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XBIvsPBEETF Comparison
SPDR S&P Biotech ETF (XBI) belongs to the US Health Care segment. Invesco Dynamic Biotechnology & Genome ETF (PBE) is part of the BioTech & Genomics segment. Both ETFs have the same top 3 sector exposures: and Health Care. XBI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.58% for PBE. XBI is up 0.54% year-to-date (YTD) with -$130M in YTD flows. PBE performs worse with -7.11% YTD performance, and +$135K in YTD flows. Run a side-by-side ETF comparison of XBI and PBE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
XBI vs PBE performance and flow charts
Performance
Cumulative Flows
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI PBE | -0.44%-5.55% | -0.07%-4.87% | +0.54%-7.11% | +41.14%+17.56% | +58.27%+26.51% | -15.85%+3.80% |
| Flows | XBI PBE | -$508M-$3M | -$176M+$969K | -$130M+$135K | -$91M-$32M | -$1.72B-$56M | +$1.46B-$39M |
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI PBE | +26.44%+19.01% | +28.20%+22.33% | +27.30%+20.20% | +32.93%+22.79% |
| Max drawdown | XBI PBE | -8.19%-11.05% | -21.44%-16.18% | -32.94%-22.21% | -57.63%-34.74% |
| Max drawdown duration | XBI PBE | 49d64d | 141d107d | 331d324d | 1823d1540d |
XBI | PBE | |
Last sale 3/13/2026 at 1:47 PM | $124.21 | $76.18 |
| Previous close 03/12/2026 | $122.62 | $78.26 |
| Consolidated volume 03/12/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
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XBI | PBE | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
XBI | PBE | |
|---|---|---|
| Last price | $124.21 | $76.18 |
| 1D performance | +1.29% | -2.66% |
| AuM | $7.79 B | $240.98 M |
| E/R | 0.35% | 0.58% |
Countries
Sectors
Diversification
Total weight of top 15 holdings out of 15
Total weight of top 15 holdings out of 15
Top 15 holdings
How have the XBI and PBE ETFs performed in 2026?
As of March 12, 2026, XBI is up 0.54% year-to-date (YTD), while PBE has lost -7.11%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or PBE?
Year-to-date, the XBI ETF saw -$130M in flows, compared to +$135K for PBE.
Which ETF is more volatile: XBI or PBE?
Over the past year, XBI had a volatility of 28.2%, while PBE experienced 22.33%.
Which ETF is bigger: XBI or PBE?
As of March 12, 2026, XBI holds $7.79 B in assets under management (AUM), while PBE manages $240.98 M.
What sectors do the XBI and PBE ETFs invest in?
XBI leans toward sectors like Health Care. Meanwhile, PBE focuses on Health Care.
What are the top holdings of the XBI ETF and PBE ETF?
XBI top holdings include MODERNA INC, MIRUM PHARMACEUTICALS INC and REVOLUTION MEDICINES INC. PBE holds in its top three: ILLUMINA, GILEAD SCIENCES and AMGEN-T.
Which ETF is more diversified: XBI or PBE?
XBI holds 149 securities with 21.6% of its assets in the top 15. PBE has 30 securities and a top 15 weight of 61.48%.
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