PTHvsXBIETF Comparison
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Invesco DWA Healthcare Momentum ETF (PTH) and State Street SPDR S&P Biotech ETF (XBI) belong to the same industry segment: US Health Care. PTH's top 2 sector exposures are Healthcare and Consumer Non-Cyclicals. In contrast, XBI's top sector exposures are Healthcare and Finance. PTH is more expensive with a Total Expense Ratio (TER) of 0.72%, versus 0.35% for XBI. PTH is up 24.18% year-to-date (YTD) with +$131M in YTD flows. XBI performs better with 32.87% YTD performance, and +$966M in YTD flows. Run a side-by-side ETF comparison of PTH and XBI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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PTH vs XBI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 09/08/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | PTH XBI | +1.24%+2.44% | +26.10%+26.14% | +24.18%+32.87% | +56.23%+72.26% | +74.28%+107.12% | +10.24%+23.20% |
| Flows | PTH XBI | +$26M+$531M | +$142M+$1.35B | +$131M+$966M | +$138M+$1.73B | +$78M+$26M | -$151M+$1.69B |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | PTH XBI | +28.96%+29.80% | +26.07%+27.90% | +26.02%+28.27% | +25.76%+32.90% |
| Max drawdown | PTH XBI | -7.42%-10.46% | -11.91%-10.46% | -27.71%-32.94% | -49.87%-53.28% |
| Max drawdown duration | PTH XBI | 40d40d | 140d40d | 353d331d | 1735d1622d |
Trading data
PTH | XBI | |
Last sale 9/8/2026 at 7:59 PM | $61.71 | $160.56 |
| Previous close 09/08/2026 | $61.13 | $161.93 |
| Consolidated volume 09/08/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of August 31, 2026
1-year trailing difference
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PTH | XBI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 9/8/2026 at 7:59 PM
Live
Closed
PTH | XBI | |
|---|---|---|
| Last price | $61.71 | $160.56 |
| 1D performance | +0.95% | -0.85% |
| AuM | $288.30 M | $11.33 B |
| E/R | 0.72% | 0.35% |
Characteristics
PTH | XBI | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | Invesco | State Street Investment Management |
| Benchmark | Dorsey Wright Healthcare Technical Leaders Index | S&P Biotechnology Select Industry Index |
| N° of holdings | 54 | 149 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | October 12, 2006 | January 31, 2006 |
| ESG | No | No |
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Exposure
Countries
PTH
USA
89.98%
Other
10.02%
XBI
USA
95.3%
Other
4.7%
Sectors
PTH
Healthcare
99.16%
Other
0.84%
XBI
Healthcare
99.41%
Other
0.59%
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Diversification
PTH
Total weight of top 15 holdings out of 15
47.09%
XBI
Total weight of top 15 holdings out of 15
20.29%
Top 15 holdings
Data as of July 31, 2026
PTH
Roivant Sciences Ltd.
4.88%
Revolution Medicines, Inc.
4.85%
BrightSpring Health Services, Inc.
4.77%
Guardant Health, Inc.
4.50%
Axsome Therapeutics, Inc.
4.38%
Liquidia Corp.
3.17%
Erasca, Inc.
2.92%
Oruka Therapeutics, Inc.
2.54%
10X Genomics, Inc.
2.27%
Relay Therapeutics, Inc.
2.23%
Travere Therapeutics, Inc.
2.18%
Agilon Health, Inc.
2.13%
Oscar Health, Inc.
2.09%
Arrowhead Pharmaceuticals, Inc.
2.09%
Tango Therapeutics, Inc.
2.09%
XBI
Apogee Therapeutics, Inc.
1.65%
Oruka Therapeutics, Inc.
1.53%
Dianthus Therapeutics, Inc.
1.42%
Erasca, Inc.
1.38%
Twist Bioscience Corp.
1.37%
Kymera Therapeutics, Inc.
1.34%
Spyre Therapeutics, Inc.
1.33%
Revolution Medicines, Inc.
1.32%
CG Oncology, Inc.
1.32%
Protagonist Therapeutics, Inc.
1.31%
Praxis Precision Medicines, Inc.
1.30%
Regeneron Pharmaceuticals, Inc.
1.29%
Cogent Biosciences, Inc.
1.26%
Natera, Inc.
1.26%
Arrowhead Pharmaceuticals, Inc.
1.22%
Frequently asked questions about PTH and XBI
How have the PTH and XBI ETFs performed in 2026?
As of September 8, 2026, PTH is up 24.18% year-to-date (YTD), while XBI has returned 32.87%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: PTH or XBI?
Year-to-date, the PTH ETF saw +$131M in flows, compared to +$966M for XBI.
Which ETF is more volatile: PTH or XBI?
Over the past year, PTH had a volatility of 26.07%, while XBI experienced 27.9%.
Which ETF is bigger: PTH or XBI?
As of September 8, 2026, PTH holds $288.30 M in assets under management (AUM), while XBI manages $11.33 B.
What sectors do the PTH and XBI ETFs invest in?
PTH leans toward sectors like Healthcare. Meanwhile, XBI focuses on Healthcare.
What are the top holdings of the PTH ETF and XBI ETF?
PTH top holdings include Roivant Sciences Ltd., Revolution Medicines, Inc. and BrightSpring Health Services, Inc.. XBI holds in its top three: Apogee Therapeutics, Inc., Oruka Therapeutics, Inc. and Dianthus Therapeutics, Inc..
Which ETF is more diversified: PTH or XBI?
PTH holds 54 securities with 47.09% of its assets in the top 15. XBI has 151 securities and a top 15 weight of 20.29%.
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