IBBvsPBEETF Comparison
VS
iShares Biotechnology ETF (IBB) belongs to the US Health Care segment. Invesco Dynamic Biotechnology & Genome ETF (PBE) is part of the BioTech & Genomics segment. IBB's top 3 sector exposures are Healthcare, Non-Corporate and Non-Energy Materials. In contrast, PBE's top sector exposures are Healthcare, IBB is less expensive with a Total Expense Ratio (TER) of 0.44%, versus 0.58% for PBE. IBB is up 11.67% year-to-date (YTD) with +$98M in YTD flows. PBE performs worse with 10.5% YTD performance, and +$2M in YTD flows. Run a side-by-side ETF comparison of IBB and PBE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
Find out how industry players manage ETF portfolios. Discover our library of Model portfolios
IBB vs PBE performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/27/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | IBB PBE | -0.75%-0.15% | +11.49%+13.39% | +11.67%+10.50% | +40.98%+38.91% | +48.54%+46.47% | +17.67%+23.94% |
| Flows | IBB PBE | +$247M+$5M | +$298M+$4M | +$98M+$2M | +$1.48B-$17M | -$917M-$51M | -$1.71B-$45M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | IBB PBE | +22.57%+18.74% | +20.32%+18.86% | +20.42%+20.27% | +22.33%+22.48% |
| Max drawdown | IBB PBE | -5.94%-4.30% | -9.61%-11.70% | -24.82%-22.21% | -39.75%-34.74% |
| Max drawdown duration | IBB PBE | 20d20d | 151d166d | 377d324d | 1611d1540d |
Trading data
IBB | PBE | |
Last sale 7/28/2026 at 1:30 PM | $190.52 | $91.74 |
| Previous close 07/27/2026 | $188.33 | $89.85 |
| Consolidated volume 07/27/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
Create an account to view replication metrics
Join for free
IBB | PBE | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
Advertisement
Main metrics
Last update 7/28/2026 at 1:30 PM
Live
Closed
IBB | PBE | |
|---|---|---|
| Last price | $190.52 | $91.74 |
| 1D performance | +1.16% | +2.10% |
| AuM | $9.36 B | $282.77 M |
| E/R | 0.44% | 0.58% |
Advertisement
Exposure
Countries
IBB
USA
86.15%
Other
13.85%
PBE
USA
97.25%
Other
2.75%
Sectors
IBB
Healthcare
99.89%
Other
0.11%
PBE
Healthcare
100%
Other
-0%
Diversification
IBB
Total weight of top 15 holdings out of 15
53.71%
PBE
Total weight of top 15 holdings out of 15
60.29%
Top 15 holdings
Data as of June 30, 2026
IBB
Vertex Pharmaceuticals, Inc.
8.07%
Amgen, Inc.
7.82%
Gilead Sciences, Inc.
6.83%
Regeneron Pharmaceuticals, Inc.
4.90%
argenx SE
3.75%
Alnylam Pharmaceuticals, Inc.
3.12%
Natera, Inc.
2.89%
Revolution Medicines, Inc.
2.78%
Biogen, Inc.
2.46%
Illumina, Inc.
2.07%
Moderna, Inc.
1.98%
Insmed, Inc.
1.78%
BeOne Medicines Ltd.
1.77%
Incyte Corp.
1.75%
United Therapeutics Corp.
1.73%
PBE
Vertex Pharmaceuticals, Inc.
5.12%
Biogen, Inc.
5.08%
Amgen, Inc.
4.84%
Royalty Pharma Plc
4.74%
Regeneron Pharmaceuticals, Inc.
4.53%
Alnylam Pharmaceuticals, Inc.
4.48%
Gilead Sciences, Inc.
4.34%
United Therapeutics Corp.
4.26%
Bio-Techne Corp.
3.67%
Veracyte, Inc.
3.39%
CareDx, Inc.
3.31%
Vericel Corp.
3.27%
Repligen Corp.
3.16%
PTC Therapeutics, Inc.
3.09%
Protagonist Therapeutics, Inc.
3.02%
Frequently asked questions about IBB and PBE
How have the IBB and PBE ETFs performed in 2026?
As of July 27, 2026, IBB is up 11.67% year-to-date (YTD), while PBE has returned 10.5%. That puts IBB better performer ahead so far this year.
Which ETF is attracting more investor money: IBB or PBE?
Year-to-date, the IBB ETF saw +$98M in flows, compared to +$2M for PBE.
Which ETF is more volatile: IBB or PBE?
Over the past year, IBB had a volatility of 20.32%, while PBE experienced 18.86%.
Which ETF is bigger: IBB or PBE?
As of July 27, 2026, IBB holds $9.36 B in assets under management (AUM), while PBE manages $282.77 M.
What sectors do the IBB and PBE ETFs invest in?
IBB leans toward sectors like Healthcare. Meanwhile, PBE focuses on Healthcare.
What are the top holdings of the IBB ETF and PBE ETF?
IBB top holdings include Vertex Pharmaceuticals, Inc., Amgen, Inc. and Gilead Sciences, Inc.. PBE holds in its top three: Vertex Pharmaceuticals, Inc., Biogen, Inc. and Amgen, Inc..
Which ETF is more diversified: IBB or PBE?
IBB holds 242 securities with 53.71% of its assets in the top 15. PBE has 30 securities and a top 15 weight of 60.29%.
Advertisement
Latest news about IBB & PBE
Small-Cap Biotech ETFs: High-Risk, High-Reward Opportunities
September 18, 2025
IBB
Are Biotechnology ETFs In the Midst of a Comeback?
August 20, 2025
IBB
Investing in the Aging Population: A Look at Bonds and Pharma ETFs
March 27, 2023
IBB
Health is Wealth: A look at the Healthcare Sector
January 24, 2023
IBB
Advertisement
Biotech ETFs – Investing in Health Innovation
July 21, 2022
IBB
Biotech ETFs – Investing in Health Innovation
July 21, 2022
IBB
Advertisement
