IBBvsXBIETF Comparison
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iShares Biotechnology ETF (IBB) and State Street SPDR S&P Biotech ETF (XBI) belong to the same industry segment: US Health Care. IBB's top 3 sector exposures are Healthcare, Non-Corporate and Non-Energy Materials. In contrast, XBI's top sector exposures are Healthcare and Finance. IBB is more expensive with a Total Expense Ratio (TER) of 0.44%, versus 0.35% for XBI. IBB is up 28.63% year-to-date (YTD) with +$154M in YTD flows. XBI performs better with 39.08% YTD performance, and +$682M in YTD flows. Run a side-by-side ETF comparison of IBB and XBI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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IBB vs XBI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 08/19/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | IBB XBI | +16.28%+12.32% | +32.12%+33.80% | +28.63%+39.08% | +57.72%+91.73% | +71.94%+117.37% | +33.62%+43.79% |
| Flows | IBB XBI | +$93M+$51M | +$784M+$1.20B | +$154M+$682M | +$1.51B+$1.29B | -$663M-$224M | -$1.74B+$1.72B |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | IBB XBI | +24.59%+31.14% | +21.39%+27.54% | +20.88%+28.11% | +22.40%+32.92% |
| Max drawdown | IBB XBI | -6.21%-10.46% | -9.61%-10.46% | -24.82%-32.94% | -39.67%-54.07% |
| Max drawdown duration | IBB XBI | 31d40d | 151d40d | 377d331d | 1587d1685d |
Trading data
IBB | XBI | |
Last sale 8/20/2026 at 1:30 PM | $210.83 | $163.38 |
| Previous close 08/19/2026 | $216.96 | $169.55 |
| Consolidated volume 08/19/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of July 31, 2026
1-year trailing difference
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IBB | XBI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 8/20/2026 at 1:30 PM
Live
Closed
IBB | XBI | |
|---|---|---|
| Last price | $210.83 | $163.38 |
| 1D performance | -2.83% | -3.64% |
| AuM | $10.84 B | $11.58 B |
| E/R | 0.44% | 0.35% |
Characteristics
IBB | XBI | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | iShares | State Street Investment Management |
| Benchmark | ICE Biotechnology Index | S&P Biotechnology Select Industry Index |
| N° of holdings | 242 | 150 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | February 5, 2001 | January 31, 2006 |
| ESG | No | No |
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Exposure
Countries
IBB
USA
86.15%
Other
13.85%
XBI
USA
95.06%
Other
4.94%
Sectors
IBB
Healthcare
99.89%
Other
0.11%
XBI
Healthcare
99.03%
Other
0.97%
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Diversification
IBB
Total weight of top 15 holdings out of 15
53.71%
XBI
Total weight of top 15 holdings out of 15
19.19%
Top 15 holdings
Data as of June 30, 2026
IBB
Vertex Pharmaceuticals, Inc.
8.07%
Amgen, Inc.
7.82%
Gilead Sciences, Inc.
6.83%
Regeneron Pharmaceuticals, Inc.
4.90%
argenx SE
3.75%
Alnylam Pharmaceuticals, Inc.
3.12%
Natera, Inc.
2.89%
Revolution Medicines, Inc.
2.78%
Biogen, Inc.
2.46%
Illumina, Inc.
2.07%
Moderna, Inc.
1.98%
Insmed, Inc.
1.78%
BeOne Medicines Ltd.
1.77%
Incyte Corp.
1.75%
United Therapeutics Corp.
1.73%
XBI
Apogee Therapeutics, Inc.
1.48%
Moderna, Inc.
1.41%
Twist Bioscience Corp.
1.40%
Oruka Therapeutics, Inc.
1.37%
Kymera Therapeutics, Inc.
1.35%
Viking Therapeutics, Inc.
1.30%
Praxis Precision Medicines, Inc.
1.29%
Erasca, Inc.
1.27%
Revolution Medicines, Inc.
1.20%
Rhythm Pharmaceuticals, Inc.
1.20%
CG Oncology, Inc.
1.20%
SELLAS Life Sciences Group, Inc.
1.19%
Vaxcyte, Inc.
1.18%
Dianthus Therapeutics, Inc.
1.18%
Cytokinetics, Inc.
1.17%
Frequently asked questions about IBB and XBI
How have the IBB and XBI ETFs performed in 2026?
As of August 19, 2026, IBB is up 28.63% year-to-date (YTD), while XBI has returned 39.08%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: IBB or XBI?
Year-to-date, the IBB ETF saw +$154M in flows, compared to +$682M for XBI.
Which ETF is more volatile: IBB or XBI?
Over the past year, IBB had a volatility of 21.39%, while XBI experienced 27.54%.
Which ETF is bigger: IBB or XBI?
As of August 19, 2026, IBB holds $10.84 B in assets under management (AUM), while XBI manages $11.58 B.
What sectors do the IBB and XBI ETFs invest in?
IBB leans toward sectors like Healthcare. Meanwhile, XBI focuses on Healthcare.
What are the top holdings of the IBB ETF and XBI ETF?
IBB top holdings include Vertex Pharmaceuticals, Inc., Amgen, Inc. and Gilead Sciences, Inc.. XBI holds in its top three: Apogee Therapeutics, Inc., Moderna, Inc. and Twist Bioscience Corp..
Which ETF is more diversified: IBB or XBI?
IBB holds 242 securities with 53.71% of its assets in the top 15. XBI has 153 securities and a top 15 weight of 19.19%.
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