SBIOvsPSCHETF Comparison
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ALPS Medical Breakthroughs ETF (SBIO) belongs to the Tomorrow's Treatments segment. Invesco S&P SmallCap Health Care ETF (PSCH) is part of the US Health Care segment. SBIO's top 3 sector exposures are Healthcare and Non-Corporate. In contrast, PSCH's top sector exposures are Healthcare SBIO is more expensive with a Total Expense Ratio (TER) of 0.5%, versus 0.29% for PSCH. SBIO is up 24.68% year-to-date (YTD) with +$41M in YTD flows. PSCH performs worse with 21.55% YTD performance, and -$10M in YTD flows. Run a side-by-side ETF comparison of SBIO and PSCH below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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SBIO vs PSCH performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/28/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | SBIO PSCH | -0.90%+2.46% | +19.27%+19.64% | +24.68%+21.55% | +92.66%+37.18% | +109.07%+21.96% | +44.84%-15.31% |
| Flows | SBIO PSCH | +$17M+$2M | +$23M+$9M | +$41M-$10M | +$51M-$12M | +$20M-$134M | -$24M-$231M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | SBIO PSCH | +35.26%+17.37% | +30.57%+20.09% | +30.92%+21.88% | +33.91%+22.90% |
| Max drawdown | SBIO PSCH | -10.73%-2.96% | -12.63%-15.36% | -42.12%-22.80% | -52.50%-46.32% |
| Max drawdown duration | SBIO PSCH | 43d21d | 60d168d | 331d488d | 1479d1790d |
Trading data
SBIO | PSCH | |
Last sale 7/29/2026 at 1:30 PM | $63.14 | $53.22 |
| Previous close 07/28/2026 | $63.52 | $53.58 |
| Consolidated volume 07/28/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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SBIO | PSCH | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
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Main metrics
Last update 7/29/2026 at 1:30 PM
Live
Closed
SBIO | PSCH | |
|---|---|---|
| Last price | $63.14 | $53.22 |
| 1D performance | -0.60% | -0.66% |
| AuM | $202.41 M | $163.98 M |
| E/R | 0.5% | 0.29% |
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Exposure
Countries
SBIO
USA
88.02%
Other
11.98%
PSCH
USA
95.33%
Other
4.67%
Sectors
SBIO
Healthcare
99.06%
Other
0.94%
PSCH
Healthcare
100%
Other
0%
Diversification
SBIO
Total weight of top 15 holdings out of 15
40.08%
PSCH
Total weight of top 15 holdings out of 15
49.48%
Top 15 holdings
Data as of June 30, 2026
SBIO
Apogee Therapeutics, Inc.
4.36%
CG Oncology, Inc.
3.33%
Xenon Pharmaceuticals, Inc.
3.09%
Oruka Therapeutics, Inc.
3.05%
Dianthus Therapeutics, Inc.
2.83%
Travere Therapeutics, Inc.
2.80%
Definium Therapeutics, Inc.
2.73%
Veradermics, Inc.
2.72%
Edgewise Therapeutics, Inc.
2.32%
ACADIA Pharmaceuticals, Inc.
2.30%
Denali Therapeutics, Inc.
2.17%
Relay Therapeutics, Inc.
2.17%
NewAmsterdam Pharma Co. NV
2.10%
Crinetics Pharmaceuticals, Inc.
2.09%
Structure Therapeutics, Inc.
2.02%
PSCH
Molina Healthcare, Inc.
5.29%
BrightSpring Health Services, Inc.
4.82%
Krystal Biotech, Inc.
4.32%
Alkermes Plc
4.06%
Glaukos Corp.
3.75%
Corcept Therapeutics, Inc.
3.69%
Protagonist Therapeutics, Inc.
3.26%
TG Therapeutics, Inc.
3.25%
PTC Therapeutics, Inc.
3.10%
Ligand Pharmaceuticals, Inc.
2.69%
Teleflex, Inc.
2.54%
Liquidia Corp.
2.43%
Indivior Pharmaceuticals, Inc.
2.25%
Veracyte, Inc.
2.13%
RadNet, Inc.
1.90%
Frequently asked questions about SBIO and PSCH
How have the SBIO and PSCH ETFs performed in 2026?
As of July 28, 2026, SBIO is up 24.68% year-to-date (YTD), while PSCH has returned 21.55%. That puts SBIO better performer ahead so far this year.
Which ETF is attracting more investor money: SBIO or PSCH?
Year-to-date, the SBIO ETF saw +$41M in flows, compared to -$10M for PSCH.
Which ETF is more volatile: SBIO or PSCH?
Over the past year, SBIO had a volatility of 30.57%, while PSCH experienced 20.09%.
Which ETF is bigger: SBIO or PSCH?
As of July 28, 2026, SBIO holds $202.41 M in assets under management (AUM), while PSCH manages $163.98 M.
What sectors do the SBIO and PSCH ETFs invest in?
SBIO leans toward sectors like Healthcare. Meanwhile, PSCH focuses on Healthcare.
What are the top holdings of the SBIO ETF and PSCH ETF?
SBIO top holdings include Apogee Therapeutics, Inc., CG Oncology, Inc. and Xenon Pharmaceuticals, Inc.. PSCH holds in its top three: Molina Healthcare, Inc., BrightSpring Health Services, Inc. and Krystal Biotech, Inc..
Which ETF is more diversified: SBIO or PSCH?
SBIO holds 104 securities with 40.08% of its assets in the top 15. PSCH has 75 securities and a top 15 weight of 49.48%.
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Latest news about SBIO & PSCH
Small-Cap Biotech ETFs: High-Risk, High-Reward Opportunities
September 18, 2025
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Two biotech ETFs to watch for the rest of 2022 and beyond
September 13, 2022
SBIO
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