PSCHvsXBIETF Comparison
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Invesco S&P SmallCap Health Care ETF (PSCH) and State Street SPDR S&P Biotech ETF (XBI) belong to the same industry segment: US Health Care. PSCH's top 1 sector exposures are Healthcare. In contrast, XBI's top sector exposures are Healthcare and Finance. PSCH is less expensive with a Total Expense Ratio (TER) of 0.29%, versus 0.35% for XBI. PSCH is up 22.45% year-to-date (YTD) with -$1M in YTD flows. XBI performs better with 22.77% YTD performance, and +$853M in YTD flows. Run a side-by-side ETF comparison of PSCH and XBI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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PSCH vs XBI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/23/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | PSCH XBI | +2.58%-3.93% | +1.83%-1.72% | +22.45%+22.77% | +26.77%+39.61% | +52.89%+130.21% | -9.76%+20.98% |
| Flows | PSCH XBI | -$13M+$229M | +$10M+$343M | -$1M+$853M | -$1M+$1.24B | -$102M+$276M | -$210M+$1.96B |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | PSCH XBI | +16.86%+30.32% | +19.43%+29.02% | +21.81%+28.46% | +22.92%+33.06% |
| Max drawdown | PSCH XBI | -8.61%-14.89% | -15.36%-14.89% | -22.80%-32.94% | -45.76%-53.28% |
| Max drawdown duration | PSCH XBI | 65d65d | 168d65d | 488d331d | 1810d1622d |
Trading data
PSCH | XBI | |
Last sale 10/23/2026 at 1:30 PM | $54.00 | $149.54 |
| Previous close 10/22/2026 | $54.29 | $151.64 |
| Consolidated volume 10/22/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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PSCH | XBI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/23/2026 at 1:30 PM
Live
Closed
PSCH | XBI | |
|---|---|---|
| Last price | $54.00 | $149.54 |
| 1D performance | -0.53% | -1.38% |
| AuM | $173.83 M | $10.36 B |
| E/R | 0.29% | 0.35% |
Characteristics
PSCH | XBI | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | Invesco | State Street Investment Management |
| Benchmark | S&P SmallCap 600 Capped Health Care Index | S&P Biotechnology Select Industry Index |
| N° of holdings | 69 | 149 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | April 7, 2010 | January 31, 2006 |
| ESG | No | No |
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Exposure
Countries
PSCH
USA
94.93%
Other
5.07%
XBI
USA
95.53%
Other
4.47%
Sectors
PSCH
Healthcare
100%
Other
0%
XBI
Healthcare
99.18%
Other
0.82%
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Diversification
PSCH
Total weight of top 15 holdings out of 15
48.62%
XBI
Total weight of top 15 holdings out of 15
21.91%
Top 15 holdings
Data as of August 31, 2026
PSCH
Corcept Therapeutics, Inc.
5.61%
Glaukos Corp.
5.37%
Protagonist Therapeutics, Inc.
4.54%
Alkermes Plc
4.09%
TG Therapeutics, Inc.
3.69%
Teleflex, Inc.
3.06%
PTC Therapeutics, Inc.
2.99%
Ligand Pharmaceuticals, Inc.
2.87%
Merit Medical Systems, Inc.
2.68%
RadNet, Inc.
2.68%
Liquidia Corp.
2.47%
ICU Medical, Inc.
2.20%
Indivior Pharmaceuticals, Inc.
2.16%
Integer Holdings Corp.
2.14%
Concentra Group Holdings Parent, Inc.
2.07%
XBI
Moderna, Inc.
2.81%
Twist Bioscience Corp.
1.89%
Apogee Therapeutics, Inc.
1.50%
Kymera Therapeutics, Inc.
1.40%
Halozyme Therapeutics, Inc.
1.39%
Natera, Inc.
1.37%
Praxis Precision Medicines, Inc.
1.34%
Oruka Therapeutics, Inc.
1.33%
Revolution Medicines, Inc.
1.31%
Travere Therapeutics, Inc.
1.30%
Protagonist Therapeutics, Inc.
1.28%
Dianthus Therapeutics, Inc.
1.27%
CG Oncology, Inc.
1.26%
Vaxcyte, Inc.
1.23%
Erasca, Inc.
1.23%
Frequently asked questions about PSCH and XBI
How have the PSCH and XBI ETFs performed in 2026?
As of October 23, 2026, PSCH is up 22.45% year-to-date (YTD), while XBI has returned 22.77%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: PSCH or XBI?
Year-to-date, the PSCH ETF saw -$1M in flows, compared to +$853M for XBI.
Which ETF is more volatile: PSCH or XBI?
Over the past year, PSCH had a volatility of 19.43%, while XBI experienced 29.02%.
Which ETF is bigger: PSCH or XBI?
As of October 23, 2026, PSCH holds $173.83 M in assets under management (AUM), while XBI manages $10.36 B.
What sectors do the PSCH and XBI ETFs invest in?
PSCH leans toward sectors like Healthcare. Meanwhile, XBI focuses on Healthcare.
What are the top holdings of the PSCH ETF and XBI ETF?
PSCH top holdings include Corcept Therapeutics, Inc., Glaukos Corp. and Protagonist Therapeutics, Inc.. XBI holds in its top three: Moderna, Inc., Twist Bioscience Corp. and Apogee Therapeutics, Inc..
Which ETF is more diversified: PSCH or XBI?
PSCH holds 69 securities with 48.62% of its assets in the top 15. XBI has 152 securities and a top 15 weight of 21.91%.
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