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XBIvsGNOMETF Comparison
SPDR S&P Biotech ETF (XBI) belongs to the US Health Care segment. Global X Genomics & Biotechnology ETF - USD (GNOM) is part of the BioTech & Genomics segment. Both ETFs have the same top 3 sector exposures: and Health Care. XBI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.5% for GNOM. XBI is up 3.65% year-to-date (YTD) with -$59M in YTD flows. GNOM performs worse with -0.99% YTD performance, and -$2M in YTD flows. Run a side-by-side ETF comparison of XBI and GNOM below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
XBI vs GNOM performance and flow charts
Performance
Cumulative Flows
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI GNOM | +1.38%-2.35% | +3.11%-3.29% | +3.65%-0.99% | +47.21%+29.80% | +63.16%-6.02% | -13.71%-51.80% |
| Flows | XBI GNOM | -$4M- | -$179M-$4M | -$59M-$2M | +$90M-$19M | -$1.64B-$115M | +$1.20B+$11M |
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI GNOM | +25.68%+23.45% | +28.04%+30.08% | +27.26%+28.53% | +32.91%+33.47% |
| Max drawdown | XBI GNOM | -8.19%-10.89% | -21.44%-22.14% | -32.94%-46.50% | -57.63%-72.17% |
| Max drawdown duration | XBI GNOM | 48d48d | 141d113d | 331d1031d | 1822d1714d |
XBI | GNOM | |
Last sale 3/12/2026 at 2:26 PM | $123.48 | $44.25 |
| Previous close 03/11/2026 | $126.38 | $45.00 |
| Consolidated volume 03/11/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
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XBI | GNOM | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
XBI | GNOM | |
|---|---|---|
| Last price | $123.48 | $44.25 |
| 1D performance | -2.29% | -1.67% |
| AuM | $8.10 B | $49.36 M |
| E/R | 0.35% | 0.5% |
Countries
Sectors
Diversification
Total weight of top 15 holdings out of 15
Total weight of top 15 holdings out of 15
Top 15 holdings
How have the XBI and GNOM ETFs performed in 2026?
As of March 11, 2026, XBI is up 3.65% year-to-date (YTD), while GNOM has lost -0.99%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or GNOM?
Year-to-date, the XBI ETF saw -$59M in flows, compared to -$2M for GNOM.
Which ETF is more volatile: XBI or GNOM?
Over the past year, XBI had a volatility of 28.04%, while GNOM experienced 30.08%.
Which ETF is bigger: XBI or GNOM?
As of March 11, 2026, XBI holds $8.10 B in assets under management (AUM), while GNOM manages $49.36 M.
What sectors do the XBI and GNOM ETFs invest in?
XBI leans toward sectors like Health Care. Meanwhile, GNOM focuses on Health Care.
What are the top holdings of the XBI ETF and GNOM ETF?
XBI top holdings include MODERNA INC, MIRUM PHARMACEUTICALS INC and REVOLUTION MEDICINES INC. GNOM holds in its top three: MODERNA INC, ARROWHEAD PHARMACEUTICALS INC and US74006W2070.
Which ETF is more diversified: XBI or GNOM?
XBI holds 149 securities with 21.6% of its assets in the top 15. GNOM has 48 securities and a top 15 weight of 63.95%.
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