IBBvsTMEDETF Comparison
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iShares Biotechnology ETF (IBB) and T. Rowe Price Health Care ETF (TMED) belong to the same industry segment: US Health Care. IBB's top 3 sector exposures are Healthcare, Non-Corporate and Non-Energy Materials. In contrast, TMED's top sector exposures are Healthcare, Consumer Non-Cyclicals and Non-Corporate. Both IBB and TMED have the same Total Expense Ratio (TER) of 0.44%. IBB is up 25.74% year-to-date (YTD) with +$593M in YTD flows. TMED performs worse with 15.18% YTD performance, and +$15M in YTD flows. Run a side-by-side ETF comparison of IBB and TMED below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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IBB vs TMED performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/27/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | IBB TMED | +0.63%-0.12% | +12.60%-0.56% | +25.74%+15.18% | +35.21%+18.64% | +90.01%n/a | +36.37%n/a |
| Flows | IBB TMED | +$274M+$839K | +$504M+$10M | +$593M+$15M | +$1.82B+$16M | -$29M- | -$961M- |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | IBB TMED | +26.12%+19.51% | +22.65%+18.74% | +21.38%n/a | +22.58%n/a |
| Max drawdown | IBB TMED | -7.78%-10.10% | -9.61%-11.09% | -24.82%n/a | -35.62%n/a |
| Max drawdown duration | IBB TMED | 69d68d | 151d125d | 377dn/a | 1468dn/a |
Trading data
IBB | TMED | |
Last sale 10/27/2026 at 1:30 PM | $212.20 | $34.56 |
| Previous close 10/26/2026 | $208.69 | $34.19 |
| Consolidated volume 10/26/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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TMED
is actively managed and doesn’t replicate an indexIBB | TMED | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/27/2026 at 1:30 PM
Live
Closed
IBB | TMED | |
|---|---|---|
| Last price | $212.20 | $34.56 |
| 1D performance | +1.68% | +1.08% |
| AuM | $11.03 B | $34.18 M |
| E/R | 0.44% | 0.44% |
Characteristics
IBB | TMED | |
|---|---|---|
| Management strategy | Passive | Active |
| Provider | iShares | T. Rowe Price |
| Benchmark | NYSE Biotechnology Index | - |
| N° of holdings | 241 | 106 |
| Asset class | Equities | - |
| Trailing 12m distribution yield | Join | Join |
| Inception date | February 5, 2001 | June 11, 2025 |
| ESG | No | No |
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Exposure
Countries
IBB
USA
86.02%
Other
13.98%
TMED
USA
92.86%
Other
7.14%
Sectors
IBB
Healthcare
99.9%
Other
0.1%
TMED
Healthcare
98.26%
Other
1.74%
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Diversification
IBB
Total weight of top 15 holdings out of 15
56.64%
TMED
Total weight of top 15 holdings out of 15
56.93%
Top 15 holdings
Data as of August 31, 2026
IBB
Amgen, Inc.
8.45%
Vertex Pharmaceuticals, Inc.
8.05%
Gilead Sciences, Inc.
7.21%
Regeneron Pharmaceuticals, Inc.
5.72%
argenx SE
3.80%
Moderna, Inc.
3.62%
Natera, Inc.
3.12%
Revolution Medicines, Inc.
2.78%
Illumina, Inc.
2.29%
Alnylam Pharmaceuticals, Inc.
2.27%
Biogen, Inc.
2.25%
BeOne Medicines Ltd.
2.03%
Insmed, Inc.
1.85%
Incyte Corp.
1.73%
United Therapeutics Corp.
1.49%
TMED
Eli Lilly & Co.
13.87%
UnitedHealth Group, Inc.
5.32%
Alnylam Pharmaceuticals, Inc.
5.20%
Thermo Fisher Scientific, Inc.
3.74%
Cencora, Inc.
3.65%
Insulet Corp.
3.23%
Gilead Sciences, Inc.
2.99%
Agilent Technologies, Inc.
2.85%
Elanco Animal Health, Inc.
2.63%
Dyne Therapeutics, Inc.
2.47%
Boston Scientific Corp.
2.25%
Stryker Corp.
2.21%
Danaher Corp.
2.20%
Waters Corp.
2.17%
West Pharmaceutical Services, Inc.
2.16%
Frequently asked questions about IBB and TMED
How have the IBB and TMED ETFs performed in 2026?
As of October 27, 2026, IBB is up 25.74% year-to-date (YTD), while TMED has returned 15.18%. That puts IBB better performer ahead so far this year.
Which ETF is attracting more investor money: IBB or TMED?
Year-to-date, the IBB ETF saw +$593M in flows, compared to +$15M for TMED.
Which ETF is more volatile: IBB or TMED?
Over the past year, IBB had a volatility of 22.65%, while TMED experienced 18.74%.
Which ETF is bigger: IBB or TMED?
As of October 27, 2026, IBB holds $11.03 B in assets under management (AUM), while TMED manages $34.18 M.
What sectors do the IBB and TMED ETFs invest in?
IBB leans toward sectors like Healthcare. Meanwhile, TMED focuses on Healthcare.
What are the top holdings of the IBB ETF and TMED ETF?
IBB top holdings include Amgen, Inc., Vertex Pharmaceuticals, Inc. and Gilead Sciences, Inc.. TMED holds in its top three: Eli Lilly & Co., UnitedHealth Group, Inc. and Alnylam Pharmaceuticals, Inc..
Which ETF is more diversified: IBB or TMED?
IBB holds 241 securities with 56.64% of its assets in the top 15. TMED has 106 securities and a top 15 weight of 56.93%.
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