BBCvsSBIOETF Comparison
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Virtus LifeSci Biotech Clinical Trials ETF (BBC) and ALPS Medical Breakthroughs ETF (SBIO) belong to the same industry segment: Tomorrow's Treatments. Both ETFs have the same top 3 sector exposures: and Healthcare. BBC is more expensive with a Total Expense Ratio (TER) of 0.65%, versus 0.5% for SBIO. BBC is up 28.23% year-to-date (YTD) with +$5M in YTD flows. SBIO performs worse with 25.91% YTD performance, and +$41M in YTD flows. Run a side-by-side ETF comparison of BBC and SBIO below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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BBC vs SBIO performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/27/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | BBC SBIO | -5.49%+0.08% | +8.79%+18.50% | +28.23%+25.91% | +126.14%+94.56% | +122.92%+116.75% | +14.49%+52.03% |
| Flows | BBC SBIO | +$83K+$17M | +$5M+$23M | +$5M+$41M | +$11M+$51M | +$15M+$20M | +$6M-$24M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | BBC SBIO | +38.48%+35.38% | +35.85%+30.61% | +37.04%+30.95% | +39.65%+33.95% |
| Max drawdown | BBC SBIO | -11.52%-10.73% | -14.64%-12.63% | -54.25%-42.12% | -70.93%-52.50% |
| Max drawdown duration | BBC SBIO | 44d43d | 60d60d | 340d331d | 1754d1479d |
Trading data
BBC | SBIO | |
Last sale 7/27/2026 at 7:57 PM | $49.74 | $63.49 |
| Previous close 07/27/2026 | $49.67 | $64.48 |
| Consolidated volume 07/27/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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BBC | SBIO | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 7/27/2026 at 7:57 PM
Live
Closed
BBC | SBIO | |
|---|---|---|
| Last price | $49.74 | $63.49 |
| 1D performance | +0.14% | -1.54% |
| AuM | $47.12 M | $204.41 M |
| E/R | 0.65% | 0.5% |
Characteristics
BBC | SBIO | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | VIRTUS Investment Partners | ALPS |
| Benchmark | LifeSci Biotechnology Clinical Trials Index | S-Network Medical Breakthroughs Index |
| N° of holdings | 125 | 103 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | December 16, 2014 | December 30, 2014 |
| ESG | No | No |
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Exposure
Countries
BBC
USA
85.4%
Other
14.6%
SBIO
USA
88.02%
Other
11.98%
Sectors
BBC
Healthcare
95.19%
Other
4.81%
SBIO
Healthcare
99.06%
Other
0.94%
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Diversification
BBC
Total weight of top 15 holdings out of 15
14.01%
SBIO
Total weight of top 15 holdings out of 15
40.08%
Top 15 holdings
Data as of June 30, 2026
BBC
uniQure NV
1.18%
REGENXBIO, Inc.
1.01%
Apogee Therapeutics, Inc.
0.99%
Monopar Therapeutics, Inc.
0.97%
Jade Biosciences, Inc.
0.94%
Aktis Oncology, Inc.
0.94%
MBX Biosciences, Inc.
0.94%
Biohaven Ltd.
0.90%
Kymera Therapeutics, Inc.
0.89%
Cullinan Therapeutics, Inc.
0.89%
SELLAS Life Sciences Group, Inc.
0.89%
Generate Biomedicines, Inc.
0.88%
Nurix Therapeutics, Inc.
0.87%
Intellia Therapeutics, Inc.
0.87%
4D Molecular Therapeutics, Inc.
0.86%
SBIO
Apogee Therapeutics, Inc.
4.36%
CG Oncology, Inc.
3.33%
Xenon Pharmaceuticals, Inc.
3.09%
Oruka Therapeutics, Inc.
3.05%
Dianthus Therapeutics, Inc.
2.83%
Travere Therapeutics, Inc.
2.80%
Definium Therapeutics, Inc.
2.73%
Veradermics, Inc.
2.72%
Edgewise Therapeutics, Inc.
2.32%
ACADIA Pharmaceuticals, Inc.
2.30%
Denali Therapeutics, Inc.
2.17%
Relay Therapeutics, Inc.
2.17%
NewAmsterdam Pharma Co. NV
2.10%
Crinetics Pharmaceuticals, Inc.
2.09%
Structure Therapeutics, Inc.
2.02%
Frequently asked questions about BBC and SBIO
How have the BBC and SBIO ETFs performed in 2026?
As of July 27, 2026, BBC is up 28.23% year-to-date (YTD), while SBIO has returned 25.91%. That puts BBC better performer ahead so far this year.
Which ETF is attracting more investor money: BBC or SBIO?
Year-to-date, the BBC ETF saw +$5M in flows, compared to +$41M for SBIO.
Which ETF is more volatile: BBC or SBIO?
Over the past year, BBC had a volatility of 35.85%, while SBIO experienced 30.61%.
Which ETF is bigger: BBC or SBIO?
As of July 27, 2026, BBC holds $47.12 M in assets under management (AUM), while SBIO manages $204.41 M.
What sectors do the BBC and SBIO ETFs invest in?
BBC leans toward sectors like Healthcare. Meanwhile, SBIO focuses on Healthcare.
What are the top holdings of the BBC ETF and SBIO ETF?
BBC top holdings include uniQure NV, REGENXBIO, Inc. and Apogee Therapeutics, Inc.. SBIO holds in its top three: Apogee Therapeutics, Inc., CG Oncology, Inc. and Xenon Pharmaceuticals, Inc..
Which ETF is more diversified: BBC or SBIO?
BBC holds 125 securities with 14.01% of its assets in the top 15. SBIO has 104 securities and a top 15 weight of 40.08%.
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Latest news about BBC & SBIO
Small-Cap Biotech ETFs: High-Risk, High-Reward Opportunities
September 18, 2025
BBC
SBIO
Two biotech ETFs to watch for the rest of 2022 and beyond
September 13, 2022
SBIO
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