EKGvsXBIETF Comparison
ETF 1
EKG
First Trust Nasdaq Lux Digital Health Solutions ETF
This fund is part of
Healthcare Technology
+1.09%
VS
First Trust Nasdaq Lux Digital Health Solutions ETF (EKG) belongs to the Healthcare Technology segment. State Street SPDR S&P Biotech ETF (XBI) is part of the US Health Care segment. EKG's top 1 sector exposures are Healthcare. In contrast, XBI's top sector exposures are Healthcare and Finance. EKG is more expensive with a Total Expense Ratio (TER) of 0.65%, versus 0.35% for XBI. EKG is up 12.28% year-to-date (YTD) with +$963K in YTD flows. XBI performs better with 29.32% YTD performance, and +$769M in YTD flows. Run a side-by-side ETF comparison of EKG and XBI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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EKG vs XBI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 09/11/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | EKG XBI | +1.13%+0.12% | +20.86%+15.69% | +12.28%+29.32% | +21.16%+69.55% | +37.08%+102.67% | n/a+22.86% |
| Flows | EKG XBI | -+$208M | +$963K+$1.04B | +$963K+$769M | +$963K+$1.50B | +$2M-$298M | -+$1.81B |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | EKG XBI | +26.16%+29.29% | +23.42%+27.91% | +23.83%+28.30% | n/a+32.91% |
| Max drawdown | EKG XBI | -7.45%-10.46% | -22.11%-10.46% | -24.32%-32.94% | n/a-53.28% |
| Max drawdown duration | EKG XBI | 28d40d | 208d40d | 264d331d | n/a1622d |
Trading data
EKG | XBI | |
Last sale 9/14/2026 at 6:44 PM | $21.81 | $153.69 |
| Previous close 09/14/2026 | $21.35 | $157.60 |
| Consolidated volume 09/14/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of August 31, 2026
1-year trailing difference
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EKG | XBI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 9/14/2026 at 6:44 PM
Live
Closed
EKG | XBI | |
|---|---|---|
| Last price | $21.81 | $153.69 |
| 1D performance | +2.16% | -2.48% |
| AuM | $4.27 M | $10.83 B |
| E/R | 0.65% | 0.35% |
Characteristics
EKG | XBI | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | First Trust | State Street Investment Management |
| Benchmark | Nasdaq Lux Health Tech Index | S&P Biotechnology Select Industry Index |
| N° of holdings | 37 | 149 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | March 22, 2022 | January 31, 2006 |
| ESG | No | No |
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Exposure
Countries
EKG
USA
95.72%
Other
4.28%
XBI
USA
95.3%
Other
4.7%
Sectors
EKG
Healthcare
98.67%
Other
1.33%
XBI
Healthcare
99.41%
Other
0.59%
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Diversification
EKG
Total weight of top 15 holdings out of 15
74.55%
XBI
Total weight of top 15 holdings out of 15
20.29%
Top 15 holdings
Data as of July 31, 2026
EKG
IQVIA Holdings, Inc.
9.37%
Veeva Systems, Inc.
9.01%
DexCom, Inc.
8.04%
Guardant Health, Inc.
5.85%
ResMed, Inc.
5.83%
Illumina, Inc.
5.19%
Natera, Inc.
5.11%
Intuitive Surgical, Inc.
4.87%
Oscar Health, Inc.
3.90%
Tempus AI, Inc.
3.64%
QIAGEN NV
2.95%
Globus Medical, Inc.
2.94%
Align Technology, Inc.
2.74%
10X Genomics, Inc.
2.57%
Hims & Hers Health, Inc.
2.54%
XBI
Apogee Therapeutics, Inc.
1.65%
Oruka Therapeutics, Inc.
1.53%
Dianthus Therapeutics, Inc.
1.42%
Erasca, Inc.
1.38%
Twist Bioscience Corp.
1.37%
Kymera Therapeutics, Inc.
1.34%
Spyre Therapeutics, Inc.
1.33%
Revolution Medicines, Inc.
1.32%
CG Oncology, Inc.
1.32%
Protagonist Therapeutics, Inc.
1.31%
Praxis Precision Medicines, Inc.
1.30%
Regeneron Pharmaceuticals, Inc.
1.29%
Cogent Biosciences, Inc.
1.26%
Natera, Inc.
1.26%
Arrowhead Pharmaceuticals, Inc.
1.22%
Frequently asked questions about EKG and XBI
How have the EKG and XBI ETFs performed in 2026?
As of September 11, 2026, EKG is up 12.28% year-to-date (YTD), while XBI has returned 29.32%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: EKG or XBI?
Year-to-date, the EKG ETF saw +$963K in flows, compared to +$769M for XBI.
Which ETF is more volatile: EKG or XBI?
Over the past year, EKG had a volatility of 23.42%, while XBI experienced 27.91%.
Which ETF is bigger: EKG or XBI?
As of September 11, 2026, EKG holds $4.27 M in assets under management (AUM), while XBI manages $10.83 B.
What sectors do the EKG and XBI ETFs invest in?
EKG leans toward sectors like Healthcare. Meanwhile, XBI focuses on Healthcare.
What are the top holdings of the EKG ETF and XBI ETF?
EKG top holdings include IQVIA Holdings, Inc., Veeva Systems, Inc. and DexCom, Inc.. XBI holds in its top three: Apogee Therapeutics, Inc., Oruka Therapeutics, Inc. and Dianthus Therapeutics, Inc..
Which ETF is more diversified: EKG or XBI?
EKG holds 37 securities with 74.55% of its assets in the top 15. XBI has 151 securities and a top 15 weight of 20.29%.
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