BBCvsSBIOETF Comparison
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Virtus LifeSci Biotech Clinical Trials ETF (BBC) and ALPS Medical Breakthroughs ETF (SBIO) belong to the same industry segment: Tomorrow's Treatments. BBC's top 1 sector exposures are Healthcare. In contrast, SBIO's top sector exposures are Healthcare and Non-Corporate. BBC is more expensive with a Total Expense Ratio (TER) of 0.65%, versus 0.5% for SBIO. BBC is up 27.77% year-to-date (YTD) with +$5M in YTD flows. SBIO performs worse with 23.92% YTD performance, and +$75M in YTD flows. Run a side-by-side ETF comparison of BBC and SBIO below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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BBC vs SBIO performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 09/11/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | BBC SBIO | -5.78%-5.45% | +17.22%+21.45% | +27.77%+23.92% | +102.82%+71.89% | +137.50%+119.59% | +6.45%+42.12% |
| Flows | BBC SBIO | -+$31M | +$83K+$51M | +$5M+$75M | +$12M+$84M | +$16M+$56M | +$8M+$17M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | BBC SBIO | +33.39%+31.69% | +36.22%+30.93% | +37.22%+31.09% | +39.64%+33.90% |
| Max drawdown | BBC SBIO | -11.65%-10.36% | -14.64%-12.63% | -54.25%-42.12% | -70.43%-52.50% |
| Max drawdown duration | BBC SBIO | 23d23d | 60d60d | 340d331d | 1666d1479d |
Trading data
BBC | SBIO | |
Last sale 9/11/2026 at 1:30 PM | $49.39 | $63.29 |
| Previous close 09/10/2026 | $49.91 | $63.80 |
| Consolidated volume 09/10/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of August 31, 2026
1-year trailing difference
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BBC | SBIO | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 9/11/2026 at 1:30 PM
Live
Closed
BBC | SBIO | |
|---|---|---|
| Last price | $49.39 | $63.29 |
| 1D performance | -1.05% | -0.80% |
| AuM | $46.95 M | $232.85 M |
| E/R | 0.65% | 0.5% |
Characteristics
BBC | SBIO | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | VIRTUS Investment Partners | ALPS |
| Benchmark | LifeSci Biotechnology Clinical Trials Index | S-Network Medical Breakthroughs Index |
| N° of holdings | 127 | 104 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | December 16, 2014 | December 30, 2014 |
| ESG | No | No |
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Exposure
Countries
BBC
USA
86.49%
Other
13.51%
SBIO
USA
89.23%
Other
10.77%
Sectors
BBC
Healthcare
95.06%
Other
4.94%
SBIO
Healthcare
100.02%
Other
-0.02%
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Diversification
BBC
Total weight of top 15 holdings out of 15
15.32%
SBIO
Total weight of top 15 holdings out of 15
42.78%
Top 15 holdings
Data as of July 31, 2026
BBC
First Tracks Biotherapeutics, Inc.
1.57%
Monopar Therapeutics, Inc.
1.22%
MBX Biosciences, Inc.
1.14%
Zenas BioPharma, Inc.
1.09%
Xencor, Inc.
1.06%
Apogee Therapeutics, Inc.
1.00%
REGENXBIO, Inc.
0.96%
Oric Pharmaceuticals, Inc.
0.96%
Dyne Therapeutics, Inc.
0.93%
uniQure NV
0.91%
SELLAS Life Sciences Group, Inc.
0.91%
Nurix Therapeutics, Inc.
0.91%
Vor Biopharma, Inc.
0.89%
Erasca, Inc.
0.89%
Amylyx Pharmaceuticals, Inc.
0.88%
SBIO
Crinetics Pharmaceuticals, Inc.
4.75%
Apogee Therapeutics, Inc.
4.48%
CG Oncology, Inc.
3.39%
Xenon Pharmaceuticals, Inc.
3.26%
Dianthus Therapeutics, Inc.
3.15%
Oruka Therapeutics, Inc.
3.14%
Travere Therapeutics, Inc.
2.80%
Definium Therapeutics, Inc.
2.56%
ACADIA Pharmaceuticals, Inc.
2.39%
Veradermics, Inc.
2.36%
Dyne Therapeutics, Inc.
2.25%
Edgewise Therapeutics, Inc.
2.23%
Relay Therapeutics, Inc.
2.22%
Denali Therapeutics, Inc.
1.97%
Structure Therapeutics, Inc.
1.84%
Frequently asked questions about BBC and SBIO
How have the BBC and SBIO ETFs performed in 2026?
As of September 11, 2026, BBC is up 27.77% year-to-date (YTD), while SBIO has returned 23.92%. That puts BBC better performer ahead so far this year.
Which ETF is attracting more investor money: BBC or SBIO?
Year-to-date, the BBC ETF saw +$5M in flows, compared to +$75M for SBIO.
Which ETF is more volatile: BBC or SBIO?
Over the past year, BBC had a volatility of 36.22%, while SBIO experienced 30.93%.
Which ETF is bigger: BBC or SBIO?
As of September 11, 2026, BBC holds $46.95 M in assets under management (AUM), while SBIO manages $232.85 M.
What sectors do the BBC and SBIO ETFs invest in?
BBC leans toward sectors like Healthcare. Meanwhile, SBIO focuses on Healthcare.
What are the top holdings of the BBC ETF and SBIO ETF?
BBC top holdings include First Tracks Biotherapeutics, Inc., Monopar Therapeutics, Inc. and MBX Biosciences, Inc.. SBIO holds in its top three: Crinetics Pharmaceuticals, Inc., Apogee Therapeutics, Inc. and CG Oncology, Inc..
Which ETF is more diversified: BBC or SBIO?
BBC holds 127 securities with 15.32% of its assets in the top 15. SBIO has 104 securities and a top 15 weight of 42.78%.
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Latest news about BBC & SBIO
Small-Cap Biotech ETFs: High-Risk, High-Reward Opportunities
September 18, 2025
BBC
SBIO
Two biotech ETFs to watch for the rest of 2022 and beyond
September 13, 2022
SBIO
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