XBIvsEKGETF Comparison
VS
ETF 2
EKG
First Trust Nasdaq Lux Digital Health Solutions ETF
This fund is part of
Healthcare Technology
-0.29%
State Street SPDR S&P Biotech ETF (XBI) belongs to the US Health Care segment. First Trust Nasdaq Lux Digital Health Solutions ETF (EKG) is part of the Healthcare Technology segment. XBI's top 2 sector exposures are Healthcare and Finance. In contrast, EKG's top sector exposures are Healthcare. XBI is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.65% for EKG. XBI is up 32.87% year-to-date (YTD) with +$966M in YTD flows. EKG performs worse with 15.47% YTD performance, and +$963K in YTD flows. Run a side-by-side ETF comparison of XBI and EKG below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XBI vs EKG performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 09/08/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XBI EKG | +2.44%+8.57% | +26.14%+24.26% | +32.87%+15.47% | +72.26%+25.83% | +107.12%+37.54% | +23.20%n/a |
| Flows | XBI EKG | +$531M- | +$1.35B+$963K | +$966M+$963K | +$1.73B+$963K | +$26M+$2M | +$1.69B- |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XBI EKG | +29.80%+26.43% | +27.90%+23.54% | +28.27%+23.87% | +32.90%n/a |
| Max drawdown | XBI EKG | -10.46%-7.45% | -10.46%-22.11% | -32.94%-24.71% | -53.28%n/a |
| Max drawdown duration | XBI EKG | 40d28d | 40d208d | 331d107d | 1622dn/a |
Trading data
XBI | EKG | |
Last sale 9/9/2026 at 3:22 PM | $160.27 | $21.58 |
| Previous close 09/08/2026 | $161.93 | $21.92 |
| Consolidated volume 09/08/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of August 31, 2026
1-year trailing difference
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XBI | EKG | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 9/9/2026 at 3:22 PM
Live
Closed
XBI | EKG | |
|---|---|---|
| Last price | $160.27 | $21.58 |
| 1D performance | -1.03% | -1.55% |
| AuM | $11.33 B | $4.39 M |
| E/R | 0.35% | 0.65% |
Characteristics
XBI | EKG | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | First Trust |
| Benchmark | S&P Biotechnology Select Industry Index | Nasdaq Lux Health Tech Index |
| N° of holdings | 149 | 37 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | January 31, 2006 | March 22, 2022 |
| ESG | No | No |
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Exposure
Countries
XBI
USA
95.3%
Other
4.7%
EKG
USA
95.72%
Other
4.28%
Sectors
XBI
Healthcare
99.41%
Other
0.59%
EKG
Healthcare
98.67%
Other
1.33%
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Diversification
XBI
Total weight of top 15 holdings out of 15
20.29%
EKG
Total weight of top 15 holdings out of 15
74.55%
Top 15 holdings
Data as of July 31, 2026
XBI
Apogee Therapeutics, Inc.
1.65%
Oruka Therapeutics, Inc.
1.53%
Dianthus Therapeutics, Inc.
1.42%
Erasca, Inc.
1.38%
Twist Bioscience Corp.
1.37%
Kymera Therapeutics, Inc.
1.34%
Spyre Therapeutics, Inc.
1.33%
Revolution Medicines, Inc.
1.32%
CG Oncology, Inc.
1.32%
Protagonist Therapeutics, Inc.
1.31%
Praxis Precision Medicines, Inc.
1.30%
Regeneron Pharmaceuticals, Inc.
1.29%
Cogent Biosciences, Inc.
1.26%
Natera, Inc.
1.26%
Arrowhead Pharmaceuticals, Inc.
1.22%
EKG
IQVIA Holdings, Inc.
9.37%
Veeva Systems, Inc.
9.01%
DexCom, Inc.
8.04%
Guardant Health, Inc.
5.85%
ResMed, Inc.
5.83%
Illumina, Inc.
5.19%
Natera, Inc.
5.11%
Intuitive Surgical, Inc.
4.87%
Oscar Health, Inc.
3.90%
Tempus AI, Inc.
3.64%
QIAGEN NV
2.95%
Globus Medical, Inc.
2.94%
Align Technology, Inc.
2.74%
10X Genomics, Inc.
2.57%
Hims & Hers Health, Inc.
2.54%
Frequently asked questions about XBI and EKG
How have the XBI and EKG ETFs performed in 2026?
As of September 8, 2026, XBI is up 32.87% year-to-date (YTD), while EKG has returned 15.47%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: XBI or EKG?
Year-to-date, the XBI ETF saw +$966M in flows, compared to +$963K for EKG.
Which ETF is more volatile: XBI or EKG?
Over the past year, XBI had a volatility of 27.9%, while EKG experienced 23.54%.
Which ETF is bigger: XBI or EKG?
As of September 8, 2026, XBI holds $11.33 B in assets under management (AUM), while EKG manages $4.39 M.
What sectors do the XBI and EKG ETFs invest in?
XBI leans toward sectors like Healthcare. Meanwhile, EKG focuses on Healthcare.
What are the top holdings of the XBI ETF and EKG ETF?
XBI top holdings include Apogee Therapeutics, Inc., Oruka Therapeutics, Inc. and Dianthus Therapeutics, Inc.. EKG holds in its top three: IQVIA Holdings, Inc., Veeva Systems, Inc. and DexCom, Inc..
Which ETF is more diversified: XBI or EKG?
XBI holds 151 securities with 20.29% of its assets in the top 15. EKG has 37 securities and a top 15 weight of 74.55%.
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