OZEMvsBBCETF Comparison
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Roundhill GLP-1 & Weight Loss ETF (OZEM) and Virtus LifeSci Biotech Clinical Trials ETF (BBC) belong to the same industry segment: Tomorrow's Treatments. Both ETFs have the same top 3 sector exposures: and Healthcare. OZEM is less expensive with a Total Expense Ratio (TER) of 0.59%, versus 0.65% for BBC. OZEM is down -4.17% year-to-date (YTD) with +$22M in YTD flows. BBC performs better with 26.6% YTD performance, and +$5M in YTD flows. Run a side-by-side ETF comparison of OZEM and BBC below, and assess how they stack up in performance, liquidity, risk, exposure, holdings, and more, helping you select the best ETF for your investments.
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OZEM vs BBC performance and flow charts
Performance
Cumulative Flows
Historic performance and flows
Data as of 07/28/2026
| 1M | 3M | YTD | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|---|---|
| Perf. | OZEM BBC | +0.15%-6.69% | +6.60%+11.16% | -4.17%+26.60% | +24.59%+123.27% | n/a+112.66% | n/a+8.85% |
| Flows | OZEM BBC | +$10M+$83K | +$9M+$5M | +$22M+$5M | +$22M+$11M | -+$15M | -+$6M |
Volatility and drawdown
| 3M | 1Y | 3Y | 5Y | ||
|---|---|---|---|---|---|
| Volatility | OZEM BBC | +21.48%+37.92% | +22.70%+35.81% | n/a+37.00% | n/a+39.62% |
| Max drawdown | OZEM BBC | -6.63%-11.52% | -19.51%-14.64% | n/a-54.25% | n/a-70.93% |
| Max drawdown duration | OZEM BBC | 51d44d | 183d60d | n/a340d | n/a1754d |
Trading data
OZEM | BBC | |
Last sale 7/29/2026 at 1:30 PM | $32.66 | $48.43 |
| Previous close 07/28/2026 | $32.81 | $48.85 |
| Consolidated volume 07/28/2026 | ||
| Average volume 30 days | ||
| Average discount or premium 30 days | ||
| Average Bid/Ask spread 30 days |
Replication quality
Data as of June 30, 2026
1-year trailing difference
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OZEM
is actively managed and doesn’t replicate an indexOZEM | BBC | |
|---|---|---|
| Tracking error | ||
| Tracking difference | ||
| 1 year cumulative return difference | ||
| Best | ||
| Worst | ||
| Daily return difference | ||
| Average | ||
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Main metrics
Last update 7/29/2026 at 1:30 PM
Live
Closed
OZEM | BBC | |
|---|---|---|
| Last price | $32.66 | $48.43 |
| 1D performance | -0.46% | -0.85% |
| AuM | $63.07 M | $46.52 M |
| E/R | 0.59% | 0.65% |
Characteristics
OZEM | BBC | |
|---|---|---|
| Management strategy | Active | Passive |
| Provider | Roundhill Investments | VIRTUS Investment Partners |
| Benchmark | - | LifeSci Biotechnology Clinical Trials Index |
| N° of holdings | 24 | 125 |
| Asset class | - | Equities |
| Trailing 12m distribution yield | Join | Join |
| Inception date | May 21, 2024 | December 16, 2014 |
| ESG | No | No |
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Exposure
Countries
OZEM
USA
44.42%
Denmark
19.13%
China
16.37%
Other
20.08%
BBC
USA
85.4%
Other
14.6%
Sectors
OZEM
Healthcare
99.56%
Other
0.44%
BBC
Healthcare
95.19%
Other
4.81%
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Diversification
OZEM
Total weight of top 15 holdings out of 15
82.24%
BBC
Total weight of top 15 holdings out of 15
14.01%
Top 15 holdings
Data as of June 30, 2026
OZEM
Novo Nordisk A/S
13.29%
Eli Lilly & Co.
13.07%
Pfizer Inc.
6.58%
Kailera Therapeutics, Inc.
6.00%
Viking Therapeutics, Inc.
5.84%
CSPC Pharmaceutical Group Ltd.
5.22%
Chugai Pharmaceutical Co., Ltd.
4.53%
Ascletis Pharma, Inc.
3.95%
Zealand Pharma A/S
3.93%
AstraZeneca PLC
3.89%
Amgen, Inc.
3.89%
Hanmi Pharmaceutical Co., Ltd.
3.33%
Roche Holding AG
3.12%
Structure Therapeutics, Inc.
2.89%
MBX Biosciences, Inc.
2.71%
BBC
uniQure NV
1.18%
REGENXBIO, Inc.
1.01%
Apogee Therapeutics, Inc.
0.99%
Monopar Therapeutics, Inc.
0.97%
Jade Biosciences, Inc.
0.94%
Aktis Oncology, Inc.
0.94%
MBX Biosciences, Inc.
0.94%
Biohaven Ltd.
0.90%
Cullinan Therapeutics, Inc.
0.89%
Kymera Therapeutics, Inc.
0.89%
SELLAS Life Sciences Group, Inc.
0.89%
Generate Biomedicines, Inc.
0.88%
Intellia Therapeutics, Inc.
0.87%
Nurix Therapeutics, Inc.
0.87%
4D Molecular Therapeutics, Inc.
0.86%
Frequently asked questions about OZEM and BBC
How have the OZEM and BBC ETFs performed in 2026?
As of July 28, 2026, OZEM is down -4.17% year-to-date (YTD), while BBC has returned 26.6%. That puts BBC better performer ahead so far this year.
Which ETF is attracting more investor money: OZEM or BBC?
Year-to-date, the OZEM ETF saw +$22M in flows, compared to +$5M for BBC.
Which ETF is more volatile: OZEM or BBC?
Over the past year, OZEM had a volatility of 22.7%, while BBC experienced 35.81%.
Which ETF is bigger: OZEM or BBC?
As of July 28, 2026, OZEM holds $63.07 M in assets under management (AUM), while BBC manages $46.52 M.
What sectors do the OZEM and BBC ETFs invest in?
OZEM leans toward sectors like Healthcare. Meanwhile, BBC focuses on Healthcare.
What are the top holdings of the OZEM ETF and BBC ETF?
OZEM top holdings include Novo Nordisk A/S, Eli Lilly & Co. and Pfizer Inc.. BBC holds in its top three: uniQure NV, REGENXBIO, Inc. and Apogee Therapeutics, Inc..
Which ETF is more diversified: OZEM or BBC?
OZEM holds 24 securities with 82.24% of its assets in the top 15. BBC has 125 securities and a top 15 weight of 14.01%.
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Latest news about OZEM & BBC
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