IBBvsWDNAETF Comparison
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iShares Biotechnology ETF (IBB) belongs to the US Health Care segment. WisdomTree BioRevolution Fund (WDNA) is part of the BioTech & Genomics segment. IBB's top 3 sector exposures are Healthcare, Non-Corporate and Non-Energy Materials. In contrast, WDNA's top sector exposures are Healthcare, Non-Energy Materials and Consumer Non-Cyclicals. IBB is less expensive with a Total Expense Ratio (TER) of 0.44%, versus 0.45% for WDNA. IBB is up 25.74% year-to-date (YTD) with +$593M in YTD flows. WDNA performs better with 41.34% YTD performance, and +$1M in YTD flows. Run a side-by-side ETF comparison of IBB and WDNA below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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IBB vs WDNA performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/27/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | IBB WDNA | +0.63%+0.26% | +12.60%+21.85% | +25.74%+41.34% | +35.21%+43.47% | +90.01%+89.33% | +36.37%+1.89% |
| Flows | IBB WDNA | +$274M+$239K | +$504M+$2M | +$593M+$1M | +$1.82B+$1M | -$29M+$1M | -$961M+$3M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | IBB WDNA | +26.12%+38.04% | +22.65%+28.13% | +21.38%+26.75% | +22.58%+26.10% |
| Max drawdown | IBB WDNA | -7.78%-8.13% | -9.61%-11.90% | -24.82%-36.45% | -35.62%-56.39% |
| Max drawdown duration | IBB WDNA | 69d38d | 151d147d | 377d595d | 1468d1819d |
Trading data
IBB | WDNA | |
Last sale 10/27/2026 at 1:30 PM | $212.20 | $23.96 |
| Previous close 10/27/2026 | $208.69 | $23.18 |
| Consolidated volume 10/27/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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IBB | WDNA | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/27/2026 at 1:30 PM
Live
Closed
IBB | WDNA | |
|---|---|---|
| Last price | $212.20 | $23.96 |
| 1D performance | +1.68% | +3.40% |
| AuM | $11.03 B | $5.02 M |
| E/R | 0.44% | 0.45% |
Characteristics
IBB | WDNA | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | iShares | WisdomTree |
| Benchmark | NYSE Biotechnology Index | WisdomTree BioRevolution ESG Screened Index |
| N° of holdings | 241 | 79 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | February 5, 2001 | June 3, 2021 |
| ESG | No | Yes |
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Exposure
Countries
IBB
USA
86.02%
Other
13.98%
WDNA
USA
84.99%
Other
15.01%
Sectors
IBB
Healthcare
99.9%
Other
0.1%
WDNA
Healthcare
90.16%
Other
9.84%
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Diversification
IBB
Total weight of top 15 holdings out of 15
56.64%
WDNA
Total weight of top 15 holdings out of 15
44.42%
Top 15 holdings
Data as of August 31, 2026
IBB
Amgen, Inc.
8.45%
Vertex Pharmaceuticals, Inc.
8.05%
Gilead Sciences, Inc.
7.21%
Regeneron Pharmaceuticals, Inc.
5.72%
argenx SE
3.80%
Moderna, Inc.
3.62%
Natera, Inc.
3.12%
Revolution Medicines, Inc.
2.78%
Illumina, Inc.
2.29%
Alnylam Pharmaceuticals, Inc.
2.27%
Biogen, Inc.
2.25%
BeOne Medicines Ltd.
2.03%
Insmed, Inc.
1.85%
Incyte Corp.
1.73%
United Therapeutics Corp.
1.49%
WDNA
Moderna, Inc.
7.75%
Twist Bioscience Corp.
7.57%
Eli Lilly & Co.
3.53%
Johnson & Johnson
2.75%
Immunome, Inc.
2.67%
10X Genomics, Inc.
2.65%
Natera, Inc.
2.53%
Tempus AI, Inc.
2.35%
United Therapeutics Corp.
2.05%
Darling Ingredients, Inc.
1.93%
Stoke Therapeutics, Inc.
1.85%
Structure Therapeutics, Inc.
1.70%
Revolution Medicines, Inc.
1.70%
Corteva, Inc.
1.69%
CRISPR Therapeutics AG
1.68%
Frequently asked questions about IBB and WDNA
How have the IBB and WDNA ETFs performed in 2026?
As of October 27, 2026, IBB is up 25.74% year-to-date (YTD), while WDNA has returned 41.34%. That puts WDNA better performer ahead so far this year.
Which ETF is attracting more investor money: IBB or WDNA?
Year-to-date, the IBB ETF saw +$593M in flows, compared to +$1M for WDNA.
Which ETF is more volatile: IBB or WDNA?
Over the past year, IBB had a volatility of 22.65%, while WDNA experienced 28.13%.
Which ETF is bigger: IBB or WDNA?
As of October 27, 2026, IBB holds $11.03 B in assets under management (AUM), while WDNA manages $5.02 M.
What sectors do the IBB and WDNA ETFs invest in?
IBB leans toward sectors like Healthcare. Meanwhile, WDNA focuses on Healthcare.
What are the top holdings of the IBB ETF and WDNA ETF?
IBB top holdings include Amgen, Inc., Vertex Pharmaceuticals, Inc. and Gilead Sciences, Inc.. WDNA holds in its top three: Moderna, Inc., Twist Bioscience Corp. and Eli Lilly & Co..
Which ETF is more diversified: IBB or WDNA?
IBB holds 241 securities with 56.64% of its assets in the top 15. WDNA has 79 securities and a top 15 weight of 44.42%.
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