XBIvsFBTETF Comparison
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SPDR S&P Biotech ETF (XBI) and First Trust NYSE Arca Biotechnology Index Fund ETF (FBT) belong to the same industry segment: US Health Care. Both ETFs have the same top 3 sector exposures: and Health Care. XBI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.54% for FBT. XBI is up 5.67% year-to-date (YTD) with +$52M in YTD flows. FBT performs worse with -2.39% YTD performance, and +$1.07B in YTD flows. Run a side-by-side ETF comparison of XBI and FBT below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI vs FBT performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/07/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI FBT | +1.42%-0.49% | +1.95%-8.19% | +5.67%-2.39% | +77.13%+32.22% | +70.14%+29.71% | -1.64%+27.00% |
| Flows | XBI FBT | +$60M-$39M | -$566M+$1.08B | +$52M+$1.07B | +$345M+$1.07B | -$1.27B+$617M | +$1.37B+$273M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI FBT | +30.72%+23.63% | +27.87%+23.76% | +27.64%+20.13% | +32.76%+21.82% |
| Max drawdown | XBI FBT | -9.66%-14.27% | -9.66%-14.27% | -32.94%-19.92% | -55.10%-29.98% |
| Max drawdown duration | XBI FBT | 75d75d | 75d75d | 331d237d | 1805d1243d |
Trading data
XBI | FBT | |
Last sale 4/8/2026 at 5:33 PM | $130.63 | $205.27 |
| Previous close 04/07/2026 | $128.85 | $200.91 |
| Consolidated volume 04/07/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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XBI | FBT | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/8/2026 at 5:33 PM
Live
Closed
XBI | FBT | |
|---|---|---|
| Last price | $130.63 | $205.27 |
| 1D performance | +1.38% | +2.17% |
| AuM | $8.31 B | $2.27 B |
| E/R | 0.35% | 0.54% |
Characteristics
XBI | FBT | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | SPDR | First Trust |
| Benchmark | S&P Biotechnology Select Industry Index | NYSE Arca Biotechnology Index |
| N° of holdings | 121 | 28 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | June 19, 2006 |
| ESG | No | No |
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Exposure
Countries
XBI
USA
93.09%
Other
6.91%
FBT
USA
96.48%
Other
3.52%
Sectors
XBI
Health Care
87.1%
Other
12.9%
FBT
Health Care
90.73%
Other
9.27%
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Diversification
XBI
Total weight of top 15 holdings out of 15
22.98%
FBT
Total weight of top 15 holdings out of 15
57.25%
Top 15 holdings
Data as of February 28, 2026
XBI
MODERNA INC
2.22%
ROIVANT SCIENCES LTD
1.72%
VAXCYTE
1.71%
ARCELLX
1.64%
REVOLUTION MEDICINES INC
1.58%
US74006W2070
1.55%
AMGEN-T
1.48%
GILEAD SCIENCES
1.48%
AMICUS THERAPEUTICS
1.46%
MIRUM PHARMACEUTICALS INC
1.39%
KRYSTAL BIOTECH INC
1.38%
BIOMARIN PHARMACEUTICAL
1.38%
VERTEX PHARMACEUTICALS
1.34%
HALOZYME THERAPEUTICS
1.33%
CELCUITY INC
1.32%
FBT
MODERNA INC
5.67%
GILEAD SCIENCES
4.43%
AMGEN-T
4.16%
UTD THERAPEUT
4.11%
EXACT SCIENCES
3.76%
VERTEX PHARMACEUTICALS
3.75%
BIOMARIN PHARMACEUTICAL
3.67%
BIOGEN INC
3.58%
NEUROCRINE BIOSCIENCES
3.54%
KRYSTAL BIOTECH INC
3.50%
REGENERON PHARMACEUTICALS
3.47%
ALKERMES
3.47%
EXELIXIS
3.47%
BIONTECH SE ADR
3.38%
US04016X1019
3.29%
Frequently asked questions about XBI and FBT
How have the XBI and FBT ETFs performed in 2026?
As of April 7, 2026, XBI is up 5.67% year-to-date (YTD), while FBT has lost -2.39%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or FBT?
Year-to-date, the XBI ETF saw +$52M in flows, compared to +$1.07B for FBT.
Which ETF is more volatile: XBI or FBT?
Over the past year, XBI had a volatility of 27.87%, while FBT experienced 23.76%.
Which ETF is bigger: XBI or FBT?
As of April 7, 2026, XBI holds $8.31 B in assets under management (AUM), while FBT manages $2.27 B.
What sectors do the XBI and FBT ETFs invest in?
XBI leans toward sectors like Health Care. Meanwhile, FBT focuses on Health Care.
What are the top holdings of the XBI ETF and FBT ETF?
XBI top holdings include MODERNA INC, ROIVANT SCIENCES LTD and VAXCYTE. FBT holds in its top three: MODERNA INC, GILEAD SCIENCES and AMGEN-T.
Which ETF is more diversified: XBI or FBT?
XBI holds 147 securities with 22.98% of its assets in the top 15. FBT has 30 securities and a top 15 weight of 57.25%.
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