BBCvsXBIETF Comparison
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Virtus LifeSci Biotech Clinical Trials ETF (BBC) belongs to the Tomorrow's Treatments segment. State Street SPDR S&P Biotech ETF (XBI) is part of the US Health Care segment. BBC's top 1 sector exposures are Healthcare. In contrast, XBI's top sector exposures are Healthcare and Finance. BBC is more expensive with a Total Expense Ratio (TER) of 0.65%, versus 0.35% for XBI. BBC is up 6.45% year-to-date (YTD) with +$5M in YTD flows. XBI performs better with 23.54% YTD performance, and +$631M in YTD flows. Run a side-by-side ETF comparison of BBC and XBI below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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BBC vs XBI performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/26/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | BBC XBI | -10.61%-3.86% | -16.99%+0.01% | +6.45%+23.54% | +31.73%+35.47% | +143.56%+128.86% | -4.51%+22.21% |
| Flows | BBC XBI | -+$311M | -+$237M | +$5M+$631M | +$12M+$1.09B | +$16M-$158M | +$8M+$1.66B |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | BBC XBI | +36.10%+30.50% | +36.84%+28.93% | +37.63%+28.42% | +39.97%+33.06% |
| Max drawdown | BBC XBI | -29.70%-14.89% | -29.70%-14.89% | -54.25%-32.94% | -70.04%-53.28% |
| Max drawdown duration | BBC XBI | 68d68d | 68d68d | 340d331d | 1625d1622d |
Trading data
BBC | XBI | |
Last sale 10/27/2026 at 1:30 PM | $42.87 | $154.84 |
| Previous close 10/26/2026 | $41.06 | $150.47 |
| Consolidated volume 10/26/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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BBC | XBI | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/27/2026 at 1:30 PM
Live
Closed
BBC | XBI | |
|---|---|---|
| Last price | $42.87 | $154.84 |
| 1D performance | +4.40% | +2.90% |
| AuM | $39.12 M | $10.20 B |
| E/R | 0.65% | 0.35% |
Characteristics
BBC | XBI | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | VIRTUS Investment Partners | State Street Investment Management |
| Benchmark | LifeSci Biotechnology Clinical Trials Index | S&P Biotechnology Select Industry Index |
| N° of holdings | 127 | 149 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | December 16, 2014 | January 31, 2006 |
| ESG | No | No |
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Exposure
Countries
BBC
USA
87.24%
Other
12.76%
XBI
USA
95.53%
Other
4.47%
Sectors
BBC
Healthcare
96.27%
Other
3.73%
XBI
Healthcare
99.18%
Other
0.82%
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Diversification
BBC
Total weight of top 15 holdings out of 15
17.14%
XBI
Total weight of top 15 holdings out of 15
21.91%
Top 15 holdings
Data as of August 31, 2026
BBC
Amylyx Pharmaceuticals, Inc.
1.50%
First Tracks Biotherapeutics, Inc.
1.48%
AbCellera Biologics, Inc.
1.38%
Xencor, Inc.
1.36%
Monopar Therapeutics, Inc.
1.12%
MBX Biosciences, Inc.
1.11%
uniQure NV
1.09%
Replimune Group, Inc.
1.06%
4D Molecular Therapeutics, Inc.
1.04%
SELLAS Life Sciences Group, Inc.
1.04%
Alto Neuroscience, Inc.
1.00%
LB Pharmaceuticals, Inc.
1.00%
Oric Pharmaceuticals, Inc.
0.99%
Zenas BioPharma, Inc.
0.98%
Cullinan Therapeutics, Inc.
0.98%
XBI
Moderna, Inc.
2.81%
Twist Bioscience Corp.
1.89%
Apogee Therapeutics, Inc.
1.50%
Kymera Therapeutics, Inc.
1.40%
Halozyme Therapeutics, Inc.
1.39%
Natera, Inc.
1.37%
Praxis Precision Medicines, Inc.
1.34%
Oruka Therapeutics, Inc.
1.33%
Revolution Medicines, Inc.
1.31%
Travere Therapeutics, Inc.
1.30%
Protagonist Therapeutics, Inc.
1.28%
Dianthus Therapeutics, Inc.
1.27%
CG Oncology, Inc.
1.26%
Vaxcyte, Inc.
1.23%
Erasca, Inc.
1.23%
Frequently asked questions about BBC and XBI
How have the BBC and XBI ETFs performed in 2026?
As of October 26, 2026, BBC is up 6.45% year-to-date (YTD), while XBI has returned 23.54%. That puts XBI better performer ahead so far this year.
Which ETF is attracting more investor money: BBC or XBI?
Year-to-date, the BBC ETF saw +$5M in flows, compared to +$631M for XBI.
Which ETF is more volatile: BBC or XBI?
Over the past year, BBC had a volatility of 36.84%, while XBI experienced 28.93%.
Which ETF is bigger: BBC or XBI?
As of October 26, 2026, BBC holds $39.12 M in assets under management (AUM), while XBI manages $10.20 B.
What sectors do the BBC and XBI ETFs invest in?
BBC leans toward sectors like Healthcare. Meanwhile, XBI focuses on Healthcare.
What are the top holdings of the BBC ETF and XBI ETF?
BBC top holdings include Amylyx Pharmaceuticals, Inc., First Tracks Biotherapeutics, Inc. and AbCellera Biologics, Inc.. XBI holds in its top three: Moderna, Inc., Twist Bioscience Corp. and Apogee Therapeutics, Inc..
Which ETF is more diversified: BBC or XBI?
BBC holds 127 securities with 17.14% of its assets in the top 15. XBI has 152 securities and a top 15 weight of 21.91%.
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