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FMEDvsIBBETF Comparison

ETF 1

FMED

Fidelity Disruptive Medicine ETF

This fund is part of

Multiple Trends

+2.93%

Full FMED fund page

VS

ETF 2

IBB

iShares Biotechnology ETF

This fund is part of

US Health Care

+0.68%

Full IBB fund page

Fidelity Disruptive Medicine ETF (FMED) belongs to the Multiple Trends segment. iShares Biotechnology ETF (IBB) is part of the US Health Care segment. FMED's top 1 sector exposures are Healthcare. In contrast, IBB's top sector exposures are Healthcare, Non-Corporate and Non-Energy Materials. FMED is more expensive with a Total Expense Ratio (TER) of 0.5%, versus 0.44% for IBB. FMED is up 17.43% year-to-date (YTD) with -$17M in YTD flows. IBB performs better with 22.87% YTD performance, and +$351M in YTD flows. Run a side-by-side ETF comparison of FMED and IBB below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.

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FMED vs IBB performance and flow charts

Performance

Cumulative Flows

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Daily, global ETF data for advanced analysis or integration into apps (API), from our partner Trackinsight.

Data Services

Historic performance and flows

Data as of 09/21/2026

		1M	3M	YTD	1Y	3Y	5Y
Perf.	FMED IBB	-2.40%-3.00%	+21.48%+17.09%	+17.43%+22.87%	+29.04%+44.80%	+43.82%+69.81%	n/a+22.47%
Flows	FMED IBB	-+$123M	-+$815M	-$17M+$351M	-$14M+$1.86B	-$3M-$521M	--$1.33B

Volatility and drawdown

		3M	1Y	3Y	5Y
Volatility	FMED IBB	+24.66%+24.47%	+21.06%+21.84%	+19.25%+21.12%	n/a+22.48%
Max drawdown	FMED IBB	-7.15%-6.84%	-17.78%-9.61%	-19.20%-24.82%	n/a-38.96%
Max drawdown duration	FMED IBB	29d33d	212d151d	267d377d	n/a1523d

Trading data

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	FMED	IBB
Last sale 9/22/2026 at 1:30 PM		$210.82
Previous close 09/21/2026		$207.16
Consolidated volume 09/21/2026
Average volume 30 days
Average discount or premium 30 days
Average Bid/Ask spread 30 days

Replication quality

Data as of August 31, 2026

1-year trailing difference

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FMED

is actively managed and doesn’t replicate an index

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	FMED	IBB
Tracking error
Tracking difference
1 year cumulative return difference
Best
Worst
Daily return difference
Average
Worst

Main metrics

Last update 9/22/2026 at 1:30 PM

Live

Closed

	FMED	IBB
Last price	–	$210.82
1D performance	–	+1.76%
AuM	$51.66 M	$10.55 B
E/R	0.5%	0.44%

Characteristics

	FMED	IBB
Management strategy	Active	Passive
Provider	Fidelity	iShares
Benchmark	-	ICE Biotechnology Index
N° of holdings	74	240
Asset class	-	Equities
Trailing 12m distribution yield	Join	Join
Inception date	June 12, 2023	February 5, 2001
ESG	No	No

More FMED data on Trackinsight

More IBB data on Trackinsight

Exposure

Countries

FMED

USA

83.4%

Other

16.6%

IBB

USA

86.04%

Other

13.96%

Sectors

FMED

Healthcare

100%

Other

0%

IBB

Healthcare

99.83%

Other

0.17%

Diversification

FMED

Total weight of top 15 holdings out of 15

43.09%

IBB

Total weight of top 15 holdings out of 15

54.48%

Top 15 holdings

Data as of July 31, 2026

FMED

10X Genomics, Inc.

4.48%

Thermo Fisher Scientific, Inc.

3.98%

Danaher Corp.

3.86%

Lifestance Health Group, Inc.

3.15%

Alnylam Pharmaceuticals, Inc.

