IBBvsIHEETF Comparison
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iShares Biotechnology ETF (IBB) and iShares U.S. Pharmaceuticals ETF (IHE) belong to the same industry segment: US Health Care. IBB's top 3 sector exposures are Healthcare, Non-Corporate and Non-Energy Materials. In contrast, IHE's top sector exposures are Healthcare and Non-Corporate. IBB is more expensive with a Total Expense Ratio (TER) of 0.44%, versus 0.37% for IHE. IBB is up 20.29% year-to-date (YTD) with +$363M in YTD flows. IHE performs worse with 20.01% YTD performance, and +$599M in YTD flows. Run a side-by-side ETF comparison of IBB and IHE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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IBB vs IHE performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 09/11/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | IBB IHE | +1.54%-1.66% | +19.02%+6.69% | +20.29%+20.01% | +41.46%+43.32% | +60.28%+67.13% | +20.74%+75.14% |
| Flows | IBB IHE | +$288M+$22M | +$782M+$602M | +$363M+$599M | +$1.85B+$756M | -$558M+$848M | -$1.34B+$853M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | IBB IHE | +24.01%+19.74% | +21.76%+18.28% | +21.05%+17.01% | +22.47%+16.58% |
| Max drawdown | IBB IHE | -6.57%-6.47% | -9.61%-8.48% | -24.82%-16.04% | -38.96%-16.12% |
| Max drawdown duration | IBB IHE | 23d23d | 151d81d | 377d210d | 1523d669d |
Trading data
IBB | IHE | |
Last sale 9/11/2026 at 1:30 PM | $202.93 | $101.07 |
| Previous close 09/10/2026 | $202.64 | $101.27 |
| Consolidated volume 09/10/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of August 31, 2026
1-year trailing difference
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IBB | IHE | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 9/11/2026 at 1:30 PM
Live
Closed
IBB | IHE | |
|---|---|---|
| Last price | $202.93 | $101.07 |
| 1D performance | +0.14% | -0.20% |
| AuM | $10.34 B | $1.62 B |
| E/R | 0.44% | 0.37% |
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Exposure
Countries
IBB
USA
86.04%
Other
13.96%
IHE
USA
95.81%
Other
4.19%
Sectors
IBB
Healthcare
99.83%
Other
0.17%
IHE
Healthcare
99.62%
Other
0.38%
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Diversification
IBB
Total weight of top 15 holdings out of 15
54.48%
IHE
Total weight of top 15 holdings out of 15
84.32%
Top 15 holdings
Data as of July 31, 2026
IBB
Amgen, Inc.
8.42%
Vertex Pharmaceuticals, Inc.
7.87%
Gilead Sciences, Inc.
7.14%
Regeneron Pharmaceuticals, Inc.
5.84%
argenx SE
3.55%
Natera, Inc.
2.88%
Revolution Medicines, Inc.
2.87%
Illumina, Inc.
2.42%
Biogen, Inc.
2.38%
Alnylam Pharmaceuticals, Inc.
2.14%
BeOne Medicines Ltd.
2.01%
Incyte Corp.
1.91%
Insmed, Inc.
1.71%
United Therapeutics Corp.
1.69%
Moderna, Inc.
1.65%
IHE
Johnson & Johnson
21.85%
Eli Lilly & Co.
20.71%
Bristol Myers Squibb Co.
4.75%
Viatris, Inc.
4.56%
Merck & Co., Inc.
4.44%
Royalty Pharma Plc
4.41%
Pfizer Inc.
3.96%
Zoetis, Inc.
3.81%
Jazz Pharmaceuticals Plc
3.58%
Elanco Animal Health, Inc.
2.92%
Corcept Therapeutics, Inc.
2.49%
Axsome Therapeutics, Inc.
2.24%
Crinetics Pharmaceuticals, Inc.
1.95%
Liquidia Corp.
1.35%
Ligand Pharmaceuticals, Inc.
1.31%
Frequently asked questions about IBB and IHE
How have the IBB and IHE ETFs performed in 2026?
As of September 11, 2026, IBB is up 20.29% year-to-date (YTD), while IHE has returned 20.01%. That puts IBB better performer ahead so far this year.
Which ETF is attracting more investor money: IBB or IHE?
Year-to-date, the IBB ETF saw +$363M in flows, compared to +$599M for IHE.
Which ETF is more volatile: IBB or IHE?
Over the past year, IBB had a volatility of 21.76%, while IHE experienced 18.28%.
Which ETF is bigger: IBB or IHE?
As of September 11, 2026, IBB holds $10.34 B in assets under management (AUM), while IHE manages $1.62 B.
What sectors do the IBB and IHE ETFs invest in?
IBB leans toward sectors like Healthcare. Meanwhile, IHE focuses on Healthcare.
What are the top holdings of the IBB ETF and IHE ETF?
IBB top holdings include Amgen, Inc., Vertex Pharmaceuticals, Inc. and Gilead Sciences, Inc.. IHE holds in its top three: Johnson & Johnson, Eli Lilly & Co. and Bristol Myers Squibb Co..
Which ETF is more diversified: IBB or IHE?
IBB holds 241 securities with 54.48% of its assets in the top 15. IHE has 57 securities and a top 15 weight of 84.32%.
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IHE
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