBB) and State Street SPDR S&P Biotech ETF (XBI) belong to the same industry segment: US Health Care. Both ETFs have the same top 3 sector exposures: and Health Care. IBB is more expensive with a Total Expense Ratio (TER) of 0.44%, versus 0.35% for XBI. IBB is down -0.53% year-to-date (YTD) with -$490M in YTD flows. XBI performs better with 7.99% YTD performance, and -$523M in YTD flows. Run a side-by-side ETF comparison of IBB and XBI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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IBB vs XBI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 05/20/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | IBB XBI | -4.55%-4.36% | -3.69%+5.57% | -0.53%+7.99% | +34.88%+62.32% | +28.97%+51.20% | +11.59%+3.82% |
| Flows | IBB XBI | -$257M-$449M | -$403M-$429M | -$490M-$523M | +$592M-$126M | -$1.62B-$1.31B | -$2.43B+$551M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | IBB XBI | +23.50%+30.95% | +19.88%+25.29% | +19.96%+27.35% | +22.12%+32.66% |
| Max drawdown | IBB XBI | -8.43%-8.56% | -9.61%-9.66% | -24.82%-32.94% | -39.75%-54.69% |
| Max drawdown duration | IBB XBI | 43d31d | 118d76d | 377d331d | 1611d1754d |
Trading data
IBB | XBI | |
Last sale 5/21/2026 at 7:57 PM | $169.11 | $132.89 |
| Previous close 05/20/2026 | $167.91 | $131.71 |
| Consolidated volume 05/20/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of April 30, 2026
1-year trailing difference
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IBB | XBI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 5/21/2026 at 7:57 PM
Live
Closed
IBB | XBI | |
|---|---|---|
| Last price | $169.11 | $132.89 |
| 1D performance | +0.71% | +0.90% |
| AuM | $7.81 B | $7.91 B |
| E/R | 0.44% | 0.35% |
Characteristics
IBB | XBI | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | iShares | State Street Investment Management |
| Benchmark | ICE Biotechnology Index | S&P Biotechnology Select Industry Index |
| N° of holdings | 179 | 122 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | February 5, 2001 | January 31, 2006 |
| ESG | No | No |
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Exposure
Countries
IBB
USA
95.97%
Other
4.03%
XBI
USA
95.16%
Other
4.84%
Sectors
IBB
Health Care
85.68%
Other
14.32%
XBI
Health Care
86.79%
Other
13.21%
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Diversification
IBB
Total weight of top 15 holdings out of 15
55.88%
XBI
Total weight of top 15 holdings out of 15
19.71%
Top 15 holdings
Data as of March 31, 2026
IBB
GILEAD SCIENCES
7.75%
AMGEN-T
7.51%
VERTEX PHARMACEUTICALS
7.44%
REGENERON PHARMACEUTICALS
7.21%
ALNYLAM PHARMACEUTICALS
3.99%
INSMED
3.20%
US04016X1019
3.07%
BIOGEN INC
2.46%
NATERA
2.41%
UTD THERAPEUT
2.30%
US07725L1026
1.93%
INCYTE
1.70%
MODERNA INC
1.68%
ILLUMINA
1.68%
REVOLUTION MEDICINES INC
1.54%
XBI
APELLIS PHARMACEUTICALS
1.83%
ALKERMES
1.45%
MADRIGAL PHARMACEUTICALS INC
1.38%
TG THERAPEUTICS
1.35%
INSMED
1.34%
SCHOLAR ROCK HOLDING CORP
1.30%
US03770N1019
1.28%
PROTAGONIST THERAPEUTICS INC
1.25%
US86627T1088
1.24%
UTD THERAPEUT
1.24%
US74006W2070
1.24%
ARROWHEAD PHARMACEUTICALS INC
1.23%
COGENT BIOSCIENCES
1.22%
BRIDGEBIO PHARMA
1.19%
PTC THERAPEUTI/D
1.18%
Frequently asked questions about IBB and XBI
How have the IBB and XBI ETFs performed in 2026?
As of May 20, 2026, IBB is down -0.53% year-to-date (YTD), while XBI has returned 7.99%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: IBB or XBI?
Year-to-date, the IBB ETF saw -$490M in flows, compared to -$523M for XBI.
Which ETF is more volatile: IBB or XBI?
Over the past year, IBB had a volatility of 19.88%, while XBI experienced 25.29%.
Which ETF is bigger: IBB or XBI?
As of May 20, 2026, IBB holds $7.81 B in assets under management (AUM), while XBI manages $7.91 B.
What sectors do the IBB and XBI ETFs invest in?
IBB leans toward sectors like Health Care. Meanwhile, XBI focuses on Health Care.
What are the top holdings of the IBB ETF and XBI ETF?
IBB top holdings include GILEAD SCIENCES, AMGEN-T and VERTEX PHARMACEUTICALS. XBI holds in its top three: APELLIS PHARMACEUTICALS, ALKERMES and MADRIGAL PHARMACEUTICALS INC.
Which ETF is more diversified: IBB or XBI?
IBB holds 249 securities with 55.88% of its assets in the top 15. XBI has 151 securities and a top 15 weight of 19.71%.
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