FMEDvsXBIETF Comparison
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Fidelity Disruptive Medicine ETF (FMED) belongs to the Multiple Trends segment. State Street SPDR S&P Biotech ETF (XBI) is part of the US Health Care segment. FMED's top 1 sector exposures are Healthcare. In contrast, XBI's top sector exposures are Healthcare and Finance. FMED is more expensive with a Total Expense Ratio (TER) of 0.5%, versus 0.35% for XBI. FMED is up 14.76% year-to-date (YTD) with -$20M in YTD flows. XBI performs better with 21.89% YTD performance, and +$607M in YTD flows. Run a side-by-side ETF comparison of FMED and XBI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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FMED vs XBI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 11/05/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | FMED XBI | -4.35%-4.85% | +7.81%-2.96% | +14.76%+21.89% | +19.85%+36.50% | +48.91%+113.95% | n/a+13.92% |
| Flows | FMED XBI | -$3M+$354M | -$3M+$361M | -$20M+$607M | -$18M+$1.36B | -$15M-$290M | -+$1.03B |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | FMED XBI | +31.58%+33.21% | +24.11%+29.92% | +20.23%+28.56% | n/a+33.17% |
| Max drawdown | FMED XBI | -7.63%-14.89% | -17.78%-14.89% | -19.20%-32.94% | n/a-52.17% |
| Max drawdown duration | FMED XBI | 69d78d | 212d78d | 267d331d | n/a1536d |
Trading data
FMED | XBI | |
Last sale 11/6/2026 at 2:30 PM | $152.21 | |
| Previous close 11/04/2026 | $148.40 | |
| Consolidated volume 11/04/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of October 30, 2026
1-year trailing difference
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FMED
is actively managed and doesn’t replicate an indexFMED | XBI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 11/6/2026 at 2:30 PM
Live
Closed
FMED | XBI | |
|---|---|---|
| Last price | – | $152.21 |
| 1D performance | – | +2.57% |
| AuM | $47.38 M | $10.03 B |
| E/R | 0.5% | 0.35% |
Characteristics
FMED | XBI | |
|---|---|---|
| Management strategy | Active | Passive |
| Provider | Fidelity | State Street Investment Management |
| Benchmark | - | S&P Biotechnology Select Industry Index |
| N° of holdings | 71 | 159 |
| Asset class | - | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 12, 2023 | January 31, 2006 |
| ESG | No | No |
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Exposure
Countries
FMED
USA
84.97%
Other
15.03%
XBI
USA
95.32%
Other
4.68%
Sectors
FMED
Healthcare
99.49%
Other
0.51%
XBI
Healthcare
99.16%
Other
0.84%
Diversification
FMED
Total weight of top 15 holdings out of 15
47.18%
XBI
Total weight of top 15 holdings out of 15
24.01%
Top 15 holdings
Data as of September 30, 2026
FMED
10X Genomics, Inc.
5.82%
Natera, Inc.
4.47%
Thermo Fisher Scientific, Inc.
4.19%
Danaher Corp.
3.92%
Illumina, Inc.
3.56%
argenx SE
2.96%
Lifestance Health Group, Inc.
2.87%
Revolution Medicines, Inc.
2.86%
Sartorius Stedim Biotech SA
2.72%
Moderna, Inc.
2.62%
Alnylam Pharmaceuticals, Inc.
2.48%
HeartFlow, Inc.
2.39%
Intuitive Surgical, Inc.
2.20%
Cogent Biosciences, Inc.
2.13%
Caris Life Sciences, Inc.
1.99%
XBI
Twist Bioscience Corp.
2.21%
Moderna, Inc.
2.04%
Natera, Inc.
1.80%
Iovance Biotherapeutics, Inc.
1.62%
Amgen, Inc.
1.55%
Biogen, Inc.
1.54%
United Therapeutics Corp.
1.54%
AbbVie, Inc.
1.50%
Halozyme Therapeutics, Inc.
1.48%
Spyre Therapeutics, Inc.
1.47%
Gilead Sciences, Inc.
1.47%
TG Therapeutics, Inc.
1.47%
CRISPR Therapeutics AG
1.46%
Vertex Pharmaceuticals, Inc.
1.44%
Exelixis, Inc.
1.44%
Frequently asked questions about FMED and XBI
How have the FMED and XBI ETFs performed in 2026?
As of November 5, 2026, FMED is up 14.76% year-to-date (YTD), while XBI has returned 21.89%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: FMED or XBI?
Year-to-date, the FMED ETF saw -$20M in flows, compared to +$607M for XBI.
Which ETF is more volatile: FMED or XBI?
Over the past year, FMED had a volatility of 24.11%, while XBI experienced 29.92%.
Which ETF is bigger: FMED or XBI?
As of November 5, 2026, FMED holds $47.38 M in assets under management (AUM), while XBI manages $10.03 B.
What sectors do the FMED and XBI ETFs invest in?
FMED leans toward sectors like Healthcare. Meanwhile, XBI focuses on Healthcare.
What are the top holdings of the FMED ETF and XBI ETF?
FMED top holdings include 10X Genomics, Inc., Natera, Inc. and Thermo Fisher Scientific, Inc.. XBI holds in its top three: Twist Bioscience Corp., Moderna, Inc. and Natera, Inc..
Which ETF is more diversified: FMED or XBI?
FMED holds 71 securities with 47.18% of its assets in the top 15. XBI has 162 securities and a top 15 weight of 24.01%.
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