XBIvsLFSCETF Comparison
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State Street SPDR S&P Biotech ETF (XBI) belongs to the US Health Care segment. F/m Emerald Life Sciences Innovation ETF (LFSC) is part of the Life Sciences segment. Both ETFs have the same top 3 sector exposures: and Health Care. XBI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.79% for LFSC. XBI is up 7.52% year-to-date (YTD) with +$23M in YTD flows. LFSC performs worse with 0.96% YTD performance, and +$5M in YTD flows. Run a side-by-side ETF comparison of XBI and LFSC below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI vs LFSC performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/28/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI LFSC | +10.37%+12.20% | +4.13%+3.01% | +7.52%+0.96% | +61.71%+63.53% | +64.28%n/a | -5.68%n/a |
| Flows | XBI LFSC | +$514M+$81K | -$371M+$6M | +$23M+$5M | +$555M+$15M | -$1.24B- | +$958M- |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI LFSC | +30.05%+28.87% | +25.87%+26.26% | +27.40%n/a | +32.69%n/a |
| Max drawdown | XBI LFSC | -7.98%-10.65% | -9.66%-16.25% | -32.94%n/a | -55.10%n/a |
| Max drawdown duration | XBI LFSC | 42d47d | 76d139d | 331dn/a | 1826dn/a |
Trading data
XBI | LFSC | |
Last sale 4/29/2026 at 1:30 PM | $128.97 | $37.35 |
| Previous close 04/28/2026 | $131.16 | $36.98 |
| Consolidated volume 04/28/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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LFSC
is actively managed and doesn’t replicate an indexXBI | LFSC | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/29/2026 at 1:30 PM
Live
Closed
XBI | LFSC | |
|---|---|---|
| Last price | $128.97 | $37.35 |
| 1D performance | -1.67% | +1.01% |
| AuM | $8.42 B | $98.58 M |
| E/R | 0.35% | 0.79% |
Characteristics
XBI | LFSC | |
|---|---|---|
| Management strategy | Passive | Active |
| Provider | State Street Investment Management | Emerald Group |
| Benchmark | S&P Biotechnology Select Industry Index | - |
| N° of holdings | 122 | 33 |
| Asset class | Equities | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | October 31, 2024 |
| ESG | No | No |
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Exposure
Countries
XBI
USA
95.16%
Other
4.84%
LFSC
USA
90.82%
United Kingdom
7.06%
Other
2.12%
Sectors
XBI
Health Care
86.79%
Other
13.21%
LFSC
Health Care
78.16%
Other
21.84%
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Diversification
XBI
Total weight of top 15 holdings out of 15
19.71%
LFSC
Total weight of top 15 holdings out of 15
69.28%
Top 15 holdings
Data as of March 31, 2026
XBI
APELLIS PHARMACEUTICALS
1.83%
ALKERMES
1.45%
MADRIGAL PHARMACEUTICALS INC
1.38%
TG THERAPEUTICS
1.35%
INSMED
1.34%
SCHOLAR ROCK HOLDING CORP
1.30%
US03770N1019
1.28%
PROTAGONIST THERAPEUTICS INC
1.25%
US86627T1088
1.24%
UTD THERAPEUT
1.24%
US74006W2070
1.24%
ARROWHEAD PHARMACEUTICALS INC
1.23%
COGENT BIOSCIENCES
1.22%
BRIDGEBIO PHARMA
1.19%
PTC THERAPEUTI/D
1.18%
LFSC
COGENT BIOSCIENCES
9.11%
LIVANOVA
7.06%
UTD THERAPEUT
5.61%
US00773J2024
5.14%
MIRUM PHARMACEUTICALS INC
5.09%
TRAVERE THERAPEUTICS INC
4.75%
KALVISTA PHARMACEUTICALS INC
4.74%
GUARDANT HEALTH INC
4.38%
BRIDGEBIO PHARMA
4.05%
US6402683063
3.78%
TRANSMEDICS GROUP
3.77%
SAVARA INC
3.74%
TREVI THERAPEUTICS
2.95%
ICU MEDICAL
2.79%
AXSOME THERA CMN STK
2.32%
Frequently asked questions about XBI and LFSC
How have the XBI and LFSC ETFs performed in 2026?
As of April 28, 2026, XBI is up 7.52% year-to-date (YTD), while LFSC has returned 0.96%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or LFSC?
Year-to-date, the XBI ETF saw +$23M in flows, compared to +$5M for LFSC.
Which ETF is more volatile: XBI or LFSC?
Over the past year, XBI had a volatility of 25.87%, while LFSC experienced 26.26%.
Which ETF is bigger: XBI or LFSC?
As of April 28, 2026, XBI holds $8.42 B in assets under management (AUM), while LFSC manages $98.58 M.
What sectors do the XBI and LFSC ETFs invest in?
XBI leans toward sectors like Health Care. Meanwhile, LFSC focuses on Health Care.
What are the top holdings of the XBI ETF and LFSC ETF?
XBI top holdings include APELLIS PHARMACEUTICALS, ALKERMES and MADRIGAL PHARMACEUTICALS INC. LFSC holds in its top three: COGENT BIOSCIENCES, LIVANOVA and UTD THERAPEUT.
Which ETF is more diversified: XBI or LFSC?
XBI holds 151 securities with 19.71% of its assets in the top 15. LFSC has 44 securities and a top 15 weight of 69.28%.
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