CANCvsIBBETF Comparison
VS
Tema Oncology ETF (CANC) belongs to the Tomorrow's Treatments segment. iShares Biotechnology ETF (IBB) is part of the US Health Care segment. Both ETFs have the same top 3 sector exposures: and Healthcare. CANC is more expensive with a Total Expense Ratio (TER) of 0.99%, versus 0.44% for IBB. CANC is up 18.64% year-to-date (YTD) with +$52M in YTD flows. IBB performs worse with 12.96% YTD performance, and +$31M in YTD flows. Run a side-by-side ETF comparison of CANC and IBB below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
Find out how industry players manage ETF portfolios. Discover our library of Model portfolios
CANC vs IBB performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/28/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | CANC IBB | -0.08%+0.40% | +10.24%+13.51% | +18.64%+12.96% | +54.08%+42.60% | n/a+47.89% | n/a+15.61% |
| Flows | CANC IBB | -$2M+$181M | +$3M+$358M | +$52M+$31M | +$76M+$1.41B | --$932M | --$1.74B |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | CANC IBB | +22.82%+22.59% | +22.66%+20.31% | n/a+20.41% | n/a+22.30% |
| Max drawdown | CANC IBB | -5.93%-5.94% | -9.20%-9.61% | n/a-24.82% | n/a-39.75% |
| Max drawdown duration | CANC IBB | 47d21d | 67d151d | n/a377d | n/a1611d |
Trading data
CANC | IBB | |
Last sale 7/29/2026 at 1:30 PM | $40.61 | $188.53 |
| Previous close 07/28/2026 | $41.18 | $190.52 |
| Consolidated volume 07/28/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
Create an account to view replication metrics
Join for free
CANC
is actively managed and doesn’t replicate an indexCANC | IBB | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
Advertisement
Main metrics
Last update 7/29/2026 at 1:30 PM
Live
Closed
CANC | IBB | |
|---|---|---|
| Last price | $40.61 | $188.53 |
| 1D performance | -1.39% | -1.04% |
| AuM | $196.01 M | $9.40 B |
| E/R | 0.99% | 0.44% |
Advertisement
Exposure
Countries
CANC
USA
80.59%
Switzerland
9.85%
Other
9.56%
IBB
USA
86.15%
Other
13.85%
Sectors
CANC
Healthcare
99.28%
Other
0.72%
IBB
Healthcare
99.89%
Other
0.11%
Advertisement
Diversification
CANC
Total weight of top 15 holdings out of 15
55.76%
IBB
Total weight of top 15 holdings out of 15
53.71%
Top 15 holdings
Data as of June 30, 2026
CANC
Revolution Medicines, Inc.
6.32%
Eli Lilly & Co.
5.24%
Cogent Biosciences, Inc.
4.94%
Novartis AG
4.19%
Roche Holding AG
3.93%
Legend Biotech Corp.
3.70%
Merck & Co., Inc.
3.66%
Bristol Myers Squibb Co.
3.33%
AstraZeneca PLC
3.15%
Johnson & Johnson
3.09%
AbbVie, Inc.
3.08%
Immunome, Inc.
2.87%
Exelixis, Inc.
2.85%
Nuvalent, Inc.
2.73%
IDEAYA Biosciences, Inc.
2.68%
IBB
Vertex Pharmaceuticals, Inc.
8.07%
Amgen, Inc.
7.82%
Gilead Sciences, Inc.
6.83%
Regeneron Pharmaceuticals, Inc.
4.90%
argenx SE
3.75%
Alnylam Pharmaceuticals, Inc.
3.12%
Natera, Inc.
2.89%
Revolution Medicines, Inc.
2.78%
Biogen, Inc.
2.46%
Illumina, Inc.
2.07%
Moderna, Inc.
1.98%
Insmed, Inc.
1.78%
BeOne Medicines Ltd.
1.77%
Incyte Corp.
1.75%
United Therapeutics Corp.
1.73%
Frequently asked questions about CANC and IBB
How have the CANC and IBB ETFs performed in 2026?
As of July 28, 2026, CANC is up 18.64% year-to-date (YTD), while IBB has returned 12.96%. That puts CANC better performer ahead so far this year.
Which ETF is attracting more investor money: CANC or IBB?
Year-to-date, the CANC ETF saw +$52M in flows, compared to +$31M for IBB.
Which ETF is more volatile: CANC or IBB?
Over the past year, CANC had a volatility of 22.66%, while IBB experienced 20.31%.
Which ETF is bigger: CANC or IBB?
As of July 28, 2026, CANC holds $196.01 M in assets under management (AUM), while IBB manages $9.40 B.
What sectors do the CANC and IBB ETFs invest in?
CANC leans toward sectors like Healthcare. Meanwhile, IBB focuses on Healthcare.
What are the top holdings of the CANC ETF and IBB ETF?
CANC top holdings include Revolution Medicines, Inc., Eli Lilly & Co. and Cogent Biosciences, Inc.. IBB holds in its top three: Vertex Pharmaceuticals, Inc., Amgen, Inc. and Gilead Sciences, Inc..
Which ETF is more diversified: CANC or IBB?
CANC holds 56 securities with 55.76% of its assets in the top 15. IBB has 242 securities and a top 15 weight of 53.71%.
Advertisement
Latest news about CANC & IBB
Small-Cap Biotech ETFs: High-Risk, High-Reward Opportunities
September 18, 2025
IBB
Are Biotechnology ETFs In the Midst of a Comeback?
August 20, 2025
IBB
Investing in the Aging Population: A Look at Bonds and Pharma ETFs
March 27, 2023
IBB
Health is Wealth: A look at the Healthcare Sector
January 24, 2023
IBB
Advertisement
Biotech ETFs – Investing in Health Innovation
July 21, 2022
IBB
Biotech ETFs – Investing in Health Innovation
July 21, 2022
IBB
Advertisement
