IBBvsIHEETF Comparison
VS
iShares Biotechnology ETF (IBB) and iShares U.S. Pharmaceuticals ETF (IHE) belong to the same industry segment: US Health Care. IBB's top 3 sector exposures are Healthcare, Non-Corporate and Non-Energy Materials. In contrast, IHE's top sector exposures are Healthcare and Non-Corporate. IBB is more expensive with a Total Expense Ratio (TER) of 0.44%, versus 0.37% for IHE. IBB is up 28.25% year-to-date (YTD) with +$614M in YTD flows. IHE performs worse with 23.42% YTD performance, and +$500M in YTD flows. Run a side-by-side ETF comparison of IBB and IHE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
Find out how industry players manage ETF portfolios. Discover our library of Model portfolios
IBB vs IHE performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/28/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | IBB IHE | +2.64%+0.57% | +13.54%-0.02% | +28.25%+23.42% | +37.47%+41.86% | +92.71%+94.59% | +36.70%+81.35% |
| Flows | IBB IHE | +$296M-$124M | +$516M-$62M | +$614M+$500M | +$1.83B+$664M | -$30M+$614M | -$947M+$754M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | IBB IHE | +26.30%+18.52% | +22.73%+18.62% | +21.41%+17.18% | +22.59%+16.77% |
| Max drawdown | IBB IHE | -7.78%-9.67% | -9.61%-9.67% | -24.82%-16.04% | -35.62%-16.12% |
| Max drawdown duration | IBB IHE | 70d70d | 151d70d | 377d210d | 1468d669d |
Trading data
IBB | IHE | |
Last sale 10/28/2026 at 1:30 PM | $216.35 | $103.67 |
| Previous close 10/28/2026 | $212.20 | $103.35 |
| Consolidated volume 10/28/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
Create an account to view replication metrics
Join for free
IBB | IHE | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
Advertisement
Main metrics
Last update 10/28/2026 at 1:30 PM
Live
Closed
IBB | IHE | |
|---|---|---|
| Last price | $216.35 | $103.67 |
| 1D performance | +1.96% | +0.31% |
| AuM | $11.27 B | $1.56 B |
| E/R | 0.44% | 0.37% |
Advertisement
Exposure
Countries
IBB
USA
86.02%
Other
13.98%
IHE
USA
95.75%
Other
4.25%
Sectors
IBB
Healthcare
99.9%
Other
0.1%
IHE
Healthcare
99.75%
Other
0.25%
Advertisement
Diversification
IBB
Total weight of top 15 holdings out of 15
56.64%
IHE
Total weight of top 15 holdings out of 15
84.42%
Top 15 holdings
Data as of August 31, 2026
IBB
Amgen, Inc.
8.45%
Vertex Pharmaceuticals, Inc.
8.05%
Gilead Sciences, Inc.
7.21%
Regeneron Pharmaceuticals, Inc.
5.72%
argenx SE
3.80%
Moderna, Inc.
3.62%
Natera, Inc.
3.12%
Revolution Medicines, Inc.
2.78%
Illumina, Inc.
2.29%
Alnylam Pharmaceuticals, Inc.
2.27%
Biogen, Inc.
2.25%
BeOne Medicines Ltd.
2.03%
Insmed, Inc.
1.85%
Incyte Corp.
1.73%
United Therapeutics Corp.
1.49%
IHE
Johnson & Johnson
22.45%
Eli Lilly & Co.
20.50%
Merck & Co., Inc.
5.00%
Bristol Myers Squibb Co.
4.84%
Royalty Pharma Plc
4.54%
Pfizer Inc.
4.48%
Viatris, Inc.
4.19%
Zoetis, Inc.
3.82%
Jazz Pharmaceuticals Plc
3.43%
Elanco Animal Health, Inc.
2.61%
Corcept Therapeutics, Inc.
2.36%
Crinetics Pharmaceuticals, Inc.
1.95%
Axsome Therapeutics, Inc.
1.87%
Ligand Pharmaceuticals, Inc.
1.24%
Definium Therapeutics, Inc.
1.12%
Frequently asked questions about IBB and IHE
How have the IBB and IHE ETFs performed in 2026?
As of October 28, 2026, IBB is up 28.25% year-to-date (YTD), while IHE has returned 23.42%. That puts IBB better performer ahead so far this year.
Which ETF is attracting more investor money: IBB or IHE?
Year-to-date, the IBB ETF saw +$614M in flows, compared to +$500M for IHE.
Which ETF is more volatile: IBB or IHE?
Over the past year, IBB had a volatility of 22.73%, while IHE experienced 18.62%.
Which ETF is bigger: IBB or IHE?
As of October 28, 2026, IBB holds $11.27 B in assets under management (AUM), while IHE manages $1.56 B.
What sectors do the IBB and IHE ETFs invest in?
IBB leans toward sectors like Healthcare. Meanwhile, IHE focuses on Healthcare.
What are the top holdings of the IBB ETF and IHE ETF?
IBB top holdings include Amgen, Inc., Vertex Pharmaceuticals, Inc. and Gilead Sciences, Inc.. IHE holds in its top three: Johnson & Johnson, Eli Lilly & Co. and Merck & Co., Inc..
Which ETF is more diversified: IBB or IHE?
IBB holds 241 securities with 56.64% of its assets in the top 15. IHE has 57 securities and a top 15 weight of 84.42%.
Advertisement
Latest news about IBB & IHE
Small-Cap Biotech ETFs: High-Risk, High-Reward Opportunities
September 18, 2025
IBB
Are Biotechnology ETFs In the Midst of a Comeback?
August 20, 2025
IBB
Analyzing the Potential ETF Winners & Losers from The Weight-Loss Drug Craze
November 20, 2023
IHE
Healthcare Stocks Rebound
August 14, 2023
IHE
Advertisement
Investing in the Aging Population: A Look at Bonds and Pharma ETFs
March 27, 2023
IBB
Investing in the Aging Population: A Look at Bonds and Pharma ETFs
March 27, 2023
IBB
Health is Wealth: A look at the Healthcare Sector
January 24, 2023
IBB
IHE
Biotech ETFs – Investing in Health Innovation
July 21, 2022
IBB
Advertisement
