IBBvsXBIETF Comparison
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iShares Biotechnology ETF (IBB) and State Street SPDR S&P Biotech ETF (XBI) belong to the same industry segment: US Health Care. IBB's top 3 sector exposures are Healthcare, Non-Corporate and Non-Energy Materials. In contrast, XBI's top sector exposures are Healthcare, Finance IBB is more expensive with a Total Expense Ratio (TER) of 0.44%, versus 0.35% for XBI. IBB is up 17.6% year-to-date (YTD) with -$90M in YTD flows. XBI performs better with 34.49% YTD performance, and +$536M in YTD flows. Run a side-by-side ETF comparison of IBB and XBI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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IBB vs XBI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/07/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | IBB XBI | +18.84%+27.68% | +17.69%+27.28% | +17.60%+34.49% | +55.18%+96.86% | +60.82%+101.68% | +24.63%+25.70% |
| Flows | IBB XBI | +$396M+$924M | +$115M+$581M | -$90M+$536M | +$1.14B+$1.30B | -$1.11B-$482M | -$1.93B+$1.54B |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | IBB XBI | +22.73%+29.51% | +20.58%+26.64% | +20.35%+27.77% | +22.30%+32.85% |
| Max drawdown | IBB XBI | -7.21%-8.56% | -9.61%-9.66% | -24.82%-32.94% | -39.75%-54.07% |
| Max drawdown duration | IBB XBI | 60d58d | 151d76d | 377d331d | 1611d1685d |
Trading data
IBB | XBI | |
Last sale 7/8/2026 at 1:42 PM | $197.60 | $163.59 |
| Previous close 07/07/2026 | $198.23 | $163.87 |
| Consolidated volume 07/07/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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IBB | XBI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 7/8/2026 at 1:42 PM
Live
Closed
IBB | XBI | |
|---|---|---|
| Last price | $197.60 | $163.59 |
| 1D performance | -0.32% | -0.17% |
| AuM | $9.66 B | $11.08 B |
| E/R | 0.44% | 0.35% |
Characteristics
IBB | XBI | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | iShares | State Street Investment Management |
| Benchmark | ICE Biotechnology Index | S&P Biotechnology Select Industry Index |
| N° of holdings | 244 | 143 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | February 5, 2001 | January 31, 2006 |
| ESG | No | No |
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Exposure
Countries
IBB
USA
86.07%
Other
13.93%
XBI
USA
94.85%
Other
5.15%
Sectors
IBB
Healthcare
99.79%
Other
0.21%
XBI
Healthcare
99.41%
Other
0.59%
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Diversification
IBB
Total weight of top 15 holdings out of 15
54.07%
XBI
Total weight of top 15 holdings out of 15
21.98%
Top 15 holdings
Data as of May 31, 2026
IBB
Gilead Sciences, Inc.
7.42%
Vertex Pharmaceuticals, Inc.
7.40%
Amgen, Inc.
7.13%
Regeneron Pharmaceuticals, Inc.
5.69%
Alnylam Pharmaceuticals, Inc.
3.61%
argenx SE
3.49%
Natera, Inc.
2.68%
Biogen, Inc.
2.61%
Revolution Medicines, Inc.
2.47%
Illumina, Inc.
2.20%
United Therapeutics Corp.
2.15%
Insmed, Inc.
2.07%
BeOne Medicines Ltd.
1.86%
Incyte Corp.
1.73%
Moderna, Inc.
1.55%
XBI
Travere Therapeutics, Inc.
1.79%
Revolution Medicines, Inc.
1.78%
Alkermes Plc
1.71%
Twist Bioscience Corp.
1.60%
TG Therapeutics, Inc.
1.52%
Arrowhead Pharmaceuticals, Inc.
1.51%
Beam Therapeutics, Inc.
1.42%
Neurocrine Biosciences, Inc.
1.37%
Krystal Biotech, Inc.
1.36%
Exelixis, Inc.
1.36%
Cytokinetics, Inc.
1.36%
Praxis Precision Medicines, Inc.
1.33%
Madrigal Pharmaceuticals, Inc.
1.30%
Celcuity, Inc.
1.29%
Scholar Rock Holding Corp.
1.28%
Frequently asked questions about IBB and XBI
How have the IBB and XBI ETFs performed in 2026?
As of July 7, 2026, IBB is up 17.6% year-to-date (YTD), while XBI has returned 34.49%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: IBB or XBI?
Year-to-date, the IBB ETF saw -$90M in flows, compared to +$536M for XBI.
Which ETF is more volatile: IBB or XBI?
Over the past year, IBB had a volatility of 20.58%, while XBI experienced 26.64%.
Which ETF is bigger: IBB or XBI?
As of July 7, 2026, IBB holds $9.66 B in assets under management (AUM), while XBI manages $11.08 B.
What sectors do the IBB and XBI ETFs invest in?
IBB leans toward sectors like Healthcare. Meanwhile, XBI focuses on Healthcare.
What are the top holdings of the IBB ETF and XBI ETF?
IBB top holdings include Gilead Sciences, Inc., Vertex Pharmaceuticals, Inc. and Amgen, Inc.. XBI holds in its top three: Travere Therapeutics, Inc., Revolution Medicines, Inc. and Alkermes Plc.
Which ETF is more diversified: IBB or XBI?
IBB holds 244 securities with 54.07% of its assets in the top 15. XBI has 146 securities and a top 15 weight of 21.98%.
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