PTHvsSBIOETF Comparison
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Invesco DWA Healthcare Momentum ETF (PTH) belongs to the US Health Care segment. ALPS Medical Breakthroughs ETF (SBIO) is part of the Tomorrow's Treatments segment. Both ETFs have the same top 3 sector exposures: and Healthcare. PTH is more expensive with a Total Expense Ratio (TER) of 0.72%, versus 0.5% for SBIO. PTH is up 17.82% year-to-date (YTD) with +$88M in YTD flows. SBIO performs better with 24.58% YTD performance, and +$41M in YTD flows. Run a side-by-side ETF comparison of PTH and SBIO below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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PTH vs SBIO performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | PTH SBIO | +5.19%+4.86% | +12.36%+17.16% | +17.82%+24.58% | +58.30%+91.81% | +56.89%+109.04% | +7.61%+48.00% |
| Flows | PTH SBIO | +$102M+$18M | +$94M+$24M | +$88M+$41M | +$92M+$51M | +$25M+$20M | -$192M-$24M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | PTH SBIO | +29.53%+35.36% | +24.63%+30.55% | +25.60%+30.92% | +25.58%+33.95% |
| Max drawdown | PTH SBIO | -8.31%-10.73% | -11.91%-12.63% | -27.71%-42.12% | -50.10%-52.50% |
| Max drawdown duration | PTH SBIO | 41d43d | 140d60d | 353d331d | 1756d1479d |
Trading data
PTH | SBIO | |
Last sale 7/24/2026 at 1:30 PM | $58.57 | $63.77 |
| Previous close 07/23/2026 | $59.39 | $64.33 |
| Consolidated volume 07/23/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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PTH | SBIO | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 7/24/2026 at 1:30 PM
Live
Closed
PTH | SBIO | |
|---|---|---|
| Last price | $58.57 | $63.77 |
| 1D performance | -1.38% | -0.88% |
| AuM | $231.95 M | $202.25 M |
| E/R | 0.72% | 0.5% |
Characteristics
PTH | SBIO | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | Invesco | ALPS |
| Benchmark | Dorsey Wright Healthcare Technical Leaders Index | S-Network Medical Breakthroughs Index |
| N° of holdings | 57 | 103 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | October 12, 2006 | December 30, 2014 |
| ESG | No | No |
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Exposure
Countries
PTH
USA
92.25%
Other
7.75%
SBIO
USA
88.02%
Other
11.98%
Sectors
PTH
Healthcare
100%
Other
0%
SBIO
Healthcare
99.06%
Other
0.94%
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Diversification
PTH
Total weight of top 15 holdings out of 15
43.88%
SBIO
Total weight of top 15 holdings out of 15
40.08%
Top 15 holdings
Data as of June 30, 2026
PTH
Roivant Sciences Ltd.
4.95%
Praxis Precision Medicines, Inc.
4.66%
Tango Therapeutics, Inc.
3.70%
SELLAS Life Sciences Group, Inc.
3.36%
United Therapeutics Corp.
2.91%
Tenet Healthcare Corp.
2.89%
Axsome Therapeutics, Inc.
2.74%
BrightSpring Health Services, Inc.
2.54%
Liquidia Corp.
2.52%
Moderna, Inc.
2.49%
Ionis Pharmaceuticals, Inc.
2.30%
Erasca, Inc.
2.29%
HCA Healthcare, Inc.
2.23%
Twist Bioscience Corp.
2.21%
Protagonist Therapeutics, Inc.
2.08%
SBIO
Apogee Therapeutics, Inc.
4.36%
CG Oncology, Inc.
3.33%
Xenon Pharmaceuticals, Inc.
3.09%
Oruka Therapeutics, Inc.
3.05%
Dianthus Therapeutics, Inc.
2.83%
Travere Therapeutics, Inc.
2.80%
Definium Therapeutics, Inc.
2.73%
Veradermics, Inc.
2.72%
Edgewise Therapeutics, Inc.
2.32%
ACADIA Pharmaceuticals, Inc.
2.30%
Denali Therapeutics, Inc.
2.17%
Relay Therapeutics, Inc.
2.17%
NewAmsterdam Pharma Co. NV
2.10%
Crinetics Pharmaceuticals, Inc.
2.09%
Structure Therapeutics, Inc.
2.02%
Frequently asked questions about PTH and SBIO
How have the PTH and SBIO ETFs performed in 2026?
As of July 24, 2026, PTH is up 17.82% year-to-date (YTD), while SBIO has returned 24.58%. That puts SBIO better performer ahead so far this year.
Which ETF is attracting more investor money: PTH or SBIO?
Year-to-date, the PTH ETF saw +$88M in flows, compared to +$41M for SBIO.
Which ETF is more volatile: PTH or SBIO?
Over the past year, PTH had a volatility of 24.63%, while SBIO experienced 30.55%.
Which ETF is bigger: PTH or SBIO?
As of July 24, 2026, PTH holds $231.95 M in assets under management (AUM), while SBIO manages $202.25 M.
What sectors do the PTH and SBIO ETFs invest in?
PTH leans toward sectors like Healthcare. Meanwhile, SBIO focuses on Healthcare.
What are the top holdings of the PTH ETF and SBIO ETF?
PTH top holdings include Roivant Sciences Ltd., Praxis Precision Medicines, Inc. and Tango Therapeutics, Inc.. SBIO holds in its top three: Apogee Therapeutics, Inc., CG Oncology, Inc. and Xenon Pharmaceuticals, Inc..
Which ETF is more diversified: PTH or SBIO?
PTH holds 57 securities with 43.88% of its assets in the top 15. SBIO has 104 securities and a top 15 weight of 40.08%.
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Latest news about PTH & SBIO
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