BBPvsSBIOETF Comparison
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Virtus LifeSci Biotech Products ETF (BBP) and ALPS Medical Breakthroughs ETF (SBIO) belong to the same industry segment: Tomorrow's Treatments. BBP's top 1 sector exposures are Healthcare. In contrast, SBIO's top sector exposures are Healthcare and Non-Corporate. BBP is less expensive with a Total Expense Ratio (TER) of 0.34%, versus 0.5% for SBIO. BBP is up 29.77% year-to-date (YTD) with +$50M in YTD flows. SBIO performs worse with 24.9% YTD performance, and +$75M in YTD flows. Run a side-by-side ETF comparison of BBP and SBIO below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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BBP vs SBIO performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 09/10/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | BBP SBIO | +2.31%-4.73% | +22.34%+26.53% | +29.77%+24.90% | +48.76%+75.78% | +95.24%+121.32% | +99.54%+43.40% |
| Flows | BBP SBIO | +$5M+$31M | +$20M+$51M | +$50M+$75M | +$62M+$84M | +$68M+$56M | +$61M+$17M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | BBP SBIO | +26.03%+32.19% | +25.17%+30.94% | +24.72%+31.10% | +26.61%+33.90% |
| Max drawdown | BBP SBIO | -9.34%-9.65% | -9.59%-12.63% | -25.54%-42.12% | -37.61%-52.50% |
| Max drawdown duration | BBP SBIO | 39d22d | 48d60d | 292d331d | 586d1479d |
Trading data
BBP | SBIO | |
Last sale 9/11/2026 at 1:30 PM | $103.46 | $63.29 |
| Previous close 09/10/2026 | $103.47 | $63.80 |
| Consolidated volume 09/10/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of August 31, 2026
1-year trailing difference
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BBP | SBIO | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 9/11/2026 at 1:30 PM
Live
Closed
BBP | SBIO | |
|---|---|---|
| Last price | $103.46 | $63.29 |
| 1D performance | -0.01% | -0.80% |
| AuM | $113.85 M | $234.69 M |
| E/R | 0.34% | 0.5% |
Characteristics
BBP | SBIO | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | VIRTUS Investment Partners | ALPS |
| Benchmark | LifeSci Biotechnology Products Index | S-Network Medical Breakthroughs Index |
| N° of holdings | 66 | 104 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | December 16, 2014 | December 30, 2014 |
| ESG | No | No |
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Exposure
Countries
BBP
USA
86.5%
Other
13.5%
SBIO
USA
89.23%
Other
10.77%
Sectors
BBP
Healthcare
98.2%
Other
1.8%
SBIO
Healthcare
100.02%
Other
-0.02%
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Diversification
BBP
Total weight of top 15 holdings out of 15
26.78%
SBIO
Total weight of top 15 holdings out of 15
42.78%
Top 15 holdings
Data as of July 31, 2026
BBP
Crinetics Pharmaceuticals, Inc.
3.24%
Verastem, Inc.
1.98%
Nuvation Bio, Inc.
1.80%
Omeros Corp.
1.73%
Geron Corp.
1.72%
BridgeBio Pharma, Inc.
1.68%
Agios Pharmaceuticals, Inc.
1.67%
Protagonist Therapeutics, Inc.
1.65%
BeOne Medicines Ltd.
1.64%
Kiniksa Pharmaceuticals International Plc
1.63%
Precigen, Inc.
1.62%
Xeris Biopharma Holdings, Inc.
1.61%
ACADIA Pharmaceuticals, Inc.
1.60%
Iovance Biotherapeutics, Inc.
1.60%
Rhythm Pharmaceuticals, Inc.
1.60%
SBIO
Crinetics Pharmaceuticals, Inc.
4.75%
Apogee Therapeutics, Inc.
4.48%
CG Oncology, Inc.
3.39%
Xenon Pharmaceuticals, Inc.
3.26%
Dianthus Therapeutics, Inc.
3.15%
Oruka Therapeutics, Inc.
3.14%
Travere Therapeutics, Inc.
2.80%
Definium Therapeutics, Inc.
2.56%
ACADIA Pharmaceuticals, Inc.
2.39%
Veradermics, Inc.
2.36%
Dyne Therapeutics, Inc.
2.25%
Edgewise Therapeutics, Inc.
2.23%
Relay Therapeutics, Inc.
2.22%
Denali Therapeutics, Inc.
1.97%
Structure Therapeutics, Inc.
1.84%
Frequently asked questions about BBP and SBIO
How have the BBP and SBIO ETFs performed in 2026?
As of September 10, 2026, BBP is up 29.77% year-to-date (YTD), while SBIO has returned 24.9%. That puts BBP better performer ahead so far this year.
Which ETF is attracting more investor money: BBP or SBIO?
Year-to-date, the BBP ETF saw +$50M in flows, compared to +$75M for SBIO.
Which ETF is more volatile: BBP or SBIO?
Over the past year, BBP had a volatility of 25.17%, while SBIO experienced 30.94%.
Which ETF is bigger: BBP or SBIO?
As of September 10, 2026, BBP holds $113.85 M in assets under management (AUM), while SBIO manages $234.69 M.
What sectors do the BBP and SBIO ETFs invest in?
BBP leans toward sectors like Healthcare. Meanwhile, SBIO focuses on Healthcare.
What are the top holdings of the BBP ETF and SBIO ETF?
BBP top holdings include Crinetics Pharmaceuticals, Inc., Verastem, Inc. and Nuvation Bio, Inc.. SBIO holds in its top three: Crinetics Pharmaceuticals, Inc., Apogee Therapeutics, Inc. and CG Oncology, Inc..
Which ETF is more diversified: BBP or SBIO?
BBP holds 66 securities with 26.78% of its assets in the top 15. SBIO has 104 securities and a top 15 weight of 42.78%.
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Latest news about BBP & SBIO
Small-Cap Biotech ETFs: High-Risk, High-Reward Opportunities
September 18, 2025
SBIO
Two biotech ETFs to watch for the rest of 2022 and beyond
September 13, 2022
SBIO
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