PBEvsIBBETF Comparison
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Invesco Dynamic Biotechnology & Genome ETF (PBE) belongs to the BioTech & Genomics segment. iShares Biotechnology ETF (IBB) is part of the US Health Care segment. PBE's top 1 sector exposures are Healthcare. In contrast, IBB's top sector exposures are Healthcare, Non-Corporate and Non-Energy Materials. PBE is more expensive with a Total Expense Ratio (TER) of 0.59%, versus 0.44% for IBB. PBE is up 25.32% year-to-date (YTD) with +$109M in YTD flows. IBB performs better with 28.25% YTD performance, and +$614M in YTD flows. Run a side-by-side ETF comparison of PBE and IBB below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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PBE vs IBB performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/28/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | PBE IBB | +4.58%+2.64% | +11.06%+13.54% | +25.32%+28.25% | +39.95%+37.47% | +96.33%+92.71% | +37.20%+36.70% |
| Flows | PBE IBB | -$5M+$296M | +$106M+$516M | +$109M+$614M | +$111M+$1.83B | +$58M-$30M | +$61M-$947M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | PBE IBB | +21.27%+26.30% | +20.03%+22.73% | +20.60%+21.41% | +22.67%+22.59% |
| Max drawdown | PBE IBB | -5.97%-7.78% | -11.70%-9.61% | -22.21%-24.82% | -32.63%-35.62% |
| Max drawdown duration | PBE IBB | 46d70d | 166d151d | 324d377d | 1468d1468d |
Trading data
PBE | IBB | |
Last sale 10/28/2026 at 1:30 PM | $101.87 | $216.35 |
| Previous close 10/28/2026 | $100.74 | $212.20 |
| Consolidated volume 10/28/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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PBE | IBB | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/28/2026 at 1:30 PM
Live
Closed
PBE | IBB | |
|---|---|---|
| Last price | $101.87 | $216.35 |
| 1D performance | +1.12% | +1.96% |
| AuM | $438.68 M | $11.27 B |
| E/R | 0.59% | 0.44% |
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Exposure
Countries
PBE
USA
97.22%
Other
2.78%
IBB
USA
86.02%
Other
13.98%
Sectors
PBE
Healthcare
100%
Other
0%
IBB
Healthcare
99.9%
Other
0.1%
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Diversification
PBE
Total weight of top 15 holdings out of 15
63.67%
IBB
Total weight of top 15 holdings out of 15
56.64%
Top 15 holdings
Data as of August 31, 2026
PBE
CareDx, Inc.
5.49%
Amgen, Inc.
5.38%
Regeneron Pharmaceuticals, Inc.
5.26%
Vertex Pharmaceuticals, Inc.
5.21%
Royalty Pharma Plc
4.76%
Biogen, Inc.
4.75%
Gilead Sciences, Inc.
4.61%
United Therapeutics Corp.
3.77%
Omeros Corp.
3.73%
Repligen Corp.
3.57%
Illumina, Inc.
3.54%
Halozyme Therapeutics, Inc.
3.51%
Bio-Techne Corp.
3.41%
Protagonist Therapeutics, Inc.
3.37%
Alnylam Pharmaceuticals, Inc.
3.31%
IBB
Amgen, Inc.
8.45%
Vertex Pharmaceuticals, Inc.
8.05%
Gilead Sciences, Inc.
7.21%
Regeneron Pharmaceuticals, Inc.
5.72%
argenx SE
3.80%
Moderna, Inc.
3.62%
Natera, Inc.
3.12%
Revolution Medicines, Inc.
2.78%
Illumina, Inc.
2.29%
Alnylam Pharmaceuticals, Inc.
2.27%
Biogen, Inc.
2.25%
BeOne Medicines Ltd.
2.03%
Insmed, Inc.
1.85%
Incyte Corp.
1.73%
United Therapeutics Corp.
1.49%
Frequently asked questions about PBE and IBB
How have the PBE and IBB ETFs performed in 2026?
As of October 28, 2026, PBE is up 25.32% year-to-date (YTD), while IBB has returned 28.25%. That puts IBB better performer ahead so far this year.
Which ETF is attracting more investor money: PBE or IBB?
Year-to-date, the PBE ETF saw +$109M in flows, compared to +$614M for IBB.
Which ETF is more volatile: PBE or IBB?
Over the past year, PBE had a volatility of 20.03%, while IBB experienced 22.73%.
Which ETF is bigger: PBE or IBB?
As of October 28, 2026, PBE holds $438.68 M in assets under management (AUM), while IBB manages $11.27 B.
What sectors do the PBE and IBB ETFs invest in?
PBE leans toward sectors like Healthcare. Meanwhile, IBB focuses on Healthcare.
What are the top holdings of the PBE ETF and IBB ETF?
PBE top holdings include CareDx, Inc., Amgen, Inc. and Regeneron Pharmaceuticals, Inc.. IBB holds in its top three: Amgen, Inc., Vertex Pharmaceuticals, Inc. and Gilead Sciences, Inc..
Which ETF is more diversified: PBE or IBB?
PBE holds 30 securities with 63.67% of its assets in the top 15. IBB has 241 securities and a top 15 weight of 56.64%.
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Latest news about PBE & IBB
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