TDNAvsXBIETF Comparison
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T. Rowe Price Biotech ETF (TDNA) belongs to the Uncategorized Equities segment. State Street SPDR S&P Biotech ETF (XBI) is part of the US Health Care segment. TDNA's top 1 sector exposures are Healthcare. In contrast, XBI's top sector exposures are Healthcare and Finance. TDNA is more expensive with a Total Expense Ratio (TER) of 0.55%, versus 0.35% for XBI. Run a side-by-side ETF comparison of TDNA and XBI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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TDNA vs XBI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/29/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | TDNA XBI | +0.68%-1.10% | n/a+2.89% | n/a+28.00% | n/a+39.90% | n/a+140.64% | n/a+21.15% |
| Flows | TDNA XBI | +$568K+$488M | -+$686M | -+$985M | -+$1.43B | -+$108M | -+$1.73B |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | TDNA XBI | n/a+30.56% | n/a+29.04% | n/a+28.37% | n/a+33.01% |
| Max drawdown | TDNA XBI | n/a-14.89% | n/a-14.89% | n/a-32.94% | n/a-53.28% |
| Max drawdown duration | TDNA XBI | n/a72d | n/a72d | n/a331d | n/a1622d |
Trading data
TDNA | XBI | |
Last sale 10/30/2026 at 1:30 PM | $24.89 | $155.98 |
| Previous close 10/29/2026 | $25.17 | $157.79 |
| Consolidated volume 10/29/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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TDNA
is actively managed and doesn’t replicate an indexTDNA | XBI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
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Main metrics
Last update 10/30/2026 at 1:30 PM
Live
Closed
TDNA | XBI | |
|---|---|---|
| Last price | $24.89 | $155.98 |
| 1D performance | -1.11% | -1.15% |
| AuM | $10.69 M | $10.92 B |
| E/R | 0.55% | 0.35% |
Characteristics
TDNA | XBI | |
|---|---|---|
| Management strategy | Active | Passive |
| Provider | T. Rowe Price | State Street Investment Management |
| Benchmark | - | S&P Biotechnology Select Industry Index |
| N° of holdings | 86 | 159 |
| Asset class | - | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | September 16, 2026 | January 31, 2006 |
| ESG | No | No |
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Exposure
Countries
TDNA
USA
88.46%
Other
11.54%
XBI
USA
95.32%
Other
4.68%
Sectors
TDNA
Healthcare
98.5%
Other
1.5%
XBI
Healthcare
99.16%
Other
0.84%
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Diversification
TDNA
Total weight of top 15 holdings out of 15
37.16%
XBI
Total weight of top 15 holdings out of 15
24.01%
Top 15 holdings
Data as of September 30, 2026
TDNA
argenx SE
5.41%
Kymera Therapeutics, Inc.
4.04%
Kodiak Sciences, Inc.
2.68%
Insmed, Inc.
2.59%
Natera, Inc.
2.41%
Revolution Medicines, Inc.
2.37%
Vertex Pharmaceuticals, Inc.
2.25%
United Therapeutics Corp.
2.20%
Alnylam Pharmaceuticals, Inc.
1.98%
Dianthus Therapeutics, Inc.
1.91%
Praxis Precision Medicines, Inc.
1.91%
Moderna, Inc.
1.90%
Vaxcyte, Inc.
1.86%
Cytokinetics, Inc.
1.83%
Rhythm Pharmaceuticals, Inc.
1.81%
XBI
Twist Bioscience Corp.
2.21%
Moderna, Inc.
2.04%
Natera, Inc.
1.80%
Iovance Biotherapeutics, Inc.
1.62%
Amgen, Inc.
1.55%
Biogen, Inc.
1.54%
United Therapeutics Corp.
1.54%
AbbVie, Inc.
1.50%
Halozyme Therapeutics, Inc.
1.48%
Spyre Therapeutics, Inc.
1.47%
Gilead Sciences, Inc.
1.47%
TG Therapeutics, Inc.
1.47%
CRISPR Therapeutics AG
1.46%
Vertex Pharmaceuticals, Inc.
1.44%
Exelixis, Inc.
1.44%
Frequently asked questions about TDNA and XBI
Which ETF is bigger: TDNA or XBI?
As of October 29, 2026, TDNA holds $10.69 M in assets under management (AUM), while XBI manages $10.92 B.
What sectors do the TDNA and XBI ETFs invest in?
TDNA leans toward sectors like Healthcare. Meanwhile, XBI focuses on Healthcare.
What are the top holdings of the TDNA ETF and XBI ETF?
TDNA top holdings include argenx SE, Kymera Therapeutics, Inc. and Kodiak Sciences, Inc.. XBI holds in its top three: Twist Bioscience Corp., Moderna, Inc. and Natera, Inc..
Which ETF is more diversified: TDNA or XBI?
TDNA holds 86 securities with 37.16% of its assets in the top 15. XBI has 162 securities and a top 15 weight of 24.01%.
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Latest news about TDNA & XBI
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