IBBvsIDNAETF Comparison
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iShares Biotechnology ETF (IBB) belongs to the US Health Care segment. iShares Genomics Immunology and Healthcare ETF (IDNA) is part of the BioTech & Genomics segment. IBB's top 3 sector exposures are Healthcare, Non-Corporate and Non-Energy Materials. In contrast, IDNA's top sector exposures are Healthcare and Non-Corporate. IBB is less expensive with a Total Expense Ratio (TER) of 0.44%, versus 0.47% for IDNA. IBB is up 25.74% year-to-date (YTD) with +$593M in YTD flows. IDNA performs better with 61.52% YTD performance, and +$107M in YTD flows. Run a side-by-side ETF comparison of IBB and IDNA below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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IBB vs IDNA performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/27/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | IBB IDNA | +0.63%+1.17% | +12.60%+30.92% | +25.74%+61.52% | +35.21%+67.04% | +90.01%+150.60% | +36.37%-9.69% |
| Flows | IBB IDNA | +$274M+$42M | +$504M+$78M | +$593M+$107M | +$1.82B+$106M | -$29M+$84M | -$961M+$64M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | IBB IDNA | +26.12%+40.23% | +22.65%+29.10% | +21.38%+25.93% | +22.58%+28.85% |
| Max drawdown | IBB IDNA | -7.78%-8.56% | -9.61%-10.60% | -24.82%-29.33% | -35.62%-65.57% |
| Max drawdown duration | IBB IDNA | 69d27d | 151d46d | 377d347d | 1468d1819d |
Trading data
IBB | IDNA | |
Last sale 10/27/2026 at 1:30 PM | $212.20 | $42.00 |
| Previous close 10/27/2026 | $208.69 | $40.95 |
| Consolidated volume 10/27/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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IBB | IDNA | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/27/2026 at 1:30 PM
Live
Closed
IBB | IDNA | |
|---|---|---|
| Last price | $212.20 | $42.00 |
| 1D performance | +1.68% | +2.56% |
| AuM | $11.03 B | $330.59 M |
| E/R | 0.44% | 0.47% |
Characteristics
IBB | IDNA | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | iShares | iShares |
| Benchmark | NYSE Biotechnology Index | NYSE FactSet Global Genomics and Immuno Biopharma Index |
| N° of holdings | 241 | 48 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | February 5, 2001 | June 11, 2019 |
| ESG | No | No |
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Exposure
Countries
IBB
USA
86.02%
Other
13.98%
IDNA
USA
63.78%
Germany
7.53%
Other
28.69%
Sectors
IBB
Healthcare
99.9%
Other
0.1%
IDNA
Healthcare
99.75%
Other
0.25%
Diversification
IBB
Total weight of top 15 holdings out of 15
56.64%
IDNA
Total weight of top 15 holdings out of 15
61.2%
Top 15 holdings
Data as of August 31, 2026
IBB
Amgen, Inc.
8.45%
Vertex Pharmaceuticals, Inc.
8.05%
Gilead Sciences, Inc.
7.21%
Regeneron Pharmaceuticals, Inc.
5.72%
argenx SE
3.80%
Moderna, Inc.
3.62%
Natera, Inc.
3.12%
Revolution Medicines, Inc.
2.78%
Illumina, Inc.
2.29%
Alnylam Pharmaceuticals, Inc.
2.27%
Biogen, Inc.
2.25%
BeOne Medicines Ltd.
2.03%
Insmed, Inc.
1.85%
Incyte Corp.
1.73%
United Therapeutics Corp.
1.49%
IDNA
Moderna, Inc.
8.85%
Twist Bioscience Corp.
6.01%
Revolution Medicines, Inc.
4.12%
Bayer AG
4.08%
Genmab A/S
4.00%
Regeneron Pharmaceuticals, Inc.
3.76%
Merck & Co., Inc.
3.66%
Vertex Pharmaceuticals, Inc.
3.65%
Incyte Corp.
3.60%
Takeda Pharmaceutical Co., Ltd.
3.51%
BioNTech SE
3.45%
Roche Holding AG
3.17%
IDEAYA Biosciences, Inc.
3.13%
Ipsen SA
3.11%
Exelixis, Inc.
3.10%
Frequently asked questions about IBB and IDNA
How have the IBB and IDNA ETFs performed in 2026?
As of October 27, 2026, IBB is up 25.74% year-to-date (YTD), while IDNA has returned 61.52%. That puts IDNA better performer ahead so far this year.
Which ETF is attracting more investor money: IBB or IDNA?
Year-to-date, the IBB ETF saw +$593M in flows, compared to +$107M for IDNA.
Which ETF is more volatile: IBB or IDNA?
Over the past year, IBB had a volatility of 22.65%, while IDNA experienced 29.1%.
Which ETF is bigger: IBB or IDNA?
As of October 27, 2026, IBB holds $11.03 B in assets under management (AUM), while IDNA manages $330.59 M.
What sectors do the IBB and IDNA ETFs invest in?
IBB leans toward sectors like Healthcare. Meanwhile, IDNA focuses on Healthcare.
What are the top holdings of the IBB ETF and IDNA ETF?
IBB top holdings include Amgen, Inc., Vertex Pharmaceuticals, Inc. and Gilead Sciences, Inc.. IDNA holds in its top three: Moderna, Inc., Twist Bioscience Corp. and Revolution Medicines, Inc..
Which ETF is more diversified: IBB or IDNA?
IBB holds 241 securities with 56.64% of its assets in the top 15. IDNA has 48 securities and a top 15 weight of 61.2%.
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