PTHvsXBIETF Comparison
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Invesco DWA Healthcare Momentum ETF (PTH) and State Street SPDR S&P Biotech ETF (XBI) belong to the same industry segment: US Health Care. Both ETFs have the same top 3 sector exposures: and Health Care. PTH is more expensive with a Total Expense Ratio (TER) of 0.72%, versus 0.35% for XBI. PTH is up 4.86% year-to-date (YTD) with -$6M in YTD flows. XBI performs better with 9.28% YTD performance, and -$19M in YTD flows. Run a side-by-side ETF comparison of PTH and XBI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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PTH vs XBI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | PTH XBI | +12.30%+11.52% | +6.29%+4.22% | +4.86%+9.28% | +38.78%+65.29% | +31.58%+64.93% | +0.54%-3.74% |
| Flows | PTH XBI | -$2M+$314M | -$5M-$560M | -$6M-$19M | -$10M+$404M | -$81M-$1.15B | -$357M+$839M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | PTH XBI | +26.84%+30.22% | +22.82%+25.87% | +24.56%+27.40% | +25.26%+32.69% |
| Max drawdown | PTH XBI | -7.51%-7.98% | -11.91%-9.66% | -29.24%-32.94% | -50.10%-55.10% |
| Max drawdown duration | PTH XBI | 40d42d | 140d76d | 271d331d | 1695d1822d |
Trading data
PTH | XBI | |
Last sale 4/24/2026 at 1:30 PM | $52.13 | $133.28 |
| Previous close 04/23/2026 | $52.31 | $134.49 |
| Consolidated volume 04/23/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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PTH | XBI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/24/2026 at 1:30 PM
Live
Closed
PTH | XBI | |
|---|---|---|
| Last price | $52.13 | $133.28 |
| 1D performance | -0.34% | -0.90% |
| AuM | $125.11 M | $8.52 B |
| E/R | 0.72% | 0.35% |
Characteristics
PTH | XBI | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | Invesco | State Street Investment Management |
| Benchmark | Dorsey Wright Healthcare Technical Leaders Index | S&P Biotechnology Select Industry Index |
| N° of holdings | 46 | 122 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | October 12, 2006 | January 31, 2006 |
| ESG | No | No |
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Exposure
Countries
PTH
USA
94.53%
Other
5.47%
XBI
USA
95.16%
Other
4.84%
Sectors
PTH
Health Care
85.2%
Other
14.8%
XBI
Health Care
86.79%
Other
13.21%
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Diversification
PTH
Total weight of top 15 holdings out of 15
52.67%
XBI
Total weight of top 15 holdings out of 15
19.71%
Top 15 holdings
Data as of March 31, 2026
PTH
TERNS PHARMACEUTICALS
6.73%
ROIVANT SCIENCES LTD
5.47%
US74006W2070
5.15%
ARROWHEAD PHARMACEUTICALS INC
3.66%
GUARDANT HEALTH INC
3.47%
REVOLUTION MEDICINES INC
3.32%
TENET HEALTHCARE
3.16%
UTD THERAPEUT
2.99%
NATERA
2.95%
HCA HEALTHCARE
2.89%
CELCUITY INC
2.88%
AXSOME THERA CMN STK
2.58%
MADRIGAL PHARMACEUTICALS INC
2.58%
PROTAGONIST THERAPEUTICS INC
2.43%
COGENT BIOSCIENCES
2.40%
XBI
APELLIS PHARMACEUTICALS
1.83%
ALKERMES
1.45%
MADRIGAL PHARMACEUTICALS INC
1.38%
TG THERAPEUTICS
1.35%
INSMED
1.34%
SCHOLAR ROCK HOLDING CORP
1.30%
US03770N1019
1.28%
PROTAGONIST THERAPEUTICS INC
1.25%
US86627T1088
1.24%
UTD THERAPEUT
1.24%
US74006W2070
1.24%
ARROWHEAD PHARMACEUTICALS INC
1.23%
COGENT BIOSCIENCES
1.22%
BRIDGEBIO PHARMA
1.19%
PTC THERAPEUTI/D
1.18%
Frequently asked questions about PTH and XBI
How have the PTH and XBI ETFs performed in 2026?
As of April 24, 2026, PTH is up 4.86% year-to-date (YTD), while XBI has returned 9.28%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: PTH or XBI?
Year-to-date, the PTH ETF saw -$6M in flows, compared to -$19M for XBI.
Which ETF is more volatile: PTH or XBI?
Over the past year, PTH had a volatility of 22.82%, while XBI experienced 25.87%.
Which ETF is bigger: PTH or XBI?
As of April 24, 2026, PTH holds $125.11 M in assets under management (AUM), while XBI manages $8.52 B.
What sectors do the PTH and XBI ETFs invest in?
PTH leans toward sectors like Health Care. Meanwhile, XBI focuses on Health Care.
What are the top holdings of the PTH ETF and XBI ETF?
PTH top holdings include TERNS PHARMACEUTICALS, ROIVANT SCIENCES LTD and US74006W2070. XBI holds in its top three: APELLIS PHARMACEUTICALS, ALKERMES and MADRIGAL PHARMACEUTICALS INC.
Which ETF is more diversified: PTH or XBI?
PTH holds 57 securities with 52.67% of its assets in the top 15. XBI has 151 securities and a top 15 weight of 19.71%.
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