XBIvsFMEDETF Comparison
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State Street SPDR S&P Biotech ETF (XBI) belongs to the US Health Care segment. Fidelity Disruptive Medicine ETF (FMED) is part of the Multiple Trends segment. XBI's top 3 sector exposures are Healthcare and Finance. In contrast, FMED's top sector exposures are Healthcare XBI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.5% for FMED. XBI is up 23.56% year-to-date (YTD) with +$394M in YTD flows. FMED performs worse with 4.92% YTD performance, and -$17M in YTD flows. Run a side-by-side ETF comparison of XBI and FMED below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI vs FMED performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI FMED | +0.59%+5.01% | +13.07%+13.03% | +23.56%+4.92% | +72.81%+18.01% | +81.55%+13.15% | +21.91%n/a |
| Flows | XBI FMED | -$259M- | +$434M-$17M | +$394M-$17M | +$1.35B-$14M | -$541M-$3M | +$1.29B- |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI FMED | +30.66%+22.48% | +26.75%+19.50% | +27.88%+18.58% | +32.89%n/a |
| Max drawdown | XBI FMED | -8.33%-5.92% | -9.66%-17.78% | -32.94%-21.42% | -54.07%n/a |
| Max drawdown duration | XBI FMED | 15d15d | 76d212d | 331d211d | 1685dn/a |
Trading data
XBI | FMED | |
Last sale 7/24/2026 at 1:30 PM | $150.48 | |
| Previous close 07/24/2026 | $152.23 | |
| Consolidated volume 07/24/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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FMED
is actively managed and doesn’t replicate an indexXBI | FMED | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 7/24/2026 at 1:30 PM
Live
Closed
XBI | FMED | |
|---|---|---|
| Last price | $150.48 | – |
| 1D performance | -1.15% | – |
| AuM | $10.02 B | $46.16 M |
| E/R | 0.35% | 0.5% |
Characteristics
XBI | FMED | |
|---|---|---|
| Management strategy | Passive | Active |
| Provider | State Street Investment Management | Fidelity |
| Benchmark | S&P Biotechnology Select Industry Index | - |
| N° of holdings | 150 | 69 |
| Asset class | Equities | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | June 12, 2023 |
| ESG | No | No |
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Exposure
Countries
XBI
USA
95.06%
Other
4.94%
FMED
USA
83.89%
Other
16.11%
Sectors
XBI
Healthcare
99.03%
Other
0.97%
FMED
Healthcare
100%
Other
-0%
Diversification
XBI
Total weight of top 15 holdings out of 15
19.19%
FMED
Total weight of top 15 holdings out of 15
41.87%
Top 15 holdings
Data as of June 30, 2026
XBI
Apogee Therapeutics, Inc.
1.48%
Moderna, Inc.
1.41%
Twist Bioscience Corp.
1.40%
Oruka Therapeutics, Inc.
1.37%
Kymera Therapeutics, Inc.
1.35%
Viking Therapeutics, Inc.
1.30%
Praxis Precision Medicines, Inc.
1.29%
Erasca, Inc.
1.27%
Revolution Medicines, Inc.
1.20%
Rhythm Pharmaceuticals, Inc.
1.20%
CG Oncology, Inc.
1.20%
SELLAS Life Sciences Group, Inc.
1.19%
Vaxcyte, Inc.
1.18%
Dianthus Therapeutics, Inc.
1.18%
Cytokinetics, Inc.
1.17%
FMED
Lifestance Health Group, Inc.
5.11%
10X Genomics, Inc.
3.56%
Danaher Corp.
3.29%
UCB SA
3.09%
Cogent Biosciences, Inc.
2.79%
Bio-Techne Corp.
2.76%
Moderna, Inc.
2.69%
Intuitive Surgical, Inc.
2.49%
argenx SE
2.43%
Alnylam Pharmaceuticals, Inc.
2.41%
Kymera Therapeutics, Inc.
2.36%
UnitedHealth Group, Inc.
2.27%
Thermo Fisher Scientific, Inc.
2.24%
Ascendis Pharma A/S
2.21%
Legend Biotech Corp.
2.17%
Frequently asked questions about XBI and FMED
How have the XBI and FMED ETFs performed in 2026?
As of July 24, 2026, XBI is up 23.56% year-to-date (YTD), while FMED has returned 4.92%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or FMED?
Year-to-date, the XBI ETF saw +$394M in flows, compared to -$17M for FMED.
Which ETF is more volatile: XBI or FMED?
Over the past year, XBI had a volatility of 26.75%, while FMED experienced 19.5%.
Which ETF is bigger: XBI or FMED?
As of July 24, 2026, XBI holds $10.02 B in assets under management (AUM), while FMED manages $46.16 M.
What sectors do the XBI and FMED ETFs invest in?
XBI leans toward sectors like Healthcare. Meanwhile, FMED focuses on Healthcare.
What are the top holdings of the XBI ETF and FMED ETF?
XBI top holdings include Apogee Therapeutics, Inc., Moderna, Inc. and Twist Bioscience Corp.. FMED holds in its top three: Lifestance Health Group, Inc., 10X Genomics, Inc. and Danaher Corp..
Which ETF is more diversified: XBI or FMED?
XBI holds 153 securities with 19.19% of its assets in the top 15. FMED has 69 securities and a top 15 weight of 41.87%.
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