IBBvsFBTETF Comparison
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iShares Biotechnology ETF (IBB) and First Trust NYSE Arca Biotechnology Index Fund ETF (FBT) belong to the same industry segment: US Health Care. IBB's top 3 sector exposures are Healthcare, Non-Corporate and Non-Energy Materials. In contrast, FBT's top sector exposures are Healthcare. IBB is less expensive with a Total Expense Ratio (TER) of 0.44%, versus 0.54% for FBT. IBB is up 25.74% year-to-date (YTD) with +$593M in YTD flows. FBT performs better with 31.8% YTD performance, and +$1.00B in YTD flows. Run a side-by-side ETF comparison of IBB and FBT below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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IBB vs FBT performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/27/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | IBB FBT | +0.63%-0.75% | +12.60%+9.93% | +25.74%+31.80% | +35.21%+42.46% | +90.01%+100.87% | +36.37%+65.30% |
| Flows | IBB FBT | +$274M+$40M | +$504M-$22M | +$593M+$1.00B | +$1.82B+$1.09B | -$29M+$709M | -$961M+$348M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | IBB FBT | +26.12%+22.81% | +22.65%+22.20% | +21.38%+21.23% | +22.58%+22.28% |
| Max drawdown | IBB FBT | -7.78%-5.30% | -9.61%-14.27% | -24.82%-19.92% | -35.62%-27.40% |
| Max drawdown duration | IBB FBT | 69d60d | 151d126d | 377d237d | 1468d1017d |
Trading data
IBB | FBT | |
Last sale 10/27/2026 at 1:30 PM | $212.20 | $273.73 |
| Previous close 10/26/2026 | $208.69 | $271.47 |
| Consolidated volume 10/26/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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IBB | FBT | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/27/2026 at 1:30 PM
Live
Closed
IBB | FBT | |
|---|---|---|
| Last price | $212.20 | $273.73 |
| 1D performance | +1.68% | +0.83% |
| AuM | $11.03 B | $3.00 B |
| E/R | 0.44% | 0.54% |
Characteristics
IBB | FBT | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | iShares | First Trust |
| Benchmark | NYSE Biotechnology Index | NYSE Arca Biotechnology Index |
| N° of holdings | 241 | 30 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | February 5, 2001 | June 19, 2006 |
| ESG | No | No |
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Exposure
Countries
IBB
USA
86.02%
Other
13.98%
FBT
USA
82.68%
Other
17.32%
Sectors
IBB
Healthcare
99.9%
Other
0.1%
FBT
Healthcare
99.86%
Other
0.14%
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Diversification
IBB
Total weight of top 15 holdings out of 15
56.64%
FBT
Total weight of top 15 holdings out of 15
55.27%
Top 15 holdings
Data as of August 31, 2026
IBB
Amgen, Inc.
8.45%
Vertex Pharmaceuticals, Inc.
8.05%
Gilead Sciences, Inc.
7.21%
Regeneron Pharmaceuticals, Inc.
5.72%
argenx SE
3.80%
Moderna, Inc.
3.62%
Natera, Inc.
3.12%
Revolution Medicines, Inc.
2.78%
Illumina, Inc.
2.29%
Alnylam Pharmaceuticals, Inc.
2.27%
Biogen, Inc.
2.25%
BeOne Medicines Ltd.
2.03%
Insmed, Inc.
1.85%
Incyte Corp.
1.73%
United Therapeutics Corp.
1.49%
FBT
Halozyme Therapeutics, Inc.
4.38%
Regeneron Pharmaceuticals, Inc.
3.84%
NeoGenomics, Inc.
3.83%
Corcept Therapeutics, Inc.
3.82%
Amgen, Inc.
3.74%
BeOne Medicines Ltd.
3.72%
Natera, Inc.
3.68%
Repligen Corp.
3.65%
argenx SE
3.63%
Gilead Sciences, Inc.
3.58%
Genmab A/S
3.56%
Vertex Pharmaceuticals, Inc.
3.50%
Sarepta Therapeutics, Inc.
3.49%
BioNTech SE
3.45%
BioMarin Pharmaceutical, Inc.
3.40%
Frequently asked questions about IBB and FBT
How have the IBB and FBT ETFs performed in 2026?
As of October 27, 2026, IBB is up 25.74% year-to-date (YTD), while FBT has returned 31.8%. That puts FBT better performer ahead so far this year.
Which ETF is attracting more investor money: IBB or FBT?
Year-to-date, the IBB ETF saw +$593M in flows, compared to +$1.00B for FBT.
Which ETF is more volatile: IBB or FBT?
Over the past year, IBB had a volatility of 22.65%, while FBT experienced 22.2%.
Which ETF is bigger: IBB or FBT?
As of October 27, 2026, IBB holds $11.03 B in assets under management (AUM), while FBT manages $3.00 B.
What sectors do the IBB and FBT ETFs invest in?
IBB leans toward sectors like Healthcare. Meanwhile, FBT focuses on Healthcare.
What are the top holdings of the IBB ETF and FBT ETF?
IBB top holdings include Amgen, Inc., Vertex Pharmaceuticals, Inc. and Gilead Sciences, Inc.. FBT holds in its top three: Halozyme Therapeutics, Inc., Regeneron Pharmaceuticals, Inc. and NeoGenomics, Inc..
Which ETF is more diversified: IBB or FBT?
IBB holds 241 securities with 56.64% of its assets in the top 15. FBT has 30 securities and a top 15 weight of 55.27%.
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