PSCHvsSBIOETF Comparison
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Invesco S&P SmallCap Health Care ETF (PSCH) belongs to the US Health Care segment. ALPS Medical Breakthroughs ETF (SBIO) is part of the Tomorrow's Treatments segment. Both ETFs have the same top 3 sector exposures: and Healthcare. PSCH is less expensive with a Total Expense Ratio (TER) of 0.29%, versus 0.5% for SBIO. PSCH is up 20.24% year-to-date (YTD) with -$10M in YTD flows. SBIO performs better with 24.58% YTD performance, and +$41M in YTD flows. Run a side-by-side ETF comparison of PSCH and SBIO below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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PSCH vs SBIO performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | PSCH SBIO | +5.27%+4.86% | +19.02%+17.16% | +20.24%+24.58% | +36.79%+91.81% | +19.78%+109.04% | -15.14%+48.00% |
| Flows | PSCH SBIO | +$6M+$18M | +$9M+$24M | -$10M+$41M | -$13M+$51M | -$133M+$20M | -$230M-$24M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | PSCH SBIO | +17.29%+35.36% | +20.07%+30.55% | +21.86%+30.92% | +22.90%+33.95% |
| Max drawdown | PSCH SBIO | -2.96%-10.73% | -15.36%-12.63% | -22.80%-42.12% | -46.32%-52.50% |
| Max drawdown duration | PSCH SBIO | 17d43d | 168d60d | 488d331d | 1786d1479d |
Trading data
PSCH | SBIO | |
Last sale 7/27/2026 at 5:11 PM | $53.16 | $64.68 |
| Previous close 07/24/2026 | $52.95 | $63.77 |
| Consolidated volume 07/24/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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PSCH | SBIO | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 7/27/2026 at 5:11 PM
Live
Closed
PSCH | SBIO | |
|---|---|---|
| Last price | $53.16 | $64.68 |
| 1D performance | +0.40% | +1.43% |
| AuM | $162.74 M | $202.25 M |
| E/R | 0.29% | 0.5% |
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Exposure
Countries
PSCH
USA
95.33%
Other
4.67%
SBIO
USA
88.02%
Other
11.98%
Sectors
PSCH
Healthcare
100%
Other
0%
SBIO
Healthcare
99.06%
Other
0.94%
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Diversification
PSCH
Total weight of top 15 holdings out of 15
49.48%
SBIO
Total weight of top 15 holdings out of 15
40.08%
Top 15 holdings
Data as of June 30, 2026
PSCH
Molina Healthcare, Inc.
5.29%
BrightSpring Health Services, Inc.
4.82%
Krystal Biotech, Inc.
4.32%
Alkermes Plc
4.06%
Glaukos Corp.
3.75%
Corcept Therapeutics, Inc.
3.69%
Protagonist Therapeutics, Inc.
3.26%
TG Therapeutics, Inc.
3.25%
PTC Therapeutics, Inc.
3.10%
Ligand Pharmaceuticals, Inc.
2.69%
Teleflex, Inc.
2.54%
Liquidia Corp.
2.43%
Indivior Pharmaceuticals, Inc.
2.25%
Veracyte, Inc.
2.13%
RadNet, Inc.
1.90%
SBIO
Apogee Therapeutics, Inc.
4.36%
CG Oncology, Inc.
3.33%
Xenon Pharmaceuticals, Inc.
3.09%
Oruka Therapeutics, Inc.
3.05%
Dianthus Therapeutics, Inc.
2.83%
Travere Therapeutics, Inc.
2.80%
Definium Therapeutics, Inc.
2.73%
Veradermics, Inc.
2.72%
Edgewise Therapeutics, Inc.
2.32%
ACADIA Pharmaceuticals, Inc.
2.30%
Denali Therapeutics, Inc.
2.17%
Relay Therapeutics, Inc.
2.17%
NewAmsterdam Pharma Co. NV
2.10%
Crinetics Pharmaceuticals, Inc.
2.09%
Structure Therapeutics, Inc.
2.02%
Frequently asked questions about PSCH and SBIO
How have the PSCH and SBIO ETFs performed in 2026?
As of July 24, 2026, PSCH is up 20.24% year-to-date (YTD), while SBIO has returned 24.58%. That puts SBIO better performer ahead so far this year.
Which ETF is attracting more investor money: PSCH or SBIO?
Year-to-date, the PSCH ETF saw -$10M in flows, compared to +$41M for SBIO.
Which ETF is more volatile: PSCH or SBIO?
Over the past year, PSCH had a volatility of 20.07%, while SBIO experienced 30.55%.
Which ETF is bigger: PSCH or SBIO?
As of July 24, 2026, PSCH holds $162.74 M in assets under management (AUM), while SBIO manages $202.25 M.
What sectors do the PSCH and SBIO ETFs invest in?
PSCH leans toward sectors like Healthcare. Meanwhile, SBIO focuses on Healthcare.
What are the top holdings of the PSCH ETF and SBIO ETF?
PSCH top holdings include Molina Healthcare, Inc., BrightSpring Health Services, Inc. and Krystal Biotech, Inc.. SBIO holds in its top three: Apogee Therapeutics, Inc., CG Oncology, Inc. and Xenon Pharmaceuticals, Inc..
Which ETF is more diversified: PSCH or SBIO?
PSCH holds 75 securities with 49.48% of its assets in the top 15. SBIO has 104 securities and a top 15 weight of 40.08%.
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Latest news about PSCH & SBIO
Small-Cap Biotech ETFs: High-Risk, High-Reward Opportunities
September 18, 2025
SBIO
Two biotech ETFs to watch for the rest of 2022 and beyond
September 13, 2022
SBIO
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