XPHvsBBCETF Comparison
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State Street SPDR S&P Pharmaceuticals ETF (XPH) belongs to the US Health Care segment. Virtus LifeSci Biotech Clinical Trials ETF (BBC) is part of the Tomorrow's Treatments segment. Both ETFs have the same top 1 sector exposures: Healthcare. XPH is less expensive with a Total Expense Ratio (TER) of 0.35%, versus 0.65% for BBC. XPH is up 12.48% year-to-date (YTD) with +$186M in YTD flows. BBC performs worse with 6.45% YTD performance, and +$5M in YTD flows. Run a side-by-side ETF comparison of XPH and BBC below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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XPH vs BBC performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 10/26/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | XPH BBC | -5.82%-10.61% | -8.05%-16.99% | +12.48%+6.45% | +28.86%+31.73% | +80.65%+143.56% | +39.77%-4.51% |
| Flows | XPH BBC | -$80M- | +$11M- | +$186M+$5M | +$206M+$12M | +$160M+$16M | +$157M+$8M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | XPH BBC | +22.75%+36.10% | +23.36%+36.84% | +20.82%+37.63% | +21.10%+39.97% |
| Max drawdown | XPH BBC | -16.58%-29.70% | -16.58%-29.70% | -23.45%-54.25% | -30.87%-70.04% |
| Max drawdown duration | XPH BBC | 68d68d | 68d68d | 322d340d | 1452d1625d |
Trading data
XPH | BBC | |
Last sale 10/27/2026 at 1:30 PM | $63.96 | $42.87 |
| Previous close 10/26/2026 | $62.90 | $41.06 |
| Consolidated volume 10/26/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of September 30, 2026
1-year trailing difference
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XPH | BBC | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
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Main metrics
Last update 10/27/2026 at 1:30 PM
Live
Closed
XPH | BBC | |
|---|---|---|
| Last price | $63.96 | $42.87 |
| 1D performance | +1.69% | +4.40% |
| AuM | $440.44 M | $39.12 M |
| E/R | 0.35% | 0.65% |
Characteristics
XPH | BBC | |
|---|---|---|
| Management strategy | Passive | Passive |
| Provider | State Street Investment Management | VIRTUS Investment Partners |
| Benchmark | S&P Pharmaceuticals Select Industry Index | LifeSci Biotechnology Clinical Trials Index |
| N° of holdings | 62 | 127 |
| Asset class | Equities | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | June 19, 2006 | December 16, 2014 |
| ESG | No | No |
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Exposure
Countries
XPH
USA
89.77%
Other
10.23%
BBC
USA
87.24%
Other
12.76%
Sectors
XPH
Healthcare
93.27%
Other
6.73%
BBC
Healthcare
96.27%
Other
3.73%
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Diversification
XPH
Total weight of top 15 holdings out of 15
34.13%
BBC
Total weight of top 15 holdings out of 15
17.14%
Top 15 holdings
Data as of August 31, 2026
XPH
Amylyx Pharmaceuticals, Inc.
3.65%
Crinetics Pharmaceuticals, Inc.
3.60%
MBX Biosciences, Inc.
2.89%
Omeros Corp.
2.68%
Enliven Therapeutics, Inc.
2.28%
Nuvation Bio, Inc.
2.12%
Corcept Therapeutics, Inc.
2.11%
Eton Pharmaceuticals, Inc.
2.08%
Perrigo Co. Plc
1.91%
Edgewise Therapeutics, Inc.
1.85%
Nektar Therapeutics
1.83%
Merck & Co., Inc.
1.81%
Trevi Therapeutics, Inc.
1.80%
Tarsus Pharmaceuticals, Inc.
1.76%
Bristol Myers Squibb Co.
1.75%
BBC
Amylyx Pharmaceuticals, Inc.
1.50%
First Tracks Biotherapeutics, Inc.
1.48%
AbCellera Biologics, Inc.
1.38%
Xencor, Inc.
1.36%
Monopar Therapeutics, Inc.
1.12%
MBX Biosciences, Inc.
1.11%
uniQure NV
1.09%
Replimune Group, Inc.
1.06%
4D Molecular Therapeutics, Inc.
1.04%
SELLAS Life Sciences Group, Inc.
1.04%
Alto Neuroscience, Inc.
1.00%
LB Pharmaceuticals, Inc.
1.00%
Oric Pharmaceuticals, Inc.
0.99%
Zenas BioPharma, Inc.
0.98%
Cullinan Therapeutics, Inc.
0.98%
Frequently asked questions about XPH and BBC
How have the XPH and BBC ETFs performed in 2026?
As of October 26, 2026, XPH is up 12.48% year-to-date (YTD), while BBC has returned 6.45%. That puts XPH better performer ahead so far this year.
Which ETF is attracting more investor money: XPH or BBC?
Year-to-date, the XPH ETF saw +$186M in flows, compared to +$5M for BBC.
Which ETF is more volatile: XPH or BBC?
Over the past year, XPH had a volatility of 23.36%, while BBC experienced 36.84%.
Which ETF is bigger: XPH or BBC?
As of October 26, 2026, XPH holds $440.44 M in assets under management (AUM), while BBC manages $39.12 M.
What sectors do the XPH and BBC ETFs invest in?
XPH leans toward sectors like Healthcare. Meanwhile, BBC focuses on Healthcare.
What are the top holdings of the XPH ETF and BBC ETF?
XPH top holdings include Amylyx Pharmaceuticals, Inc., Crinetics Pharmaceuticals, Inc. and MBX Biosciences, Inc.. BBC holds in its top three: Amylyx Pharmaceuticals, Inc., First Tracks Biotherapeutics, Inc. and AbCellera Biologics, Inc..
Which ETF is more diversified: XPH or BBC?
XPH holds 62 securities with 34.13% of its assets in the top 15. BBC has 127 securities and a top 15 weight of 17.14%.
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