XHEvsXBIETF Comparison
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State Street SPDR S&P Health Care Equipment ETF (XHE) and State Street SPDR S&P Biotech ETF (XBI) belong to the same industry segment: US Health Care. Both ETFs have the same top 3 sector exposures: and Health Care. Both XHE and XBI have the same Total Expense Ratio (TER) of 0.35%. XHE is down -6.1% year-to-date (YTD) with -$6M in YTD flows. XBI performs better with 9.28% YTD performance, and -$19M in YTD flows. Run a side-by-side ETF comparison of XHE and XBI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XHE vs XBI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XHE XBI | +4.44%+11.52% | -6.33%+4.22% | -6.10%+9.28% | +4.10%+65.29% | -16.38%+64.93% | -34.81%-3.74% |
| Flows | XHE XBI | +$345K+$314M | -$4M-$560M | -$6M-$19M | -$35M+$404M | -$282M-$1.15B | -$404M+$839M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XHE XBI | +23.06%+30.22% | +21.27%+25.87% | +21.32%+27.40% | +24.31%+32.69% |
| Max drawdown | XHE XBI | -14.31%-7.98% | -18.20%-9.66% | -32.60%-32.94% | -49.90%-55.10% |
| Max drawdown duration | XHE XBI | 57d42d | 106d76d | 1096d331d | 1695d1822d |
Trading data
XHE | XBI | |
Last sale 4/27/2026 at 1:59 PM | $82.92 | $133.32 |
| Previous close 04/24/2026 | $82.71 | $133.28 |
| Consolidated volume 04/24/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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XHE | XBI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/27/2026 at 1:59 PM
Live
Closed
XHE | XBI | |
|---|---|---|
| Last price | $82.92 | $133.32 |
| 1D performance | +0.25% | +0.03% |
| AuM | $138.61 M | $8.52 B |
| E/R | 0.35% | 0.35% |
Characteristics
XHE | XBI | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | State Street Investment Management |
| Benchmark | S&P Health Care Equipment Select Industry Index | S&P Biotechnology Select Industry Index |
| N° of holdings | 61 | 122 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 26, 2011 | January 31, 2006 |
| ESG | No | No |
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Exposure
Countries
XHE
USA
92.19%
Other
7.81%
XBI
USA
95.16%
Other
4.84%
Sectors
XHE
Health Care
89.87%
Other
10.13%
XBI
Health Care
86.79%
Other
13.21%
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Diversification
XHE
Total weight of top 15 holdings out of 15
26.74%
XBI
Total weight of top 15 holdings out of 15
19.71%
Top 15 holdings
Data as of March 31, 2026
XHE
TELEFLEX
1.86%
STAAR SURGICAL
1.84%
BUTTERFLY NETWORK INC
1.84%
US58507V1070
1.83%
GLAUKOS
1.82%
INTEGER HOLDINGS
1.79%
AXOGEN
1.79%
LIVANOVA
1.78%
MASIMO
1.76%
LEMAITRE VASCULAR
1.75%
ARTIVION INC
1.75%
HOLOGIC
1.74%
STERIS
1.74%
GLOBUS MEDICAL
1.72%
IRHYTHM TECHNOLOGIES
1.72%
XBI
APELLIS PHARMACEUTICALS
1.83%
ALKERMES
1.45%
MADRIGAL PHARMACEUTICALS INC
1.38%
TG THERAPEUTICS
1.35%
INSMED
1.34%
SCHOLAR ROCK HOLDING CORP
1.30%
US03770N1019
1.28%
PROTAGONIST THERAPEUTICS INC
1.25%
US86627T1088
1.24%
UTD THERAPEUT
1.24%
US74006W2070
1.24%
ARROWHEAD PHARMACEUTICALS INC
1.23%
COGENT BIOSCIENCES
1.22%
BRIDGEBIO PHARMA
1.19%
PTC THERAPEUTI/D
1.18%
Frequently asked questions about XHE and XBI
How have the XHE and XBI ETFs performed in 2026?
As of April 24, 2026, XHE is down -6.1% year-to-date (YTD), while XBI has returned 9.28%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XHE or XBI?
Year-to-date, the XHE ETF saw -$6M in flows, compared to -$19M for XBI.
Which ETF is more volatile: XHE or XBI?
Over the past year, XHE had a volatility of 21.27%, while XBI experienced 25.87%.
Which ETF is bigger: XHE or XBI?
As of April 24, 2026, XHE holds $138.61 M in assets under management (AUM), while XBI manages $8.52 B.
What sectors do the XHE and XBI ETFs invest in?
XHE leans toward sectors like Health Care. Meanwhile, XBI focuses on Health Care.
What are the top holdings of the XHE ETF and XBI ETF?
XHE top holdings include TELEFLEX, STAAR SURGICAL and BUTTERFLY NETWORK INC. XBI holds in its top three: APELLIS PHARMACEUTICALS, ALKERMES and MADRIGAL PHARMACEUTICALS INC.
Which ETF is more diversified: XHE or XBI?
XHE holds 67 securities with 26.74% of its assets in the top 15. XBI has 151 securities and a top 15 weight of 19.71%.
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