BBCvsSBIOETF Comparison
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Virtus LifeSci Biotech Clinical Trials ETF (BBC) and ALPS Medical Breakthroughs ETF (SBIO) belong to the same industry segment: Tomorrow's Treatments. BBC's top 1 sector exposures are Healthcare. In contrast, SBIO's top sector exposures are Healthcare and Non-Corporate. BBC is more expensive with a Total Expense Ratio (TER) of 0.65%, versus 0.5% for SBIO. BBC is up 10.7% year-to-date (YTD) with +$5M in YTD flows. SBIO performs worse with 8.39% YTD performance, and +$58M in YTD flows. Run a side-by-side ETF comparison of BBC and SBIO below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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BBC vs SBIO performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/27/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | BBC SBIO | -7.04%-5.02% | -13.67%-13.92% | +10.70%+8.39% | +36.99%+24.99% | +160.59%+144.50% | +1.02%+27.09% |
| Flows | BBC SBIO | --$14M | -+$17M | +$5M+$58M | +$12M+$90M | +$16M+$42M | +$8M+$2M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | BBC SBIO | +36.77%+32.48% | +36.97%+32.19% | +37.66%+31.51% | +40.00%+34.24% |
| Max drawdown | BBC SBIO | -29.70%-29.19% | -29.70%-29.19% | -54.25%-42.12% | -70.04%-52.50% |
| Max drawdown duration | BBC SBIO | 69d69d | 69d69d | 340d331d | 1625d1479d |
Trading data
BBC | SBIO | |
Last sale 10/27/2026 at 1:30 PM | $42.87 | $55.48 |
| Previous close 10/27/2026 | $41.06 | $53.78 |
| Consolidated volume 10/27/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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BBC | SBIO | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 10/27/2026 at 1:30 PM
Live
Closed
BBC | SBIO | |
|---|---|---|
| Last price | $42.87 | $55.48 |
| 1D performance | +4.40% | +3.16% |
| AuM | $40.68 M | $187.04 M |
| E/R | 0.65% | 0.5% |
Characteristics
BBC | SBIO | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | VIRTUS Investment Partners | ALPS |
| Benchmark | LifeSci Biotechnology Clinical Trials Index | S-Network Medical Breakthroughs Index |
| N° of holdings | 127 | 104 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | December 16, 2014 | December 30, 2014 |
| ESG | No | No |
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Exposure
Countries
BBC
USA
87.24%
Other
12.76%
SBIO
USA
89.31%
Other
10.69%
Sectors
BBC
Healthcare
96.27%
Other
3.73%
SBIO
Healthcare
100.01%
Other
-0.01%
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Diversification
BBC
Total weight of top 15 holdings out of 15
17.14%
SBIO
Total weight of top 15 holdings out of 15
41.55%
Top 15 holdings
Data as of August 31, 2026
BBC
Amylyx Pharmaceuticals, Inc.
1.50%
First Tracks Biotherapeutics, Inc.
1.48%
AbCellera Biologics, Inc.
1.38%
Xencor, Inc.
1.36%
Monopar Therapeutics, Inc.
1.12%
MBX Biosciences, Inc.
1.11%
uniQure NV
1.09%
Replimune Group, Inc.
1.06%
4D Molecular Therapeutics, Inc.
1.04%
SELLAS Life Sciences Group, Inc.
1.04%
Alto Neuroscience, Inc.
1.00%
LB Pharmaceuticals, Inc.
1.00%
Oric Pharmaceuticals, Inc.
0.99%
Zenas BioPharma, Inc.
0.98%
Cullinan Therapeutics, Inc.
0.98%
SBIO
Crinetics Pharmaceuticals, Inc.
4.60%
Apogee Therapeutics, Inc.
4.29%
CG Oncology, Inc.
3.41%
Travere Therapeutics, Inc.
3.16%
Xenon Pharmaceuticals, Inc.
2.99%
Dianthus Therapeutics, Inc.
2.96%
Oruka Therapeutics, Inc.
2.87%
ACADIA Pharmaceuticals, Inc.
2.54%
Edgewise Therapeutics, Inc.
2.31%
Definium Therapeutics, Inc.
2.23%
Dyne Therapeutics, Inc.
2.16%
Veradermics, Inc.
2.11%
Relay Therapeutics, Inc.
2.05%
Denali Therapeutics, Inc.
1.94%
Amylyx Pharmaceuticals, Inc.
1.93%
Frequently asked questions about BBC and SBIO
How have the BBC and SBIO ETFs performed in 2026?
As of October 27, 2026, BBC is up 10.7% year-to-date (YTD), while SBIO has returned 8.39%. That puts BBC better performer ahead so far this year.
Which ETF is attracting more investor money: BBC or SBIO?
Year-to-date, the BBC ETF saw +$5M in flows, compared to +$58M for SBIO.
Which ETF is more volatile: BBC or SBIO?
Over the past year, BBC had a volatility of 36.97%, while SBIO experienced 32.19%.
Which ETF is bigger: BBC or SBIO?
As of October 27, 2026, BBC holds $40.68 M in assets under management (AUM), while SBIO manages $187.04 M.
What sectors do the BBC and SBIO ETFs invest in?
BBC leans toward sectors like Healthcare. Meanwhile, SBIO focuses on Healthcare.
What are the top holdings of the BBC ETF and SBIO ETF?
BBC top holdings include Amylyx Pharmaceuticals, Inc., First Tracks Biotherapeutics, Inc. and AbCellera Biologics, Inc.. SBIO holds in its top three: Crinetics Pharmaceuticals, Inc., Apogee Therapeutics, Inc. and CG Oncology, Inc..
Which ETF is more diversified: BBC or SBIO?
BBC holds 127 securities with 17.14% of its assets in the top 15. SBIO has 104 securities and a top 15 weight of 41.55%.
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Latest news about BBC & SBIO
Small-Cap Biotech ETFs: High-Risk, High-Reward Opportunities
September 18, 2025
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Two biotech ETFs to watch for the rest of 2022 and beyond
September 13, 2022
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