3.10%

argenx SE

2.99%

Cogent Biosciences, Inc.

2.98%

Revolution Medicines, Inc.

2.85%

Illumina, Inc.

2.62%

Intuitive Surgical, Inc.

2.34%

Kymera Therapeutics, Inc.

2.29%

UnitedHealth Group, Inc.

2.24%

Ascendis Pharma A/S

2.12%

Kiniksa Pharmaceuticals International Plc

2.06%

UCB SA

2.03%

IBB

Amgen, Inc.

8.42%

Vertex Pharmaceuticals, Inc.

7.87%

Gilead Sciences, Inc.

7.14%

Regeneron Pharmaceuticals, Inc.

5.84%

argenx SE

3.55%

Natera, Inc.

2.88%

Revolution Medicines, Inc.

2.87%

Illumina, Inc.

2.42%

Biogen, Inc.

2.38%

Alnylam Pharmaceuticals, Inc.

2.14%

BeOne Medicines Ltd.

2.01%

Incyte Corp.

1.91%

Insmed, Inc.

1.71%

United Therapeutics Corp.

1.69%

Moderna, Inc.

1.65%

Frequently asked questions about FMED and IBB

How have the FMED and IBB ETFs performed in 2026?

As of September 21, 2026, FMED is up 17.43% year-to-date (YTD), while IBB has returned 22.87%. That puts IBB better performer ahead so far this year.

Which ETF is attracting more investor money: FMED or IBB?

Year-to-date, the FMED ETF saw -$17M in flows, compared to +$351M for IBB.

Which ETF is more volatile: FMED or IBB?

Over the past year, FMED had a volatility of 21.06%, while IBB experienced 21.84%.

Which ETF is bigger: FMED or IBB?

As of September 21, 2026, FMED holds $51.66 M in assets under management (AUM), while IBB manages $10.55 B.

What sectors do the FMED and IBB ETFs invest in?

FMED leans toward sectors like Healthcare. Meanwhile, IBB focuses on Healthcare.

What are the top holdings of the FMED ETF and IBB ETF?

FMED top holdings include 10X Genomics, Inc., Thermo Fisher Scientific, Inc. and Danaher Corp.. IBB holds in its top three: Amgen, Inc., Vertex Pharmaceuticals, Inc. and Gilead Sciences, Inc..

FMEDvsIBBETF Comparison

Fidelity Disruptive Medicine ETF

iShares Biotechnology ETF

FMED vs IBB performance and flow charts

Performance

Cumulative Flows

Get all the metrics on this page, and more, through a reliable ETF data feed

Countries

Sectors

Diversification

Top 15 holdings

How have the FMED and IBB ETFs performed in 2026?

As of September 21, 2026, FMED is up 17.43% year-to-date (YTD), while IBB has returned 22.87%. That puts IBB better performer ahead so far this year.

Which ETF is attracting more investor money: FMED or IBB?

Year-to-date, the FMED ETF saw -$17M in flows, compared to +$351M for IBB.

Which ETF is more volatile: FMED or IBB?

Over the past year, FMED had a volatility of 21.06%, while IBB experienced 21.84%.

Which ETF is bigger: FMED or IBB?

As of September 21, 2026, FMED holds $51.66 M in assets under management (AUM), while IBB manages $10.55 B.

What sectors do the FMED and IBB ETFs invest in?

FMED leans toward sectors like Healthcare. Meanwhile, IBB focuses on Healthcare.

What are the top holdings of the FMED ETF and IBB ETF?

FMED top holdings include 10X Genomics, Inc., Thermo Fisher Scientific, Inc. and Danaher Corp.. IBB holds in its top three: Amgen, Inc., Vertex Pharmaceuticals, Inc. and Gilead Sciences, Inc..

Which ETF is more diversified: FMED or IBB?

FMED holds 74 securities with 43.09% of its assets in the top 15. IBB has 241 securities and a top 15 weight of 54.48%.

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