IBBvsWDNAETF Comparison
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iShares Biotechnology ETF (IBB) belongs to the US Health Care segment. WisdomTree BioRevolution Fund (WDNA) is part of the BioTech & Genomics segment. Both ETFs have the same top 3 sector exposures: and Health Care. IBB is less expensive with a Total Expense Ratio (TER) of 0.44%, versus 0.45% for WDNA. IBB is up 0.16% year-to-date (YTD) with -$327M in YTD flows. WDNA performs better with 4.07% YTD performance, and -$357K in YTD flows. Run a side-by-side ETF comparison of IBB and WDNA below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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IBB vs WDNA performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/27/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | IBB WDNA | +5.31%+5.33% | -4.45%-3.11% | +0.16%+4.07% | +35.85%+40.90% | +31.87%+9.37% | +8.56%n/a |
| Flows | IBB WDNA | -$138M- | -$331M-$357K | -$327M-$357K | +$772M-$357K | -$1.59B-$524K | -$2.08B- |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | IBB WDNA | +22.34%+23.61% | +21.20%+26.74% | +19.78%+24.79% | +22.09%n/a |
| Max drawdown | IBB WDNA | -9.27%-9.30% | -9.61%-11.90% | -24.82%-37.80% | -39.75%n/a |
| Max drawdown duration | IBB WDNA | 90d49d | 95d96d | 377d901d | 1611dn/a |
Trading data
IBB | WDNA | |
Last sale 4/29/2026 at 1:30 PM | $165.38 | $17.34 |
| Previous close 04/28/2026 | $167.81 | $17.65 |
| Consolidated volume 04/28/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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IBB | WDNA | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/29/2026 at 1:30 PM
Live
Closed
IBB | WDNA | |
|---|---|---|
| Last price | $165.38 | $17.34 |
| 1D performance | -1.45% | -1.73% |
| AuM | $8.03 B | $2.29 M |
| E/R | 0.44% | 0.45% |
Characteristics
IBB | WDNA | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | iShares | WisdomTree |
| Benchmark | ICE Biotechnology Index | WisdomTree BioRevolution Index |
| N° of holdings | 179 | 75 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | February 5, 2001 | June 3, 2021 |
| ESG | No | No |
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Exposure
Countries
IBB
USA
95.97%
Other
4.03%
WDNA
USA
80.59%
Other
19.41%
Sectors
IBB
Health Care
85.68%
Other
14.32%
WDNA
Health Care
82.52%
Other
17.48%
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Diversification
IBB
Total weight of top 15 holdings out of 15
55.88%
WDNA
Total weight of top 15 holdings out of 15
38.65%
Top 15 holdings
Data as of March 31, 2026
IBB
GILEAD SCIENCES
7.75%
AMGEN-T
7.51%
VERTEX PHARMACEUTICALS
7.44%
REGENERON PHARMACEUTICALS
7.21%
ALNYLAM PHARMACEUTICALS
3.99%
INSMED
3.20%
US04016X1019
3.07%
BIOGEN INC
2.46%
NATERA
2.41%
UTD THERAPEUT
2.30%
US07725L1026
1.93%
INCYTE
1.70%
MODERNA INC
1.68%
ILLUMINA
1.68%
REVOLUTION MEDICINES INC
1.54%
WDNA
MODERNA INC
4.49%
JOHNSON&JOHNSON
3.26%
UTD THERAPEUT
2.90%
PFIZER
2.82%
LILLY
2.65%
STOKE THERAPEUTICS INC
2.57%
NATERA
2.46%
AMGEN-T
2.43%
ASTRAZENECA
2.34%
AMICUS THERAPEUTICS
2.28%
TWIST BIOSCIENCE CORP
2.20%
BIONTECH SE ADR
2.09%
US86366E1064
2.09%
IONIS PHARMACEUTICALS INC
2.07%
GILEAD SCIENCES
2.00%
Frequently asked questions about IBB and WDNA
How have the IBB and WDNA ETFs performed in 2026?
As of April 27, 2026, IBB is up 0.16% year-to-date (YTD), while WDNA has returned 4.07%. That puts WDNA better performer ahead so far this year.
Which ETF is attracting more investor money: IBB or WDNA?
Year-to-date, the IBB ETF saw -$327M in flows, compared to -$357K for WDNA.
Which ETF is more volatile: IBB or WDNA?
Over the past year, IBB had a volatility of 21.2%, while WDNA experienced 26.74%.
Which ETF is bigger: IBB or WDNA?
As of April 27, 2026, IBB holds $8.03 B in assets under management (AUM), while WDNA manages $2.29 M.
What sectors do the IBB and WDNA ETFs invest in?
IBB leans toward sectors like Health Care. Meanwhile, WDNA focuses on Health Care.
What are the top holdings of the IBB ETF and WDNA ETF?
IBB top holdings include GILEAD SCIENCES, AMGEN-T and VERTEX PHARMACEUTICALS. WDNA holds in its top three: MODERNA INC, JOHNSON&JOHNSON and UTD THERAPEUT.
Which ETF is more diversified: IBB or WDNA?
IBB holds 249 securities with 55.88% of its assets in the top 15. WDNA has 84 securities and a top 15 weight of 38.65%.
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