XHEvsXBIETF Comparison
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State Street SPDR S&P Health Care Equipment ETF (XHE) and State Street SPDR S&P Biotech ETF (XBI) belong to the same industry segment: US Health Care. Both ETFs have the same top 3 sector exposures: and Health Care. Both XHE and XBI have the same Total Expense Ratio (TER) of 0.35%. XHE is down -7.02% year-to-date (YTD) with -$535K in YTD flows. XBI performs better with 11.78% YTD performance, and -$218M in YTD flows. Run a side-by-side ETF comparison of XHE and XBI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XHE vs XBI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 06/15/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XHE XBI | +5.77%+4.34% | +1.88%+10.08% | -7.02%+11.78% | +1.32%+64.22% | -16.03%+53.65% | -34.52%+2.77% |
| Flows | XHE XBI | +$12M-$70M | +$6M+$362M | -$535K-$218M | -$33M+$764M | -$323M-$1.17B | -$381M+$721M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XHE XBI | +25.34%+32.75% | +21.82%+26.18% | +21.72%+27.62% | +24.47%+32.76% |
| Max drawdown | XHE XBI | -8.81%-8.56% | -18.20%-9.66% | -32.46%-32.94% | -49.90%-54.69% |
| Max drawdown duration | XHE XBI | 57d57d | 158d76d | 1064d331d | 1747d1754d |
Trading data
XHE | XBI | |
Last sale 6/15/2026 at 1:30 PM | $82.09 | $136.40 |
| Previous close 06/15/2026 | $81.88 | $133.79 |
| Consolidated volume 06/15/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of May 29, 2026
1-year trailing difference
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XHE | XBI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 6/15/2026 at 1:30 PM
Live
Closed
XHE | XBI | |
|---|---|---|
| Last price | $82.09 | $136.40 |
| 1D performance | +0.26% | +1.95% |
| AuM | $143.39 M | $8.51 B |
| E/R | 0.35% | 0.35% |
Characteristics
XHE | XBI | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | State Street Investment Management |
| Benchmark | S&P Health Care Equipment Select Industry Index | S&P Biotechnology Select Industry Index |
| N° of holdings | 60 | 119 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 26, 2011 | January 31, 2006 |
| ESG | No | No |
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Exposure
Countries
XHE
USA
92.03%
Other
7.97%
XBI
USA
94.81%
Other
5.19%
Sectors
XHE
Health Care
89.92%
Other
10.08%
XBI
Health Care
85.15%
Other
14.85%
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Diversification
XHE
Total weight of top 15 holdings out of 15
29.69%
XBI
Total weight of top 15 holdings out of 15
20.97%
Top 15 holdings
Data as of April 30, 2026
XHE
STAAR SURGICAL
2.55%
GLAUKOS
2.39%
AXOGEN
2.29%
BUTTERFLY NETWORK INC
2.14%
NOVOCURE LTD
2.07%
AVANOS MEDICAL INC
2.05%
TELEFLEX
1.89%
OMNICELL
1.89%
IRHYTHM TECHNOLOGIES
1.84%
US58507V1070
1.79%
INTEGER HOLDINGS
1.78%
GLOBUS MEDICAL
1.77%
LANTHEUS HOLDINGS
1.76%
MASIMO
1.74%
LEMAITRE VASCULAR
1.73%
XBI
APELLIS PHARMACEUTICALS
1.87%
REVOLUTION MEDICINES INC
1.65%
TRAVERE THERAPEUTICS INC
1.62%
ARROWHEAD PHARMACEUTICALS INC
1.44%
TWIST BIOSCIENCE CORP
1.42%
US86627T1088
1.40%
ALKERMES
1.38%
TG THERAPEUTICS
1.37%
MADRIGAL PHARMACEUTICALS INC
1.36%
BEAM THERAPEUTICS
1.32%
US03770N1019
1.26%
SCHOLAR ROCK HOLDING CORP
1.23%
US74006W2070
1.22%
EXELIXIS
1.21%
MIRUM PHARMACEUTICALS INC
1.21%
Frequently asked questions about XHE and XBI
How have the XHE and XBI ETFs performed in 2026?
As of June 15, 2026, XHE is down -7.02% year-to-date (YTD), while XBI has returned 11.78%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XHE or XBI?
Year-to-date, the XHE ETF saw -$535K in flows, compared to -$218M for XBI.
Which ETF is more volatile: XHE or XBI?
Over the past year, XHE had a volatility of 21.82%, while XBI experienced 26.18%.
Which ETF is bigger: XHE or XBI?
As of June 15, 2026, XHE holds $143.39 M in assets under management (AUM), while XBI manages $8.51 B.
What sectors do the XHE and XBI ETFs invest in?
XHE leans toward sectors like Health Care. Meanwhile, XBI focuses on Health Care.
What are the top holdings of the XHE ETF and XBI ETF?
XHE top holdings include STAAR SURGICAL, GLAUKOS and AXOGEN. XBI holds in its top three: APELLIS PHARMACEUTICALS, REVOLUTION MEDICINES INC and TRAVERE THERAPEUTICS INC.
Which ETF is more diversified: XHE or XBI?
XHE holds 66 securities with 29.69% of its assets in the top 15. XBI has 148 securities and a top 15 weight of 20.97%.
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