ARKGvsSBIOETF Comparison
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ARK Genomic Revolution ETF (ARKG) belongs to the BioTech & Genomics segment. ALPS Medical Breakthroughs ETF (SBIO) is part of the Tomorrow's Treatments segment. Both ETFs have the same top 3 sector exposures: and Healthcare. ARKG is more expensive with a Total Expense Ratio (TER) of 0.75%, versus 0.5% for SBIO. ARKG is up 29.47% year-to-date (YTD) with +$39M in YTD flows. SBIO performs worse with 24.58% YTD performance, and +$41M in YTD flows. Run a side-by-side ETF comparison of ARKG and SBIO below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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ARKG vs SBIO performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/24/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | ARKG SBIO | -1.87%+4.86% | +27.92%+17.16% | +29.47%+24.58% | +45.31%+91.81% | +4.16%+109.04% | -54.66%+48.00% |
| Flows | ARKG SBIO | +$81M+$18M | +$62M+$24M | +$39M+$41M | -$3M+$51M | -$550M+$20M | -$2.57B-$24M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | ARKG SBIO | +44.86%+35.36% | +42.64%+30.55% | +43.40%+30.92% | +45.98%+33.95% |
| Max drawdown | ARKG SBIO | -13.14%-10.73% | -27.52%-12.63% | -51.67%-42.12% | -79.29%-52.50% |
| Max drawdown duration | ARKG SBIO | 18d43d | 126d60d | 1058d331d | 1814d1479d |
Trading data
ARKG | SBIO | |
Last sale 7/27/2026 at 1:30 PM | $37.75 | $64.67 |
| Previous close 07/24/2026 | $37.81 | $63.77 |
| Consolidated volume 07/24/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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ARKG
is actively managed and doesn’t replicate an indexARKG | SBIO | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
| Worst | ||
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Main metrics
Last update 7/27/2026 at 1:30 PM
Live
Closed
ARKG | SBIO | |
|---|---|---|
| Last price | $37.75 | $64.67 |
| 1D performance | -0.16% | +1.41% |
| AuM | $1.53 B | $202.25 M |
| E/R | 0.75% | 0.5% |
Characteristics
ARKG | SBIO | |
|---|---|---|
| Management strategy | Active | Passive |
| Provider | Ark Investment | ALPS |
| Benchmark | - | S-Network Medical Breakthroughs Index |
| N° of holdings | 31 | 103 |
| Asset class | - | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | April 2, 2019 | December 30, 2014 |
| ESG | No | No |
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Exposure
Countries
ARKG
USA
86.99%
Other
13.01%
SBIO
USA
88.02%
Other
11.98%
Sectors
ARKG
Healthcare
96.93%
Other
3.07%
SBIO
Healthcare
99.06%
Other
0.94%
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Diversification
ARKG
Total weight of top 15 holdings out of 15
74.95%
SBIO
Total weight of top 15 holdings out of 15
40.08%
Top 15 holdings
Data as of June 30, 2026
ARKG
Twist Bioscience Corp.
9.15%
Tempus AI, Inc.
7.64%
Absci Corp.
7.01%
10X Genomics, Inc.
7.00%
CRISPR Therapeutics AG
6.56%
Personalis, Inc.
6.19%
Beam Therapeutics, Inc.
4.34%
Guardant Health, Inc.
4.28%
Natera, Inc.
4.11%
Illumina, Inc.
3.98%
Veracyte, Inc.
3.24%
CareDx, Inc.
3.08%
Recursion Pharmaceuticals, Inc.
2.85%
Eli Lilly & Co.
2.81%
Compass Pathways Plc
2.70%
SBIO
Apogee Therapeutics, Inc.
4.36%
CG Oncology, Inc.
3.33%
Xenon Pharmaceuticals, Inc.
3.09%
Oruka Therapeutics, Inc.
3.05%
Dianthus Therapeutics, Inc.
2.83%
Travere Therapeutics, Inc.
2.80%
Definium Therapeutics, Inc.
2.73%
Veradermics, Inc.
2.72%
Edgewise Therapeutics, Inc.
2.32%
ACADIA Pharmaceuticals, Inc.
2.30%
Denali Therapeutics, Inc.
2.17%
Relay Therapeutics, Inc.
2.17%
NewAmsterdam Pharma Co. NV
2.10%
Crinetics Pharmaceuticals, Inc.
2.09%
Structure Therapeutics, Inc.
2.02%
Frequently asked questions about ARKG and SBIO
How have the ARKG and SBIO ETFs performed in 2026?
As of July 24, 2026, ARKG is up 29.47% year-to-date (YTD), while SBIO has returned 24.58%. That puts ARKG better performer ahead so far this year.
Which ETF is attracting more investor money: ARKG or SBIO?
Year-to-date, the ARKG ETF saw +$39M in flows, compared to +$41M for SBIO.
Which ETF is more volatile: ARKG or SBIO?
Over the past year, ARKG had a volatility of 42.64%, while SBIO experienced 30.55%.
Which ETF is bigger: ARKG or SBIO?
As of July 24, 2026, ARKG holds $1.53 B in assets under management (AUM), while SBIO manages $202.25 M.
What sectors do the ARKG and SBIO ETFs invest in?
ARKG leans toward sectors like Healthcare. Meanwhile, SBIO focuses on Healthcare.
What are the top holdings of the ARKG ETF and SBIO ETF?
ARKG top holdings include Twist Bioscience Corp., Tempus AI, Inc. and Absci Corp.. SBIO holds in its top three: Apogee Therapeutics, Inc., CG Oncology, Inc. and Xenon Pharmaceuticals, Inc..
Which ETF is more diversified: ARKG or SBIO?
ARKG holds 31 securities with 74.95% of its assets in the top 15. SBIO has 104 securities and a top 15 weight of 40.08%.
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