SBIOvsPSCHETF Comparison
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ALPS Medical Breakthroughs ETF (SBIO) belongs to the Tomorrow's Treatments segment. Invesco S&P SmallCap Health Care ETF (PSCH) is part of the US Health Care segment. SBIO's top 2 sector exposures are Healthcare and Non-Corporate. In contrast, PSCH's top sector exposures are Healthcare. SBIO is more expensive with a Total Expense Ratio (TER) of 0.5%, versus 0.29% for PSCH. SBIO is up 4.3% year-to-date (YTD) with +$62M in YTD flows. PSCH performs better with 22.45% YTD performance, and -$1M in YTD flows. Run a side-by-side ETF comparison of SBIO and PSCH below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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SBIO vs PSCH performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/23/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | SBIO PSCH | -11.00%+2.58% | -17.10%+1.83% | +4.30%+22.45% | +26.73%+26.77% | +130.96%+52.89% | +19.37%-9.76% |
| Flows | SBIO PSCH | -$10M-$13M | +$21M+$10M | +$62M-$1M | +$79M-$1M | +$45M-$102M | +$6M-$210M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | SBIO PSCH | +31.85%+16.86% | +32.35%+19.43% | +31.52%+21.81% | +34.22%+22.92% |
| Max drawdown | SBIO PSCH | -29.19%-8.61% | -29.19%-15.36% | -42.12%-22.80% | -52.50%-45.76% |
| Max drawdown duration | SBIO PSCH | 65d65d | 65d168d | 331d488d | 1479d1810d |
Trading data
SBIO | PSCH | |
Last sale 10/26/2026 at 3:11 PM | $53.82 | $54.20 |
| Previous close 10/23/2026 | $53.38 | $54.00 |
| Consolidated volume 10/23/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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SBIO | PSCH | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
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Main metrics
Last update 10/26/2026 at 3:11 PM
Live
Closed
SBIO | PSCH | |
|---|---|---|
| Last price | $53.82 | $54.20 |
| 1D performance | +0.82% | +0.37% |
| AuM | $183.99 M | $173.83 M |
| E/R | 0.5% | 0.29% |
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Exposure
Countries
SBIO
USA
89.31%
Other
10.69%
PSCH
USA
94.93%
Other
5.07%
Sectors
SBIO
Healthcare
100.01%
Other
-0.01%
PSCH
Healthcare
100%
Other
0%
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Diversification
SBIO
Total weight of top 15 holdings out of 15
41.55%
PSCH
Total weight of top 15 holdings out of 15
48.62%
Top 15 holdings
Data as of August 31, 2026
SBIO
Crinetics Pharmaceuticals, Inc.
4.60%
Apogee Therapeutics, Inc.
4.29%
CG Oncology, Inc.
3.41%
Travere Therapeutics, Inc.
3.16%
Xenon Pharmaceuticals, Inc.
2.99%
Dianthus Therapeutics, Inc.
2.96%
Oruka Therapeutics, Inc.
2.87%
ACADIA Pharmaceuticals, Inc.
2.54%
Edgewise Therapeutics, Inc.
2.31%
Definium Therapeutics, Inc.
2.23%
Dyne Therapeutics, Inc.
2.16%
Veradermics, Inc.
2.11%
Relay Therapeutics, Inc.
2.05%
Denali Therapeutics, Inc.
1.94%
Amylyx Pharmaceuticals, Inc.
1.93%
PSCH
Corcept Therapeutics, Inc.
5.61%
Glaukos Corp.
5.37%
Protagonist Therapeutics, Inc.
4.54%
Alkermes Plc
4.09%
TG Therapeutics, Inc.
3.69%
Teleflex, Inc.
3.06%
PTC Therapeutics, Inc.
2.99%
Ligand Pharmaceuticals, Inc.
2.87%
Merit Medical Systems, Inc.
2.68%
RadNet, Inc.
2.68%
Liquidia Corp.
2.47%
ICU Medical, Inc.
2.20%
Indivior Pharmaceuticals, Inc.
2.16%
Integer Holdings Corp.
2.14%
Concentra Group Holdings Parent, Inc.
2.07%
Frequently asked questions about SBIO and PSCH
How have the SBIO and PSCH ETFs performed in 2026?
As of October 23, 2026, SBIO is up 4.3% year-to-date (YTD), while PSCH has returned 22.45%. That puts PSCH better performer ahead so far this year.
Which ETF is attracting more investor money: SBIO or PSCH?
Year-to-date, the SBIO ETF saw +$62M in flows, compared to -$1M for PSCH.
Which ETF is more volatile: SBIO or PSCH?
Over the past year, SBIO had a volatility of 32.35%, while PSCH experienced 19.43%.
Which ETF is bigger: SBIO or PSCH?
As of October 23, 2026, SBIO holds $183.99 M in assets under management (AUM), while PSCH manages $173.83 M.
What sectors do the SBIO and PSCH ETFs invest in?
SBIO leans toward sectors like Healthcare. Meanwhile, PSCH focuses on Healthcare.
What are the top holdings of the SBIO ETF and PSCH ETF?
SBIO top holdings include Crinetics Pharmaceuticals, Inc., Apogee Therapeutics, Inc. and CG Oncology, Inc.. PSCH holds in its top three: Corcept Therapeutics, Inc., Glaukos Corp. and Protagonist Therapeutics, Inc..
Which ETF is more diversified: SBIO or PSCH?
SBIO holds 104 securities with 41.55% of its assets in the top 15. PSCH has 69 securities and a top 15 weight of 48.62%.
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Latest news about SBIO & PSCH
Small-Cap Biotech ETFs: High-Risk, High-Reward Opportunities
September 18, 2025
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Two biotech ETFs to watch for the rest of 2022 and beyond
September 13, 2022
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