XHEvsXBIETF Comparison
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State Street SPDR S&P Health Care Equipment ETF (XHE) and State Street SPDR S&P Biotech ETF (XBI) belong to the same industry segment: US Health Care. Both ETFs have the same top 2 sector exposures: Healthcare and Finance. Both XHE and XBI have the same Total Expense Ratio (TER) of 0.35%. XHE is up 5.54% year-to-date (YTD) with -$11M in YTD flows. XBI performs better with 22.77% YTD performance, and +$853M in YTD flows. Run a side-by-side ETF comparison of XHE and XBI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XHE vs XBI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/23/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XHE XBI | +1.87%-3.93% | +9.46%-1.72% | +5.54%+22.77% | +14.34%+39.61% | +33.01%+130.21% | -25.86%+20.98% |
| Flows | XHE XBI | -$45M+$229M | -$15M+$343M | -$11M+$853M | -$21M+$1.24B | -$225M+$276M | -$401M+$1.96B |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XHE XBI | +20.85%+30.32% | +22.71%+29.02% | +21.97%+28.46% | +24.86%+33.06% |
| Max drawdown | XHE XBI | -9.09%-14.89% | -18.20%-14.89% | -24.35%-32.94% | -49.37%-53.28% |
| Max drawdown duration | XHE XBI | 65d65d | 207d65d | 565d331d | 1815d1622d |
Trading data
XHE | XBI | |
Last sale 10/23/2026 at 1:30 PM | $93.08 | $149.54 |
| Previous close 10/22/2026 | $93.34 | $151.64 |
| Consolidated volume 10/22/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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XHE | XBI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/23/2026 at 1:30 PM
Live
Closed
XHE | XBI | |
|---|---|---|
| Last price | $93.08 | $149.54 |
| 1D performance | -0.28% | -1.38% |
| AuM | $151.14 M | $10.36 B |
| E/R | 0.35% | 0.35% |
Characteristics
XHE | XBI | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | State Street Investment Management |
| Benchmark | S&P Health Care Equipment Select Industry Index | S&P Biotechnology Select Industry Index |
| N° of holdings | 67 | 149 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 26, 2011 | January 31, 2006 |
| ESG | No | No |
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Exposure
Countries
XHE
USA
93.57%
Other
6.43%
XBI
USA
95.53%
Other
4.47%
Sectors
XHE
Healthcare
97.47%
Other
2.53%
XBI
Healthcare
99.18%
Other
0.82%
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Diversification
XHE
Total weight of top 15 holdings out of 15
30.96%
XBI
Total weight of top 15 holdings out of 15
21.91%
Top 15 holdings
Data as of August 31, 2026
XHE
AtriCure, Inc.
2.59%
Strive, Inc. (United States)
2.47%
Inspire Medical Systems, Inc.
2.19%
Glaukos Corp.
2.16%
Butterfly Network, Inc.
2.15%
CONMED Corp.
2.02%
Integer Holdings Corp.
2.02%
Tandem Diabetes Care, Inc.
2.00%
Merit Medical Systems, Inc.
1.99%
Artivion, Inc.
1.94%
Haemonetics Corp.
1.93%
UFP Technologies, Inc.
1.89%
Baxter International, Inc.
1.88%
Becton, Dickinson & Co.
1.87%
Neogen Corp.
1.86%
XBI
Moderna, Inc.
2.81%
Twist Bioscience Corp.
1.89%
Apogee Therapeutics, Inc.
1.50%
Kymera Therapeutics, Inc.
1.40%
Halozyme Therapeutics, Inc.
1.39%
Natera, Inc.
1.37%
Praxis Precision Medicines, Inc.
1.34%
Oruka Therapeutics, Inc.
1.33%
Revolution Medicines, Inc.
1.31%
Travere Therapeutics, Inc.
1.30%
Protagonist Therapeutics, Inc.
1.28%
Dianthus Therapeutics, Inc.
1.27%
CG Oncology, Inc.
1.26%
Vaxcyte, Inc.
1.23%
Erasca, Inc.
1.23%
Frequently asked questions about XHE and XBI
How have the XHE and XBI ETFs performed in 2026?
As of October 23, 2026, XHE is up 5.54% year-to-date (YTD), while XBI has returned 22.77%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XHE or XBI?
Year-to-date, the XHE ETF saw -$11M in flows, compared to +$853M for XBI.
Which ETF is more volatile: XHE or XBI?
Over the past year, XHE had a volatility of 22.71%, while XBI experienced 29.02%.
Which ETF is bigger: XHE or XBI?
As of October 23, 2026, XHE holds $151.14 M in assets under management (AUM), while XBI manages $10.36 B.
What sectors do the XHE and XBI ETFs invest in?
XHE leans toward sectors like Healthcare. Meanwhile, XBI focuses on Healthcare.
What are the top holdings of the XHE ETF and XBI ETF?
XHE top holdings include AtriCure, Inc., Strive, Inc. (United States) and Inspire Medical Systems, Inc.. XBI holds in its top three: Moderna, Inc., Twist Bioscience Corp. and Apogee Therapeutics, Inc..
Which ETF is more diversified: XHE or XBI?
XHE holds 67 securities with 30.96% of its assets in the top 15. XBI has 152 securities and a top 15 weight of 21.91%.
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