IBBvsIBBQETF Comparison
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iShares Biotechnology ETF (IBB) and Invesco Nasdaq Biotechnology ETF (IBBQ) belong to the same industry segment: US Health Care. IBB's top 3 sector exposures are Healthcare, Non-Corporate and Non-Energy Materials. In contrast, IBBQ's top sector exposures are Healthcare and Non-Energy Materials. IBB is more expensive with a Total Expense Ratio (TER) of 0.44%, versus 0.19% for IBBQ. IBB is up 23.74% year-to-date (YTD) with +$487M in YTD flows. IBBQ performs worse with 23.33% YTD performance, and +$38M in YTD flows. Run a side-by-side ETF comparison of IBB and IBBQ below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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IBB vs IBBQ performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/26/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | IBB IBBQ | -0.97%-1.52% | +10.81%+7.85% | +23.74%+23.33% | +33.06%+33.67% | +82.71%+91.50% | +32.03%+45.44% |
| Flows | IBB IBBQ | +$168M+$14M | +$398M+$35M | +$487M+$38M | +$1.71B+$55M | -$135M+$74M | -$1.04B+$52M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | IBB IBBQ | +26.18%+25.69% | +22.65%+22.47% | +21.41%+21.24% | +22.59%+22.22% |
| Max drawdown | IBB IBBQ | -7.78%-8.58% | -9.61%-8.58% | -24.82%-23.78% | -35.62%-34.86% |
| Max drawdown duration | IBB IBBQ | 68d68d | 151d68d | 377d375d | 1468d1429d |
Trading data
IBB | IBBQ | |
Last sale 10/27/2026 at 1:30 PM | $212.20 | $35.38 |
| Previous close 10/26/2026 | $208.69 | $34.68 |
| Consolidated volume 10/26/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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IBB | IBBQ | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/27/2026 at 1:30 PM
Live
Closed
IBB | IBBQ | |
|---|---|---|
| Last price | $212.20 | $35.38 |
| 1D performance | +1.68% | +2.01% |
| AuM | $10.75 B | $115.51 M |
| E/R | 0.44% | 0.19% |
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Exposure
Countries
IBB
USA
86.02%
Other
13.98%
IBBQ
USA
88.22%
Other
11.78%
Sectors
IBB
Healthcare
99.9%
Other
0.1%
IBBQ
Healthcare
99.99%
Other
0.01%
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Diversification
IBB
Total weight of top 15 holdings out of 15
56.64%
IBBQ
Total weight of top 15 holdings out of 15
52.06%
Top 15 holdings
Data as of August 31, 2026
IBB
Amgen, Inc.
8.45%
Vertex Pharmaceuticals, Inc.
8.05%
Gilead Sciences, Inc.
7.21%
Regeneron Pharmaceuticals, Inc.
5.72%
argenx SE
3.80%
Moderna, Inc.
3.62%
Natera, Inc.
3.12%
Revolution Medicines, Inc.
2.78%
Illumina, Inc.
2.29%
Alnylam Pharmaceuticals, Inc.
2.27%
Biogen, Inc.
2.25%
BeOne Medicines Ltd.
2.03%
Insmed, Inc.
1.85%
Incyte Corp.
1.73%
United Therapeutics Corp.
1.49%
IBBQ
Amgen, Inc.
8.60%
Vertex Pharmaceuticals, Inc.
8.10%
Gilead Sciences, Inc.
7.34%
Regeneron Pharmaceuticals, Inc.
5.26%
Moderna, Inc.
3.58%
Revolution Medicines, Inc.
2.97%
Illumina, Inc.
2.18%
Biogen, Inc.
2.07%
Alnylam Pharmaceuticals, Inc.
2.00%
argenx SE
1.84%
Royalty Pharma Plc
1.73%
Roivant Sciences Ltd.
1.71%
Insmed, Inc.
1.66%
Incyte Corp.
1.61%
United Therapeutics Corp.
1.42%
Frequently asked questions about IBB and IBBQ
How have the IBB and IBBQ ETFs performed in 2026?
As of October 26, 2026, IBB is up 23.74% year-to-date (YTD), while IBBQ has returned 23.33%. That puts IBB better performer ahead so far this year.
Which ETF is attracting more investor money: IBB or IBBQ?
Year-to-date, the IBB ETF saw +$487M in flows, compared to +$38M for IBBQ.
Which ETF is more volatile: IBB or IBBQ?
Over the past year, IBB had a volatility of 22.65%, while IBBQ experienced 22.47%.
Which ETF is bigger: IBB or IBBQ?
As of October 26, 2026, IBB holds $10.75 B in assets under management (AUM), while IBBQ manages $115.51 M.
What sectors do the IBB and IBBQ ETFs invest in?
IBB leans toward sectors like Healthcare. Meanwhile, IBBQ focuses on Healthcare.
What are the top holdings of the IBB ETF and IBBQ ETF?
IBB top holdings include Amgen, Inc., Vertex Pharmaceuticals, Inc. and Gilead Sciences, Inc.. IBBQ holds in its top three: Amgen, Inc., Vertex Pharmaceuticals, Inc. and Gilead Sciences, Inc..
Which ETF is more diversified: IBB or IBBQ?
IBB holds 241 securities with 56.64% of its assets in the top 15. IBBQ has 249 securities and a top 15 weight of 52.06%.
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Latest news about IBB & IBBQ
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