IBBvsPBEETF Comparison
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iShares Biotechnology ETF (IBB) belongs to the US Health Care segment. Invesco Dynamic Biotechnology & Genome ETF (PBE) is part of the BioTech & Genomics segment. IBB's top 3 sector exposures are Healthcare, Non-Corporate and Non-Energy Materials. In contrast, PBE's top sector exposures are Healthcare. IBB is less expensive with a Total Expense Ratio (TER) of 0.44%, versus 0.59% for PBE. IBB is up 25.74% year-to-date (YTD) with +$593M in YTD flows. PBE performs worse with 24.01% YTD performance, and +$113M in YTD flows. Run a side-by-side ETF comparison of IBB and PBE below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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IBB vs PBE performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/27/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | IBB PBE | +0.63%+3.48% | +12.60%+12.22% | +25.74%+24.01% | +35.21%+38.47% | +90.01%+95.94% | +36.37%+38.86% |
| Flows | IBB PBE | +$274M-$947K | +$504M+$111M | +$593M+$113M | +$1.82B+$115M | -$29M+$62M | -$961M+$65M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | IBB PBE | +26.12%+21.55% | +22.65%+20.01% | +21.38%+20.60% | +22.58%+22.69% |
| Max drawdown | IBB PBE | -7.78%-5.97% | -9.61%-11.70% | -24.82%-22.21% | -35.62%-32.63% |
| Max drawdown duration | IBB PBE | 69d46d | 151d166d | 377d324d | 1468d1468d |
Trading data
IBB | PBE | |
Last sale 10/27/2026 at 1:30 PM | $212.20 | $100.74 |
| Previous close 10/27/2026 | $208.69 | $99.21 |
| Consolidated volume 10/27/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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IBB | PBE | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/27/2026 at 1:30 PM
Live
Closed
IBB | PBE | |
|---|---|---|
| Last price | $212.20 | $100.74 |
| 1D performance | +1.68% | +1.54% |
| AuM | $11.03 B | $438.13 M |
| E/R | 0.44% | 0.59% |
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Exposure
Countries
IBB
USA
86.02%
Other
13.98%
PBE
USA
97.22%
Other
2.78%
Sectors
IBB
Healthcare
99.9%
Other
0.1%
PBE
Healthcare
100%
Other
0%
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Diversification
IBB
Total weight of top 15 holdings out of 15
56.64%
PBE
Total weight of top 15 holdings out of 15
63.67%
Top 15 holdings
Data as of August 31, 2026
IBB
Amgen, Inc.
8.45%
Vertex Pharmaceuticals, Inc.
8.05%
Gilead Sciences, Inc.
7.21%
Regeneron Pharmaceuticals, Inc.
5.72%
argenx SE
3.80%
Moderna, Inc.
3.62%
Natera, Inc.
3.12%
Revolution Medicines, Inc.
2.78%
Illumina, Inc.
2.29%
Alnylam Pharmaceuticals, Inc.
2.27%
Biogen, Inc.
2.25%
BeOne Medicines Ltd.
2.03%
Insmed, Inc.
1.85%
Incyte Corp.
1.73%
United Therapeutics Corp.
1.49%
PBE
CareDx, Inc.
5.49%
Amgen, Inc.
5.38%
Regeneron Pharmaceuticals, Inc.
5.26%
Vertex Pharmaceuticals, Inc.
5.21%
Royalty Pharma Plc
4.76%
Biogen, Inc.
4.75%
Gilead Sciences, Inc.
4.61%
United Therapeutics Corp.
3.77%
Omeros Corp.
3.73%
Repligen Corp.
3.57%
Illumina, Inc.
3.54%
Halozyme Therapeutics, Inc.
3.51%
Bio-Techne Corp.
3.41%
Protagonist Therapeutics, Inc.
3.37%
Alnylam Pharmaceuticals, Inc.
3.31%
Frequently asked questions about IBB and PBE
How have the IBB and PBE ETFs performed in 2026?
As of October 27, 2026, IBB is up 25.74% year-to-date (YTD), while PBE has returned 24.01%. That puts IBB better performer ahead so far this year.
Which ETF is attracting more investor money: IBB or PBE?
Year-to-date, the IBB ETF saw +$593M in flows, compared to +$113M for PBE.
Which ETF is more volatile: IBB or PBE?
Over the past year, IBB had a volatility of 22.65%, while PBE experienced 20.01%.
Which ETF is bigger: IBB or PBE?
As of October 27, 2026, IBB holds $11.03 B in assets under management (AUM), while PBE manages $438.13 M.
What sectors do the IBB and PBE ETFs invest in?
IBB leans toward sectors like Healthcare. Meanwhile, PBE focuses on Healthcare.
What are the top holdings of the IBB ETF and PBE ETF?
IBB top holdings include Amgen, Inc., Vertex Pharmaceuticals, Inc. and Gilead Sciences, Inc.. PBE holds in its top three: CareDx, Inc., Amgen, Inc. and Regeneron Pharmaceuticals, Inc..
Which ETF is more diversified: IBB or PBE?
IBB holds 241 securities with 56.64% of its assets in the top 15. PBE has 30 securities and a top 15 weight of 63.67%.
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Latest news about IBB & PBE
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