LFSCvsXBIETF Comparison
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F/m Emerald Life Sciences Innovation ETF (LFSC) belongs to the Life Sciences segment. State Street SPDR S&P Biotech ETF (XBI) is part of the US Health Care segment. LFSC's top 3 sector exposures are Health Care and Sovereign. In contrast, XBI's top sector exposures are Health Care LFSC is more expensive with a Total Expense Ratio (TER) of 0.79%, versus 0.35% for XBI. LFSC is up 8.38% year-to-date (YTD) with +$5M in YTD flows. XBI performs better with 8.8% YTD performance, and -$387M in YTD flows. Run a side-by-side ETF comparison of LFSC and XBI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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LFSC vs XBI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 06/11/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | LFSC XBI | +3.25%-1.49% | +13.25%+4.97% | +8.38%+8.80% | +60.86%+57.80% | n/a+50.49% | n/a-1.76% |
| Flows | LFSC XBI | +$352K-$63M | -$1M-$223M | +$5M-$387M | +$15M+$365M | --$1.26B | -+$526M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | LFSC XBI | +30.50%+33.04% | +26.55%+26.10% | n/a+27.61% | n/a+32.77% |
| Max drawdown | LFSC XBI | -6.53%-8.56% | -16.25%-9.66% | n/a-32.94% | n/a-54.69% |
| Max drawdown duration | LFSC XBI | 20d53d | 168d76d | n/a331d | n/a1754d |
Trading data
LFSC | XBI | |
Last sale 6/11/2026 at 7:14 PM | $39.91 | $134.87 |
| Previous close 06/11/2026 | $38.58 | $132.74 |
| Consolidated volume 06/11/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of May 29, 2026
1-year trailing difference
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LFSC
is actively managed and doesn’t replicate an indexLFSC | XBI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 6/11/2026 at 7:14 PM
Live
Closed
LFSC | XBI | |
|---|---|---|
| Last price | $39.91 | $134.87 |
| 1D performance | +3.45% | +1.60% |
| AuM | $106.22 M | $8.11 B |
| E/R | 0.79% | 0.35% |
Characteristics
LFSC | XBI | |
|---|---|---|
| Management strategy | Active | Passive |
| Provider | Emerald Group | State Street Investment Management |
| Benchmark | - | S&P Biotechnology Select Industry Index |
| N° of holdings | 33 | 119 |
| Asset class | - | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | October 31, 2024 | January 31, 2006 |
| ESG | No | No |
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Exposure
Countries
LFSC
USA
91.24%
Other
8.76%
XBI
USA
94.81%
Other
5.19%
Sectors
LFSC
Health Care
73.79%
Other
26.21%
XBI
Health Care
85.15%
Other
14.85%
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Diversification
LFSC
Total weight of top 15 holdings out of 15
69.25%
XBI
Total weight of top 15 holdings out of 15
20.97%
Top 15 holdings
Data as of April 30, 2026
LFSC
COGENT BIOSCIENCES
8.24%
TRAVERE THERAPEUTICS INC
6.94%
US00773J2024
6.56%
LIVANOVA
6.39%
MIRUM PHARMACEUTICALS INC
4.69%
UTD THERAPEUT
4.43%
US6402683063
4.39%
KALVISTA PHARMACEUTICALS INC
4.33%
GUARDANT HEALTH INC
3.94%
BRIDGEBIO PHARMA
3.81%
TRANSMEDICS GROUP
3.78%
SAVARA INC
3.34%
TREVI THERAPEUTICS
3.29%
US9229671048
2.75%
AXSOME THERA CMN STK
2.37%
XBI
APELLIS PHARMACEUTICALS
1.87%
REVOLUTION MEDICINES INC
1.65%
TRAVERE THERAPEUTICS INC
1.62%
ARROWHEAD PHARMACEUTICALS INC
1.44%
TWIST BIOSCIENCE CORP
1.42%
US86627T1088
1.40%
ALKERMES
1.38%
TG THERAPEUTICS
1.37%
MADRIGAL PHARMACEUTICALS INC
1.36%
BEAM THERAPEUTICS
1.32%
US03770N1019
1.26%
SCHOLAR ROCK HOLDING CORP
1.23%
US74006W2070
1.22%
EXELIXIS
1.21%
MIRUM PHARMACEUTICALS INC
1.21%
Frequently asked questions about LFSC and XBI
How have the LFSC and XBI ETFs performed in 2026?
As of June 11, 2026, LFSC is up 8.38% year-to-date (YTD), while XBI has returned 8.8%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: LFSC or XBI?
Year-to-date, the LFSC ETF saw +$5M in flows, compared to -$387M for XBI.
Which ETF is more volatile: LFSC or XBI?
Over the past year, LFSC had a volatility of 26.55%, while XBI experienced 26.1%.
Which ETF is bigger: LFSC or XBI?
As of June 11, 2026, LFSC holds $106.22 M in assets under management (AUM), while XBI manages $8.11 B.
What sectors do the LFSC and XBI ETFs invest in?
LFSC leans toward sectors like Health Care. Meanwhile, XBI focuses on Health Care.
What are the top holdings of the LFSC ETF and XBI ETF?
LFSC top holdings include COGENT BIOSCIENCES, TRAVERE THERAPEUTICS INC and US00773J2024. XBI holds in its top three: APELLIS PHARMACEUTICALS, REVOLUTION MEDICINES INC and TRAVERE THERAPEUTICS INC.
Which ETF is more diversified: LFSC or XBI?
LFSC holds 46 securities with 69.25% of its assets in the top 15. XBI has 148 securities and a top 15 weight of 20.97%.
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