IBBvsPBEETF Comparison
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iShares Biotechnology ETF (IBB) belongs to the US Health Care segment. Invesco Dynamic Biotechnology & Genome ETF (PBE) is part of the BioTech & Genomics segment. Both ETFs have the same top 3 sector exposures: and Health Care. IBB is less expensive with a Total Expense Ratio (TER) of 0.44%, versus 0.58% for PBE. IBB is up 0.16% year-to-date (YTD) with -$327M in YTD flows. PBE performs worse with -3.02% YTD performance, and -$4M in YTD flows. Run a side-by-side ETF comparison of IBB and PBE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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IBB vs PBE performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 04/27/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | IBB PBE | +5.31%+3.54% | -4.45%-3.31% | +0.16%-3.02% | +35.85%+30.84% | +31.87%+28.68% | +8.56%+4.30% |
| Flows | IBB PBE | -$138M+$18K | -$331M-$8M | -$327M-$4M | +$772M-$32M | -$1.59B-$60M | -$2.08B-$44M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | IBB PBE | +22.34%+19.47% | +21.20%+19.83% | +19.78%+20.12% | +22.09%+22.54% |
| Max drawdown | IBB PBE | -9.27%-9.36% | -9.61%-11.70% | -24.82%-22.21% | -39.75%-34.74% |
| Max drawdown duration | IBB PBE | 90d79d | 95d111d | 377d324d | 1611d1540d |
Trading data
IBB | PBE | |
Last sale 4/29/2026 at 1:30 PM | $165.38 | $78.51 |
| Previous close 04/28/2026 | $167.81 | $79.56 |
| Consolidated volume 04/28/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of March 31, 2026
1-year trailing difference
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IBB | PBE | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 4/29/2026 at 1:30 PM
Live
Closed
IBB | PBE | |
|---|---|---|
| Last price | $165.38 | $78.51 |
| 1D performance | -1.45% | -1.32% |
| AuM | $8.03 B | $247.37 M |
| E/R | 0.44% | 0.58% |
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Exposure
Countries
IBB
USA
95.97%
Other
4.03%
PBE
USA
92.18%
Other
7.82%
Sectors
IBB
Health Care
85.68%
Other
14.32%
PBE
Health Care
97.59%
Other
2.41%
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Diversification
IBB
Total weight of top 15 holdings out of 15
55.88%
PBE
Total weight of top 15 holdings out of 15
63.66%
Top 15 holdings
Data as of March 31, 2026
IBB
GILEAD SCIENCES
7.75%
AMGEN-T
7.51%
VERTEX PHARMACEUTICALS
7.44%
REGENERON PHARMACEUTICALS
7.21%
ALNYLAM PHARMACEUTICALS
3.99%
INSMED
3.20%
US04016X1019
3.07%
BIOGEN INC
2.46%
NATERA
2.41%
UTD THERAPEUT
2.30%
US07725L1026
1.93%
INCYTE
1.70%
MODERNA INC
1.68%
ILLUMINA
1.68%
REVOLUTION MEDICINES INC
1.54%
PBE
UTD THERAPEUT
6.05%
ILLUMINA
5.24%
REGENERON PHARMACEUTICALS
5.23%
ALNYLAM PHARMACEUTICALS
5.22%
BIOGEN INC
5.16%
AMGEN-T
4.99%
GILEAD SCIENCES
4.98%
INCYTE
4.89%
BIOCRYST PHARMACEUTICALS
3.66%
PROTAGONIST THERAPEUTICS INC
3.38%
TG THERAPEUTICS
3.11%
ROYALTY PHARMA
3.05%
NEUROCRINE BIOSCIENCES
2.93%
CATALYST PHARMACEUTICALS INC
2.89%
PTC THERAPEUTI/D
2.86%
Frequently asked questions about IBB and PBE
How have the IBB and PBE ETFs performed in 2026?
As of April 27, 2026, IBB is up 0.16% year-to-date (YTD), while PBE has lost -3.02%. That puts IBB better performer ahead so far this year.
Which ETF is attracting more investor money: IBB or PBE?
Year-to-date, the IBB ETF saw -$327M in flows, compared to -$4M for PBE.
Which ETF is more volatile: IBB or PBE?
Over the past year, IBB had a volatility of 21.2%, while PBE experienced 19.83%.
Which ETF is bigger: IBB or PBE?
As of April 27, 2026, IBB holds $8.03 B in assets under management (AUM), while PBE manages $247.37 M.
What sectors do the IBB and PBE ETFs invest in?
IBB leans toward sectors like Health Care. Meanwhile, PBE focuses on Health Care.
What are the top holdings of the IBB ETF and PBE ETF?
IBB top holdings include GILEAD SCIENCES, AMGEN-T and VERTEX PHARMACEUTICALS. PBE holds in its top three: UTD THERAPEUT, ILLUMINA and REGENERON PHARMACEUTICALS.
Which ETF is more diversified: IBB or PBE?
IBB holds 249 securities with 55.88% of its assets in the top 15. PBE has 30 securities and a top 15 weight of 63.66%.
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Latest news about IBB & PBE
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Biotech ETFs – Investing in Health Innovation
July 21, 2022
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Biotech ETFs – Investing in Health Innovation
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