IBBvsFBTETF Comparison
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iShares Biotechnology ETF (IBB) and First Trust NYSE Arca Biotechnology Index Fund ETF (FBT) belong to the same industry segment: US Health Care. IBB's top 3 sector exposures are Healthcare, Non-Corporate and Non-Energy Materials. In contrast, FBT's top sector exposures are Healthcare, IBB is less expensive with a Total Expense Ratio (TER) of 0.44%, versus 0.54% for FBT. IBB is up 11.67% year-to-date (YTD) with +$98M in YTD flows. FBT performs better with 20.24% YTD performance, and +$1.03B in YTD flows. Run a side-by-side ETF comparison of IBB and FBT below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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IBB vs FBT performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/27/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | IBB FBT | -0.75%+4.30% | +11.49%+21.28% | +11.67%+20.24% | +40.98%+49.10% | +48.54%+60.11% | +17.67%+49.90% |
| Flows | IBB FBT | +$247M-$98M | +$298M-$45M | +$98M+$1.03B | +$1.48B+$1.08B | -$917M+$634M | -$1.71B+$293M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | IBB FBT | +22.57%+21.65% | +20.32%+21.18% | +20.42%+20.61% | +22.33%+22.14% |
| Max drawdown | IBB FBT | -5.94%-4.37% | -9.61%-14.27% | -24.82%-19.92% | -39.75%-29.91% |
| Max drawdown duration | IBB FBT | 20d17d | 151d126d | 377d237d | 1611d1159d |
Trading data
IBB | FBT | |
Last sale 7/27/2026 at 1:30 PM | $188.33 | $246.74 |
| Previous close 07/27/2026 | $188.14 | $247.39 |
| Consolidated volume 07/27/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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IBB | FBT | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 7/27/2026 at 1:30 PM
Live
Closed
IBB | FBT | |
|---|---|---|
| Last price | $188.33 | $246.74 |
| 1D performance | +0.10% | -0.26% |
| AuM | $9.36 B | $2.76 B |
| E/R | 0.44% | 0.54% |
Characteristics
IBB | FBT | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | iShares | First Trust |
| Benchmark | ICE Biotechnology Index | NYSE Arca Biotechnology Index |
| N° of holdings | 242 | 30 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | February 5, 2001 | June 19, 2006 |
| ESG | No | No |
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Exposure
Countries
IBB
USA
86.15%
Other
13.85%
FBT
USA
84.94%
Other
15.06%
Sectors
IBB
Healthcare
99.89%
Other
0.11%
FBT
Healthcare
99.93%
Other
0.07%
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Diversification
IBB
Total weight of top 15 holdings out of 15
53.71%
FBT
Total weight of top 15 holdings out of 15
59.85%
Top 15 holdings
Data as of June 30, 2026
IBB
Vertex Pharmaceuticals, Inc.
8.07%
Amgen, Inc.
7.82%
Gilead Sciences, Inc.
6.83%
Regeneron Pharmaceuticals, Inc.
4.90%
argenx SE
3.75%
Alnylam Pharmaceuticals, Inc.
3.12%
Natera, Inc.
2.89%
Revolution Medicines, Inc.
2.78%
Biogen, Inc.
2.46%
Illumina, Inc.
2.07%
Moderna, Inc.
1.98%
Insmed, Inc.
1.78%
BeOne Medicines Ltd.
1.77%
Incyte Corp.
1.75%
United Therapeutics Corp.
1.73%
FBT
Corcept Therapeutics, Inc.
5.66%
NeoGenomics, Inc.
5.22%
Veracyte, Inc.
5.16%
Bruker Corp.
4.33%
Alkermes Plc
4.16%
Illumina, Inc.
4.08%
Krystal Biotech, Inc.
3.85%
Natera, Inc.
3.84%
Axsome Therapeutics, Inc.
3.62%
Neurocrine Biosciences, Inc.
3.49%
Bio-Techne Corp.
3.43%
Arrowhead Pharmaceuticals, Inc.
3.31%
Exelixis, Inc.
3.27%
Biogen, Inc.
3.25%
Incyte Corp.
3.18%
Frequently asked questions about IBB and FBT
How have the IBB and FBT ETFs performed in 2026?
As of July 27, 2026, IBB is up 11.67% year-to-date (YTD), while FBT has returned 20.24%. That puts FBT better performer ahead so far this year.
Which ETF is attracting more investor money: IBB or FBT?
Year-to-date, the IBB ETF saw +$98M in flows, compared to +$1.03B for FBT.
Which ETF is more volatile: IBB or FBT?
Over the past year, IBB had a volatility of 20.32%, while FBT experienced 21.18%.
Which ETF is bigger: IBB or FBT?
As of July 27, 2026, IBB holds $9.36 B in assets under management (AUM), while FBT manages $2.76 B.
What sectors do the IBB and FBT ETFs invest in?
IBB leans toward sectors like Healthcare. Meanwhile, FBT focuses on Healthcare.
What are the top holdings of the IBB ETF and FBT ETF?
IBB top holdings include Vertex Pharmaceuticals, Inc., Amgen, Inc. and Gilead Sciences, Inc.. FBT holds in its top three: Corcept Therapeutics, Inc., NeoGenomics, Inc. and Veracyte, Inc..
Which ETF is more diversified: IBB or FBT?
IBB holds 242 securities with 53.71% of its assets in the top 15. FBT has 30 securities and a top 15 weight of 59.85%.
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