IBBvsXBIETF Comparison
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iShares Biotechnology ETF (IBB) and State Street SPDR S&P Biotech ETF (XBI) belong to the same industry segment: US Health Care. IBB's top 3 sector exposures are Healthcare, Non-Corporate and Non-Energy Materials. In contrast, XBI's top sector exposures are Healthcare and Finance. IBB is more expensive with a Total Expense Ratio (TER) of 0.44%, versus 0.35% for XBI. IBB is up 23.31% year-to-date (YTD) with +$350M in YTD flows. XBI performs better with 28.11% YTD performance, and +$359M in YTD flows. Run a side-by-side ETF comparison of IBB and XBI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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IBB vs XBI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/05/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | IBB XBI | +0.32%-3.58% | +6.49%-2.84% | +23.31%+28.11% | +38.41%+51.29% | +71.98%+117.56% | +35.17%+27.07% |
| Flows | IBB XBI | +$48M-$566M | +$498M-$257M | +$350M+$359M | +$1.70B+$957M | -$345M-$511M | -$1.46B+$1.14B |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | IBB XBI | +24.09%+28.62% | +21.79%+28.21% | +21.19%+28.28% | +22.42%+32.89% |
| Max drawdown | IBB XBI | -6.84%-10.46% | -9.61%-10.46% | -24.82%-32.94% | -35.62%-53.28% |
| Max drawdown duration | IBB XBI | 47d40d | 151d40d | 377d331d | 1468d1622d |
Trading data
IBB | XBI | |
Last sale 10/6/2026 at 1:30 PM | $203.10 | $150.90 |
| Previous close 10/05/2026 | $207.96 | $156.19 |
| Consolidated volume 10/05/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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IBB | XBI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/6/2026 at 1:30 PM
Live
Closed
IBB | XBI | |
|---|---|---|
| Last price | $203.10 | $150.90 |
| 1D performance | -2.34% | -3.39% |
| AuM | $10.57 B | $10.31 B |
| E/R | 0.44% | 0.35% |
Characteristics
IBB | XBI | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | iShares | State Street Investment Management |
| Benchmark | NYSE Biotechnology Index | S&P Biotechnology Select Industry Index |
| N° of holdings | 241 | 149 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | February 5, 2001 | January 31, 2006 |
| ESG | No | No |
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Exposure
Countries
IBB
USA
86.02%
Other
13.98%
XBI
USA
95.53%
Other
4.47%
Sectors
IBB
Healthcare
99.9%
Other
0.1%
XBI
Healthcare
99.18%
Other
0.82%
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Diversification
IBB
Total weight of top 15 holdings out of 15
56.64%
XBI
Total weight of top 15 holdings out of 15
21.91%
Top 15 holdings
Data as of August 31, 2026
IBB
Amgen, Inc.
8.45%
Vertex Pharmaceuticals, Inc.
8.05%
Gilead Sciences, Inc.
7.21%
Regeneron Pharmaceuticals, Inc.
5.72%
argenx SE
3.80%
Moderna, Inc.
3.62%
Natera, Inc.
3.12%
Revolution Medicines, Inc.
2.78%
Illumina, Inc.
2.29%
Alnylam Pharmaceuticals, Inc.
2.27%
Biogen, Inc.
2.25%
BeOne Medicines Ltd.
2.03%
Insmed, Inc.
1.85%
Incyte Corp.
1.73%
United Therapeutics Corp.
1.49%
XBI
Moderna, Inc.
2.81%
Twist Bioscience Corp.
1.89%
Apogee Therapeutics, Inc.
1.50%
Kymera Therapeutics, Inc.
1.40%
Halozyme Therapeutics, Inc.
1.39%
Natera, Inc.
1.37%
Praxis Precision Medicines, Inc.
1.34%
Oruka Therapeutics, Inc.
1.33%
Revolution Medicines, Inc.
1.31%
Travere Therapeutics, Inc.
1.30%
Protagonist Therapeutics, Inc.
1.28%
Dianthus Therapeutics, Inc.
1.27%
CG Oncology, Inc.
1.26%
Vaxcyte, Inc.
1.23%
Erasca, Inc.
1.23%
Frequently asked questions about IBB and XBI
How have the IBB and XBI ETFs performed in 2026?
As of October 5, 2026, IBB is up 23.31% year-to-date (YTD), while XBI has returned 28.11%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: IBB or XBI?
Year-to-date, the IBB ETF saw +$350M in flows, compared to +$359M for XBI.
Which ETF is more volatile: IBB or XBI?
Over the past year, IBB had a volatility of 21.79%, while XBI experienced 28.21%.
Which ETF is bigger: IBB or XBI?
As of October 5, 2026, IBB holds $10.57 B in assets under management (AUM), while XBI manages $10.31 B.
What sectors do the IBB and XBI ETFs invest in?
IBB leans toward sectors like Healthcare. Meanwhile, XBI focuses on Healthcare.
What are the top holdings of the IBB ETF and XBI ETF?
IBB top holdings include Amgen, Inc., Vertex Pharmaceuticals, Inc. and Gilead Sciences, Inc.. XBI holds in its top three: Moderna, Inc., Twist Bioscience Corp. and Apogee Therapeutics, Inc..
Which ETF is more diversified: IBB or XBI?
IBB holds 241 securities with 56.64% of its assets in the top 15. XBI has 152 securities and a top 15 weight of 21.91%.
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