PSCHvsSBIOETF Comparison
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Invesco S&P SmallCap Health Care ETF (PSCH) belongs to the US Health Care segment. ALPS Medical Breakthroughs ETF (SBIO) is part of the Tomorrow's Treatments segment. PSCH's top 1 sector exposures are Healthcare. In contrast, SBIO's top sector exposures are Healthcare and Non-Corporate. PSCH is less expensive with a Total Expense Ratio (TER) of 0.29%, versus 0.5% for SBIO. PSCH is up 21.86% year-to-date (YTD) with +$7M in YTD flows. SBIO performs better with 27.38% YTD performance, and +$75M in YTD flows. Run a side-by-side ETF comparison of PSCH and SBIO below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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PSCH vs SBIO performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 09/09/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | PSCH SBIO | -2.89%-2.83% | +13.44%+26.52% | +21.86%+27.38% | +30.10%+77.27% | +36.07%+125.72% | -13.90%+44.41% |
| Flows | PSCH SBIO | +$14M+$31M | +$25M+$51M | +$7M+$75M | +$2M+$87M | -$109M+$56M | -$207M+$17M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | PSCH SBIO | +15.73%+32.19% | +19.67%+30.89% | +21.83%+31.10% | +22.87%+33.90% |
| Max drawdown | PSCH SBIO | -4.27%-8.12% | -15.36%-12.63% | -22.80%-42.12% | -45.76%-52.50% |
| Max drawdown duration | PSCH SBIO | 21d39d | 168d60d | 488d331d | 1766d1479d |
Trading data
PSCH | SBIO | |
Last sale 9/10/2026 at 1:30 PM | $53.11 | $63.80 |
| Previous close 09/09/2026 | $53.71 | $65.20 |
| Consolidated volume 09/09/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of August 31, 2026
1-year trailing difference
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PSCH | SBIO | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 9/10/2026 at 1:30 PM
Live
Closed
PSCH | SBIO | |
|---|---|---|
| Last price | $53.11 | $63.80 |
| 1D performance | -1.12% | -2.14% |
| AuM | $181.59 M | $239.35 M |
| E/R | 0.29% | 0.5% |
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Exposure
Countries
PSCH
USA
95.04%
Other
4.96%
SBIO
USA
89.23%
Other
10.77%
Sectors
PSCH
Healthcare
100%
Other
0%
SBIO
Healthcare
100.02%
Other
-0.02%
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Diversification
PSCH
Total weight of top 15 holdings out of 15
48.1%
SBIO
Total weight of top 15 holdings out of 15
42.78%
Top 15 holdings
Data as of July 31, 2026
PSCH
Glaukos Corp.
4.96%
Corcept Therapeutics, Inc.
4.64%
Alkermes Plc
4.21%
Protagonist Therapeutics, Inc.
4.20%
TG Therapeutics, Inc.
3.68%
PTC Therapeutics, Inc.
3.23%
Liquidia Corp.
3.19%
Teleflex, Inc.
3.11%
Ligand Pharmaceuticals, Inc.
3.01%
Indivior Pharmaceuticals, Inc.
2.55%
Merit Medical Systems, Inc.
2.52%
RadNet, Inc.
2.34%
Veracyte, Inc.
2.32%
ICU Medical, Inc.
2.17%
Concentra Group Holdings Parent, Inc.
1.96%
SBIO
Crinetics Pharmaceuticals, Inc.
4.75%
Apogee Therapeutics, Inc.
4.48%
CG Oncology, Inc.
3.39%
Xenon Pharmaceuticals, Inc.
3.26%
Dianthus Therapeutics, Inc.
3.15%
Oruka Therapeutics, Inc.
3.14%
Travere Therapeutics, Inc.
2.80%
Definium Therapeutics, Inc.
2.56%
ACADIA Pharmaceuticals, Inc.
2.39%
Veradermics, Inc.
2.36%
Dyne Therapeutics, Inc.
2.25%
Edgewise Therapeutics, Inc.
2.23%
Relay Therapeutics, Inc.
2.22%
Denali Therapeutics, Inc.
1.97%
Structure Therapeutics, Inc.
1.84%
Frequently asked questions about PSCH and SBIO
How have the PSCH and SBIO ETFs performed in 2026?
As of September 9, 2026, PSCH is up 21.86% year-to-date (YTD), while SBIO has returned 27.38%. That puts SBIO better performer ahead so far this year.
Which ETF is attracting more investor money: PSCH or SBIO?
Year-to-date, the PSCH ETF saw +$7M in flows, compared to +$75M for SBIO.
Which ETF is more volatile: PSCH or SBIO?
Over the past year, PSCH had a volatility of 19.67%, while SBIO experienced 30.89%.
Which ETF is bigger: PSCH or SBIO?
As of September 9, 2026, PSCH holds $181.59 M in assets under management (AUM), while SBIO manages $239.35 M.
What sectors do the PSCH and SBIO ETFs invest in?
PSCH leans toward sectors like Healthcare. Meanwhile, SBIO focuses on Healthcare.
What are the top holdings of the PSCH ETF and SBIO ETF?
PSCH top holdings include Glaukos Corp., Corcept Therapeutics, Inc. and Alkermes Plc. SBIO holds in its top three: Crinetics Pharmaceuticals, Inc., Apogee Therapeutics, Inc. and CG Oncology, Inc..
Which ETF is more diversified: PSCH or SBIO?
PSCH holds 69 securities with 48.1% of its assets in the top 15. SBIO has 104 securities and a top 15 weight of 42.78%.
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Latest news about PSCH & SBIO
Small-Cap Biotech ETFs: High-Risk, High-Reward Opportunities
September 18, 2025
SBIO
Two biotech ETFs to watch for the rest of 2022 and beyond
September 13, 2022
SBIO
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