IBBQvsIBBETF Comparison
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Invesco Nasdaq Biotechnology ETF (IBBQ) and iShares Biotechnology ETF (IBB) belong to the same industry segment: US Health Care. IBBQ's top 2 sector exposures are Healthcare and Non-Energy Materials. In contrast, IBB's top sector exposures are Healthcare, Non-Corporate and Non-Energy Materials. IBBQ is less expensive with a Total Expense Ratio (TER) of 0.19%, versus 0.44% for IBB. IBBQ is up 21.65% year-to-date (YTD) with +$19M in YTD flows. IBB performs worse with 20.29% YTD performance, and +$363M in YTD flows. Run a side-by-side ETF comparison of IBBQ and IBB below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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IBBQ vs IBB performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 09/11/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | IBBQ IBB | +1.15%+1.54% | +16.95%+19.02% | +21.65%+20.29% | +43.35%+41.46% | +72.25%+60.28% | +35.18%+20.74% |
| Flows | IBBQ IBB | +$15M+$288M | +$18M+$782M | +$19M+$363M | +$38M+$1.85B | +$54M-$558M | +$28M-$1.34B |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | IBBQ IBB | +23.63%+24.01% | +21.58%+21.76% | +20.88%+21.05% | +22.08%+22.47% |
| Max drawdown | IBBQ IBB | -6.48%-6.57% | -8.38%-9.61% | -23.78%-24.82% | -37.23%-38.96% |
| Max drawdown duration | IBBQ IBB | 23d23d | 48d151d | 375d377d | 1485d1523d |
Trading data
IBBQ | IBB | |
Last sale 9/14/2026 at 3:33 PM | $34.68 | $205.07 |
| Previous close 09/11/2026 | $34.47 | $202.93 |
| Consolidated volume 09/11/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of August 31, 2026
1-year trailing difference
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IBBQ | IBB | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 9/14/2026 at 3:33 PM
Live
Closed
IBBQ | IBB | |
|---|---|---|
| Last price | $34.68 | $205.07 |
| 1D performance | +0.60% | +1.05% |
| AuM | $95.74 M | $10.34 B |
| E/R | 0.19% | 0.44% |
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Exposure
Countries
IBBQ
USA
88.05%
Other
11.95%
IBB
USA
86.04%
Other
13.96%
Sectors
IBBQ
Healthcare
99.91%
Other
0.09%
IBB
Healthcare
99.83%
Other
0.17%
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Diversification
IBBQ
Total weight of top 15 holdings out of 15
50.47%
IBB
Total weight of top 15 holdings out of 15
54.48%
Top 15 holdings
Data as of July 31, 2026
IBBQ
Amgen, Inc.
8.55%
Vertex Pharmaceuticals, Inc.
8.03%
Gilead Sciences, Inc.
7.34%
Regeneron Pharmaceuticals, Inc.
5.08%
Revolution Medicines, Inc.
2.73%
Alnylam Pharmaceuticals, Inc.
2.71%
Biogen, Inc.
2.19%
Illumina, Inc.
2.09%
Royalty Pharma Plc
1.86%
Incyte Corp.
1.80%
argenx SE
1.73%
Roivant Sciences Ltd.
1.68%
Insmed, Inc.
1.58%
United Therapeutics Corp.
1.58%
Moderna, Inc.
1.53%
IBB
Amgen, Inc.
8.42%
Vertex Pharmaceuticals, Inc.
7.87%
Gilead Sciences, Inc.
7.14%
Regeneron Pharmaceuticals, Inc.
5.84%
argenx SE
3.55%
Natera, Inc.
2.88%
Revolution Medicines, Inc.
2.87%
Illumina, Inc.
2.42%
Biogen, Inc.
2.38%
Alnylam Pharmaceuticals, Inc.
2.14%
BeOne Medicines Ltd.
2.01%
Incyte Corp.
1.91%
Insmed, Inc.
1.71%
United Therapeutics Corp.
1.69%
Moderna, Inc.
1.65%
Frequently asked questions about IBBQ and IBB
How have the IBBQ and IBB ETFs performed in 2026?
As of September 11, 2026, IBBQ is up 21.65% year-to-date (YTD), while IBB has returned 20.29%. That puts IBBQ better performer ahead so far this year.
Which ETF is attracting more investor money: IBBQ or IBB?
Year-to-date, the IBBQ ETF saw +$19M in flows, compared to +$363M for IBB.
Which ETF is more volatile: IBBQ or IBB?
Over the past year, IBBQ had a volatility of 21.58%, while IBB experienced 21.76%.
Which ETF is bigger: IBBQ or IBB?
As of September 11, 2026, IBBQ holds $95.74 M in assets under management (AUM), while IBB manages $10.34 B.
What sectors do the IBBQ and IBB ETFs invest in?
IBBQ leans toward sectors like Healthcare. Meanwhile, IBB focuses on Healthcare.
What are the top holdings of the IBBQ ETF and IBB ETF?
IBBQ top holdings include Amgen, Inc., Vertex Pharmaceuticals, Inc. and Gilead Sciences, Inc.. IBB holds in its top three: Amgen, Inc., Vertex Pharmaceuticals, Inc. and Gilead Sciences, Inc..
Which ETF is more diversified: IBBQ or IBB?
IBBQ holds 249 securities with 50.47% of its assets in the top 15. IBB has 241 securities and a top 15 weight of 54.48%.
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