SBIOvsBBCETF Comparison
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ALPS Medical Breakthroughs ETF (SBIO) and Virtus LifeSci Biotech Clinical Trials ETF (BBC) belong to the same industry segment: Tomorrow's Treatments. SBIO's top 3 sector exposures are Healthcare and Non-Corporate. In contrast, BBC's top sector exposures are Healthcare SBIO is less expensive with a Total Expense Ratio (TER) of 0.5%, versus 0.65% for BBC. SBIO is up 25.91% year-to-date (YTD) with +$41M in YTD flows. BBC performs better with 28.23% YTD performance, and +$5M in YTD flows. Run a side-by-side ETF comparison of SBIO and BBC below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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SBIO vs BBC performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/27/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | SBIO BBC | +0.08%-5.49% | +18.50%+8.79% | +25.91%+28.23% | +94.56%+126.14% | +116.75%+122.92% | +52.03%+14.49% |
| Flows | SBIO BBC | +$17M+$83K | +$23M+$5M | +$41M+$5M | +$51M+$11M | +$20M+$15M | -$24M+$6M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | SBIO BBC | +35.38%+38.48% | +30.61%+35.85% | +30.95%+37.04% | +33.95%+39.65% |
| Max drawdown | SBIO BBC | -10.73%-11.52% | -12.63%-14.64% | -42.12%-54.25% | -52.50%-70.93% |
| Max drawdown duration | SBIO BBC | 43d44d | 60d60d | 331d340d | 1479d1754d |
Trading data
SBIO | BBC | |
Last sale 7/28/2026 at 1:30 PM | $63.52 | $48.85 |
| Previous close 07/27/2026 | $64.48 | $49.74 |
| Consolidated volume 07/27/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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SBIO | BBC | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 7/28/2026 at 1:30 PM
Live
Closed
SBIO | BBC | |
|---|---|---|
| Last price | $63.52 | $48.85 |
| 1D performance | -1.49% | -1.79% |
| AuM | $204.41 M | $47.12 M |
| E/R | 0.5% | 0.65% |
Characteristics
SBIO | BBC | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | ALPS | VIRTUS Investment Partners |
| Benchmark | S-Network Medical Breakthroughs Index | LifeSci Biotechnology Clinical Trials Index |
| N° of holdings | 103 | 125 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | December 30, 2014 | December 16, 2014 |
| ESG | No | No |
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Exposure
Countries
SBIO
USA
88.02%
Other
11.98%
BBC
USA
85.4%
Other
14.6%
Sectors
SBIO
Healthcare
99.06%
Other
0.94%
BBC
Healthcare
95.19%
Other
4.81%
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Diversification
SBIO
Total weight of top 15 holdings out of 15
40.08%
BBC
Total weight of top 15 holdings out of 15
14.01%
Top 15 holdings
Data as of June 30, 2026
SBIO
Apogee Therapeutics, Inc.
4.36%
CG Oncology, Inc.
3.33%
Xenon Pharmaceuticals, Inc.
3.09%
Oruka Therapeutics, Inc.
3.05%
Dianthus Therapeutics, Inc.
2.83%
Travere Therapeutics, Inc.
2.80%
Definium Therapeutics, Inc.
2.73%
Veradermics, Inc.
2.72%
Edgewise Therapeutics, Inc.
2.32%
ACADIA Pharmaceuticals, Inc.
2.30%
Denali Therapeutics, Inc.
2.17%
Relay Therapeutics, Inc.
2.17%
NewAmsterdam Pharma Co. NV
2.10%
Crinetics Pharmaceuticals, Inc.
2.09%
Structure Therapeutics, Inc.
2.02%
BBC
uniQure NV
1.18%
REGENXBIO, Inc.
1.01%
Apogee Therapeutics, Inc.
0.99%
Monopar Therapeutics, Inc.
0.97%
Jade Biosciences, Inc.
0.94%
Aktis Oncology, Inc.
0.94%
MBX Biosciences, Inc.
0.94%
Biohaven Ltd.
0.90%
Kymera Therapeutics, Inc.
0.89%
Cullinan Therapeutics, Inc.
0.89%
SELLAS Life Sciences Group, Inc.
0.89%
Generate Biomedicines, Inc.
0.88%
Nurix Therapeutics, Inc.
0.87%
Intellia Therapeutics, Inc.
0.87%
4D Molecular Therapeutics, Inc.
0.86%
Frequently asked questions about SBIO and BBC
How have the SBIO and BBC ETFs performed in 2026?
As of July 27, 2026, SBIO is up 25.91% year-to-date (YTD), while BBC has returned 28.23%. That puts BBC better performer ahead so far this year.
Which ETF is attracting more investor money: SBIO or BBC?
Year-to-date, the SBIO ETF saw +$41M in flows, compared to +$5M for BBC.
Which ETF is more volatile: SBIO or BBC?
Over the past year, SBIO had a volatility of 30.61%, while BBC experienced 35.85%.
Which ETF is bigger: SBIO or BBC?
As of July 27, 2026, SBIO holds $204.41 M in assets under management (AUM), while BBC manages $47.12 M.
What sectors do the SBIO and BBC ETFs invest in?
SBIO leans toward sectors like Healthcare. Meanwhile, BBC focuses on Healthcare.
What are the top holdings of the SBIO ETF and BBC ETF?
SBIO top holdings include Apogee Therapeutics, Inc., CG Oncology, Inc. and Xenon Pharmaceuticals, Inc.. BBC holds in its top three: uniQure NV, REGENXBIO, Inc. and Apogee Therapeutics, Inc..
Which ETF is more diversified: SBIO or BBC?
SBIO holds 104 securities with 40.08% of its assets in the top 15. BBC has 125 securities and a top 15 weight of 14.01%.
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Latest news about SBIO & BBC
Small-Cap Biotech ETFs: High-Risk, High-Reward Opportunities
September 18, 2025
SBIO
BBC
Two biotech ETFs to watch for the rest of 2022 and beyond
September 13, 2022
SBIO
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